Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport

ABSTRACT

Isolated nucleic acid molecules, designated MCT nucleic acid molecules, which encode novel MCT proteins from  Corynebacterium glutamicum  are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCT proteins, mutated MCT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from  C. glutamicum  based on genetic engineering of MCT genes in this organism.

RELATED APPLICATIONS

This application is a continuation of U.S. patent application Ser. No. 09/603,024, filed Jun. 23, 2000, which claims priority to prior filed U.S. Provisional Patent Application Ser. No. 60/141,031, filed Jun. 25, 1999, U.S. Provisional Patent Application Ser. No. 60/143,262, filed Jul. 9, 1999, U.S. Provisional Patent Application Ser. No. 60/151,281, filed Aug. 27, 1999, German Patent Application No. 19930487.4, filed Jul. 1, 1999, German Patent Application No. 19930489.0, filed Jul. 1, 1999, German Patent Application No. 19931549.3, filed Jul. 8, 1999, German Patent Application No. 19931550.7, filed Jul. 8, 1999, German Patent Application No. 19932134.5, filed Jul. 9, 1999, German Patent Application No. 19941379.7, filed Aug. 31, 1999, German Patent Application No. 19942088.2, filed Sep. 3, 1999, and German Patent Application No. 19942097.1, filed Sep. 3, 1999. The entire contents of all of the aforementioned applications are hereby expressly incorporated herein by this reference.

BACKGROUND OF THE INVENTION

Certain products and by-products of naturally-occurring metabolic processes in cells have utility in a wide array of industries, including the food, feed, cosmetics, and pharmaceutical industries. These molecules, collectively termed ‘fine chemicals’, include organic acids, both proteinogenic and non-proteinogenic amino acids, nucleotides and nucleosides, lipids and fatty acids, diols, carbohydrates, aromatic compounds, vitamins and cofactors, and enzymes. Their production is most conveniently performed through the large-scale culture of bacteria developed to produce and secrete large quantities of one or more desired molecules. One particularly useful organism for this purpose is Corynebacterium glutamicum, a gram positive, nonpathogenic bacterium. Through strain selection, a number of mutant strains have been developed which produce an array of desirable compounds. However, selection of strains improved for the production of a particular molecule is a time-consuming and difficult process.

SUMMARY OF THE INVENTION

The invention provides novel bacterial nucleic acid molecules which have a variety of uses. These uses include the identification of microorganisms which can be used to produce fine chemicals, the modulation of fine chemical production in C. glutamicum or related bacteria, the typing or identification of C. glutamicum or related bacteria, as reference points for mapping the C. glutamicum genome, and as markers for transformation. These novel nucleic acid molecules encode proteins, referred to herein as membrane construction and membrane transport (MCT) proteins.

C. glutamicum is a gram positive, aerobic bacterium which is commonly used in industry for the large-scale production of a variety of fine chemicals, and also for the degradation of hydrocarbons (such as in petroleum spills) and for the oxidation of terpenoids. The MCT nucleic acid molecules of the invention, therefore, can be used to identify microorganisms which can be used to produce fine chemicals, e.g., by fermentation processes. Modulation of the expression of the MCT nucleic acids of the invention, or modification of the sequence of the MCT nucleic acid molecules of the invention, can be used to modulate the production of one or more fine chemicals from a microorganism (e.g., to improve the yield or production of one or more fine chemicals from a Corynebacterium or Brevibacterium species).

The MCT nucleic acids of the invention may also be used to identify an organism as being Corynebacterium glutamicum or a close relative thereof, or to identify the presence of C. glutamicum or a relative thereof in a mixed population of microorganisms. The invention provides the nucleic acid sequences of a number of C. glutamicum genes; by probing the extracted genomic DNA of a culture of a unique or mixed population of microorganisms under stringent conditions with a probe spanning a region of a C. glutamicum gene which is unique to this organism, one can ascertain whether this organism is present. Although Corynebacterium glutamicum itself is nonpathogenic, it is related to species pathogenic in humans, such as Corynebacterium diphtheriae (the causative agent of diphtheria); the detection of such organisms is of significant clinical relevance.

The MCT nucleic acid molecules of the invention may also serve as reference points for mapping of the C. glutamicum genome, or of genomes of related organisms. Similarly, these molecules, or variants or portions thereof, may serve as markers for genetically engineered Corynebacterium or Brevibacterium species.

The MCT proteins encoded by the novel nucleic acid molecules of the invention are capable of, for example, performing a function involved in the metabolism (e.g., the biosynthesis or degradation) of compounds necessary for membrane biosynthesis, or of assisting in the transmembrane transport of one or more compounds either into or out of the cell. Given the availability of cloning vectors for use in Corynebacterium glutamicum, such as those disclosed in Sinskey et al., U.S. Pat. No. 4,649,119, and techniques for genetic manipulation of C. glutamicum and the related Brevibacterium species (e.g., lactofermentum) (Yoshihama et al, J. Bacteriol. 162: 591-597 (1985); Katsumata et al., J. Bacteriol. 159: 306-311 (1984); and Santamaria et al., J. Gen. Microbiol. 130: 2237-2246 (1984)), the nucleic acid molecules of the invention may be utilized in the genetic engineering of this organism to make it a better or more efficient producer of one or more fine chemicals. This improved production or efficiency of production of a fine chemical may be due to a direct effect of manipulation of a gene of the invention, or it may be due to an indirect effect of such manipulation.

There are a number of mechanisms by which the alteration of an MCT protein of the invention may directly affect the yield, production, and/or efficiency of production of a fine chemical from a C. glutamicum strain incorporating such an altered protein. Those MCT proteins involved in the export of fine chemical molecules from the cell may be increased in number or activity such that greater quantities of these compounds are secreted to the extracellular medium, from which they are more readily recovered. Similarly, those MCT proteins involved in the import of nutrients necessary for the biosynthesis of one or more fine chemicals (e.g., phosphate, sulfate, nitrogen compounds, etc.) may be increased in number or activity such that these precursors, cofactors, or intermediate compounds are increased in concentration within the cell. Further, fatty acids and lipids themselves are desirable fine chemicals; by optimizing the activity or increasing the number of one or more MCT proteins of the invention which participate in the biosynthesis of these compounds, or by impairing the activity of one or more MCT proteins which are involved in the degradation of these compounds, it may be possible to increase the yield, production, and/or efficiency of production of fatty acid and lipid molecules from C. glutamicum.

The mutagenesis of one or more MCT genes of the invention may also result in MCT proteins having altered activities which indirectly impact the production of one or more desired fine chemicals from C. glutamicum. For example, MCT proteins of the invention involved in the export of waste products may be increased in number or activity such that the normal metabolic wastes of the cell (possibly increased in quantity due to the overproduction of the desired fine chemical) are efficiently exported before they are able to damage nucleotides and proteins within the cell (which would decrease the viability of the cell) or to interfere with fine chemical biosynthetic pathways (which would decrease the yield, production, or efficiency of production of the desired fine chemical). Further, the relatively large intracellular quantities of the desired fine chemical may in itself be toxic to the cell, so by increasing the activity or number of transporters able to export this compound from the cell, one may increase the viability of the cell in culture, in turn leading to a greater number of cells in the culture producing the desired fine chemical. The MCT proteins of the invention may also be manipulated such that the relative amounts of different lipid and fatty acid molecules are produced. This may have a profound effect on the lipid composition of the membrane of the cell. Since each type of lipid has different physical properties, an alteration in the lipid composition of a membrane may significantly alter membrane fluidity. Changes in membrane fluidity can impact the transport of molecules across the membrane, as well as the integrity of the cell, both of which have a profound effect on the production of fine chemicals from C. glutamicum in large-scale fermentative culture.

The invention provides novel nucleic acid molecules which encode proteins, referred to herein as MCT proteins, which are capable of, for example, participating in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes. Nucleic acid molecules encoding an MCT protein are referred to herein as MCT nucleic acid molecules. In a preferred embodiment, the MCT protein participates in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes. Examples of such proteins include those encoded by the genes set forth in Table 1.

Accordingly, one aspect of the invention pertains to isolated nucleic acid molecules (e.g., cDNAs, DNAs, or RNAs) comprising a nucleotide sequence encoding an MCT protein or biologically active portions thereof, as well as nucleic acid fragments suitable as primers or hybridization probes for the detection or amplification of MCT-encoding nucleic acid (e.g., DNA or mRNA). In particularly preferred embodiments, the isolated nucleic acid molecule comprises one of the nucleotide sequences set forth in Appendix A or the coding region or a complement thereof of one of these nucleotide sequences. In other particularly preferred embodiments, the isolated nucleic acid molecule of the invention comprises a nucleotide sequence which hybridizes to or is at least about 50%, preferably at least about 60%, more preferably at least about 70%, 80% or 90%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more homologous to a nucleotide sequence set forth in Appendix A, or a portion thereof. In other preferred embodiments, the isolated nucleic acid molecule encodes one of the amino acid sequences set forth in Appendix B. The preferred MCT proteins of the present invention also preferably possess at least one of the MCT activities described herein.

In another embodiment, the isolated nucleic acid molecule encodes a protein or portion thereof wherein the protein or portion thereof includes an amino acid sequence which is sufficiently homologous to an amino acid sequence of Appendix B, e.g., sufficiently homologous to an amino acid sequence of Appendix B such that the protein or portion thereof maintains an MCT activity. Preferably, the protein or portion thereof encoded by the nucleic acid molecule maintains the ability to participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes. In one embodiment, the protein encoded by the nucleic acid molecule is at least about 50%, preferably at least about 60%, and more preferably at least about 70%, 80%, or 90% and most preferably at least about 95%, 96%, 97%, 98%, or 99% or more homologous to an amino acid sequence of Appendix B (e.g., an entire amino acid sequence selected from those sequences set forth in Appendix B). In another preferred embodiment, the protein is a full length C. glutamicum protein which is substantially homologous to an entire amino acid sequence of Appendix B (encoded by an open reading frame shown in Appendix A).

In another preferred embodiment, the isolated nucleic acid molecule is derived from C. glutamicum and encodes a protein (e.g., an MCT fusion protein) which includes a biologically active domain which is at least about 50% or more homologous to one of the amino acid sequences of Appendix B and is able to participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes, or has one or more of the activities set forth in Table 1, and which also includes heterologous nucleic acid sequences encoding a heterologous polypeptide or regulatory regions.

In another embodiment, the isolated nucleic acid molecule is at least 15 nucleotides in length and hybridizes under stringent conditions to a nucleic acid molecule comprising a nucleotide sequence of Appendix A. Preferably, the isolated nucleic acid molecule corresponds to a naturally-occurring nucleic acid molecule. More preferably, the isolated nucleic acid encodes a naturally-occurring C. glutamicum MCT protein, or a biologically active portion thereof.

Another aspect of the invention pertains to vectors, e.g., recombinant expression vectors, containing the nucleic acid molecules of the invention, and host cells into which such vectors have been introduced. In one embodiment, such a host cell is used to produce an MCT protein by culturing the host cell in a suitable medium. The MCT protein can be then isolated from the medium or the host cell.

Yet another aspect of the invention pertains to a genetically altered microorganism in which an MCT gene has been introduced or altered. In one embodiment, the genome of the microorganism has been altered by introduction of a nucleic acid molecule of the invention encoding wild-type or mutated MCT sequence as a transgene. In another embodiment, an endogenous MCT gene within the genome of the microorganism has been altered, e.g., functionally disrupted, by homologous recombination with an altered MCT gene. In another embodiment, an endogenous or introduced MCT gene in a microorganism has been altered by one or more point mutations, deletions, or inversions, but still encodes a functional MCT protein. In still another embodiment, one or more of the regulatory regions (e.g., a promoter, repressor, or inducer) of an MCT gene in a microorganism has been altered (e.g., by deletion, truncation, inversion, or point mutation) such that the expression of the MCT gene is modulated. In a preferred embodiment, the microorganism belongs to the genus Corynebacterium or Brevibacterium, with Corynebacterium glutamicum being particularly preferred. In a preferred embodiment, the microorganism is also utilized for the production of a desired compound, such as an amino acid, with lysine being particularly preferred.

In another aspect, the invention provides a method of identifying the presence or activity of Cornyebacterium diphtheriae in a subject. This method includes detection of one or more of the nucleic acid or amino acid sequences of the invention (e.g., the sequences set forth in Appendix A or Appendix B) in a subject, thereby detecting the presence or activity of Corynebacterium diphtheriae in the subject.

Still another aspect of the invention pertains to an isolated MCT protein or a portion, e.g., a biologically active portion, thereof. In a preferred embodiment, the isolated MCT protein or portion thereof can participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes. In another preferred embodiment, the isolated MCT protein or portion thereof is sufficiently homologous to an amino acid sequence of Appendix B such that the protein or portion thereof maintains the ability to participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes.

The invention also provides an isolated preparation of an MCT protein. In preferred embodiments, the MCT protein comprises an amino acid sequence of Appendix B. In another preferred embodiment, the invention pertains to an isolated full length protein which is substantially homologous to an entire amino acid sequence of Appendix B (encoded by an open reading frame set forth in Appendix A). In yet another embodiment, the protein is at least about 50%, preferably at least about 60%, and more preferably at least about 70%, 80%, or 90%, and most preferably at least about 95%, 96%, 97%, 98%, or 99% or more homologous to an entire amino acid sequence of Appendix B. In other embodiments, the isolated MCT protein comprises an amino acid sequence which is at least about 50% or more homologous to one of the amino acid sequences of Appendix B and is able to participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes, or has one or more of the activities set forth in Table 1.

Alternatively, the isolated MCT protein can comprise an amino acid sequence which is encoded by a nucleotide sequence which hybridizes, e.g., hybridizes under stringent conditions, or is at least about 50%, preferably at least about 60%, more preferably at least about 70%, 80%, or 90%, and even more preferably at least about 95%, 96%, 97%, 98,%, or 99% or more homologous, to a nucleotide sequence of Appendix B. It is also preferred that the preferred forms of MCT proteins also have one or more of the MCT bioactivities described herein.

The MCT polypeptide, or a biologically active portion thereof, can be operatively linked to a non-MCT polypeptide to form a fusion protein. In preferred embodiments, this fusion protein has an activity which differs from that of the MCT protein alone. In other preferred embodiments, this fusion protein participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes. In particularly preferred embodiments, integration of this fusion protein into a host cell modulates production of a desired compound from the cell.

In another aspect, the invention provides methods for screening molecules which modulate the activity of an MCT protein, either by interacting with the protein itself or a substrate or binding partner of the MCT protein, or by modulating the transcription or translation of an MCT nucleic acid molecule of the invention.

Another aspect of the invention pertains to a method for producing a fine chemical. This method involves the culturing of a cell containing a vector directing the expression of an MCT nucleic acid molecule of the invention, such that a fine chemical is produced. In a preferred embodiment, this method further includes the step of obtaining a cell containing such a vector, in which a cell is transfected with a vector directing the expression of an MCT nucleic acid. In another preferred embodiment, this method further includes the step of recovering the fine chemical from the culture. In a particularly preferred embodiment, the cell is from the genus Corynebacterium or Brevibacterium, or is selected from those strains set forth in Table 3.

Another aspect of the invention pertains to methods for modulating production of a molecule from a microorganism. Such methods include contacting the cell with an agent which modulates MCT protein activity or MCT nucleic acid expression such that a cell associated activity is altered relative to this same activity in the absence of the agent. In a preferred embodiment, the cell is modulated for one or more C. glutamicum metabolic pathways for cell membrane components or is modulated for the transport of compounds across such membranes, such that the yields or rate of production of a desired fine chemical by this microorganism is improved. The agent which modulates MCT protein activity can be an agent which stimulates MCT protein activity or MCT nucleic acid expression. Examples of agents which stimulate MCT protein activity or MCT nucleic acid expression include small molecules, active MCT proteins, and nucleic acids encoding MCT proteins that have been introduced into the cell. Examples of agents which inhibit MCT activity or expression include small molecules and antisense MCT nucleic acid molecules.

Another aspect of the invention pertains to methods for modulating yields of a desired compound from a cell, involving the introduction of a wild-type or mutant MCT gene into a cell, either maintained on a separate plasmid or integrated into the genome of the host cell. If integrated into the genome, such integration can be random, or it can take place by homologous recombination such that the native gene is replaced by the introduced copy, causing the production of the desired compound from the cell to be modulated. In a preferred embodiment, said yields are increased. In another preferred embodiment, said chemical is a fine chemical. In a particularly preferred embodiment, said fine chemical is an amino acid. In especially preferred embodiments, said amino acid is L-lysine.

DETAILED DESCRIPTION OF THE INVENTION

The present invention provides MCT nucleic acid and protein molecules which are involved in the metabolism of cellular membrane components in C. glutamicum or in the transport of compounds across such membranes. The molecules of the invention may be utilized in the modulation of production of fine chemicals from microorganisms, such as C. glutamicum, either directly (e.g., where overexpression or optimization of a fatty acid biosynthesis protein has a direct impact on the yield, production, and/or efficiency of production of the fatty acid from modified C. glutamicum), or may have an indirect impact which nonetheless results in an increase of yield, production, and/or efficiency of production of the desired compound (e.g., where modulation of the metabolism of cell membrane components results in alterations in the yield, production, and/or efficiency of production or the composition of the cell membrane, which in turn may impact the production of one or more fine chemicals). Aspects of the invention are further explicated below.

I. Fine Chemicals

The term ‘fine chemical’ is art-recognized and includes molecules produced by an organism which have applications in various industries, such as, but not limited to, the pharmaceutical, agriculture, and cosmetics industries. Such compounds include organic acids, such as tartaric acid, itaconic acid, and diaminopimelic acid, both proteinogenic and non-proteinogenic amino acids, purine and pyrimidine bases, nucleosides, and nucleotides (as described e.g. in Kuninaka, A. (1996) Nucleotides and related compounds, p. 561-612, in Biotechnology vol. 6, Rehm et al., eds. VCH: Weinheim, and references contained therein), lipids, both saturated and unsaturated fatty acids (e.g., arachidonic acid), diols (e.g., propane diol, and butane diol), carbohydrates (e.g., hyaluronic acid and trehalose), aromatic compounds (e.g., aromatic amines, vanillin, and indigo), vitamins and cofactors (as described in Ullmann's Encyclopedia of Industrial Chemistry, vol. A27, “Vitamins”, p. 443-613 (1996) VCH: Weinheim and references therein; and Ong, A. S., Niki, E. & Packer, L. (1995) “Nutrition, Lipids, Health, and Disease” Proceedings of the UNESCO/Confederation of Scientific and Technological Associations in Malaysia, and the Society for Free Radical Research—Asia, held Sep. 1-3, 1994 at Penang, Malaysia, AOCS Press, (1995)), enzymes, polyketides (Cane et al. (1998) Science 282: 63-68), and all other chemicals described in Gutcho (1983) Chemicals by Fermentation, Noyes Data Corporation, ISBN: 0818805086 and references therein. The metabolism and uses of certain of these fine chemicals are further explicated below.

A. Amino Acid Metabolism and Uses

Amino acids comprise the basic structural units of all proteins, and as such are essential for normal cellular functioning in all organisms. The term “amino acid” is art-recognized. The proteinogenic amino acids, of which there are 20 species, serve as structural units for proteins, in which they are linked by peptide bonds, while the nonproteinogenic amino acids (hundreds of which are known) are not normally found in proteins (see Ulmann's Encyclopedia of Industrial Chemistry, vol. A2, p. 57-97 VCH: Weinheim (1985)). Amino acids may be in the D- or L-optical configuration, though L-amino acids are generally the only type found in naturally-occurring proteins. Biosynthetic and degradative pathways of each of the 20 proteinogenic amino acids have been well characterized in both prokaryotic and eukaryotic cells (see, for example, Stryer, L. Biochemistry, 3^(rd) edition, pages 578-590 (1988)). The ‘essential’ amino acids (histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine), so named because they are generally a nutritional requirement due to the complexity of their biosyntheses, are readily converted by simple biosynthetic pathways to the remaining 11 ‘nonessential’ amino acids (alanine, arginine, asparagine, aspartate, cysteine, glutamate, glutamine, glycine, proline, serine, and tyrosine). Higher animals do retain the ability to synthesize some of these amino acids, but the essential amino acids must be supplied from the diet in order for normal protein synthesis to occur.

Aside from their function in protein biosynthesis, these amino acids are interesting chemicals in their own right, and many have been found to have various applications in the food, feed, chemical, cosmetics, agriculture, and pharmaceutical industries. Lysine is an important amino acid in the nutrition not only of humans, but also of monogastric animals such as poultry and swine. Glutamate is most commonly used as a flavor additive (mono-sodium glutamate, MSG) and is widely used throughout the food industry, as are aspartate, phenylalanine, glycine, and cysteine. Glycine, L-methionine and tryptophan are all utilized in the pharmaceutical industry. Glutamine, valine, leucine, isoleucine, histidine, arginine, pro line, serine and alanine are of use in both the pharmaceutical and cosmetics industries. Threonine, tryptophan, and D/L-methionine are common feed additives. (Leuchtenberger, W. (1996) Amino aids-technical production and use, p. 466-502 in Rehm et al. (eds.) Biotechnology vol. 6, chapter 14a, VCH: Weinheim). Additionally, these amino acids have been found to be useful as precursors for the synthesis of synthetic amino acids and proteins, such as N-acetylcysteine, S-carboxymethyl-L-cysteine, (S)-5-hydroxytryptophan, and others described in Ulmann's Encyclopedia of Industrial Chemistry, vol. A2, p. 57-97, VCH: Weinheim, 1985.

The biosynthesis of these natural amino acids in organisms capable of producing them, such as bacteria, has been well characterized (for review of bacterial amino acid biosynthesis and regulation thereof, see Umbarger, H. E. (1978) Ann. Rev. Biochem. 47: 533-606). Glutamate is synthesized by the reductive amination of α-ketoglutarate, an intermediate in the citric acid cycle. Glutamine, proline, and arginine are each subsequently produced from glutamate. The biosynthesis of serine is a three-step process beginning with 3-phosphoglycerate (an intermediate in glycolysis), and resulting in this amino acid after oxidation, transamination, and hydrolysis steps. Both cysteine and glycine are produced from serine; the former by the condensation of homocysteine with serine, and the latter by the transferal of the side-chain β-carbon atom to tetrahydrofolate, in a reaction catalyzed by serine transhydroxymethylase. Phenylalanine, and tyrosine are synthesized from the glycolytic and pentose phosphate pathway precursors erythrose 4-phosphate and phosphoenolpyruvate in a 9-step biosynthetic pathway that differ only at the final two steps after synthesis of prephenate. Tryptophan is also produced from these two initial molecules, but its synthesis is an 11-step pathway. Tyrosine may also be synthesized from phenylalanine, in a reaction catalyzed by phenylalanine hydroxylase. Alanine, valine, and leucine are all biosynthetic products of pyruvate, the final product of glycolysis. Aspartate is formed from oxaloacetate, an intermediate of the citric acid cycle. Asparagine, methionine, threonine, and lysine are each produced by the conversion of aspartate. Isoleucine is formed from threonine. A complex 9-step pathway results in the production of histidine from 5-phosphoribosyl-1-pyrophosphate, an activated sugar.

Amino acids in excess of the protein synthesis needs of the cell cannot be stored, and are instead degraded to provide intermediates for the major metabolic pathways of the cell (for review see Stryer, L. Biochemistry 3^(rd) ed. Ch. 21 “Amino Acid Degradation and the Urea Cycle” p. 495-516 (1988)). Although the cell is able to convert unwanted amino acids into useful metabolic intermediates, amino acid production is costly in terms of energy, precursor molecules, and the enzymes necessary to synthesize them. Thus it is not surprising that amino acid biosynthesis is regulated by feedback inhibition, in which the presence of a particular amino acid serves to slow or entirely stop its own production (for overview of feedback mechanisms in amino acid biosynthetic pathways, see Stryer, L. Biochemistry, 3^(rd) ed. Ch. 24: “Biosynthesis of Amino Acids and Heme” p. 575-600 (1988)). Thus, the output of any particular amino acid is limited by the amount of that amino acid present in the cell.

B. Vitamin, Cofactor, and Nutraceutical Metabolism and Uses

Vitamins, cofactors, and nutraceuticals comprise another group of molecules which the higher animals have lost the ability to synthesize and so must ingest, although they are readily synthesized by other organisms such as bacteria. These molecules are either bioactive substances themselves, or are precursors of biologically active substances which may serve as electron carriers or intermediates in a variety of metabolic pathways. Aside from their nutritive value, these compounds also have significant industrial value as coloring agents, antioxidants, and catalysts or other processing aids. (For an overview of the structure, activity, and industrial applications of these compounds, see, for example, Ullman's Encyclopedia of Industrial Chemistry, “Vitamins” vol. A27, p. 443-613, VCH: Weinheim, 1996.) The term “vitamin” is art-recognized, and includes nutrients which are required by an organism for normal functioning, but which that organism cannot synthesize by itself. The group of vitamins may encompass cofactors and nutraceutical compounds. The language “cofactor” includes nonproteinaceous compounds required for a normal enzymatic activity to occur. Such compounds may be organic or inorganic; the cofactor molecules of the invention are preferably organic. The term “nutraceutical” includes dietary supplements having health benefits in plants and animals, particularly humans. Examples of such molecules are vitamins, antioxidants, and also certain lipids (e.g., polyunsaturated fatty acids).

The biosynthesis of these molecules in organisms capable of producing them, such as bacteria, has been largely characterized (Ullman's Encyclopedia of Industrial Chemistry, “Vitamins” vol. A27, p. 443-613, VCH: Weinheim, 1996; Michal, G. (1999) Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, John Wiley & Sons; Ong, A. S., Niki, E. & Packer, L. (1995) “Nutrition, Lipids, Health, and Disease” Proceedings of the UNESCO/Confederation of Scientific and Technological Associations in Malaysia, and the Society for Free Radical Research—Asia, held Sep. 1-3, 1994 at Penang, Malaysia, AOCS Press: Champaign, Ill. X, 374 S).

Thiamin (vitamin B₁) is produced by the chemical coupling of pyrimidine and thiazole moieties. Riboflavin (vitamin B₂) is synthesized from guanosine-5′-triphosphate (GTP) and ribose-5′-phosphate. Riboflavin, in turn, is utilized for the synthesis of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). The family of compounds collectively termed ‘vitamin B₆’ (e.g., pyridoxine, pyridoxamine, pyridoxa-5′-phosphate, and the commercially used pyridoxin hydrochloride) are all derivatives of the common structural unit, 5-hydroxy-6-methylpyridine. Pantothenate (pantothenic acid, (R)-(+)-N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine) can be produced either by chemical synthesis or by fermentation. The final steps in pantothenate biosynthesis consist of the ATP-driven condensation of β-alanine and pantoic acid. The enzymes responsible for the biosynthesis steps for the conversion to pantoic acid, to β-alanine and for the condensation to panthotenic acid are known. The metabolically active form of pantothenate is Coenzyme A, for which the biosynthesis proceeds in 5 enzymatic steps. Pantothenate, pyridoxal-5′-phosphate, cysteine and ATP are the precursors of Coenzyme A. These enzymes not only catalyze the formation of panthothante, but also the production of (R)-pantoic acid, (R)-pantolacton, (R)-panthenol (provitamin B₅), pantetheine (and its derivatives) and coenzyme A.

Biotin biosynthesis from the precursor molecule pimeloyl-CoA in microorganisms has been studied in detail and several of the genes involved have been identified. Many of the corresponding proteins have been found to also be involved in Fe-cluster synthesis and are members of the nifS class of proteins. Lipoic acid is derived from octanoic acid, and serves as a coenzyme in energy metabolism, where it becomes part of the pyruvate dehydrogenase complex and the α-ketoglutarate dehydrogenase complex. The folates are a group of substances which are all derivatives of folic acid, which is turn is derived from L-glutamic acid, p-amino-benzoic acid and 6-methylpterin. The biosynthesis of folic acid and its derivatives, starting from the metabolism intermediates guanosine-5′-triphosphate (GTP), L-glutamic acid and p-amino-benzoic acid has been studied in detail in certain microorganisms.

Corrinoids (such as the cobalamines and particularly vitamin B₁₂) and porphyrines belong to a group of chemicals characterized by a tetrapyrole ring system. The biosynthesis of vitamin B₁₂ is sufficiently complex that it has not yet been completely characterized, but many of the enzymes and substrates involved are now known. Nicotinic acid (nicotinate), and nicotinamide are pyridine derivatives which are also termed ‘niacin’. Niacin is the precursor of the important coenzymes NAD (nicotinamide adenine dinucleotide) and NADP (nicotinamide adenine dinucleotide phosphate) and their reduced forms.

The large-scale production of these compounds has largely relied on cell-free chemical syntheses, though some of these chemicals have also been produced by large-scale culture of microorganisms, such as riboflavin, Vitamin B₆, pantothenate, and biotin. Only Vitamin B₁₂ is produced solely by fermentation, due to the complexity of its synthesis. In vitro methodologies require significant inputs of materials and time, often at great cost.

C. Purine, Pyrimidine, Nucleoside and Nucleotide Metabolism and Uses

Purine and pyrimidine metabolism genes and their corresponding proteins are important targets for the therapy of tumor diseases and viral infections. The language “purine” or “pyrimidine” includes the nitrogenous bases which are constituents of nucleic acids, co-enzymes, and nucleotides. The term “nucleotide” includes the basic structural units of nucleic acid molecules, which are comprised of a nitrogenous base, a pentose sugar (in the case of RNA, the sugar is ribose; in the case of DNA, the sugar is D-deoxyribose), and phosphoric acid. The language “nucleoside” includes molecules which serve as precursors to nucleotides, but which are lacking the phosphoric acid moiety that nucleotides possess. By inhibiting the biosynthesis of these molecules, or their mobilization to form nucleic acid molecules, it is possible to inhibit RNA and DNA synthesis; by inhibiting this activity in a fashion targeted to cancerous cells, the ability of tumor cells to divide and replicate may be inhibited. Additionally, there are nucleotides which do not form nucleic acid molecules, but rather serve as energy stores (i.e., AMP) or as coenzymes (i.e., FAD and NAD).

Several publications have described the use of these chemicals for these medical indications, by influencing purine and/or pyrimidine metabolism (e.g. Christopherson, R. I., and Lyons, S. D. (1990) “Potent inhibitors of de novo pyrimidine and purine biosynthesis as chemotherapeutic agents.” Med. Res. Reviews 10: 505-548). Studies of enzymes involved in purine and pyrimidine metabolism have been focused on the development of new drugs which can be used, for example, as immunosuppressants or anti-proliferants (Smith, J. L., (1995) “Enzymes in nucleotide synthesis.” Curr. Opin. Struct. Biol. 5: 752-757; (1995) Biochem Soc. Transact. 23: 877-902). However, purine and pyrimidine bases, nucleosides and nucleotides have other utilities: as intermediates in the biosynthesis of several fine chemicals (e.g., thiamine, S-adenosyl-methionine, folates, or riboflavin), as energy carriers for the cell (e.g., ATP or GTP), and for chemicals themselves, commonly used as flavor enhancers (e.g., IMP or GMP) or for several medicinal applications (see, for example, Kuninaka, A. (1996) Nucleotides and Related Compounds in Biotechnology vol. 6, Rehm et al., eds. VCH: Weinheim, p. 561-612). Also, enzymes involved in purine, pyrimidine, nucleoside, or nucleotide metabolism are increasingly serving as targets against which chemicals for crop protection, including fungicides, herbicides and insecticides, are developed.

The metabolism of these compounds in bacteria has been characterized (for reviews see, for example, Zalkin, H. and Dixon, J. E. (1992) “de novo purine nucleotide biosynthesis”, in: Progress in Nucleic Acid Research and Molecular Biology, vol. 42, Academic Press: p. 259-287; and Michal, G. (1999) “Nucleotides and Nucleosides”, Chapter 8 in: Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, Wiley: New York). Purine metabolism has been the subject of intensive research, and is essential to the normal functioning of the cell. Impaired purine metabolism in higher animals can cause severe disease, such as gout. Purine nucleotides are synthesized from ribose-5-phosphate, in a series of steps through the intermediate compound inosine-5′-phosphate (IMP), resulting in the production of guanosine-5′-monophosphate (GMP) or adenosine-5′-monophosphate (AMP), from which the triphosphate forms utilized as nucleotides are readily formed. These compounds are also utilized as energy stores, so their degradation provides energy for many different biochemical processes in the cell. Pyrimidine biosynthesis proceeds by the formation of uridine-5′-monophosphate (UMP) from ribose-5-phosphate. UMP, in turn, is converted to cytidine-5′-triphosphate (CTP). The deoxy-forms of all of these nucleotides are produced in a one step reduction reaction from the diphosphate ribose form of the nucleotide to the diphosphate deoxyribose form of the nucleotide. Upon phosphorylation, these molecules are able to participate in DNA synthesis.

D. Trehalose Metabolism and Uses

Trehalose consists of two glucose molecules, bound in α, α-1,1 linkage. It is commonly used in the food industry as a sweetener, an additive for dried or frozen foods, and in beverages. However, it also has applications in the pharmaceutical, cosmetics and biotechnology industries (see, for example, Nishimoto et al., (1998) U.S. Pat. No. 5,759,610; Singer, M. A. and Lindquist, S. (1998) Trends Biotech. 16: 460-467; Paiva, C. L. A. and Panek, A. D. (1996) Biotech. Ann. Rev. 2: 293-314; and Shiosaka, M. (1997) J. Japan 172: 97-102). Trehalose is produced by enzymes from many microorganisms and is naturally released into the surrounding medium, from which it can be collected using methods known in the art.

II. Membrane Biosynthesis and Transmembrane Transport

Cellular membranes serve a variety of functions in a cell. First and foremost, a membrane differentiates the contents of a cell from the surrounding environment, thus giving integrity to the cell. Membranes may also serve as barriers to the influx of hazardous or unwanted compounds, and also to the efflux of desired compounds. Cellular membranes are by nature impervious to the unfacilitated diffusion of hydrophilic compounds such as proteins, water molecules and ions due to their structure: a bilayer of lipid molecules in which the polar head groups face outwards (towards the exterior and interior of the cell, respectively) and the nonpolar tails face inwards at the center of the bilayer, forming a hydrophobic core (for a general review of membrane structure and function, see Gennis, R. B. (1989) Biomembranes, Molecular Structure and Function, Springer: Heidelberg). This barrier enables cells to maintain a relatively higher concentration of desired compounds and a relatively lower concentration of undesired compounds than are contained within the surrounding medium, since the diffusion of these compounds is effectively blocked by the membrane. However, the membrane also presents an effective barrier to the import of desired compounds and the export of waste molecules. To overcome this difficulty, cellular membranes incorporate many kinds of transporter proteins which are able to facilitate the transmembrane transport of different kinds of compounds. There are two general classes of these transport proteins: pores or channels and transporters. The former are integral membrane proteins, sometimes complexes of proteins, which form a regulated hole through the membrane. This regulation, or ‘gating’ is generally specific to the molecules to be transported by the pore or channel, rendering these transmembrane constructs selectively permeable to a specific class of substrates; for example, a potassium channel is constructed such that only ions having a like charge and size to that of potassium may pass through. Channel and pore proteins tend to have discrete hydrophobic and hydrophilic domains, such that the hydrophobic face of the protein may associate with the interior of the membrane while the hydrophilic face lines the interior of the channel, thus providing a sheltered hydrophilic environment through which the selected hydrophilic molecule may pass. Many such pores/channels are known in the art, including those for potassium, calcium, sodium, and chloride ions.

This pore and channel-mediated system of facilitated diffusion is limited to very small molecules, such as ions, because pores or channels large enough to permit the passage of whole proteins by facilitated diffusion would be unable to prevent the passage of smaller hydrophilic molecules as well. Transport of molecules by this process is sometimes termed ‘facilitated diffusion’ since the driving force of a concentration gradient is required for the transport to occur. Permeases also permit facilitated diffusion of larger molecules, such as glucose or other sugars, into the cell when the concentration of these molecules on one side of the membrane is greater than that on the other (also called ‘uniport’). In contrast to pores or channels, these integral membrane proteins (often having between 6-14 membrane-spanning α-helices) do not form open channels through the membrane, but rather bind to the target molecule at the surface of the membrane and then undergo a conformational shift such that the target molecule is released on the opposite side of the membrane.

However, cells frequently require the import or export of molecules against the existing concentration gradient (‘active transport’), a situation in which facilitated diffusion cannot occur. There are two general mechanisms used by cells for such membrane transport: symport or antiport, and energy-coupled transport such as that mediated by the ABC transporters. Symport and antiport systems couple the movement of two different molecules across the membrane (via permeases having two separate binding sites for the two different molecules); in symport, both molecules are transported in the same direction, while in antiport, one molecule is imported while the other is exported. This is possible energetically because one of the two molecules moves in accordance with a concentration gradient, and this energetically favorable event is permitted only upon concomitant movement of a desired compound against the prevailing concentration gradient. Single molecules may be transported across the membrane against the concentration gradient in an energy-driven process, such as that utilized by the ABC transporters. In this system, the transport protein located in the membrane has an ATP-binding cassette; upon binding of the target molecule, the ATP is converted to ADP+Pi, and the resulting release of energy is used to drive the movement of the target molecule to the opposite face of the membrane, facilitated by the transporter. For more detailed descriptions of all of these transport systems, see: Bamberg, E. et al., (1993) “Charge transport of ion pumps on lipid bilayer membranes”, Q. Rev. Biophys. 26: 1-25; Findlay, J. B. C. (1991) “Structure and function in membrane transport systems”, Curr. Opin. Struct. Biol. 1: 804-810; Higgins, C. F. (1992) “ABC transporters from microorganisms to man”, Ann. Rev. Cell Biol. 8: 67-113; Gennis, R. B. (1989) “Pores, Channels and Transporters”, in: Biomembranes, Molecular Structure and Function, Springer: Heidelberg, p. 270-322; and Nikaido, H. and Saier, H. (1992) “Transport proteins in bacteria: common themes in their design”, Science 258: 936-942, and references contained within each of these references.

The synthesis of membranes is a well-characterized process involving a number of components, the most important of which are lipid molecules. Lipid synthesis may be divided into two parts: the synthesis of fatty acids and their attachment to sn-glycerol-3-phosphate, and the addition or modification of a polar head group. Typical lipids utilized in bacterial membranes include phospholipids, glycolipids, sphingolipids, and phosphoglycerides. Fatty acid synthesis begins with the conversion of acetyl CoA either to malonyl CoA by acetyl CoA carboxylase, or to acetyl-ACP by acetyltransacylase. Following a condensation reaction, these two product molecules together form acetoacetyl-ACP, which is converted by a series of condensation, reduction and dehydration reactions to yield a saturated fatty acid molecule having a desired chain length. The production of unsaturated fatty acids from such molecules is catalyzed by specific desaturases either aerobically, with the help of molecular oxygen, or anaerobically (for reference on fatty acid synthesis, see F. C. Neidhardt et al. (1996) E. coli and Salmonella. ASM Press: Washington, D.C., p. 612-636 and references contained therein; Lengeler et al. (eds) (1999) Biology of Procaryotes. Thieme: Stuttgart, N.Y., and references contained therein; and Magnuson, K. et al., (1993) Microbiological Reviews 57: 522-542, and references contained therein). The cyclopropane fatty acids (CFA) are synthesized by a specific CFA-synthase using SAM as a cosubstrate. Branched chain fatty acids are synthesized from branched chain amino acids that are deaminated to yield branched chain 2-oxo-acids (see Lengeler et al., eds. (1999) Biology of Procaryotes. Thieme: Stuttgart, N.Y., and references contained therein). Another essential step in lipid synthesis is the transfer of fatty acids onto the polar head groups by, for example, glycerol-phosphate-acyltransferases. The combination of various precursor molecules and biosynthetic enzymes results in the production of different fatty acid molecules, which has a profound effect on the composition of the membrane.

III. Elements and Methods of the Invention

The present invention is based, at least in part, on the discovery of novel molecules, referred to herein as MCT nucleic acid and protein molecules, which control the production of cellular membranes in C. glutamicum and govern the movement of molecules across such membranes. In one embodiment, the MCT molecules participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes. In a preferred embodiment, the activity of the MCT molecules of the present invention to regulate membrane component production and membrane transport has an impact on the production of a desired fine chemical by this organism. In a particularly preferred embodiment, the MCT molecules of the invention are modulated in activity, such that the C. glutamicum metabolic pathways which the MCT proteins of the invention regulate are modulated in yield, production, and/or efficiency of production and the transport of compounds through the membranes is altered in efficiency, which either directly or indirectly modulates the yield, production, and/or efficiency of production of a desired fine chemical by C. glutamicum.

The language, “MCT protein” or “MCT polypeptide” includes proteins which participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes. Examples of MCT proteins include those encoded by the MCT genes set forth in Table 1 and Appendix A. The terms “MCT gene” or “MCT nucleic acid sequence” include nucleic acid sequences encoding an MCT protein, which consist of a coding region and also corresponding untranslated 5′ and 3′ sequence regions. Examples of MCT genes include those set forth in Table 1. The terms “production” or “productivity” are art-recognized and include the concentration of the fermentation product (for example, the desired fine chemical) formed within a given time and a given fermentation volume (e.g., kg product per hour per liter). The term “efficiency of production” includes the time required for a particular level of production to be achieved (for example, how long it takes for the cell to attain a particular rate of output of a fine chemical). The term “yield” or “product/carbon yield” is art-recognized and includes the efficiency of the conversion of the carbon source into the product (i.e., fine chemical). This is generally written as, for example, kg product per kg carbon source. By increasing the yield or production of the compound, the quantity of recovered molecules, or of useful recovered molecules of that compound in a given amount of culture over a given amount of time is increased. The terms “biosynthesis” or a “biosynthetic pathway” are art-recognized and include the synthesis of a compound, preferably an organic compound, by a cell from intermediate compounds in what may be a multistep and highly regulated process. The terms “degradation” or a “degradation pathway” are art-recognized and include the breakdown of a compound, preferably an organic compound, by a cell to degradation products (generally speaking, smaller or less complex molecules) in what may be a multistep and highly regulated process. The language “metabolism” is art-recognized and includes the totality of the biochemical reactions that take place in an organism. The metabolism of a particular compound, then, (e.g., the metabolism of an amino acid such as glycine) comprises the overall biosynthetic, modification, and degradation pathways in the cell related to this compound.

In another embodiment, the MCT molecules of the invention are capable of modulating the production of a desired molecule, such as a fine chemical, in a microorganism such as C. glutamicum. There are a number of mechanisms by which the alteration of an MCT protein of the invention may directly affect the yield, production, and/or efficiency of production of a fine chemical from a C. glutamicum strain incorporating such an altered protein. Those MCT proteins involved in the export of fine chemical molecules from the cell may be increased in number or activity such that greater quantities of these compounds are secreted to the extracellular medium, from which they are more readily recovered. Similarly, those MCT proteins involved in the import of nutrients necessary for the biosynthesis of one or more fine chemicals (e.g., phosphate, sulfate, nitrogen compounds, etc.) may be increased in number or activity such that these precursor, cofactor, or intermediate compounds are increased in concentration within the cell. Further, fatty acids and lipids themselves are desirable fine chemicals; by optimizing the activity or increasing the number of one or more MCT proteins of the invention which participate in the biosynthesis of these compounds, or by impairing the activity of one or more MCT proteins which are involved in the degradation of these compounds, it may be possible to increase the yield, production, and/or efficiency of production of fatty acid and lipid molecules from C. glutamicum.

The mutagenesis of one or more MCT genes of the invention may also result in MCT proteins having altered activities which indirectly impact the production of one or more desired fine chemicals from C. glutamicum. For example, MCT proteins of the invention involved in the export of waste products may be increased in number or activity such that the normal metabolic wastes of the cell (possibly increased in quantity due to the overproduction of the desired fine chemical) are efficiently exported before they are able to damage nucleotides and proteins within the cell (which would decrease the viability of the cell) or to interfere with fine chemical biosynthetic pathways (which would decrease the yield, production, or efficiency of production of the desired fine chemical). Further, the relatively large intracellular quantities of the desired fine chemical may in itself be toxic to the cell, so by increasing the activity or number of transporters able to export this compound from the cell, one may increase the viability of the cell in culture, in turn leading to a greater number of cells in the culture producing the desired fine chemical. The MCT proteins of the invention may also be manipulated such that the relative amounts of different lipid and fatty acid molecules are produced. This may have a profound effect on the lipid composition of the membrane of the cell. Since each type of lipid has different physical properties, an alteration in the lipid composition of a membrane may significantly alter membrane fluidity. Changes in membrane fluidity can impact the transport of molecules across the membrane, as well as the integrity of the cell, both of which have a profound effect on the production of fine chemicals from C. glutamicum in large-scale fermentative culture.

The isolated nucleic acid sequences of the invention are contained within the genome of a Corynebacterium glutamicum strain available through the American Type Culture Collection, given designation ATCC 13032. The nucleotide sequence of the isolated C. glutamicum MCT DNAs and the predicted amino acid sequences of the C. glutamicum MCT proteins are shown in Appendices A and B, respectively. Computational analyses were performed which classified and/or identified these nucleotide sequences as sequences which encode proteins involved in the metabolism of cellular membrane components or proteins involved in the transport of compounds across such membranes.

The present invention also pertains to proteins which have an amino acid sequence which is substantially homologous to an amino acid sequence of Appendix B. As used herein, a protein which has an amino acid sequence which is substantially homologous to a selected amino acid sequence is least about 50% homologous to the selected amino acid sequence, e.g., the entire selected amino acid sequence. A protein which has an amino acid sequence which is substantially homologous to a selected amino acid sequence can also be least about 50-60%, preferably at least about 60-70%, and more preferably at least about 70-80%, 80-90%, or 90-95%, and most preferably at least about 96%, 97%, 98%, 99% or more homologous to the selected amino acid sequence.

The MCT protein or a biologically active portion or fragment thereof of the invention can participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes, or have one or more of the activities set forth in Table 1.

Various aspects of the invention are described in further detail in the following subsections:

A. Isolated Nucleic Acid Molecules

One aspect of the invention pertains to isolated nucleic acid molecules that encode MCT polypeptides or biologically active portions thereof, as well as nucleic acid fragments sufficient for use as hybridization probes or primers for the identification or amplification of MCT-encoding nucleic acid (e.g., MCT DNA). As used herein, the term “nucleic acid molecule” is intended to include DNA molecules (e.g., cDNA or genomic DNA) and RNA molecules (e.g., mRNA) and analogs of the DNA or RNA generated using nucleotide analogs. This term also encompasses untranslated sequence located at both the 3′ and 5′ ends of the coding region of the gene: at least about 100 nucleotides of sequence upstream from the 5′ end of the coding region and at least about 20 nucleotides of sequence downstream from the 3′end of the coding region of the gene. The nucleic acid molecule can be single-stranded or double-stranded, but preferably is double-stranded DNA. An “isolated” nucleic acid molecule is one which is separated from other nucleic acid molecules which are present in the natural source of the nucleic acid. Preferably, an “isolated” nucleic acid is free of sequences which naturally flank the nucleic acid (i.e., sequences located at the 5′ and 3′ ends of the nucleic acid) in the genomic DNA of the organism from which the nucleic acid is derived. For example, in various embodiments, the isolated MCT nucleic acid molecule can contain less than about 5 kb, 4 kb, 3 kb, 2 kb, 1 kb, 0.5 kb or 0.1 kb of nucleotide sequences which naturally flank the nucleic acid molecule in genomic DNA of the cell from which the nucleic acid is derived (e.g, a C. glutamicum cell). Moreover, an “isolated” nucleic acid molecule, such as a DNA molecule, can be substantially free of other cellular material, or culture medium when produced by recombinant techniques, or chemical precursors or other chemicals when chemically synthesized.

A nucleic acid molecule of the present invention, e.g., a nucleic acid molecule having a nucleotide sequence of Appendix A, or a portion thereof, can be isolated using standard molecular biology techniques and the sequence information provided herein. For example, a C. glutamicum MCT DNA can be isolated from a C. glutamicum library using all or portion of one of the sequences of Appendix A as a hybridization probe and standard hybridization techniques (e.g., as described in Sambrook, J., Fritsh, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual. 2nd, ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989). Moreover, a nucleic acid molecule encompassing all or a portion of one of the sequences of Appendix A can be isolated by the polymerase chain reaction using oligonucleotide primers designed based upon this sequence (e.g., a nucleic acid molecule encompassing all or a portion of one of the sequences of Appendix A can be isolated by the polymerase chain reaction using oligonucleotide primers designed based upon this same sequence of Appendix A). For example, mRNA can be isolated from normal endothelial cells (e.g., by the guanidinium-thiocyanate extraction procedure of Chirgwin et al. (1979) Biochemistry 18: 5294-5299) and DNA can be prepared using reverse transcriptase (e.g., Moloney MLV reverse transcriptase, available from Gibco/BRL, Bethesda, Md.; or AMV reverse transcriptase, available from Seikagaku America, Inc., St. Petersburg, Fla.). Synthetic oligonucleotide primers for polymerase chain reaction amplification can be designed based upon one of the nucleotide sequences shown in Appendix A. A nucleic acid of the invention can be amplified using cDNA or, alternatively, genomic DNA, as a template and appropriate oligonucleotide primers according to standard PCR amplification techniques. The nucleic acid so amplified can be cloned into an appropriate vector and characterized by DNA sequence analysis. Furthermore, oligonucleotides corresponding to an MCT nucleotide sequence can be prepared by standard synthetic techniques, e.g., using an automated DNA synthesizer.

In a preferred embodiment, an isolated nucleic acid molecule of the invention comprises one of the nucleotide sequences shown in Appendix A. The sequences of Appendix A correspond to the Corynebacterium glutamicum MCT DNAs of the invention. This DNA comprises sequences encoding MCT proteins (i.e., the “coding region”, indicated in each sequence in Appendix A), as well as 5′ untranslated sequences and 3′ untranslated sequences, also indicated in Appendix A. Alternatively, the nucleic acid molecule can comprise only the coding region of any of the sequences in Appendix A.

For the purposes of this application, it will be understood that each of the sequences set forth in Appendix A has an identifying RXA, RXN, or RXS number having the designation “RXA”, “RXN”, or “RXS” followed by 5 digits (i.e., RXA00775, RXN02994, or RXS03221). Each of these sequences comprises up to three parts: a 5′ upstream region, a coding region, and a downstream region. Each of these three regions is identified by the same RXA, RXN, or RXS designation to eliminate confusion. The recitation “one of the sequences in Appendix A”, then, refers to any of the sequences in Appendix A, which may be distinguished by their differing RXA, RXN, or RXS designations. The coding region of each of these sequences is translated into a corresponding amino acid sequence, which is set forth in Appendix B. The sequences of Appendix B are identified by the same RXA, RXN, or RXS designations as Appendix A, such that they can be readily correlated. For example, the amino acid sequences in Appendix B designated RXA00775, RXN02994, and RXS03221 are translations of the coding regions of the nucleotide sequence of nucleic acid molecules RXA00775, RXN02994, and RXS03221, respectively, in Appendix A. Each of the RXA, RXN, and RXS nucleotide and amino acid sequences of the invention has also been assigned a SEQ ID NO, as indicated in Table 1. For example, as set forth in Table 1, the nucleic acid sequence of RXA00774 is SEQ ID NO:7, and the amino acid sequence of RXA00774 is SEQ ID NO:8.

Several of the genes of the invention are “F-designated genes”. An F-designated gene includes those genes set forth in Table 1 which have an ‘F’ in front of the RXA, RXN, or RXS designation. For example, SEQ ID NO:21, designated, as indicated on Table 1, as “F RXA01245”, is an F-designated gene, as are SEQ ID NOs: 35, 39, and 43 (designated on Table 1 as “F RXA01164”, “F RXA01168”, and “F RXA02062”, respectively).

In one embodiment, the nucleic acid molecules of the present invention are not intended to include those compiled in Table 2. In the case of the dapD gene, a sequence for this gene was published in Wehrmann, A., et al. (1998) J. Bacteriol. 180 (12): 3159-3165. However, the sequence obtained by the inventors of the present application is significantly longer than the published version. It is believed that the published version relied on an incorrect start codon, and thus represents only a fragment of the actual coding region.

In another preferred embodiment, an isolated nucleic acid molecule of the invention comprises a nucleic acid molecule which is a complement of one of the nucleotide sequences shown in Appendix A, or a portion thereof. A nucleic acid molecule which is complementary to one of the nucleotide sequences shown in Appendix A is one which is sufficiently complementary to one of the nucleotide sequences shown in Appendix A such that it can hybridize to one of the nucleotide sequences shown in Appendix A, thereby forming a stable duplex.

In still another preferred embodiment, an isolated nucleic acid molecule of the invention comprises a nucleotide sequence which is at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more homologous to a nucleotide sequence shown in Appendix A, or a portion thereof. Ranges and identity values intermediate to the above-recited ranges, (e.g., 70-90% identical or 80-95% identical) are also intended to be encompassed by the present invention. For example, ranges of identity values using a combination of any of the above values recited as upper and/or lower limits are intended to be included. In an additional preferred embodiment, an isolated nucleic acid molecule of the invention comprises a nucleotide sequence which hybridizes, e.g., hybridizes under stringent conditions, to one of the nucleotide sequences shown in Appendix A, or a portion thereof.

Moreover, the nucleic acid molecule of the invention can comprise only a portion of the coding region of one of the sequences in Appendix A, for example a fragment which can be used as a probe or primer or a fragment encoding a biologically active portion of an MCT protein. The nucleotide sequences determined from the cloning of the MCT genes from C. glutamicum allows for the generation of probes and primers designed for use in identifying and/or cloning MCT homologues in other cell types and organisms, as well as MCT homologues from other Corynebacteria or related species. The probe/primer typically comprises substantially purified oligonucleotide. The oligonucleotide typically comprises a region of nucleotide sequence that hybridizes under stringent conditions to at least about 12, preferably about 25, more preferably about 40, 50 or 75 consecutive nucleotides of a sense strand of one of the sequences set forth in Appendix A, an anti-sense sequence of one of the sequences set forth in Appendix A, or naturally occurring mutants thereof. Primers based on a nucleotide sequence of Appendix A can be used in PCR reactions to clone MCT homologues. Probes based on the MCT nucleotide sequences can be used to detect transcripts or genomic sequences encoding the same or homologous proteins. In preferred embodiments, the probe further comprises a label group attached thereto, e.g. the label group can be a radioisotope, a fluorescent compound, an enzyme, or an enzyme co-factor. Such probes can be used as a part of a diagnostic test kit for identifying cells which misexpress an MCT protein, such as by measuring a level of an MCT-encoding nucleic acid in a sample of cells, e.g., detecting MCT mRNA levels or determining whether a genomic MCT gene has been mutated or deleted.

In one embodiment, the nucleic acid molecule of the invention encodes a protein or portion thereof which includes an amino acid sequence which is sufficiently homologous to an amino acid sequence of Appendix B such that the protein or portion thereof maintains the ability to participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes. As used herein, the language “sufficiently homologous” refers to proteins or portions thereof which have amino acid sequences which include a minimum number of identical or equivalent (e.g., an amino acid residue which has a similar side chain as an amino acid residue in one of the sequences of Appendix B) amino acid residues to an amino acid sequence of Appendix B such that the protein or portion thereof is able to participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes. Protein members of such membrane component metabolic pathways or membrane transport systems, as described herein, may play a role in the production and secretion of one or more fine chemicals. Examples of such activities are also described herein. Thus, “the function of an MCT protein” contributes either directly or indirectly to the yield, production, and/or efficiency of production of one or more fine chemicals. Examples of MCT protein activities are set forth in Table 1.

In another embodiment, the protein is at least about 50-60%, preferably at least about 60-70%, and more preferably at least about 70-80%, 80-90%, 90-95%, and most preferably at least about 96%, 97%, 98%, 99% or more homologous to an entire amino acid sequence of Appendix B.

Portions of proteins encoded by the MCT nucleic acid molecules of the invention are preferably biologically active portions of one of the MCT proteins. As used herein, the term “biologically active portion of an MCT protein” is intended to include a portion, e.g., a domain/motif, of an MCT protein that participates in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes, or has an activity as set forth in Table 1. To determine whether an MCT protein or a biologically active portion thereof can participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes, an assay of enzymatic activity may be performed. Such assay methods are well known to those of ordinary skill in the art, as detailed in Example 8 of the Exemplification.

Additional nucleic acid fragments encoding biologically active portions of an MCT protein can be prepared by isolating a portion of one of the sequences in Appendix B, expressing the encoded portion of the MCT protein or peptide (e.g., by recombinant expression in vitro) and assessing the activity of the encoded portion of the MCT protein or peptide.

The invention further encompasses nucleic acid molecules that differ from one of the nucleotide sequences shown in Appendix A (and portions thereof) due to degeneracy of the genetic code and thus encode the same MCT protein as that encoded by the nucleotide sequences shown in Appendix A. In another embodiment, an isolated nucleic acid molecule of the invention has a nucleotide sequence encoding a protein having an amino acid sequence shown in Appendix B. In a still further embodiment, the nucleic acid molecule of the invention encodes a full length C. glutamicum protein which is substantially homologous to an amino acid sequence of Appendix B (encoded by an open reading frame shown in Appendix A).

It will be understood by one of ordinary skill in the art that in one embodiment the sequences of the invention are not meant to include the sequences of the prior art, such as those Genbank sequences set forth in Tables 2 or 4 which were available prior to the present invention. In one embodiment, the invention includes nucleotide and amino acid sequences having a percent identity to a nucleotide or amino acid sequence of the invention which is greater than that of a sequence of the prior art (e.g., a Genbank sequence (or the protein encoded by such a sequence) set forth in Tables 2 or 4). For example, the invention includes a nucleotide sequence which is greater than and/or at least 50% identical to the nucleotide sequence designated RXA00777 (SEQ ID NO:5), a nucleotide sequence which is greater than and/or at least 40% identical to the nucleotide sequence designated RXA02439 (SEQ ID NO:17), and a nucleotide sequence which is greater than and/or at least 39% identical to the nucleotide sequence designated RXA00002 (SEQ ID NO:23). One of ordinary skill in the art would be able to calculate the lower threshold of percent identity for any given sequence of the invention by examining the GAP-calculated percent identity scores set forth in Table 4 for each of the three top hits for the given sequence, and by subtracting the highest GAP-calculated percent identity from 100 percent. One of ordinary skill in the art will also appreciate that nucleic acid and amino acid sequences having percent identities greater than the lower threshold so calculated (e.g., at least 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more identical) are also encompassed by the invention.

In addition to the C. glutamicum MCT nucleotide sequences shown in Appendix A, it will be appreciated by one of ordinary skill in the art that DNA sequence polymorphisms that lead to changes in the amino acid sequences of MCT proteins may exist within a population (e.g., the C. glutamicum population). Such genetic polymorphism in the MCT gene may exist among individuals within a population due to natural variation. As used herein, the terms “gene” and “recombinant gene” refer to nucleic acid molecules comprising an open reading frame encoding an MCT protein, preferably a C. glutamicum MCT protein. Such natural variations can typically result in 1-5% variance in the nucleotide sequence of the MCT gene. Any and all such nucleotide variations and resulting amino acid polymorphisms in MCT that are the result of natural variation and that do not alter the functional activity of MCT proteins are intended to be within the scope of the invention.

Nucleic acid molecules corresponding to natural variants and non-C. glutamicum homologues of the C. glutamicum MCT DNA of the invention can be isolated based on their homology to the C. glutamicum MCT nucleic acid disclosed herein using the C. glutamicum DNA, or a portion thereof, as a hybridization probe according to standard hybridization techniques under stringent hybridization conditions. Accordingly, in another embodiment, an isolated nucleic acid molecule of the invention is at least 15 nucleotides in length and hybridizes under stringent conditions to the nucleic acid molecule comprising a nucleotide sequence of Appendix A. In other embodiments, the nucleic acid is at least 30, 50, 100, 250 or more nucleotides in length. As used herein, the term “hybridizes under stringent conditions” is intended to describe conditions for hybridization and washing under which nucleotide sequences at least 60% homologous to each other typically remain hybridized to each other. Preferably, the conditions are such that sequences at least about 65%, more preferably at least about 70%, and even more preferably at least about 75% or more homologous to each other typically remain hybridized to each other. Such stringent conditions are known to those of ordinary skill in the art and can be found in Current Protocols in Molecular Biology, John Wiley & Sons, N.Y. (1989), 6.3.1-6.3.6. A preferred, non-limiting example of stringent hybridization conditions are hybridization in 6× sodium chloride/sodium citrate (SSC) at about 45° C., followed by one or more washes in 0.2×SSC, 0.1% SDS at 50-65° C. Preferably, an isolated nucleic acid molecule of the invention that hybridizes under stringent conditions to a sequence of Appendix A corresponds to a naturally-occurring nucleic acid molecule. As used herein, a “naturally-occurring” nucleic acid molecule refers to an RNA or DNA molecule having a nucleotide sequence that occurs in nature (e.g., encodes a natural protein). In one embodiment, the nucleic acid encodes a natural C. glutamicum MCT protein.

In addition to naturally-occurring variants of the MCT sequence that may exist in the population, one of ordinary skill in the art will further appreciate that changes can be introduced by mutation into a nucleotide sequence of Appendix A, thereby leading to changes in the amino acid sequence of the encoded MCT protein, without altering the functional ability of the MCT protein. For example, nucleotide substitutions leading to amino acid substitutions at “non-essential” amino acid residues can be made in a sequence of Appendix A. A “non-essential” amino acid residue is a residue that can be altered from the wild-type sequence of one of the MCT proteins (Appendix B) without altering the activity of said MCT protein, whereas an “essential” amino acid residue is required for MCT protein activity. Other amino acid residues, however, (e.g., those that are not conserved or only semi-conserved in the domain having MCT activity) may not be essential for activity and thus are likely to be amenable to alteration without altering MCT activity.

Accordingly, another aspect of the invention pertains to nucleic acid molecules encoding MCT proteins that contain changes in amino acid residues that are not essential for MCT activity. Such MCT proteins differ in amino acid sequence from a sequence contained in Appendix B yet retain at least one of the MCT activities described herein. In one embodiment, the isolated nucleic acid molecule comprises a nucleotide sequence encoding a protein, wherein the protein comprises an amino acid sequence at least about 50% homologous to an amino acid sequence of Appendix B and is capable of participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes, or has one or more activities set forth in Table 1. Preferably, the protein encoded by the nucleic acid molecule is at least about 50-60% homologous to one of the sequences in Appendix B, more preferably at least about 60-70% homologous to one of the sequences in Appendix B, even more preferably at least about 70-80%, 80-90%, 90-95% homologous to one of the sequences in Appendix B, and most preferably at least about 96%, 97%, 98%, or 99% homologous to one of the sequences in Appendix B.

To determine the percent homology of two amino acid sequences (e.g., one of the sequences of Appendix B and a mutant form thereof) or of two nucleic acids, the sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in the sequence of one protein or nucleic acid for optimal alignment with the other protein or nucleic acid). The amino acid residues or nucleotides at corresponding amino acid positions or nucleotide positions are then compared. When a position in one sequence (e.g., one of the sequences of Appendix B) is occupied by the same amino acid residue or nucleotide as the corresponding position in the other sequence (e.g., a mutant form of the sequence selected from Appendix B), then the molecules are homologous at that position (i.e., as used herein amino acid or nucleic acid “homology” is equivalent to amino acid or nucleic acid “identity”). The percent homology between the two sequences is a function of the number of identical positions shared by the sequences (i.e., % homology=# of identical positions/total # of positions×100).

An isolated nucleic acid molecule encoding an MCT protein homologous to a protein sequence of Appendix B can be created by introducing one or more nucleotide substitutions, additions or deletions into a nucleotide sequence of Appendix A such that one or more amino acid substitutions, additions or deletions are introduced into the encoded protein. Mutations can be introduced into one of the sequences of Appendix A by standard techniques, such as site-directed mutagenesis and PCR-mediated mutagenesis. Preferably, conservative amino acid substitutions are made at one or more predicted non-essential amino acid residues. A “conservative amino acid substitution” is one in which the amino acid residue is replaced with an amino acid residue having a similar side chain. Families of amino acid residues having similar side chains have been defined in the art. These families include amino acids with basic side chains (e.g., lysine, arginine, histidine), acidic side chains (e.g., aspartic acid, glutamic acid), uncharged polar side chains (e.g., glycine, asparagine, glutamine, serine, threonine, tyrosine, cysteine), nonpolar side chains (e.g., alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine, tryptophan), beta-branched side chains (e.g., threonine, valine, isoleucine) and aromatic side chains (e.g., tyrosine, phenylalanine, tryptophan, histidine). Thus, a predicted nonessential amino acid residue in an MCT protein is preferably replaced with another amino acid residue from the same side chain family. Alternatively, in another embodiment, mutations can be introduced randomly along all or part of an MCT coding sequence, such as by saturation mutagenesis, and the resultant mutants can be screened for an MCT activity described herein to identify mutants that retain MCT activity. Following mutagenesis of one of the sequences of Appendix A, the encoded protein can be expressed recombinantly and the activity of the protein can be determined using, for example, assays described herein (see Example 8 of the Exemplification).

In addition to the nucleic acid molecules encoding MCT proteins described above, another aspect of the invention pertains to isolated nucleic acid molecules which are antisense thereto. An “antisense” nucleic acid comprises a nucleotide sequence which is complementary to a “sense” nucleic acid encoding a protein, e.g., complementary to the coding strand of a double-stranded cDNA molecule or complementary to an mRNA sequence. Accordingly, an antisense nucleic acid can hydrogen bond to a sense nucleic acid. The antisense nucleic acid can be complementary to an entire MCT coding strand, or to only a portion thereof. In one embodiment, an antisense nucleic acid molecule is antisense to a “coding region” of the coding strand of a nucleotide sequence encoding an MCT protein. The term “coding region” refers to the region of the nucleotide sequence comprising codons which are translated into amino acid residues (e.g., the entire coding region of NO. 3 (RXA00777) comprises nucleotides 1 to 1065). In another embodiment, the antisense nucleic acid molecule is antisense to a “noncoding region” of the coding strand of a nucleotide sequence encoding MCT. The term “noncoding region” refers to 5′ and 3′ sequences which flank the coding region that are not translated into amino acids (i.e., also referred to as 5′ and 3′ untranslated regions).

Given the coding strand sequences encoding MCT disclosed herein (e.g., the sequences set forth in Appendix A), antisense nucleic acids of the invention can be designed according to the rules of Watson and Crick base pairing. The antisense nucleic acid molecule can be complementary to the entire coding region of MCT mRNA, but more preferably is an oligonucleotide which is antisense to only a portion of the coding or noncoding region of MCT mRNA. For example, the antisense oligonucleotide can be complementary to the region surrounding the translation start site of MCT mRNA. An antisense oligonucleotide can be, for example, about 5, 10, 15, 20, 25, 30, 35, 40, 45 or 50 nucleotides in length. An antisense nucleic acid of the invention can be constructed using chemical synthesis and enzymatic ligation reactions using procedures known in the art. For example, an antisense nucleic acid (e.g., an antisense oligonucleotide) can be chemically synthesized using naturally occurring nucleotides or variously modified nucleotides designed to increase the biological stability of the molecules or to increase the physical stability of the duplex formed between the antisense and sense nucleic acids, e.g., phosphorothioate derivatives and acridine substituted nucleotides can be used. Examples of modified nucleotides which can be used to generate the antisense nucleic acid include 5-fluorouracil, 5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xanthine, 4-acetylcytosine, 5-(carboxyhydroxylmethyl) uracil, 5-carboxymethylaminomethyl-2-thiouridine, 5-carboxymethylaminomethyluracil, dihydrouracil, beta-D-galactosylqueosine, inosine, N6-isopentenyladenine, 1-methylguanine, 1-methylinosine, 2,2-dimethylguanine, 2-methyladenine, 2-methylguanine, 3-methylcytosine, 5-methylcytosine, N6-adenine, 7-methylguanine, 5-methylaminomethyluracil, 5-methoxyaminomethyl-2-thiouracil, beta-D-mannosylqueosine, 5′-methoxycarboxymethyluracil, 5-methoxyuracil, 2-methylthio-N-6-isopentenyladenine, uracil-5-oxyacetic acid (v), wybutoxosine, pseudouracil, queosine, 2-thiocytosine, 5-methyl-2-thiouracil, 2-thiouracil, 4-thiouracil, 5-methyluracil, uracil-5-oxyacetic acid methylester, uracil-5-oxyacetic acid (v), 5-methyl-2-thiouracil, 3-(3-amino-3-N-2-carboxypropyl) uracil, (acp3)w, and 2,6-diaminopurine. Alternatively, the antisense nucleic acid can be produced biologically using an expression vector into which a nucleic acid has been subcloned in an antisense orientation (i.e., RNA transcribed from the inserted nucleic acid will be of an antisense orientation to a target nucleic acid of interest, described further in the following subsection).

The antisense nucleic acid molecules of the invention are typically administered to a cell or generated in situ such that they hybridize with or bind to cellular mRNA and/or genomic DNA encoding an MCT protein to thereby inhibit expression of the protein, e.g., by inhibiting transcription and/or translation. The hybridization can be by conventional nucleotide complementarity to form a stable duplex, or, for example, in the case of an antisense nucleic acid molecule which binds to DNA duplexes, through specific interactions in the major groove of the double helix. The antisense molecule can be modified such that it specifically binds to a receptor or an antigen expressed on a selected cell surface, e.g., by linking the antisense nucleic acid molecule to a peptide or an antibody which binds to a cell surface receptor or antigen. The antisense nucleic acid molecule can also be delivered to cells using the vectors described herein. To achieve sufficient intracellular concentrations of the antisense molecules, vector constructs in which the antisense nucleic acid molecule is placed under the control of a strong prokaryotic, viral, or eukaryotic promoter are preferred.

In yet another embodiment, the antisense nucleic acid molecule of the invention is an α-anomeric nucleic acid molecule. An α-anomeric nucleic acid molecule forms specific double-stranded hybrids with complementary RNA in which, contrary to the usual β-units, the strands run parallel to each other (Gaultier et al. (1987) Nucleic Acids. Res. 15: 6625-6641). The antisense nucleic acid molecule can also comprise a 2′-o-methylribonucleotide (Inoue et al. (1987) Nucleic Acids Res. 15: 6131-6148) or a chimeric RNA-DNA analogue (Inoue et al. (1987) FEBS Lett. 215: 327-330).

In still another embodiment, an antisense nucleic acid of the invention is a ribozyme. Ribozymes are catalytic RNA molecules with ribonuclease activity which are capable of cleaving a single-stranded nucleic acid, such as an mRNA, to which they have a complementary region. Thus, ribozymes (e.g., hammerhead ribozymes (described in Haselhoff and Gerlach (1988) Nature 334: 585-591)) can be used to catalytically cleave MCT mRNA transcripts to thereby inhibit translation of MCT mRNA. A ribozyme having specificity for an MCT-encoding nucleic acid can be designed based upon the nucleotide sequence of an MCT DNA disclosed herein (i.e., NO. 3 (RXA00777 in Appendix A)). For example, a derivative of a Tetrahymena L-19 IVS RNA can be constructed in which the nucleotide sequence of the active site is complementary to the nucleotide sequence to be cleaved in an MCT-encoding mRNA. See, e.g., Cech et al. U.S. Pat. No. 4,987,071 and Cech et al. U.S. Pat. No. 5,116,742. Alternatively, MCT mRNA can be used to select a catalytic RNA having a specific ribonuclease activity from a pool of RNA molecules. See, e.g., Bartel, D. and Szostak, J. W. (1993) Science 261: 1411-1418.

Alternatively, MCT gene expression can be inhibited by targeting nucleotide sequences complementary to the regulatory region of an MCT nucleotide sequence (e.g., an MCT promoter and/or enhancers) to form triple helical structures that prevent transcription of an MCT gene in target cells. See generally, Helene, C. (1991) Anticancer Drug Des. 6(6): 569-84; Helene, C. et al. (1992) Ann. N.Y. Acad. Sci. 660: 27-36; and Maher, L. J. (1992) Bioassays 14(12): 807-15.

B. Recombinant Expression Vectors and Host Cells

Another aspect of the invention pertains to vectors, preferably expression vectors, containing a nucleic acid encoding an MCT protein (or a portion thereof). As used herein, the term “vector” refers to a nucleic acid molecule capable of transporting another nucleic acid to which it has been linked. One type of vector is a “plasmid”, which refers to a circular double stranded DNA loop into which additional DNA segments can be ligated. Another type of vector is a viral vector, wherein additional DNA segments can be ligated into the viral genome. Certain vectors are capable of autonomous replication in a host cell into which they are introduced (e.g., bacterial vectors having a bacterial origin of replication and episomal mammalian vectors). Other vectors (e.g., non-episomal mammalian vectors) are integrated into the genome of a host cell upon introduction into the host cell, and thereby are replicated along with the host genome. Moreover, certain vectors are capable of directing the expression of genes to which they are operatively linked. Such vectors are referred to herein as “expression vectors”. In general, expression vectors of utility in recombinant DNA techniques are often in the form of plasmids. In the present specification, “plasmid” and “vector” can be used interchangeably as the plasmid is the most commonly used form of vector. However, the invention is intended to include such other forms of expression vectors, such as viral vectors (e.g., replication defective retroviruses, adenoviruses and adeno-associated viruses), which serve equivalent functions.

The recombinant expression vectors of the invention comprise a nucleic acid of the invention in a form suitable for expression of the nucleic acid in a host cell, which means that the recombinant expression vectors include one or more regulatory sequences, selected on the basis of the host cells to be used for expression, which is operatively linked to the nucleic acid sequence to be expressed. Within a recombinant expression vector, “operably linked” is intended to mean that the nucleotide sequence of interest is linked to the regulatory sequence(s) in a manner which allows for expression of the nucleotide sequence (e.g., in an in vitro transcription/translation system or in a host cell when the vector is introduced into the host cell). The term “regulatory sequence” is intended to include promoters, enhancers and other expression control elements (e.g., polyadenylation signals). Such regulatory sequences are described, for example, in Goeddel; Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, Calif. (1990). Regulatory sequences include those which direct constitutive expression of a nucleotide sequence in many types of host cell and those which direct expression of the nucleotide sequence only in certain host cells. Preferred regulatory sequences are, for example, promoters such as cos-, tac-, trp-, tet-, trp-tet-, lpp-, lac-, lpp-lac-, lacI^(q)-, T7-, T5-, T3-, gal-, trc-, ara-, SP6-, arny, SPO2, λ-P_(R)- or λ P_(L), which are used preferably in bacteria. Additional regulatory sequences are, for example, promoters from yeasts and fungi, such as ADC1, MFα, AC, P-60, CYC1, GAPDH, TEF, rp28, ADH, promoters from plants such as CaMV/35S, SSU, OCS, lib4, usp, STLS1, B33, nos or ubiquitin- or phaseolin-promoters. It is also possible to use artificial promoters. It will be appreciated by one of ordinary skill in the art that the design of the expression vector can depend on such factors as the choice of the host cell to be transformed, the level of expression of protein desired, etc. The expression vectors of the invention can be introduced into host cells to thereby produce proteins or peptides, including fusion proteins or peptides, encoded by nucleic acids as described herein (e.g., MCT proteins, mutant forms of MCT proteins, fusion proteins, etc.).

The recombinant expression vectors of the invention can be designed for expression of MCT proteins in prokaryotic or eukaryotic cells. For example, MCT genes can be expressed in bacterial cells such as C. glutamicum, insect cells (using baculovirus expression vectors), yeast and other fungal cells (see Romanos, M. A. et al. (1992) “Foreign gene expression in yeast: a review”, Yeast 8: 423-488; van den Hondel, C. A. M. J. J. et al. (1991) “Heterologous gene expression in filamentous fungi” in: More Gene Manipulations in Fungi, J. W. Bennet & L. L. Lasure, eds., p. 396-428: Academic Press: San Diego; and van den Hondel, C. A. M. J. J. & Punt, P. J. (1991) “Gene transfer systems and vector development for filamentous fungi, in: Applied Molecular Genetics of Fungi, Peberdy, J. F. et al., eds., p. 1-28, Cambridge University Press: Cambridge), algae and multicellular plant cells (see Schmidt, R. and Willmitzer, L. (1988) High efficiency Agrobacterium tumefaciens—mediated transformation of Arabidopsis thaliana leaf and cotyledon explants” Plant Cell Rep.: 583-586), or mammalian cells. Suitable host cells are discussed further in Goeddel, Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, Calif. (1990). Alternatively, the recombinant expression vector can be transcribed and translated in vitro, for example using T7 promoter regulatory sequences and T7 polymerase.

Expression of proteins in prokaryotes is most often carried out with vectors containing constitutive or inducible promoters directing the expression of either fusion or non-fusion proteins. Fusion vectors add a number of amino acids to a protein encoded therein, usually to the amino terminus of the recombinant protein but also to the C-terminus or fused within suitable regions in the proteins. Such fusion vectors typically serve three purposes: 1) to increase expression of recombinant protein; 2) to increase the solubility of the recombinant protein; and 3) to aid in the purification of the recombinant protein by acting as a ligand in affinity purification. Often, in fusion expression vectors, a proteolytic cleavage site is introduced at the junction of the fusion moiety and the recombinant protein to enable separation of the recombinant protein from the fusion moiety subsequent to purification of the fusion protein. Such enzymes, and their cognate recognition sequences, include Factor Xa, thrombin and enterokinase.

Typical fusion expression vectors include pGEX (Pharmacia Biotech Inc; Smith, D. B. and Johnson, K. S. (1988) Gene 67: 31-40), pMAL (New England Biolabs, Beverly, Mass.) and pRIT5 (Pharmacia, Piscataway, N.J.) which fuse glutathione S-transferase (GST), maltose E binding protein, or protein A, respectively, to the target recombinant protein. In one embodiment, the coding sequence of the MCT protein is cloned into a pGEX expression vector to create a vector encoding a fusion protein comprising, from the N-terminus to the C-terminus, GST-thrombin cleavage site-X protein. The fusion protein can be purified by affinity chromatography using glutathione-agarose resin. Recombinant MCT protein unfused to GST can be recovered by cleavage of the fusion protein with thrombin.

Examples of suitable inducible non-fusion E. coli expression vectors include pTrc (Amann et al., (1988) Gene 69: 301-315) pLG338, pACYC184, pBR322, pUC18, pUC19, pKC30, pRep4, pHS1, pHS2, pPLc236, pMBL24, pLG200, pUR290, pIN-III113-B1, λgt11, pBdCl, and pET 11d (Studier et al., Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, Calif. (1990) 60-89; and Pouwels et al., eds. (1985) Cloning Vectors. Elsevier: New York IBSN 0 444 904018). Target gene expression from the pTrc vector relies on host RNA polymerase transcription from a hybrid trp-lac fusion promoter. Target gene expression from the pET 11d vector relies on transcription from a T7 gn10-lac fusion promoter mediated by a coexpressed viral RNA polymerase (T7 gn1). This viral polymerase is supplied by host strains BL21(DE3) or HMS 174(DE3) from a resident λ prophage harboring a T7 gn1 gene under the transcriptional control of the lacUV 5 promoter. For transformation of other varieties of bacteria, appropriate vectors may be selected. For example, the plasmids pIJ101, pIJ364, pIJ702 and pIJ361 are known to be useful in transforming Streptomyces, while plasmids pUB110, pC194, or pBD214 are suited for transformation of Bacillus species. Several plasmids of use in the transfer of genetic information into Corynebacterium include pHM1519, pBL1, pSA77, or pAJ667 (Pouwels et al., eds. (1985) Cloning Vectors. Elsevier: New York IBSN 0 444 904018).

One strategy to maximize recombinant protein expression is to express the protein in a host bacteria with an impaired capacity to proteolytically cleave the recombinant protein (Gottesman, S., Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, Calif. (1990) 119-128). Another strategy is to alter the nucleic acid sequence of the nucleic acid to be inserted into an expression vector so that the individual codons for each amino acid are those preferentially utilized in the bacterium chosen for expression, such as C. glutamicum (Wada et al. (1992) Nucleic Acids Res. 20: 2111-2118). Such alteration of nucleic acid sequences of the invention can be carried out by standard DNA synthesis techniques.

In another embodiment, the MCT protein expression vector is a yeast expression vector. Examples of vectors for expression in yeast S. cerevisiae include pYepSec1 (Baldari, et al., (1987) Embo J. 6: 229-234), 2μ, pAG-1, Yep6, Yep13, pEMBLYe23, pMFa (Kurjan and Herskowitz, (1982) Cell 30: 933-943), pJRY88 (Schultz et al., (1987) Gene 54: 113-123), and pYES2 (Invitrogen Corporation, San Diego, Calif.). Vectors and methods for the construction of vectors appropriate for use in other fungi, such as the filamentous fungi, include those detailed in: van den Hondel, C. A. M. J. J. & Punt, P. J. (1991) “Gene transfer systems and vector development for filamentous fungi, in: Applied Molecular Genetics of Fungi, J. F. Peberdy, et al., eds., p. 1-28, Cambridge University Press: Cambridge, and Pouwels et al., eds. (1985) Cloning Vectors. Elsevier: New York (IBSN 0 444 904018).

Alternatively, the MCT proteins of the invention can be expressed in insect cells using baculovirus expression vectors. Baculovirus vectors available for expression of proteins in cultured insect cells (e.g., Sf9 cells) include the pAc series (Smith et al. (1983) Mol. Cell Biol. 3: 2156-2165) and the pVL series (Lucklow and Summers (1989) Virology 170: 31-39).

In another embodiment, the MCT proteins of the invention may be expressed in unicellular plant cells (such as algae) or in plant cells from higher plants (e.g., the spermatophytes, such as crop plants). Examples of plant expression vectors include those detailed in: Becker, D., Kemper, E., Schell, J. and Masterson, R. (1992) “New plant binary vectors with selectable markers located proximal to the left border”, Plant Mol. Biol. 20: 1195-1197; and Bevan, M. W. (1984) “Binary Agrobacterium vectors for plant transformation”, Nucl. Acid. Res. 12: 8711-8721, and include pLGV23, pGHlac+, pBIN19, pAK2004, and pDH51 (Pouwels et al., eds. (1985) Cloning Vectors. Elsevier: New York IBSN 0 444 904018).

In yet another embodiment, a nucleic acid of the invention is expressed in mammalian cells using a mammalian expression vector. Examples of mammalian expression vectors include pCDM8 (Seed, B. (1987) Nature 329: 840) and pMT2PC (Kaufman et al. (1987) EMBO J. 6: 187-195). When used in mammalian cells, the expression vector's control functions are often provided by viral regulatory elements. For example, commonly used promoters are derived from polyoma, Adenovirus 2, cytomegalovirus and Simian Virus 40. For other suitable expression systems for both prokaryotic and eukaryotic cells see chapters 16 and 17 of Sambrook, J., Fritsh, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual. 2nd, ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989.

In another embodiment, the recombinant mammalian expression vector is capable of directing expression of the nucleic acid preferentially in a particular cell type (e.g., tissue-specific regulatory elements are used to express the nucleic acid). Tissue-specific regulatory elements are known in the art. Non-limiting examples of suitable tissue-specific promoters include the albumin promoter (liver-specific; Pinkert et al. (1987) Genes Dev. 1: 268-277), lymphoid-specific promoters (Calame and Eaton (1988) Adv. Immunol. 43: 235-275), in particular promoters of T cell receptors (Winoto and Baltimore (1989) EMBO J. 8: 729-733) and immunoglobulins (Banerji et al. (1983) Cell 33: 729-740; Queen and Baltimore (1983) Cell 33: 741-748), neuron-specific promoters (e.g., the neurofilament promoter; Byrne and Ruddle (1989) PNAS 86: 5473-5477), pancreas-specific promoters (Edlund et al. (1985) Science 230: 912-916), and mammary gland-specific promoters (e.g., milk whey promoter; U.S. Pat. No. 4,873,316 and European Application Publication No. 264,166). Developmentally-regulated promoters are also encompassed, for example the murine hox promoters (Kessel and Gruss (1990) Science 249: 374-379) and the α-fetoprotein promoter (Campes and Tilghman (1989) Genes Dev. 3: 537-546).

The invention further provides a recombinant expression vector comprising a DNA molecule of the invention cloned into the expression vector in an antisense orientation. That is, the DNA molecule is operatively linked to a regulatory sequence in a manner which allows for expression (by transcription of the DNA molecule) of an RNA molecule which is antisense to MCT mRNA. Regulatory sequences operatively linked to a nucleic acid cloned in the antisense orientation can be chosen which direct the continuous expression of the antisense RNA molecule in a variety of cell types, for instance viral promoters and/or enhancers, or regulatory sequences can be chosen which direct constitutive, tissue specific or cell type specific expression of antisense RNA. The antisense expression vector can be in the form of a recombinant plasmid, phagemid or attenuated virus in which antisense nucleic acids are produced under the control of a high efficiency regulatory region, the activity of which can be determined by the cell type into which the vector is introduced. For a discussion of the regulation of gene expression using antisense genes see Weintraub, H. et al., Antisense RNA as a molecular tool for genetic analysis, Reviews—Trends in Genetics, Vol. 1(1) 1986.

Another aspect of the invention pertains to host cells into which a recombinant expression vector of the invention has been introduced. The terms “host cell” and “recombinant host cell” are used interchangeably herein. It is understood that such terms refer not only to the particular subject cell but to the progeny or potential progeny of such a cell. Because certain modifications may occur in succeeding generations due to either mutation or environmental influences, such progeny may not, in fact, be identical to the parent cell, but are still included within the scope of the term as used herein.

A host cell can be any prokaryotic or eukaryotic cell. For example, an MCT protein can be expressed in bacterial cells such as C. glutamicum, insect cells, yeast or mammalian cells (such as Chinese hamster ovary cells (CHO) or COS cells). Other suitable host cells are known to one of ordinary skill in the art. Microorganisms related to Corynebacterium glutamicum which may be conveniently used as host cells for the nucleic acid and protein molecules of the invention are set forth in Table 3.

Vector DNA can be introduced into prokaryotic or eukaryotic cells via conventional transformation or transfection techniques. As used herein, the terms “transformation” and “transfection”, “conjugation” and “transduction” are intended to refer to a variety of art-recognized techniques for introducing foreign nucleic acid (e.g., linear DNA or RNA (e.g., a linearized vector or a gene construct alone without a vector) or nucleic acid in the form of a vector (e.g., a plasmid, phage, phasmid, phagemid, transposon or other DNA) into a host cell, including calcium phosphate or calcium chloride co-precipitation, DEAE-dextran-mediated transfection, lipofection, natural competence, chemical-mediated transfer, or electroporation. Suitable methods for transforming or transfecting host cells can be found in Sambrook, et al. (Molecular Cloning: A Laboratory Manual. 2nd, ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989), and other laboratory manuals.

For stable transfection of mammalian cells, it is known that, depending upon the expression vector and transfection technique used, only a small fraction of cells may integrate the foreign DNA into their genome. In order to identify and select these integrants, a gene that encodes a selectable marker (e.g., resistance to antibiotics) is generally introduced into the host cells along with the gene of interest. Preferred selectable markers include those which confer resistance to drugs, such as G418, hygromycin and methotrexate. Nucleic acid encoding a selectable marker can be introduced into a host cell on the same vector as that encoding an MCT protein or can be introduced on a separate vector. Cells stably transfected with the introduced nucleic acid can be identified by, for example, drug selection (e.g., cells that have incorporated the selectable marker gene will survive, while the other cells die).

To create a homologous recombinant microorganism, a vector is prepared which contains at least a portion of an MCT gene into which a deletion, addition or substitution has been introduced to thereby alter, e.g., functionally disrupt, the MCT gene. Preferably, this MCT gene is a Corynebacterium glutamicum MCT gene, but it can be a homologue from a related bacterium or even from a mammalian, yeast, or insect source. In a preferred embodiment, the vector is designed such that, upon homologous recombination, the endogenous MCT gene is functionally disrupted (i.e., no longer encodes a functional protein; also referred to as a “knock out” vector). Alternatively, the vector can be designed such that, upon homologous recombination, the endogenous MCT gene is mutated or otherwise altered but still encodes functional protein (e.g., the upstream regulatory region can be altered to thereby alter the expression of the endogenous MCT protein). In the homologous recombination vector, the altered portion of the MCT gene is flanked at its 5′ and 3′ ends by additional nucleic acid of the MCT gene to allow for homologous recombination to occur between the exogenous MCT gene carried by the vector and an endogenous MCT gene in a microorganism. The additional flanking MCT nucleic acid is of sufficient length for successful homologous recombination with the endogenous gene. Typically, several kilobases of flanking DNA (both at the 5′ and 3′ ends) are included in the vector (see e.g., Thomas, K. R., and Capecchi, M. R. (1987) Cell 51: 503 for a description of homologous recombination vectors). The vector is introduced into a microorganism (e.g., by electroporation) and cells in which the introduced MCT gene has homologously recombined with the endogenous MCT gene are selected, using art-known techniques.

In another embodiment, recombinant microorganisms can be produced which contain selected systems which allow for regulated expression of the introduced gene. For example, inclusion of an MCT gene on a vector placing it under control of the lac operon permits expression of the MCT gene only in the presence of IPTG. Such regulatory systems are well known in the art.

In another embodiment, an endogenous MCT gene in a host cell is disrupted (e.g., by homologous recombination or other genetic means known in the art) such that expression of its protein product does not occur. In another embodiment, an endogenous or introduced MCT gene in a host cell has been altered by one or more point mutations, deletions, or inversions, but still encodes a functional MCT protein. In still another embodiment, one or more of the regulatory regions (e.g., a promoter, repressor, or inducer) of an MCT gene in a microorganism has been altered (e.g., by deletion, truncation, inversion, or point mutation) such that the expression of the MCT gene is modulated. One of ordinary skill in the art will appreciate that host cells containing more than one of the described MCT gene and protein modifications may be readily produced using the methods of the invention, and are meant to be included in the present invention.

A host cell of the invention, such as a prokaryotic or eukaryotic host cell in culture, can be used to produce (i.e., express) an MCT protein. Accordingly, the invention further provides methods for producing MCT proteins using the host cells of the invention. In one embodiment, the method comprises culturing the host cell of invention (into which a recombinant expression vector encoding an MCT protein has been introduced, or into which genome has been introduced a gene encoding a wild-type or altered MCT protein) in a suitable medium until MCT protein is produced. In another embodiment, the method further comprises isolating MCT proteins from the medium or the host cell.

C. Isolated MCT Proteins

Another aspect of the invention pertains to isolated MCT proteins, and biologically active portions thereof. An “isolated” or “purified” protein or biologically active portion thereof is substantially free of cellular material when produced by recombinant DNA techniques, or chemical precursors or other chemicals when chemically synthesized. The language “substantially free of cellular material” includes preparations of MCT protein in which the protein is separated from cellular components of the cells in which it is naturally or recombinantly produced. In one embodiment, the language “substantially free of cellular material” includes preparations of MCT protein having less than about 30% (by dry weight) of non-MCT protein (also referred to herein as a “contaminating protein”), more preferably less than about 20% of non-MCT protein, still more preferably less than about 10% of non-MCT protein, and most preferably less than about 5% non-MCT protein. When the MCT protein or biologically active portion thereof is recombinantly produced, it is also preferably substantially free of culture medium, i.e., culture medium represents less than about 20%, more preferably less than about 10%, and most preferably less than about 5% of the volume of the protein preparation. The language “substantially free of chemical precursors or other chemicals” includes preparations of MCT protein in which the protein is separated from chemical precursors or other chemicals which are involved in the synthesis of the protein. In one embodiment, the language “substantially free of chemical precursors or other chemicals” includes preparations of MCT protein having less than about 30% (by dry weight) of chemical precursors or non-MCT chemicals, more preferably less than about 20% chemical precursors or non-MCT chemicals, still more preferably less than about 10% chemical precursors or non-MCT chemicals, and most preferably less than about 5% chemical precursors or non-MCT chemicals. In preferred embodiments, isolated proteins or biologically active portions thereof lack contaminating proteins from the same organism from which the MCT protein is derived. Typically, such proteins are produced by recombinant expression of, for example, a C. glutamicum MCT protein in a microorganism such as C. glutamicum.

An isolated MCT protein or a portion thereof of the invention can participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes, or has one or more of the activities set forth in Table 1. In preferred embodiments, the protein or portion thereof comprises an amino acid sequence which is sufficiently homologous to an amino acid sequence of Appendix B such that the protein or portion thereof maintains the ability participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes. The portion of the protein is preferably a biologically active portion as described herein. In another preferred embodiment, an MCT protein of the invention has an amino acid sequence shown in Appendix B. In yet another preferred embodiment, the MCT protein has an amino acid sequence which is encoded by a nucleotide sequence which hybridizes, e.g., hybridizes under stringent conditions, to a nucleotide sequence of Appendix A. In still another preferred embodiment, the MCT protein has an amino acid sequence which is encoded by a nucleotide sequence that is at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more homologous to one of the nucleic acid sequences of Appendix A, or a portion thereof. Ranges and identity values intermediate to the above-recited values, (e.g., 70-90% identical or 80-95% identical) are also intended to be encompassed by the present invention. For example, ranges of identity values using a combination of any of the above values recited as upper and/or lower limits are intended to be included. The preferred MCT proteins of the present invention also preferably possess at least one of the MCT activities described herein. For example, a preferred MCT protein of the present invention includes an amino acid sequence encoded by a nucleotide sequence which hybridizes, e.g., hybridizes under stringent conditions, to a nucleotide sequence of Appendix A, and which can participate in the metabolism of compounds necessary for the construction of cellular membranes in C. glutamicum, or in the transport of molecules across these membranes, or which has one or more of the activities set forth in Table 1.

In other embodiments, the MCT protein is substantially homologous to an amino acid sequence of Appendix B and retains the functional activity of the protein of one of the sequences of Appendix B yet differs in amino acid sequence due to natural variation or mutagenesis, as described in detail in subsection I above. Accordingly, in another embodiment, the MCT protein is a protein which comprises an amino acid sequence which is at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more homologous to an entire amino acid sequence of Appendix B and which has at least one of the MCT activities described herein. Ranges and identity values intermediate to the above-recited values, (e.g., 70-90% identical or 80-95% identical) are also intended to be encompassed by the present invention. For example, ranges of identity values using a combination of any of the above values recited as upper and/or lower limits are intended to be included. In another embodiment, the invention pertains to a full length C. glutamicum protein which is substantially homologous to an entire amino acid sequence of Appendix B.

Biologically active portions of an MCT protein include peptides comprising amino acid sequences derived from the amino acid sequence of an MCT protein, e.g., the an amino acid sequence shown in Appendix B or the amino acid sequence of a protein homologous to an MCT protein, which include fewer amino acids than a full length MCT protein or the full length protein which is homologous to an MCT protein, and exhibit at least one activity of an MCT protein. Typically, biologically active portions (peptides, e.g., peptides which are, for example, 5, 10, 15, 20, 30, 35, 36, 37, 38, 39, 40, 50, 100 or more amino acids in length) comprise a domain or motif with at least one activity of an MCT protein. Moreover, other biologically active portions, in which other regions of the protein are deleted, can be prepared by recombinant techniques and evaluated for one or more of the activities described herein. Preferably, the biologically active portions of an MCT protein include one or more selected domains/motifs or portions thereof having biological activity.

MCT proteins are preferably produced by recombinant DNA techniques. For example, a nucleic acid molecule encoding the protein is cloned into an expression vector (as described above), the expression vector is introduced into a host cell (as described above) and the MCT protein is expressed in the host cell. The MCT protein can then be isolated from the cells by an appropriate purification scheme using standard protein purification techniques. Alternative to recombinant expression, an MCT protein, polypeptide, or peptide can be synthesized chemically using standard peptide synthesis techniques. Moreover, native MCT protein can be isolated from cells (e.g., endothelial cells), for example using an anti-MCT antibody, which can be produced by standard techniques utilizing an MCT protein or fragment thereof of this invention.

The invention also provides MCT chimeric or fusion proteins. As used herein, an MCT “chimeric protein” or “fusion protein” comprises an MCT polypeptide operatively linked to a non-MCT polypeptide. An “MCT polypeptide” refers to a polypeptide having an amino acid sequence corresponding to an MCT protein, whereas a “non-MCT polypeptide” refers to a polypeptide having an amino acid sequence corresponding to a protein which is not substantially homologous to the MCT protein, e.g., a protein which is different from the MCT protein and which is derived from the same or a different organism. Within the fusion protein, the term “operatively linked” is intended to indicate that the MCT polypeptide and the non-MCT polypeptide are fused in-frame to each other. The non-MCT polypeptide can be fused to the N-terminus or C-terminus of the MCT polypeptide. For example, in one embodiment the fusion protein is a GST-MCT fusion protein in which the MCT sequences are fused to the C-terminus of the GST sequences. Such fusion proteins can facilitate the purification of recombinant MCT proteins. In another embodiment, the fusion protein is an MCT protein containing a heterologous signal sequence at its N-terminus. In certain host cells (e.g., mammalian host cells), expression and/or secretion of an MCT protein can be increased through use of a heterologous signal sequence.

Preferably, an MCT chimeric or fusion protein of the invention is produced by standard recombinant DNA techniques. For example, DNA fragments coding for the different polypeptide sequences are ligated together in-frame in accordance with conventional techniques, for example by employing blunt-ended or stagger-ended termini for ligation, restriction enzyme digestion to provide for appropriate termini, filling-in of cohesive ends as appropriate, alkaline phosphatase treatment to avoid undesirable joining, and enzymatic ligation. In another embodiment, the fusion gene can be synthesized by conventional techniques including automated DNA synthesizers. Alternatively, PCR amplification of gene fragments can be carried out using anchor primers which give rise to complementary overhangs between two consecutive gene fragments which can subsequently be annealed and reamplified to generate a chimeric gene sequence (see, for example, Current Protocols in Molecular Biology, eds. Ausubel et al. John Wiley & Sons: 1992). Moreover, many expression vectors are commercially available that already encode a fusion moiety (e.g., a GST polypeptide). An MCT-encoding nucleic acid can be cloned into such an expression vector such that the fusion moiety is linked in-frame to the MCT protein.

Homologues of the MCT protein can be generated by mutagenesis, e.g., discrete point mutation or truncation of the MCT protein. As used herein, the term “homologue” refers to a variant form of the MCT protein which acts as an agonist or antagonist of the activity of the MCT protein. An agonist of the MCT protein can retain substantially the same, or a subset, of the biological activities of the MCT protein. An antagonist of the MCT protein can inhibit one or more of the activities of the naturally occurring form of the MCT protein, by, for example, competitively binding to a downstream or upstream member of the cell membrane component metabolic cascade which includes the MCT protein, or by binding to an MCT protein which mediates transport of compounds across such membranes, thereby preventing translocation from taking place.

In an alternative embodiment, homologues of the MCT protein can be identified by screening combinatorial libraries of mutants, e.g., truncation mutants, of the MCT protein for MCT protein agonist or antagonist activity. In one embodiment, a variegated library of MCT variants is generated by combinatorial mutagenesis at the nucleic acid level and is encoded by a variegated gene library. A variegated library of MCT variants can be produced by, for example, enzymatically ligating a mixture of synthetic oligonucleotides into gene sequences such that a degenerate set of potential MCT sequences is expressible as individual polypeptides, or alternatively, as a set of larger fusion proteins (e.g., for phage display) containing the set of MCT sequences therein. There are a variety of methods which can be used to produce libraries of potential MCT homologues from a degenerate oligonucleotide sequence. Chemical synthesis of a degenerate gene sequence can be performed in an automatic DNA synthesizer, and the synthetic gene then ligated into an appropriate expression vector. Use of a degenerate set of genes allows for the provision, in one mixture, of all of the sequences encoding the desired set of potential MCT sequences. Methods for synthesizing degenerate oligonucleotides are known in the art (see, e.g., Narang, S. A. (1983) Tetrahedron 39: 3; Itakura et al. (1984) Annu. Rev. Biochem. 53: 323; Itakura et al. (1984) Science 198: 1056; Ike et al. (1983) Nucleic Acid Res. 11: 477.

In addition, libraries of fragments of the MCT protein coding can be used to generate a variegated population of MCT fragments for screening and subsequent selection of homologues of an MCT protein. In one embodiment, a library of coding sequence fragments can be generated by treating a double stranded PCR fragment of an MCT coding sequence with a nuclease under conditions wherein nicking occurs only about once per molecule, denaturing the double stranded DNA, renaturing the DNA to form double stranded DNA which can include sense/antisense pairs from different nicked products, removing single stranded portions from reformed duplexes by treatment with S1 nuclease, and ligating the resulting fragment library into an expression vector. By this method, an expression library can be derived which encodes N-terminal, C-terminal and internal fragments of various sizes of the MCT protein.

Several techniques are known in the art for screening gene products of combinatorial libraries made by point mutations or truncation, and for screening cDNA libraries for gene products having a selected property. Such techniques are adaptable for rapid screening of the gene libraries generated by the combinatorial mutagenesis of MCT homologues. The most widely used techniques, which are amenable to high through-put analysis, for screening large gene libraries typically include cloning the gene library into replicable expression vectors, transforming appropriate cells with the resulting library of vectors, and expressing the combinatorial genes under conditions in which detection of a desired activity facilitates isolation of the vector encoding the gene whose product was detected. Recursive ensemble mutagenesis (REM), a new technique which enhances the frequency of functional mutants in the libraries, can be used in combination with the screening assays to identify MCT homologues (Arkin and Yourvan (1992) PNAS 89: 7811-7815; Delgrave et al. (1993) Protein Engineering 6(3): 327-331).

In another embodiment, cell based assays can be exploited to analyze a variegated MCT library, using methods well known in the art.

D. Uses and Methods of the Invention

The nucleic acid molecules, proteins, protein homologues, fusion proteins, primers, vectors, and host cells described herein can be used in one or more of the following methods: identification of C. glutamicum and related organisms; mapping of genomes of organisms related to C. glutamicum; identification and localization of C. glutamicum sequences of interest; evolutionary studies; determination of MCT protein regions required for function; modulation of an MCT protein activity; modulation of the metabolism of one or more cell membrane components; modulation of the transmembrane transport of one or more compounds; and modulation of cellular production of a desired compound, such as a fine chemical.

The MCT nucleic acid molecules of the invention have a variety of uses. First, they may be used to identify an organism as being Corynebacterium glutamicum or a close relative thereof. Also, they may be used to identify the presence of C. glutamicum or a relative thereof in a mixed population of microorganisms. The invention provides the nucleic acid sequences of a number of C. glutamicum genes; by probing the extracted genomic DNA of a culture of a unique or mixed population of microorganisms under stringent conditions with a probe spanning a region of a C. glutamicum gene which is unique to this organism, one can ascertain whether this organism is present.

Although Corynebacterium glutamicum itself is nonpathogenic, it is related to pathogenic species, such as Corynebacterium diphtheriae. Corynebacterium diphtheriae is the causative agent of diphtheria, a rapidly developing, acute, febrile infection which involves both local and systemic pathology. In this disease, a local lesion develops in the upper respiratory tract and involves necrotic injury to epithelial cells; the bacilli secrete toxin which is disseminated through this lesion to distal susceptible tissues of the body. Degenerative changes brought about by the inhibition of protein synthesis in these tissues, which include heart, muscle, peripheral nerves, adrenals, kidneys, liver and spleen, result in the systemic pathology of the disease. Diphtheria continues to have high incidence in many parts of the world, including Africa, Asia, Eastern Europe and the independent states of the former Soviet Union. An ongoing epidemic of diphtheria in the latter two regions has resulted in at least 5,000 deaths since 1990. In one embodiment, the invention provides a method of identifying the presence or activity of Cornyebacterium diphtheriae in a subject. This method includes detection of one or more of the nucleic acid or amino acid sequences of the invention (e.g., the sequences set forth in Appendix A or Appendix B) in a subject, thereby detecting the presence or activity of Corynebacterium diphtheriae in the subject. C. glutamicum and C. diphtheriae are related bacteria, and many of the nucleic acid and protein molecules in C. glutamicum are homologous to C. diphtheriae nucleic acid and protein molecules, and can therefore be used to detect C. diphtheriae in a subject.

The nucleic acid and protein molecules of the invention may also serve as markers for specific regions of the genome. This has utility not only in the mapping of the genome, but also for functional studies of C. glutamicum proteins. For example, to identify the region of the genome to which a particular C. glutamicum DNA-binding protein binds, the C. glutamicum genome could be digested, and the fragments incubated with the DNA-binding protein. Those which bind the protein may be additionally probed with the nucleic acid molecules of the invention, preferably with readily detectable labels; binding of such a nucleic acid molecule to the genome fragment enables the localization of the fragment to the genome map of C. glutamicum, and, when performed multiple times with different enzymes, facilitates a rapid determination of the nucleic acid sequence to which the protein binds. Further, the nucleic acid molecules of the invention may be sufficiently homologous to the sequences of related species such that these nucleic acid molecules may serve as markers for the construction of a genomic map in related bacteria, such as Brevibacterium lactofermentum.

The MCT nucleic acid molecules of the invention are also useful for evolutionary and protein structural studies. The metabolic and transport processes in which the molecules of the invention participate are utilized by a wide variety of prokaryotic and eukaryotic cells; by comparing the sequences of the nucleic acid molecules of the present invention to those encoding similar enzymes from other organisms, the evolutionary relatedness of the organisms can be assessed. Similarly, such a comparison permits an assessment of which regions of the sequence are conserved and which are not, which may aid in determining those regions of the protein which are essential for the functioning of the enzyme. This type of determination is of value for protein engineering studies and may give an indication of what the protein can tolerate in terms of mutagenesis without losing function.

Manipulation of the MCT nucleic acid molecules of the invention may result in the production of MCT proteins having functional differences from the wild-type MCT proteins. These proteins may be improved in efficiency or activity, may be present in greater numbers in the cell than is usual, or may be decreased in efficiency or activity.

The invention provides methods for screening molecules which modulate the activity of an MCT protein, either by interacting with the protein itself or a substrate or binding partner of the MCT protein, or by modulating the transcription or translation of an MCT nucleic acid molecule of the invention. In such methods, a microorganism expressing one or more MCT proteins of the invention is contacted with one or more test compounds, and the effect of each test compound on the activity or level of expression of the MCT protein is assessed.

There are a number of mechanisms by which the alteration of an MCT protein of the invention may directly affect the yield, production, and/or efficiency of production of a fine chemical from a C. glutamicum strain incorporating such an altered protein. Recovery of fine chemical compounds from large-scale cultures of C. glutamicum is significantly improved if C. glutamicum secretes the desired compounds, since such compounds may be readily purified from the culture medium (as opposed to extracted from the mass of C. glutamicum cells). By either increasing the number or the activity of transporter molecules which export fine chemicals from the cell, it may be possible to increase the amount of the produced fine chemical which is present in the extracellular medium, thus permitting greater ease of harvesting and purification. Conversely, in order to efficiently overproduce one or more fine chemicals, increased amounts of the cofactors, precursor molecules, and intermediate compounds for the appropriate biosynthetic pathways are required. Therefore, by increasing the number and/or activity of transporter proteins involved in the import of nutrients, such as carbon sources (i.e., sugars), nitrogen sources (i.e., amino acids, ammonium salts), phosphate, and sulfur, it may be possible to improve the production of a fine chemical, due to the removal of any nutrient supply limitations on the biosynthetic process. Further, fatty acids and lipids are themselves desirable fine chemicals, so by optimizing the activity or increasing the number of one or more MCT proteins of the invention which participate in the biosynthesis of these compounds, or by impairing the activity of one or more MCT proteins which are involved in the degradation of these compounds, it may be possible to increase the yield, production, and/or efficiency of production of fatty acid and lipid molecules from C. glutamicum.

The engineering of one or more MCT genes of the invention may also result in MCT proteins having altered activities which indirectly impact the production of one or more desired fine chemicals from C. glutamicum. For example, the normal biochemical processes of metabolism result in the production of a variety of waste products (e.g., hydrogen peroxide and other reactive oxygen species) which may actively interfere with these same metabolic processes (for example, peroxynitrite is known to nitrate tyrosine side chains, thereby inactivating some enzymes having tyrosine in the active site (Groves, J. T. (1999) Curr. Opin. Chem. Biol. 3(2): 226-235). While these waste products are typically excreted, the C. glutamicum strains utilized for large-scale fermentative production are optimized for the overproduction of one or more fine chemicals, and thus may produce more waste products than is typical for a wild-type C. glutamicum. By optimizing the activity of one or more MCT proteins of the invention which are involved in the export of waste molecules, it may be possible to improve the viability of the cell and to maintain efficient metabolic activity. Also, the presence of high intracellular levels of the desired fine chemical may actually be toxic to the cell, so by increasing the ability of the cell to secrete these compounds, one may improve the viability of the cell.

Further, the MCT proteins of the invention may be manipulated such that the relative amounts of various lipid and fatty acid molecules produced are altered. This may have a profound effect on the lipid composition of the membrane of the cell. Since each type of lipid has different physical properties, an alteration in the lipid composition of a membrane may significantly alter membrane fluidity. Changes in membrane fluidity can impact the transport of molecules across the membrane, which, as previously explicated, may modify the export of waste products or the produced fine chemical or the import of necessary nutrients. Such membrane fluidity changes may also profoundly affect the integrity of the cell; cells with relatively weaker membranes are more vulnerable in the large-scale fermentor environment to mechanical stresses which may damage or kill the cell. By manipulating MCT proteins involved in the production of fatty acids and lipids for membrane construction such that the resulting membrane has a membrane composition more amenable to the environmental conditions extant in the cultures utilized to produce fine chemicals, a greater proportion of the C. glutamicum cells should survive and multiply. Greater numbers of C. glutamicum cells in a culture should translate into greater yields, production, or efficiency of production of the fine chemical from the culture.

The aforementioned mutagenesis strategies for MCT proteins to result in increased yields of a fine chemical from C. glutamicum are not meant to be limiting; variations on these strategies will be readily apparent to one of ordinary skill in the art. Using such strategies, and incorporating the mechanisms disclosed herein, the nucleic acid and protein molecules of the invention may be utilized to generate C. glutamicum or related strains of bacteria expressing mutated MCT nucleic acid and protein molecules such that the yield, production, and/or efficiency of production of a desired compound is improved. This desired compound may be any natural product of C. glutamicum, which includes the final products of biosynthesis pathways and intermediates of naturally-occurring metabolic pathways, as well as molecules which do not naturally occur in the metabolism of C. glutamicum, but which are produced by a C. glutamicum strain of the invention.

This invention is further illustrated by the following examples which should not be construed as limiting. The contents of all references, patent applications, patents, published patent applications, Tables, Appendices, and the sequence listing cited throughout this application are hereby incorporated by reference.

EXEMPLIFICATION Example 1 Preparation of Total Genomic DNA of Corynebacterium glutamicum ATCC 13032

A culture of Corynebacterium glutamicum (ATCC 13032) was grown overnight at 30° C. with vigorous shaking in BHI medium (Difco). The cells were harvested by centrifugation, the supernatant was discarded and the cells were resuspended in 5 ml buffer-I (5% of the original volume of the culture—all indicated volumes have been calculated for 100 ml of culture volume). Composition of buffer-I: 140.34 g/l sucrose, 2.46 g/l MgSO₄×7H₂O, 10 ml/l KH₂PO₄ solution (100 g/l, adjusted to pH 6.7 with KOH), 50 ml/l M12 concentrate (10 g/l (NH₄)₂SO₄, 1 g/l NaCl, 2 g/l MgSO₄×7H₂O, 0.2 g/l CaCl₂, 0.5 g/l yeast extract (Difco), 10 ml/l trace-elements-mix (200 mg/l FeSO₄×H₂O, 10 mg/l ZnSO₄×7H₂O, 3 mg/l MnCl₂×4H₂O, 30 mg/l H₃BO₃ 20 mg/l CoCl₂×6H₂O, 1 mg/l NiCl₂×6H₂O, 3 mg/l Na₂MoO₄×2H₂O, 500 mg/l complexing agent (EDTA or critic acid), 100 ml/l vitamins-mix (0.2 mg/l biotin, 0.2 mg/l folic acid, 20 mg/l p-amino benzoic acid, 20 mg/l riboflavin, 40 mg/l ca-panthothenate, 140 mg/l nicotinic acid, 40 mg/l pyridoxole hydrochloride, 200 mg/l myo-inositol). Lysozyme was added to the suspension to a final concentration of 2.5 mg/ml. After an approximately 4 h incubation at 37° C., the cell wall was degraded and the resulting protoplasts are harvested by centrifugation. The pellet was washed once with 5 ml buffer-I and once with 5 ml TE-buffer (10 mM Tris-HCl, 1 mM EDTA, pH 8). The pellet was resuspended in 4 ml TE-buffer and 0.5 ml SDS solution (10%) and 0.5 ml NaCl solution (5 M) are added. After adding of proteinase K to a final concentration of 200 μg/ml, the suspension is incubated for ca. 18 h at 37° C. The DNA was purified by extraction with phenol, phenol-chloroform-isoamylalcohol and chloroform-isoamylalcohol using standard procedures. Then, the DNA was precipitated by adding 1/50 volume of 3 M sodium acetate and 2 volumes of ethanol, followed by a 30 min incubation at −20° C. and a 30 min centrifugation at 12,000 rpm in a high speed centrifuge using a SS34 rotor (Sorvall). The DNA was dissolved in 1 ml TE-buffer containing 20 μg/ml RNaseA and dialysed at 4° C. against 1000 ml TE-buffer for at least 3 hours. During this time, the buffer was exchanged 3 times. To aliquots of 0.4 ml of the dialysed DNA solution, 0.4 ml of 2 M LiCl and 0.8 ml of ethanol are added. After a 30 min incubation at −20° C., the DNA was collected by centrifugation (13,000 rpm, Biofuge Fresco, Heraeus, Hanau, Germany). The DNA pellet was dissolved in TE-buffer. DNA prepared by this procedure could be used for all purposes, including southern blotting or construction of genomic libraries.

Example 2 Construction of Genomic Libraries in Escherichia coli of Corynebacterium glutamicum ATCC13032

Using DNA prepared as described in Example 1, cosmid and plasmid libraries were constructed according to known and well established methods (see e.g., Sambrook, J. et al. (1989) “Molecular Cloning: A Laboratory Manual”, Cold Spring Harbor Laboratory Press, or Ausubel, F. M. et al. (1994) “Current Protocols in Molecular Biology”, John Wiley & Sons.)

Any plasmid or cosmid could be used. Of particular use were the plasmids pBR322 (Sutcliffe, J. G. (1979) Proc. Natl. Acad. Sci. USA, 75: 3737-3741); pACYC177 (Change & Cohen (1978) J. Bacteriol 134: 1141-1156), plasmids of the pBS series (pBSSK+, pBSSK− and others; Stratagene, LaJolla, USA), or cosmids as SuperCos1 (Stratagene, LaJolla, USA) or Lorist6 (Gibson, T. J., Rosenthal A. and Waterson, R. H. (1987) Gene 53: 283-286. Gene libraries specifically for use in C. glutamicum may be constructed using plasmid pSL109 (Lee, H.-S. and A. J. Sinskey (1994) J. Microbiol. Biotechnol. 4: 256-263).

Example 3 DNA Sequencing and Computational Functional Analysis

Genomic libraries as described in Example 2 were used for DNA sequencing according to standard methods, in particular by the chain termination method using ABI377 sequencing machines (see e.g., Fleischman, R. D. et al. (1995) “Whole-genome Random Sequencing and Assembly of Haemophilus Influenzae Rd., Science, 269: 496-512). Sequencing primers with the following nucleotide sequences were used: 5′-GGAAACAGTATGACCATG-3′ or 5′-GTAAAACGACGGCCAGT-3′.

Example 4 In Vivo Mutagenesis

In vivo mutagenesis of Corynebacterium glutamicum can be performed by passage of plasmid (or other vector) DNA through E. coli or other microorganisms (e.g. Bacillus spp. or yeasts such as Saccharomyces cerevisiae) which are impaired in their capabilities to maintain the integrity of their genetic information. Typical mutator strains have mutations in the genes for the DNA repair system (e.g., mutHLS, mutD, mutT, etc.; for reference, see Rupp, W. D. (1996) DNA repair mechanisms, in: Escherichia coli and Salmonella, p. 2277-2294, ASM: Washington.) Such strains are well known to those of ordinary skill in the art. The use of such strains is illustrated, for example, in Greener, A. and Callahan, M. (1994) Strategies 7: 32-34.

Example 5 DNA Transfer Between Escherichia coli and Corynebacterium glutamicum

Several Corynebacterium and Brevibacterium species contain endogenous plasmids (as e.g., pHM1519 or pBL1) which replicate autonomously (for review see, e.g., Martin, J. F. et al. (1987) Biotechnology, 5: 137-146). Shuttle vectors for Escherichia coli and Corynebacterium glutamicum can be readily constructed by using standard vectors for E. coli (Sambrook, J. et al. (1989), “Molecular Cloning: A Laboratory Manual”, Cold Spring Harbor Laboratory Press or Ausubel, F. M. et al. (1994) “Current Protocols in Molecular Biology”, John Wiley & Sons) to which a origin or replication for and a suitable marker from Corynebacterium glutamicum is added. Such origins of replication are preferably taken from endogenous plasmids isolated from Corynebacterium and Brevibacterium species. Of particular use as transformation markers for these species are genes for kanamycin resistance (such as those derived from the Tn5 or Tn903 transposons) or chloramphenicol (Winnacker, E. L. (1987) “From Genes to Clones—Introduction to Gene Technology, VCH, Weinheim). There are numerous examples in the literature of the construction of a wide variety of shuttle vectors which replicate in both E. coli and C. glutamicum, and which can be used for several purposes, including gene over-expression (for reference, see e.g., Yoshihama, M. et al. (1985) J. Bacteriol. 162: 591-597, Martin J. F. et al. (1987) Biotechnology, 5: 137-146 and Eikmanns, B. J. et al. (1991) Gene, 102: 93-98).

Using standard methods, it is possible to clone a gene of interest into one of the shuttle vectors described above and to introduce such a hybrid vectors into strains of Corynebacterium glutamicum. Transformation of C. glutamicum can be achieved by protoplast transformation (Kastsumata, R. et al. (1984) J. Bacteriol. 159306-311), electroporation (Liebl, E. et al. (1989) FEMS Microbiol. Letters, 53: 399-303) and in cases where special vectors are used, also by conjugation (as described e.g. in Schäfer, A et al. (1990) J. Bacteriol. 172: 1663-1666). It is also possible to transfer the shuttle vectors for C. glutamicum to E. coli by preparing plasmid DNA from C. glutamicum (using standard methods well-known in the art) and transforming it into E. coli. This transformation step can be performed using standard methods, but it is advantageous to use an Mcr-deficient E. coli strain, such as NM522 (Gough & Murray (1983) J. Mol. Biol. 166: 1-19).

Genes may be overexpressed in C. glutamicum strains using plasmids which comprise pCG1 (U.S. Pat. No. 4,617,267) or fragments thereof, and optionally the gene for kanamycin resistance from TN903 (Grindley, N. D. and Joyce, C. M. (1980) Proc. Natl. Acad. Sci. USA 77(12): 7176-7180). In addition, genes may be overexpressed in C. glutamicum strains using plasmid pSL109 (Lee, H.-S. and A. J. Sinskey (1994) J. Microbiol. Biotechnol. 4: 256-263).

Aside from the use of replicative plasmids, gene overexpression can also be achieved by integration into the genome. Genomic integration in C. glutamicum or other Corynebacterium or Brevibacterium species may be accomplished by well-known methods, such as homologous recombination with genomic region(s), restriction endonuclease mediated integration (REMI) (see, e.g., DE Patent 19823834), or through the use of transposons. It is also possible to modulate the activity of a gene of interest by modifying the regulatory regions (e.g., a promoter, a repressor, and/or an enhancer) by sequence modification, insertion, or deletion using site-directed methods (such as homologous recombination) or methods based on random events (such as transposon mutagenesis or REMI). Nucleic acid sequences which function as transcriptional terminators may also be inserted 3′ to the coding region of one or more genes of the invention; such terminators are well-known in the art and are described, for example, in Winnacker, E. L. (1987) From Genes to Clones—Introduction to Gene Technology. VCH: Weinheim.

Example 6 Assessment of the Expression of the Mutant Protein

Observations of the activity of a mutated protein in a transformed host cell rely on the fact that the mutant protein is expressed in a similar fashion and in a similar quantity to that of the wild-type protein. A useful method to ascertain the level of transcription of the mutant gene (an indicator of the amount of mRNA available for translation to the gene product) is to perform a Northern blot (for reference see, for example, Ausubel et al. (1988) Current Protocols in Molecular Biology, Wiley: New York), in which a primer designed to bind to the gene of interest is labeled with a detectable tag (usually radioactive or chemiluminescent), such that when the total RNA of a culture of the organism is extracted, run on gel, transferred to a stable matrix and incubated with this probe, the binding and quantity of binding of the probe indicates the presence and also the quantity of mRNA for this gene. This information is evidence of the degree of transcription of the mutant gene. Total cellular RNA can be prepared from Corynebacterium glutamicum by several methods, all well-known in the art, such as that described in Bormann, E. R. et al. (1992) Mol. Microbiol. 6: 317-326.

To assess the presence or relative quantity of protein translated from this mRNA, standard techniques, such as a Western blot, may be employed (see, for example, Ausubel et al. (1988) Current Protocols in Molecular Biology, Wiley: New York). In this process, total cellular proteins are extracted, separated by gel electrophoresis, transferred to a matrix such as nitrocellulose, and incubated with a probe, such as an antibody, which specifically binds to the desired protein. This probe is generally tagged with a chemiluminescent or colorimetric label which may be readily detected. The presence and quantity of label observed indicates the presence and quantity of the desired mutant protein present in the cell.

Example 7 Growth of Genetically Modified Corynebacterium glutamicum—Media and Culture Conditions

Genetically modified Corynebacteria are cultured in synthetic or natural growth media. A number of different growth media for Corynebacteria are both well-known and readily available (Lieb et al. (1989) Appl. Microbiol. Biotechnol., 32: 205-210; von der Osten et al. (1998) Biotechnology Letters, 11: 11-16; Patent DE 4,120,867; Liebl (1992) “The Genus Corynebacterium, in: The Procaryotes, Volume II, Balows, A. et al., eds. Springer-Verlag). These media consist of one or more carbon sources, nitrogen sources, inorganic salts, vitamins and trace elements. Preferred carbon sources are sugars, such as mono-, di-, or polysaccharides. For example, glucose, fructose, mannose, galactose, ribose, sorbose, ribulose, lactose, maltose, sucrose, raffinose, starch or cellulose serve as very good carbon sources. It is also possible to supply sugar to the media via complex compounds such as molasses or other by-products from sugar refinement. It can also be advantageous to supply mixtures of different carbon sources. Other possible carbon sources are alcohols and organic acids, such as methanol, ethanol, acetic acid or lactic acid. Nitrogen sources are usually organic or inorganic nitrogen compounds, or materials which contain these compounds. Exemplary nitrogen sources include ammonia gas or ammonia salts, such as NH₄Cl or (NH₄)₂SO₄, NH₄OH, nitrates, urea, amino acids or complex nitrogen sources like corn steep liquor, soy bean flour, soy bean protein, yeast extract, meat extract and others.

Inorganic salt compounds which may be included in the media include the chloride-, phosphorous- or sulfate-salts of calcium, magnesium, sodium, cobalt, molybdenum, potassium, manganese, zinc, copper and iron. Chelating compounds can be added to the medium to keep the metal ions in solution. Particularly useful chelating compounds include dihydroxyphenols, like catechol or protocatechuate, or organic acids, such as citric acid. It is typical for the media to also contain other growth factors, such as vitamins or growth promoters, examples of which include biotin, riboflavin, thiamin, folic acid, nicotinic acid, pantothenate and pyridoxin. Growth factors and salts frequently originate from complex media components such as yeast extract, molasses, corn steep liquor and others. The exact composition of the media compounds depends strongly on the immediate experiment and is individually decided for each specific case. Information about media optimization is available in the textbook “Applied Microbiol. Physiology, A Practical Approach (eds. P. M. Rhodes, P. F. Stanbury, IRL Press (1997) pp. 53-73, ISBN 0 19 963577 3). It is also possible to select growth media from commercial suppliers, like standard 1 (Merck) or BHI (grain heart infusion, DIFCO) or others.

All medium components are sterilized, either by heat (20 minutes at 1.5 bar and 121° C.) or by sterile filtration. The components can either be sterilized together or, if necessary, separately. All media components can be present at the beginning of growth, or they can optionally be added continuously or batchwise.

Culture conditions are defined separately for each experiment. The temperature should be in a range between 15° C. and 45° C. The temperature can be kept constant or can be altered during the experiment. The pH of the medium should be in the range of 5 to 8.5, preferably around 7.0, and can be maintained by the addition of buffers to the media. An exemplary buffer for this purpose is a potassium phosphate buffer. Synthetic buffers such as MOPS, HEPES, ACES and others can alternatively or simultaneously be used. It is also possible to maintain a constant culture pH through the addition of NaOH or NH₄OH during growth. If complex medium components such as yeast extract are utilized, the necessity for additional buffers may be reduced, due to the fact that many complex compounds have high buffer capacities. If a fermentor is utilized for culturing the micro-organisms, the pH can also be controlled using gaseous ammonia.

The incubation time is usually in a range from several hours to several days. This time is selected in order to permit the maximal amount of product to accumulate in the broth. The disclosed growth experiments can be carried out in a variety of vessels, such as microtiter plates, glass tubes, glass flasks or glass or metal fermentors of different sizes. For screening a large number of clones, the microorganisms should be cultured in microtiter plates, glass tubes or shake flasks, either with or without baffles. Preferably 100 ml shake flasks are used, filled with 10% (by volume) of the required growth medium. The flasks should be shaken on a rotary shaker (amplitude 25 mm) using a speed-range of 100-300 rpm. Evaporation losses can be diminished by the maintenance of a humid atmosphere; alternatively, a mathematical correction for evaporation losses should be performed.

If genetically modified clones are tested, an unmodified control clone or a control clone containing the basic plasmid without any insert should also be tested. The medium is inoculated to an OD₆₀₀ of 0.5-1.5 using cells grown on agar plates, such as CM plates (10 g/l glucose, 2.5 g/l NaCl, 2 g/l urea, 10 g/l polypeptone, 5 g/l yeast extract, 5 g/l meat extract, 22 g/l NaCl, 2 g/l urea, 10 g/l polypeptone, 5 g/l yeast extract, 5 g/l meat extract, 22 g/l agar, pH 6.8 with 2M NaOH) that had been incubated at 30° C. Inoculation of the media is accomplished by either introduction of a saline suspension of C. glutamicum cells from CM plates or addition of a liquid preculture of this bacterium.

Example 8 In Vitro Analysis of the Function of Mutant Proteins

The determination of activities and kinetic parameters of enzymes is well established in the art. Experiments to determine the activity of any given altered enzyme must be tailored to the specific activity of the wild-type enzyme, which is well within the ability of one of ordinary skill in the art. Overviews about enzymes in general, as well as specific details concerning structure, kinetics, principles, methods, applications and examples for the determination of many enzyme activities may be found, for example, in the following references: Dixon, M., and Webb, E. C., (1979) Enzymes. Longmans: London; Fersht, (1985) Enzyme Structure and Mechanism. Freeman: New York; Walsh, (1979) Enzymatic Reaction Mechanisms. Freeman: San Francisco; Price, N.C., Stevens, L. (1982) Fundamentals of Enzymology. Oxford Univ. Press: Oxford; Boyer, P. D., ed. (1983) The Enzymes, 3^(rd) ed. Academic Press: New York; Bisswanger, H., (1994) Enzymkinetik, 2^(nd) ed. VCH: Weinheim (ISBN 3527300325); Bergmeyer, H. U., Bergmeyer, J., Graβl, M., eds. (1983-1986) Methods of Enzymatic Analysis, 3^(rd) ed., vol. I-XII, Verlag Chemie: Weinheim; and Ullmann's Encyclopedia of Industrial Chemistry (1987) vol. A9, “Enzymes”. VCH: Weinheim, p. 352-363.

The activity of proteins which bind to DNA can be measured by several well-established methods, such as DNA band-shift assays (also called gel retardation assays). The effect of such proteins on the expression of other molecules can be measured using reporter gene assays (such as that described in Kolmar, H. et al. (1995) EMBO J. 14: 3895-3904 and references cited therein). Reporter gene test systems are well known and established for applications in both pro- and eukaryotic cells, using enzymes such as beta-galactosidase, green fluorescent protein, and several others.

The determination of activity of membrane-transport proteins can be performed according to techniques such as those described in Gennis, R. B. (1989) “Pores, Channels and Transporters”, in Biomembranes, Molecular Structure and Function, Springer: Heidelberg, p. 85-137; 199-234; and 270-322.

Example 9 Analysis of Impact of Mutant Protein on the Production of the Desired Product

The effect of the genetic modification in C. glutamicum on production of a desired compound (such as an amino acid) can be assessed by growing the modified microorganism under suitable conditions (such as those described above) and analyzing the medium and/or the cellular component for increased production of the desired product (i.e., an amino acid). Such analysis techniques are well known to one of ordinary skill in the art, and include spectroscopy, thin layer chromatography, staining methods of various kinds, enzymatic and microbiological methods, and analytical chromatography such as high performance liquid chromatography (see, for example, Ullman, Encyclopedia of Industrial Chemistry, vol. A2, p. 89-90 and p. 443-613, VCH: Weinheim (1985); Fallon, A. et al., (1987) “Applications of HPLC in Biochemistry” in: Laboratory Techniques in Biochemistry and Molecular Biology, vol. 17; Rehm et al. (1993) Biotechnology, vol. 3, Chapter III: “Product recovery and purification”, page 469-714, VCH: Weinheim; Belter, P. A. et al. (1988) Bioseparations: downstream processing for biotechnology, John Wiley and Sons; Kennedy, J. F. and Cabral, J. M. S. (1992) Recovery processes for biological materials, John Wiley and Sons; Shaeiwitz, J. A. and Henry, J. D. (1988) Biochemical separations, in: Ulmann's Encyclopedia of Industrial Chemistry, vol. B3, Chapter 11, page 1-27, VCH: Weinheim; and Dechow, F. J. (1989) Separation and purification techniques in biotechnology, Noyes Publications.)

In addition to the measurement of the final product of fermentation, it is also possible to analyze other components of the metabolic pathways utilized for the production of the desired compound, such as intermediates and side-products, to determine the overall efficiency of production of the compound. Analysis methods include measurements of nutrient levels in the medium (e.g., sugars, hydrocarbons, nitrogen sources, phosphate, and other ions), measurements of biomass composition and growth, analysis of the production of common metabolites of biosynthetic pathways, and measurement of gasses produced during fermentation. Standard methods for these measurements are outlined in Applied Microbial Physiology, A Practical Approach, P. M. Rhodes and P. F. Stanbury, eds., IRL Press, p. 103-129; 131-163; and 165-192 (ISBN: 0199635773) and references cited therein.

Example 10 Purification of the Desired Product from C. glutamicum Culture

Recovery of the desired product from the C. glutamicum cells or supernatant of the above-described culture can be performed by various methods well known in the art. If the desired product is not secreted from the cells, the cells can be harvested from the culture by low-speed centrifugation, the cells can be lysed by standard techniques, such as mechanical force or sonication. The cellular debris is removed by centrifugation, and the supernatant fraction containing the soluble proteins is retained for further purification of the desired compound. If the product is secreted from the C. glutamicum cells, then the cells are removed from the culture by low-speed centrifugation, and the supernate fraction is retained for further purification.

The supernatant fraction from either purification method is subjected to chromatography with a suitable resin, in which the desired molecule is either retained on a chromatography resin while many of the impurities in the sample are not, or where the impurities are retained by the resin while the sample is not. Such chromatography steps may be repeated as necessary, using the same or different chromatography resins. One of ordinary skill in the art would be well-versed in the selection of appropriate chromatography resins and in their most efficacious application for a particular molecule to be purified. The purified product may be concentrated by filtration or ultrafiltration, and stored at a temperature at which the stability of the product is maximized.

There are a wide array of purification methods known to the art and the preceding method of purification is not meant to be limiting. Such purification techniques are described, for example, in Bailey, J. E. & Ollis, D. F. Biochemical Engineering Fundamentals, McGraw-Hill: New York (1986).

The identity and purity of the isolated compounds may be assessed by techniques standard in the art. These include high-performance liquid chromatography (HPLC), spectroscopic methods, staining methods, thin layer chromatography, NIRS, enzymatic assay, or microbiologically. Such analysis methods are reviewed in: Patek et al. (1994) Appl. Environ. Microbiol. 60: 133-140; Malakhova et al. (1996) Biotekhnologiya 11: 27-32; and Schmidt et al. (1998) Bioprocess Engineer. 19: 67-70. Ulmann's Encyclopedia of Industrial Chemistry, (1996) vol. A27, VCH: Weinheim, p. 89-90, p. 521-540, p. 540-547, p. 559-566, 575-581 and p. 581-587; Michal, G. (1999) Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, John Wiley and Sons; Fallon, A. et al. (1987) Applications of HPLC in Biochemistry in: Laboratory Techniques in Biochemistry and Molecular Biology, vol. 17.

Example 11 Analysis of the Gene Sequences of the Invention

The comparison of sequences and determination of percent homology between two sequences are art-known techniques, and can be accomplished using a mathematical algorithm, such as the algorithm of Karlin and Altschul (1990) Proc. Natl. Acad. Sci. USA 87: 2264-68, modified as in Karlin and Altschul (1993) Proc. Natl. Acad. Sci. USA 90: 5873-77. Such an algorithm is incorporated into the NBLAST and XBLAST programs (version 2.0) of Altschul, et al. (1990) J. Mol. Biol. 215: 403-10. BLAST nucleotide searches can be performed with the NBLAST program, score=100, wordlength=12 to obtain nucleotide sequences homologous to MCT nucleic acid molecules of the invention. BLAST protein searches can be performed with the XBLAST program, score=50, wordlength=3 to obtain amino acid sequences homologous to MCT protein molecules of the invention. To obtain gapped alignments for comparison purposes, Gapped BLAST can be utilized as described in Altschul et al., (1997) Nucleic Acids Res. 25(17): 3389-3402. When utilizing BLAST and Gapped BLAST programs, one of ordinary skill in the art will know how to optimize the parameters of the program (e.g., XBLAST and NBLAST) for the specific sequence being analyzed.

Another example of a mathematical algorithm utilized for the comparison of sequences is the algorithm of Meyers and Miller ((1988) Comput. Appl. Biosci. 4: 11-17). Such an algorithm is incorporated into the ALIGN program (version 2.0) which is part of the GCG sequence alignment software package. When utilizing the ALIGN program for comparing amino acid sequences, a PAM120 weight residue table, a gap length penalty of 12, and a gap penalty of 4 can be used. Additional algorithms for sequence analysis are known in the art, and include ADVANCE and ADAM. described in Torelli and Robotti (1994) Comput. Appl. Biosci. 10: 3-5; and FASTA, described in Pearson and Lipman (1988) P.N.A.S. 85: 2444-8.

The percent homology between two amino acid sequences can also be accomplished using the GAP program in the GCG software package (available at http://www.gcg.com), using either a Blosum 62 matrix or a PAM250 matrix, and a gap weight of 12, 10, 8, 6, or 4 and a length weight of 2, 3, or 4. The percent homology between two nucleic acid sequences can be accomplished using the GAP program in the GCG software package, using standard parameters, such as a gap weight of 50 and a length weight of 3.

A comparative analysis of the gene sequences of the invention with those present in Genbank has been performed using techniques known in the art (see, e.g., Bexevanis and Ouellette, eds. (1998) Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins. John Wiley and Sons: New York). The gene sequences of the invention were compared to genes present in Genbank in a three-step process. In a first step, a BLASTN analysis (e.g., a local alignment analysis) was performed for each of the sequences of the invention against the nucleotide sequences present in Genbank, and the top 500 hits were retained for further analysis. A subsequent FASTA search (e.g., a combined local and global alignment analysis, in which limited regions of the sequences are aligned) was performed on these 500 hits. Each gene sequence of the invention was subsequently globally aligned to each of the top three FASTA hits, using the GAP program in the GCG software package (using standard parameters). In order to obtain correct results, the length of the sequences extracted from Genbank were adjusted to the length of the query sequences by methods well-known in the art. The results of this analysis are set forth in Table 4. The resulting data is identical to that which would have been obtained had a GAP (global) analysis alone been performed on each of the genes of the invention in comparison with each of the references in Genbank, but required significantly reduced computational time as compared to such a database-wide GAP (global) analysis. Sequences of the invention for which no alignments above the cutoff values were obtained are indicated on Table 4 by the absence of alignment information. It will further be understood by one of ordinary skill in the art that the GAP alignment homology percentages set forth in Table 4 under the heading “% homology (GAP)” are listed in the European numerical format, wherein a ‘,’ represents a decimal point. For example, a value of “40,345” in this column represents “40.345%”.

Example 12 Construction and Operation of DNA Microarrays

The sequences of the invention may additionally be used in the construction and application of DNA microarrays (the design, methodology, and uses of DNA arrays are well known in the art, and are described, for example, in Schena, M. et al. (1995) Science 270: 467-470; Wodicka, L. et al. (1997) Nature Biotechnology 15: 1359-1367; DeSaizieu, A. et al. (1998) Nature Biotechnology 16: 45-48; and DeRisi, J. L. et al. (1997) Science 278: 680-686).

DNA microarrays are solid or flexible supports consisting of nitrocellulose, nylon, glass, silicone, or other materials. Nucleic acid molecules may be attached to the surface in an ordered manner. After appropriate labeling, other nucleic acids or nucleic acid mixtures can be hybridized to the immobilized nucleic acid molecules, and the label may be used to monitor and measure the individual signal intensities of the hybridized molecules at defined regions. This methodology allows the simultaneous quantification of the relative or absolute amount of all or selected nucleic acids in the applied nucleic acid sample or mixture. DNA microarrays, therefore, permit an analysis of the expression of multiple (as many as 6800 or more) nucleic acids in parallel (see, e.g., Schena, M. (1996) BioEssays 18(5): 427-431).

The sequences of the invention may be used to design oligonucleotide primers which are able to amplify defined regions of one or more C. glutamicum genes by a nucleic acid amplification reaction such as the polymerase chain reaction. The choice and design of the 5′ or 3′ oligonucleotide primers or of appropriate linkers allows the covalent attachment of the resulting PCR products to the surface of a support medium described above (and also described, for example, Schena, M. et al. (1995) Science 270: 467-470).

Nucleic acid microarrays may also be constructed by in situ oligonucleotide synthesis as described by Wodicka, L. et al. (1997) Nature Biotechnology 15: 1359-1367. By photolithographic methods, precisely defined regions of the matrix are exposed to light. Protective groups which are photolabile are thereby activated and undergo nucleotide addition, whereas regions that are masked from light do not undergo any modification. Subsequent cycles of protection and light activation permit the synthesis of different oligonucleotides at defined positions. Small, defined regions of the genes of the invention may be synthesized on microarrays by solid phase oligonucleotide synthesis.

The nucleic acid molecules of the invention present in a sample or mixture of nucleotides may be hybridized to the microarrays. These nucleic acid molecules can be labeled according to standard methods. In brief, nucleic acid molecules (e.g., mRNA molecules or DNA molecules) are labeled by the incorporation of isotopically or fluorescently labeled nucleotides, e.g., during reverse transcription or DNA synthesis. Hybridization of labeled nucleic acids to microarrays is described (e.g., in Schena, M. et al. (1995) supra; Wodicka, L. et al. (1997), supra; and DeSaizieu A. et al. (1998), supra). The detection and quantification of the hybridized molecule are tailored to the specific incorporated label. Radioactive labels can be detected, for example, as described in Schena, M. et al. (1995) supra) and fluorescent labels may be detected, for example, by the method of Shalon et al. (1996) Genome Research 6: 639-645).

The application of the sequences of the invention to DNA microarray technology, as described above, permits comparative analyses of different strains of C. glutamicum or other Corynebacteria. For example, studies of inter-strain variations based on individual transcript profiles and the identification of genes that are important for specific and/or desired strain properties such as pathogenicity, productivity and stress tolerance are facilitated by nucleic acid array methodologies. Also, comparisons of the profile of expression of genes of the invention during the course of a fermentation reaction are possible using nucleic acid array technology.

Example 13 Analysis of the Dynamics of Cellular Protein Populations (Proteomics)

The genes, compositions, and methods of the invention may be applied to study the interactions and dynamics of populations of proteins, termed ‘proteomics’. Protein populations of interest include, but are not limited to, the total protein population of C. glutamicum (e.g., in comparison with the protein populations of other organisms), those proteins which are active under specific environmental or metabolic conditions (e.g., during fermentation, at high or low temperature, or at high or low pH), or those proteins which are active during specific phases of growth and development.

Protein populations can be analyzed by various well-known techniques, such as gel electrophoresis. Cellular proteins may be obtained, for example, by lysis or extraction, and may be separated from one another using a variety of electrophoretic techniques. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) separates proteins largely on the basis of their molecular weight. Isoelectric focusing polyacrylamide gel electrophoresis (IEF-PAGE) separates proteins by their isoelectric point (which reflects not only the amino acid sequence but also posttranslational modifications of the protein). Another, more preferred method of protein analysis is the consecutive combination of both IEF-PAGE and SDS-PAGE, known as 2-D-gel electrophoresis (described, for example, in Hermann et al. (1998) Electrophoresis 19: 3217-3221; Fountoulakis et al. (1998) Electrophoresis 19: 1193-1202; Langen et al. (1997) Electrophoresis 18: 1184-1192; Antelmann et al. (1997) Electrophoresis 18: 1451-1463). Other separation techniques may also be utilized for protein separation, such as capillary gel electrophoresis; such techniques are well known in the art.

Proteins separated by these methodologies can be visualized by standard techniques, such as by staining or labeling. Suitable stains are known in the art, and include Coomassie Brilliant Blue, silver stain, or fluorescent dyes such as Sypro Ruby (Molecular Probes). The inclusion of radioactively labeled amino acids or other protein precursors (e.g., ³⁵S-methionine, ³⁵S-cysteine, ¹⁴C-labelled amino acids, ¹⁵N-amino acids, ¹⁵NO₃ or ¹⁵NH₄ ⁺ or ¹³C-labelled amino acids) in the medium of C. glutamicum permits the labeling of proteins from these cells prior to their separation. Similarly, fluorescent labels may be employed. These labeled proteins can be extracted, isolated and separated according to the previously described techniques.

Proteins visualized by these techniques can be further analyzed by measuring the amount of dye or label used. The amount of a given protein can be determined quantitatively using, for example, optical methods and can be compared to the amount of other proteins in the same gel or in other gels. Comparisons of proteins on gels can be made, for example, by optical comparison, by spectroscopy, by image scanning and analysis of gels, or through the use of photographic films and screens. Such techniques are well-known in the art.

To determine the identity of any given protein, direct sequencing or other standard techniques may be employed. For example, N- and/or C-terminal amino acid sequencing (such as Edman degradation) may be used, as may mass spectrometry (in particular MALDI or ESI techniques (see, e.g., Langen et al. (1997) Electrophoresis 18: 1184-1192)). The protein sequences provided herein can be used for the identification of C. glutamicum proteins by these techniques.

The information obtained by these methods can be used to compare patterns of protein presence, activity, or modification between different samples from various biological conditions (e.g., different organisms, time points of fermentation, media conditions, or different biotopes, among others). Data obtained from such experiments alone, or in combination with other techniques, can be used for various applications, such as to compare the behavior of various organisms in a given (e.g., metabolic) situation, to increase the productivity of strains which produce fine chemicals or to increase the efficiency of the production of fine chemicals.

Equivalents

Those of ordinary skill in the art will recognize, or will be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. Such equivalents are intended to be encompassed by the following claims.

Appendix B: Amino Acid Sequences

> RXA00001 (1-1128, translated) 376 residues MATVTFKDAS LSYPGAKEPT VKKFNLEIAD GEFLVLVGPS GCGKSTTLRM LAGLENVTDG AIFIGDKDVT HVAPRDRDIA MVFQNYALYP HMTVGENMGF ALKIAGKSQD EINKRVDEAA ATLGLTEFLE RKPKALSGGQ RQRVAMGRAI VRNPQVFLMD EPLSNLDAKL RVQTRTQIAA LQRKLGVTTV YVTHDQTEAL TMGDRIAVLK DGYLQQVGAP RELYDRPANV FVAGFIGSPA MNLGTESVKD GDATSGHARI KLSPETLAAM TPEDNGRITI GFRPEALEII PEGESTDLSI PIKLDFVEEL GSDSELYGKL VGEGDLGSSS EDVPESGQIV VRAAPNAAPA PGSVFHARIV EGGQHNFSAS TGKRLP > RXA00002 (1-684, translated) 228 residues VLHREGKGGL LGAYIAGFEW GLEKDYHVLC EMDADGSHAP EQLHLLLEEI EKGADLVIGS RYVPGGETVN WPANRELLSR LGNKYISVAL GAGINDMTAG YRAERRELLE HLDFEELSNA GYIFQVDVAF RAIKDGEDVR EVPITFTERE LGESKLDGSF VKDSLLEVTK WGVAHRSEQI SDFTSEVSKI ASRTVKDMEL GPKATTAKNA VPDFVSEVSN LAKGTFKK > RXA00089 (1-999, translated) 333 residues MATPASAPTS EPRLKRTRAK LEDWKLLIGI IFVAGLVVLS LLTGQYDIFG GDDGQLMFEA VRIPRTVSLI LSGAAMAMCG LVMQLLTQNK FVEPSTTGTT EWAGLGLLFV IYFVPAATVL DRMLGAVVFS FIGTMVFFLF LRRVTLRSSL IVPIIGIMLG AVVSSISSFF ALQFDMLQQL GTWFAGSFNT VFRGQYEVLW IVVIVVIAVF FFADRLTVAG LGEEIATNVG LNYNRMVLIG TGLIAIATGV VTVVVGSLPF LGLIVPNVVS MFRGDDLRSN LPWVCLTGIA IVTICDLISR TIIAPFEIPV SVILGIIGAV VFVIMIVRQR GRG > RXA00090 (1-1119, translated) 373 residues VAVDKDIENR TSDLSRWETM EESATVEGRT DVELASAPSK RRTSGAFQTA RAKRRYWIIM AALLVTALAF TWGLIWYKNP MPVGHPAFAL IAERRMESVF VMLIVAVCQG FATVAFQTVT NNRIITPSIM GFESLYTLIH TSTVFFFGAT ALLATRNLEM FVGQLVIMVL LTLVLYTWLL SGKRGDMHAM LLVGIIIGGG LGSISTFMQR ILTPSEFDIL SARLFGSVNN AETEYFPIAV PLVVVASVLL LLSSRRLNVV GLGKDAATNL GINHRRSSIY TLVLVSVLMA VSTALVGPMT FLGELVATLA YQFADTYDHR YILPMSALIG FVVLSGAYFV MNHVFRAQGV VSIIIEMVGG TVFLIVILRK GRL > RXA00099 (1-1173, translated) 391 residues VKNPRLIALA AIILTSFNLR TAITALAPLV SEIRDDLGVS ASLIGVLGMI PTAMFADAAF ALPSLKRKFT TSQLLMFAML LTAAGQIIRV AGPASLLMVG TVFAMFAIGV TNVLLPIAVR EYFPRHVGGM STTYLVSFQI VQALAPTLAV PISQWATHVG LTGWRVSLGS WALLGLVAAI SWIPLLSLQG ARVVAAPSKV SLPVWKSSVG VGLGLMFGFT SFATYILMGF MPQMVGDPQL GAVLLGWWSI LGLPLNILGP WLVTRFTNCF PMVVIASVMF LIGNGGFCLA PDVAPWLWAT LSGLGPLAFP MALTLINIRA ETSAGASALS SFGQGLGYTI ACFGPLLTGF IVDATGSFRT IFLLFAGATL FVTRGGYFAT RQVYVEKLLN R > RXA00123 (1-1119, translated) 373 residues MPKNYDINGA IRRRDMLRRR YLPDSANSTP VPEEVSPLTR YVTDGIPKRP PLGATVADGL KFAEGASNRM VMSLYPAPSK PAIEELAEAW DLHPTIVEDL LLGQQRPKLD RYEDIIFIAI RSARYIDSRE EVDFSEFHIL MKPQAIAILC QDNQWIDGTS AASFSNPEEI DKRIKTLLAD AELLSSGPRA AAYRLLDAIV DGFSPVLRGI AIDQEQIERQ VFSGDAAVAE RIYNLSQEII DMQHTTSSVT EVVQRLNKDF IRSGMSEELR AYLDDVADHL TRDNTRVSEY RESLSQILNV NATLVAQRQN EDMKKISGWA AIIFAPTLVS SIYGMNFDIM PELHWAFGYP LALLANLGFT LLLYWIFKRS KWM > RXA00160 (1-573, translated) 191 residues MLNIARNRNM KRRLAIAAFV ATATATATMA PASAQTDYAG LSSGVADTVA EAAGVATTAV APAATVARPA NGTFTSGFGP RWGTFHNGID IANSIGTPIY AVMAGTVISS GPASGYGQWI RIQHDDGSIS IYGHMEYLYV SVGERVAAGQ EIAGMGSQGF STGSHLHFEI HPDGVTPVDP QAWLANHGIY V > RXA00193 (1-843, translated) 281 residues MQATLKKYFP VFVLPTLLAF MIAFLVPFIV GFFLSFTKFT TITNAKWVGI DNYVKAFSQR EGFISAFGFT VLVVIVSVIT VNIFAFLLAW LLTRKLRGTN FFRTVFFMPN LIGGIVLGYT WQTMINAVLS HYATTISADW KFGYAGLIML LNWQLIGYMM IIYIAGLQNV PPELIEAAEL DGVNKWEMLR HVTIPMVMPS ITICLFLTLS NSFKLFDQNL ALTNGAPGGQ TEMVALNIIN TLFNRMNVEG VGQAKAVIFV VVVVVIAYFQ LRATRSKEIE A > RXA00203 (1-912, translated) 304 residues MLNNGALVGL IALCVGLFIA TPHFLTIPNL INIGIQSATV AILAFGMTFV IVTAGIDLSV GSVAALGAMT SAYFFAEVGL PGWITLLIGL FIGLLAGAIS GISIAYGKLP AFIATLAMMS IARGITLVIS QGSPIPSAPA VNALGRTYFG IPMPILMMAL AGIVCWFILS RTVLGRSMYA IGGNMEAARL SGLPVKKILV MVYALAGVYA ALAGLVMTGR LSSAQPQAGV GYELDAIAAV VIGGASLAGG TGKATGTLIG AILLAVIRNG LNILNVSSFW QQIVIGCVIA LAVGFDVIRN KTSR > RXA00204 (1-1572, translated) 524 residues MVNSEQALHQ HDPAPILQLD KVSKSFGPVN VINQVSIDVR PGRVLALLGE NGAGKSTLIK MMSGVYQPDG GQILVDGKPT TLPDTKTAES FGIATIHQEL NLVPTMTVAE NVMLGRTPRK WGLVNFKHLR RQAQAALDLI GVDVDLNAQV GSLGIARQQM VEIAKALSMN ARILILDEPT AALTGREIDQ LFKVVDQLKE KGVAMVFISH HLDEIARIGD TVSVLRDGQF IAELPADTDE DELVRLMVGR SIENQYPRSA PEIGQPLLEV KNLNAEGRFT DISLTVRAGE VVGLAGLVGA GRTEVVRSIA GVDKVDSGEV IVAGKKLRGG DISEAIKNGI GHIPEDRKAQ GLVLGSSVED NLGLATLAST ARAGLVDRSG QHKRAAEVAE KLRIRMASLK QPISDLSGGN QQKAVFGRWV LAGSNVLLLD EPTRGVDVGA KVEIYNIINE MTEKGGAVLM VSSELPEVLG MADRILVMSG GRIAGELPAK GTTQDDVMAL AVSQVDDSIT EEAAAEIENT KEDR > RXA00270 (1-888, translated) 296 residues MIGAFEFGLL YGVVALGVYL TFRVLNFPDL TVDGSLTTGA ATAATALMSG WPPLMATAAG FVTGFIAGMI TGLLHTKGKI DGLLAGILTM IALWSVNLRI MGGANVPLLR TDNLFTPLRD AGLLGTWAGP AILAVAVGIL GLIVIWFLNT DIGLSLRSTG DNGPMVQSFG VSTDFTKILT ISLSNGFVGL AGALIAQYQG FADISMGIGL IVIGLASVIL GQAIFGQRRV WLAVLAVIVG AIAYRLIIFA ALRVGLDPND MKAISAILVV VAMLLPRWRA KFSKAPKPKQ PVAVEA > RXA00311 (1-855, translated) 285 residues MEHSPEGKRG FFTSSVMAGC SVGNVLAGLV FIPFLMLPEE HLMSWGWRVP FLLSALVLVV AYFVRTRLEE ASTEKAEEDA GAPALAVLRT QGIDVARVFL ITFFAVVQTT FNVYALAYAA NEIGIDRSFM VMVNTIALGL SIGTIPLAAW VSDRIGRKPV LLFGAITCAI TTYFYFQAIS EADLVLIFAL CLVNQGLFYS CWNGVWTIFF PEMFASSVRY TGMAMGNQLG LIIVGFAPTI ATALYAWNGW EAVAGFIIGA IALSAAVILT TKETAFTKLE DLGKK > RXA00312 (1-426, translated) 142 residues METVRTATAA PETASLKLRE AESPAKSPKK AALASLLGST LEYYDFVIYG TASALLFNHL FFPQGDPVVA TIGSLASFGV AYIARPIGGL VMGHVGDKIS RKTALMVTLM IMGIASISIG LLPTYGQIGI WATVLLMIAR IA > RXA00345 (1-951, translated) 317 residues MAGMKKLLWT LPILPLVLAG CSTGSADSAD STNAAGSNSL KVVTSTQVWA DVAEAVAPDV DIEAIITGGD IDPHSFEPSA TDMAKVSEAD IIIVGGGGYD SWLYGTLEDD DRIIHALDLS EHDHSEHDDH EHEAEEAHEH DHDEEGHDHD VDNEHVWYST EYVSEVAEEF AEKVTELDPE AQADATAVTT KMDELHNQIH DLPAVRIAQT EPIADHILSH SDMVESTPEG YRATTLSESE PTAADVASFQ DAINNGDLDV LTYNPQSAST VATSLKDLAE EKGIPVVEIY ETPQNTENFL DAFTKAVDDL TAATNQV > RXA00378 (1-1773, translated) 591 residues KSWRSYPSWF AFDHGTLTQN EIYFDVACGI TVLLLAGRLL TRRRSQSSLL AELGRLQIDP QRIVTVVRKH RLKRVVQELN IPVQEVRVND DVKVPPNTTI PVDGTVIGGG SRIAASIIMG QDQRDVKVND KVFAGSLNLE SEIKVRVIRT GHRTRIAAVH RWVKEATLKE NRHNRAAIRS AGNLVPITFT LAVVDFCLWA LISGNINAAF TTTLAVLACV APVALALSAP LATRNSIEAA ARHGILVRSG EIFRVLDDVD TAVFNRVGTL TDGEMTVETV TADKGEDPEL VLRVAGALAM ESHHAISKAL VKASREARDT GAGGEDVPHW IEVGNVEITE AGSFQATIEL PLIKPSGEKI MRTTEALLWR PRSMTEVREH LSPRLVAAAT SGGAPLIVRW KGKDRGVITL SDHVRSDSSD AIIAIEEQGI ETMMLSRDTY PVARRYADSL GITHVLAGIA PGKKAQVVRA VHTRGSTVAM IGDESVMDCL KVADVGVLMG VDRPSDLRDD SDDPAADVVV MREEVMSVPT LFKLARRYAK LVNGNIALAW IYNGVAMVLA VSGLLHPMAA TVAMLASSLL IEWRSGRARK Y > RXA00412 (1-1080, translated) 360 residues VSHTASTPTP EEYSAQQPST QGTRVEFRGI TKVFSNNKSA KTTALDNVTL TVEPGEVIGI IGYSGAGKST LVRLINGLDS PTSGSLLLNG TDIVGMPESK LRKLRSNIGM IFQQFNLFQS RTAAGNVEYP LEVAKMDKAA RKARVQEMLE FVGLGDKGKN YPEQLSGGQK QRVGIARALA TNPTLLLADE ATSALDPETT HEVLELLRKV NRELGITIVV ITHEMEVVRS IADKVAVMES GKVVEYGSVY EVFSNPQTQV AQKFVATALR NTPDQVESED LLSHEGRLFT IDLTETSGFF AATARAAEQG AFVNIVHGGV TTLQRQSFGK MTVRLTGNTA AIEEFYQTLT KTTTIKEITR > RXA00413 (1-897, translated) 299 residues MKLRRITTTA IAGLFAATAL VACGSDSDGS STTVAEGTEG VTIRIGTTDA AKEAWTVFED KAAEEGITLD IVPFSDYSTP NEALAQDQLD VNLFQHLKFL AEYNVGSGAD LTPVGSSEIV PLALFWKDHD SIDGIDGESV AIPNDPSNQG RAINVLVQAG LVTLKTPGLV TPAPVDIDEA ASKVSVIPVD AAQAPTAYQE GRPAIINNSF LDRAGIDPNL AVFEDDPESE EAEPYINVFV TKAEDKDDAN IARLVELWHD PEVLAAVDRD SEGTSVPVDR PGADLQEILD RLEADQENA > RXA00431 (1-675, translated) 225 residues MVSIDTYNAC VDFPIFDAKS RSMKKAFLGA AGGAIGRNQD NVVVVEALKN VNLHLREGDR VGLVGHNGAG KSTLLRLLSG IYEPTRGSAD IRGRVAPVFD LGVGMDPEIS GYENIIIRGL FLGQTRKQMK AKMEEIADFT ELGEYLSMPL RTYSTGMRIR LALGVVTSIE PEILLLDEGI GAVDAAFMAK ARDRLQALVE RSGILVEAST QRLSCQLCNT ALWVD > RXA00444 (1-777, translated) 259 residues LLIPATLAML LIIGPIEALL LQIPWDRSWE LLTAPESLGT ARLSIGTALF STALCAIVGF PLALALHLYE RSHPRVTSVL TVLVYAPLVL SPVVSGLALT FLWGRRGFLG SWLDQVGLPI AFTTTAVVFA QVFVALPFFI STVTTALRGI PKQFEEIAAT EGATRWEIMH KMIIPLAMPG IFTGMILGFA RALGEYGATL TFAGNIAGVT RTIPLHIELG LSSNDMDKAL GAVIMLLAVY VLIIGAIGAL RLESKVRKV > RXA00445 (1-912, translated) 304 residues MADLSIEHVS RFFGDAIALN DVSLTVPSGS ITAIIGPSGS GKTTLLRLLA GLDSPDEGTV SIGNKIAKLG DTALCEQDSP LYPHLNVWEN VAFPLKLKAT NTADEVVKKR VSDVLEMLEI APLARRKITE LSGGQKQRVG IARALVRDVE VYLFDEPMAH LDQALARDIV ADLRKIQQSL GLTFVYVTHS KSEAFALADQ IVVLVDGQVA QVGEAEELVE KPKTLEIAEF LSPTELNVRR RGDAVEAWRP EDTQLARGGT ATVEAVTYLG REWLVQTTEG HAVSEEKEDV GESVTLTQKK VESF > RXA00466 (1-987, translated) 329 residues VQSRLSKILR SSVVGVAVLA LLAGCSNNAD DTDADSTSTG NSAFPVSIEH EFGTTTIDDV PERVVTLGVT DADIVLALGT VPVGNTGYKF FENGLGPWTD ELVEGKELTL LDSDSTPDLE QVAALEPDLI IGVSAGFDDV VYEQLSDIAP VVARPAGTAA YAVAREEATN LVARAMGQSE KGQELNEETD ALIQAARDEN PSFDGKTGTV ILPYQGKYGA YLPGDARGQF LDSLGISLPE AVLSRDTGDS FFVDVPAESV KDVDGDVLLV LSNDENLDIT AENPLFETLN VVQKDAVIVA TTEERGAITY NSVLSVPFAL EHLAPRIAE > RXA00482 (1-648, translated) 216 residues MRISSKLVTT ALLAAISLFG ISTAQAQDIF DGGRLAGGSS QVSNLSSVPE NLALPEIENS IDLERYKGKW YQVAAIPQPF SLQCSHDVTA DYGVIDSDTI SVTNKCGTFF GPSVIEGSAK VVSNASLKVS FPGIPFQSED NQANYRVTYI EDDYSLAIVG SPSRSSGFIL SRTPQLSSDQ WSHVRNITED SGWWPCAFIT VPATGGLNTA TPLCTL > RXA00523 (1-750, translated) 250 residues VLRNQLASPD IIGISSGASA AGVICIVFFG MSQSAVSAIS LCASLAVALL IYLVAYRGGF SATRLILTGI GIAAMLNSLV SYSLSKADSW DLPTATRWLT GSLNGATWDR AMPLIVTTVV LIPLLVANAR NVDLMRLGND SAVGLGVATN RTRVIAIIAA VALIAVATAA CGPIAFVAFV SGPIAARILG SGGSLIIPSA LIGGLIVLIA DLIGQYFLGT RYPVGVVTGA FGAPFLIYLL IRSNRAGVTL > RXA00525 (1-660, translated) 220 residues MSLAESILLA LTSLRSNKMR ALLTLLGVII GIASVIGILT IGKALQDQTL NSLESLGAND LSAQVEERPD EDSPEPDMFA FSGAANSSGN LIPEETVDTL RDRFAGSITG ISVGGMGTQG TLIGDTADLK SDLLGVNEDY MWMNGVEMNY GRAITQDDVA AQRPVAVIAP DTFNTLFDAN PNLALGSEVA FELNGQETFL RVIGVYKEAA AGGLVGSNPT > RXA00556 (1-594, translated) 198 residues YTPYTVANDI THTKDGLNTL SIRAAQGVDQ DSLKGSLQTY FDALYANNDS HHVAMLDFRK QIEEFNTILG AMSLGISAIG GISLLVGGIG VMNIMLVSVT ERTREIGVRK ALGARRRDIR LQFVVEAMII CFIGGILGVL LGGILGLIMS SAIGYISLPP LSGIVIALVF SMAIGLFFGY YPANKAAKLD PIDALRYE > RXA00596 (1-453, translated) 151 residues MLNALKFIPW LIGQIFLSGF SVITAAVKKD TGFNPVVIRY PLRVTTDFQI AALSTCITAT PSTLSLGLRE PRKPGDPTIL LIQAVFGSDP VEVFESIADM EQRLVPSVAS IDHGVPGQGP YKEIRPSDAE WPSREIADTA QNTVSQDKRE F > RXA00634 (1-1383, translated) 461 residues MWERFSFYGM QALLVYYLYF DVAAGGLGLD QTQATGLVGV YGALLYLCCW AGGWVSDRVL GAEKTLLGGA ISVTIGHLVL AGLGGKIGLA IGLGCIAIGS GFVKTAAITV LGSRHGEQEG DAKADPAFQL FYLGINVGAL LGPLLTGWLS SRYSFEMGFG AAAVLMIGGL GIYAALRKPM LQSFPLEVKK ALLRAQNPAE KHVISTAFAA VAVLCGVLLY LLLTETVSAD QLAGALLLVT IGAALWLIIQ PLRHPQVSSE EKRKVLAFIP IFVCSTAFWA VQAQTYGVLA VYSQERVDRM VGDFEIPAAW SQSLNPFFIL ALSIPISLWF MRGSRAPRVK IGISIGVIIA GSGLLVLIPF VGMPLAPVWV LPLSVFLISL GELFIGPGGM AATAHHAPRI FATRFSALYF LTLAIGMSIA GNVSKFYDPT NHTSELRYFA VFGISIIVIG VGSLMVAKKV G > RXA00665 (1-438, translated) 146 residues MSSSTLLLAS GQVTALAADY TLSHTPSDGI LVVLGFAMIL TFMTLIMLGR LTPMVAMLLV PTIFGLIAGA GLGLGDMALD AIKDMAPTAA LLMFAIMFFG IMIDVGLFDP LIRVITRVLH DDPAKVVIGT AVLAGVVSLD GDGSTT > RXA00702 (1-1320, translated) 440 residues LGLPPAVMRK RVEETLDLLG IAELRYVPLA ELSGGEQQRV AIGAVLTTRP ALIILDEPTS ALDPNGAEDV LATVTKLAHD LAMTVVLAEH RIERVLQYVD RVAHVGADGH VTVGTPEEIM ADSDVAPPIV ELGRWAGWAP LPLSIRDARA HSADMRKRLY QRGLVVNKLH NHAVQPLLIA EDIMVDFPEI RAVDGVNLNL NSGEITVLMG RNGCGKSSLL WALQGSGTRN QGSVQVLDEA AGFSWTDPKT LKPAKRRNLV SMVPQTPTDI LYESTVHAEL ARSDKDAAAP AGTTREILDS LVPNIPDHLH PRDLSEGQKL SLALSIQLAA KPRVVFFDEP TRGLDYDGKK SLARSFQQLA DDGHAILVVT HDVEFSALCA DRVLFMASGK IISDGTAVEI LPASPAYAPQ VAKITAGIQE ESHWLTVSAV KAALGHGEIS > RXA00728 (1-792, translated) 264 residues VAAAIIVALL AWFIISALNN EAYGWDTYRS YLFDTRIATA ALHTIALTLL SMILGVVLGA ILAVMRMSGN PVMQGVAWLY LWIFRGTPIY VQLVFWGLLG SLYQSINLGF AEIDLQSLLS NMFLLAVIGL GLNEAAYMAE IVRSGIQAVP EGQMEASKAL GMNWSMTMRR TILPQAMRII IPPTGNELIS MLKTTSLVVA IPYSLELYGR SMDIAYSLFE PVPMLLVAAS WYLVITSILM VGQYYLEKHF EKGSTRTLTA RQLA > RXA00732 (1-822, translated) 274 residues MLVQMTSTLM ISAPMLAIGG IIMAVRQDLG LSWLMVVSIP VLIIVVALII VRMVPLFQTM QKRIDRINQI IREQLTGIRV IRAFVREDVE RERFTTASKD VADIGVRTGN LMALMFPAVM LIMNLSAVAV IWFGAFQVES GETQIGTLFA FLQYIMQILM GVMMAAFMFV MVPRAAVSAD RIGEVLETTP SVQAPETPAQ PSTSAGEIVF NNATFAYPGA DDPVLNNVSF RVAPGSTTAI IGSTGSGKTT LIGLVPRLFD VTEGDVTVDG TDVR > RXA00734 (1-453, translated) 151 residues RHLRYGNEDA TETQLWQALA IAQAADFVRE MPEGLDSEIA QGGTNVSGGQ RQRLAIARAL LKQPEIYIFD DSFSALDVST DAALRRALST NLPDATKLIV AQRVSTIRDA DQIVVLDNGE VVGIGTHTNL LNTCGTYREI VESQETAQAQ S > RXA00759 (1-924, translated) 308 residues MLRYVGRRLL QMIPVFFGAT LLIYALVFLM PGDPVQALGG DRGLTEAAAE KIRQEYNLDK PFIVQYLLYI KGIFVLDFGT TFSGQPVIDV MARAFPVTIK LAIMALLFES ILGIIFGVIA GIRRGGIFDS TVLVLSLIVI AVPTFVIGFV LQFLXGVKWG LLPVTVGSNT SITALIMPAV VLGAVSFAYV LRLTRQSVSE NLRADYVRTA RAKGMSGENV MNRHVLRNSL IPVATFLGAD LGALMGGAIV TEGIEGINGV GGTLYQAILK GEPTTVVSIV TVLVIVYIIA NLLVDLIYAV LDPRIRYA > RXA00760 (1-1032, translated) 344 residues MPNNEFHTNH SLGQDDQTPD QAHFFPQGRG EALVRPGQEH FIAATDETGL GAVDAVADDS APTSMWGEAW RDLRRRPLFW VSAVLIILAL LLAAVPQLFT STDPQFCVLA NSLDGPQSGH PEGFDRQGCD IFARTVYGAR ASVAVGVLTT LLVALIGTVF GALAGFFGGI MDTILSRITD MEFAIPLVLA AIVVMQMFKE HRTIVTVVLV LGLFGWTNIA RITRGAVMTA KNEEYVTSAR ALGASKAKIL LSHIMPNAAA PIIVYATVAL GTFIVAEATL SFLGIGLPPS IVSWGADIAK AQTSLRTQPM VLFYPAMALA LTVLSFIMMG DVVRDALDPK SRKR > RXA00761 (1-591, translated) 197 residues MTTNIPQTPN HEGEQPLLEL KDLKISFTSS TGVVDAVRGA NLTIYPGQSV AIVGESGSGK STTAMSIIGL LPGTGKVTEG SIMFDGQDIT GLSNKQMEKY RGSEIGLVPQ DPMTNLNPVW RIGTQVKESL RANHVVPGSE MDKRVAEVLA EAGLPDAERR AKQYPHEFSG GMRHRALIAI GLAARPKLLI ADEPTSA > RXA00774 (1-654, translated) 218 residues MDKATDALLR TSLASAESAL GNAEKLEELR TGCESQAVEL LALETPVARD LRQVVSSIYI VEEITRMGAL AMHVANSVRR RYPDPVIPED MRGYFKEMAR LAADMTDHIR QILIDPEPDL ALEMAKSDDA VDDLHQHIMR ILTLRPWPHD TKSAVDLTLL SRFYERYADH TVNVAARIIY LSTGLHPEEY MEKREQQRAD ADMEKRWAEL ERQFRTSE > RXA00775 (1-771, translated) 257 residues MSKLKLNDVN IYYGDFHAVQ NVNLEVPARS VTAFIGPSGC GKSTVLRSIN RMHEVTPGAY VKGEILLDGE NIYGSKIDPV AVRNTIGMVF QKANPFPTMS IEDNVVAGLK LSGEKNKKKL KEVAEKSLRG ANLWEEVKDR LDKPGGGLSG GQQQRLCIAR AIAVEPEILL MDEPCSALDP ISTLAVEDLI HELKEEFTIV IVTHNMQQAA RVSDQTAFYS LEATGRPGRL VEIGPTKKIF ENPDQKETED YISGRFG > RXA00776 (1-921, translated) 307 residues MTNNVVTPRM DEPLKKSSAF TDISSSRKTT NTAATVIIYG AMLIAAVPLV WVLWTVISRG IAPILTADWW STSQAGVMLM LPGGGAAHAM IGTFMQAVVT SVISIPIGIF TAIYLVEYSN GNRLGRLTTF MVDILTGVPS IVAALFVYSL WIVLFGFDRS GFAVSLSLVI LMVPVIIRNT EEMLRVVPQD LREASYALGV PKWKTIAKIV LPTALSGIVT GVMLAVARVM GESAPVLVLV GSSQAINWNP FGGPQASLPL MMLDMYKAGT APATLDKLWG AALTLVLIIA VLNIGARIIS AKFSVKQ > RXA00777 (1-1065, translated) 355 residues MATNESVSEK QRLDATRVQA HPVAVNANSS QTKPSKKIVA EGGGSVKRPG DRIFEVLSTA SAAIITAIII AIAAFLIWRA VPALMRNAEG IGGFFTYSGA WNTTDIDAMY FGIPNLLAAT LLISVIALII AMPIALGIAI FLSNYSPKRL VKPLGYMVDM LAAVPSIVYG LWGWQVLGPA LSGFYTWIES WGGSFFLFAT YQNSPSFATG RNMLTGGIVL AVMILPVIEA TAREVFIQTP KGHIESALAL GATRWEVVRL TVLPFGMSGY VSGAMLGLGR ALGETMALYM VVSPSSAFRF SLFDGGTTFA TAIANAAPEF NDNTRAGAYI SAGLVLFALT FIVNAGARAM VNRGK > RXA00828 (1-369, translated) 123 residues EHQFVARTVR DELEIGPKIM KVDASERIEE LLDRLRLRHL ENANPFTLSG GEKRRLSVAT ALVAAPKLLI LDEPTFGQDP ETFTELVTML RELTDNGISI VSVTHDPDFI AALGDHHIEV SAK > RXA00832 (1-555, translated) 185 residues TLTAVVYGFF LFRQMGAQAG EFQEVEVAEK ADDAAKWEVP FRGLILIITV LPIVLLSHDM ATVMDEVLAS LGAPVAMAGL IIATIVFLPE TITSLKAAWT GEIQRVSNLA HGAQVSTVGL TIPAVLVIGV ITGQDVVLGE TPINLLLLGT TIAVTAIAFS SKKVSAVHGS VLLMLFGVYM MSMFA > RXA00934 (1-789, translated) 263 residues PSFSMAALPF AEGPIVATYH ASSSGSKLLK AFLPVLSPML EKVRAGIAVS EMARRWQVEQ VGGDPVLIPN GVETSMFKAA RQIEPNDPVE IVFLGRLDES RKGLDILLRA LTRLDRPFTC TVIGGGTPRE VAGINFVGRV SDEEKAAILG RADIYVAPNT GGESFGIVLV EAMAAGCAVV ASDLEAFSLV TDSEAAQPAG VLFKTGSDAD LAKKLQALID DPSSRSTLIA AGLKRANAYD WSTVSTQVMA VYETIAIDKV RLG > RXA00939 (1-168, translated) 56 residues GVLLGGVTMS IGMLVHEASV LLVIAIAMLL LRPTLKEDKD KADVSTADAA KETLSA > RXA00942 (1-204, translated) 68 residues LSTKNYHVEG LTCANGVASV EDEIGIVAGT QGVDIDIETG RVTVTGEGFT DEEIIEAVAN AGYKVSGR > RXA00950 (1-906, translated) 302 residues MNTPAVQVQN LSLSEGSFTA VNGLSLTVEQ GSIHGFLGPN GAGKSTTIRA LIGVLKPQTG SVAILGQDPV AHPDVLRRVG YVPGDATLWD NLTGAEVFRA LESLRKTPSN RALENELIDA FQLDPSKKIR EYSTGNRRKV SLIAALSHEP ELLIVDEPTA GLDPIMEQVF VTYVRKARTN GASVLLSSHI LSEVEQLCDY VTVLKEGRAV ASNEVSYLRK ISAHRITATI PAVPQHLAGR GEVDFDAGHL SITCDASEVP DILRIIIDAG GQDIISTAAS LEEIFLRHYG ETVSGSESKA SQ > RXA00960 (1-459, translated) 153 residues LKNDVDVNVA GFVVPLCATI HLAGSMMKIG LFTFAVVFMY DMEVGVGLSI GFLLMLGITM IAAPGVPGGA IMAATGMLAS MLGFNTEQVA LMIAAYIAID SFGTAANVTG DGAIAVIVNK FAKGQLHTTS PDEIEEDDRV AFDITPSDVE HHK > RXA00980 (1-639, translated) 213 residues MFVGVNGHAI GIVAVADAVR SDSASAIESL HKAGIQVVMA TGDAHRVAQN VASKLGVDEV YSELLPEQKL ELVRDLQAAG KTVAMVGDGV NDTPALAAAD IGVAMGVAGS PAAIETADIA LMADRLPRLA HAVTLAKRTV RTMRINILIA LATVMVLLAG VLFGGVTMSV GMLVHEASVL LVISIAMLLL RPTLKEDAAQ ASDIKRSEIQ QIA > RXA01000 (1-540, translated) 180 residues MLAARGVGPY WLRTVLRFVF AVIRAFPEVV IAIILLTVTG LTPFTGALAL GISGIGQQAK WTYEAIESTP TGPSEAVRAA GGTTPEVLRW ALWPQVAPSI ASFALYRFEI NIRTSAVLGI VGAGGIGSML ANYTNYRQWD TVGMLLIVVV VATMIVDLIS GTIRRRIMKG ASDRVVAPSN > RXA01002 (1-417, translated) 139 residues PTEHDKQIAF HALESVGILD KVWTRAGALS GGQKQRVAIA RALSQDPSVM LADEPVASLD PPTAHSVMRD LENINNVEGL TVLVNLHLID LARQYTTRLV GLRAGKLVYD GPISEATDKD FEAIYGRPIQ AKDLLGDRA > RXA01003 (1-804, translated) 268 residues MTTPSSTLIP QKPRAGVKTY LIIGAIVVFT VATATPALGG IELDFASIAA NWRNGANKLL QMLQPNFAFL PRTWLPMLET LQMALVGAVL SAAVSVPLTL WAAQATNTSA IGRGIVRTII NVVRSVPDLV YATILVAMVG VGALPGILTL FLFNLGIVVK LVSEAIDSTE HPYMEAGRAA GGSQFQINRV SALPEVMPLF ANQWLYTLEL NVRISAILGI VGAGGIGRLL DERRAFYAYA DVSVIILEIL IVVIVIEVIS NALRKRLV > RXA01006 (1-858, translated) 286 residues MTTSQILRRI GQAVLVLLVT FTLAFIMLSA LPGDAVSARY SSPDLGLSPE QIAQIRESYG ADESLIAQYF STLGGFLVGN FGYSVQTGTA VATQLAEALP GTLTLAILAF LLAAILALVI SILATMDRFA WIKGIFQALP PFFVSLPSFW LGIILIQIVS FRLGWVPVIG TTPAQGLILP TITLSIPITA PLAQVLIRSI EEVKAQPFIA AVRARGAGEM WIFFRNIIRN ALLPTLTIAG ILFGELVGGA VVTEAVFGRA GLGQMTVNAV ANRDMPVMLA IVVIAA > RXA01012 (1-1641, translated) 547 residues MTTPLLEIND LVVSYQTAKG LVHAVNNVSL EVHPGQITAI VGESGSGKST TAQAVIGLLA DNAEVDSGRI SFNGRSLVGL NAREWKNVRG TKIGLIPQDP NNSLNPVKTI GASVGEGLAI HKRGTAAERK KKVIELLERV GIDNPEVRYD QYPHELSGGM KQRALIAAAI ALEPELIIAD EPTSALDVTV QKIILDLLED MQRELGMGIL FITHDLAVAG DRADRIVVMQ KGEVRESGYA ASVLTDPQHE YSKKLLADAP SLTIGEIPTR VPAVDPEVAQ AKGPLLVVDK FRKEHQRGKE GAFVAANDIS FEVLPGTTHA IVGESGSGKT TLGRAIAMFN TPTSGSISVS GKDITNLSKA QQRELRQQIQ LVYQNPYSSL DPRQTIGSTI AEPLRNFTKV SKQEADEKVA HYLELVALDP ALATRRPREL SGGQRQRVAI ARAMILEPEL VVFDEAVSAL DVTVQAQILR LLDDLQRELG LTYVFISHDL AVVREISDTV SVMSRGNQVE LGKTAEVFNN PQTDFTRRLI DAIPGSRYRG GELNLGL > RXA01013 (1-795, translated) 265 residues LGNPWTRPAA VISIVVLAVA VLMALVPGLF TSQDPFTGDD VALLGPSGTH WFGTDSVGRD LYSRVVYGAR ETLLGALIAV LVGLIVGTLI GLLAGAQRGW VDTVLMRFVD VLLSIPALLL SLTVIILLGF GTMNAAIAVG ITSVATFARL ARSQVMTVAG SDFVEAAYGS GGTQAQVLFR HILPNSLTPV FALAALQFGS AILQLSVLGF LGYGAPAPTP EWGLLISDAR DYMATSWWLT VLPGFVIIAV VMSANYLSRI IQKEA > RXA01070 (1-1386, translated) 462 residues MANATAQKGR FGLPGWMTGF GAQVIAGLIL GLILGLVARG MDSGAADGEA SWLTGLLSGV GSAYVSLLKV MVPPLVFAAV VTSVAKLREV ANAARLAVST LVWFAITAFF SVLAGIAVAL IMQPGVGSTV DASNAADPSR VGSWLGFIQS VIPSNILGLS GSYSENSGVN LSFNVLQILV ISIAIGVAAL KAGKSAEPFL KFTESFLKII QIVLWWIIRL APIGSAALIG NAVATYGWSA LGSLGKFVLA IYVGLAIVMF VIYPVVLKLN GIPVLGFFKR VWPVTSLGFV TRSSMGVMPV TQRVTEQSLG VPSAYASFAI PLGATSKMDG CAAVYPAVAA IFVAQFYGID LSIMDYVLIM IVSVLGSAAT AGTTGATVML TLTLSTLGLP LAGVGLLLAI EPIIDMGRTA TNVTGQALVP AIVAKREGIL DQDVWDAAEK GGAAIEMATV SEKETEPAEV RS > RXA01094 (1-948, translated) 316 residues MTLATIPSPP QGVWYLGPIP IRAYAMCIIA GIIVAIWLTR KRYAARGGNP EIVLDAAIVA VPAGIIGGRI YHVITDNQKY FCDTCNPVDA FKITNGGLGI WGAVILGGLA VAVFFRYKKL PLAPFADAVA PAVILAQGIG RLGNWFNQEL YGAETTVPWA LEIYYRVDEN GKFAPVTGTS TGEVMATVHP TFLYELLWNL LIFALLMWAD KRFKLEHGRV FALYVAGYTL GRFWIEQMRV DEATLIGGIR INTIVSAVVF AGAIIVFFLL KKGRETPEEV DPTFAASVAA DAVASPDRKP LPKAGEGIDG ETPSTR > RXA01135 (1-324, translated) 108 residues VTHILEDSRR FLQLGAFASL STALAGAARY VTSTSNNEPA DNTPLTIGYV PIAGSAPIAI ADALGLFKKH GVNVTLKKYS GWSDLWTAYA TEQLDVAHML SPMTVAIN > RXA01141 (1-462, translated) 154 residues VNSAADLKGM VLGIPFEYSV HALLLRDYLV SNAVDPIADL ELRLLRPADM VAQLTVEGID GFIGPGPFNE RAISNGSGRI WLLTKQLWDK HPCCAVAMAK EWKAEHPTAA QGVLNALEEA SAILSNPAQF DSSARTLSQE KYLNQPATLL DGPS > RXA01142 (1-420, translated) 140 residues TRTHLEQVGL TDAAERRPAR LSGGMQQRVG IARAFAIDPP IMLLDEPFGA LDALTRRELQ LQLLNIWEAS RRTVVMVTHD VDEAILLSDR VLVMSKSPEA TIITDIPVNL PRPRHELSED ASVEAETTAL RKRMLHLLEH > RXA01164 (1-1575, translated) 525 residues VTLFVRLALA AVGGLFVFAS NEPIGWFVAG IVGTALFFIS LAPWDLGVPQ KRRKKNEPVP FLQQMSTGPT VVQGMLLGFV HGLVTYLQLL PWIGEFVGSL PYVALSVVEA LYSIALGAFG VLIARWRDWK VLLFPAMYVA VEYLRSSWPF DGFAWVRLAW GQINGPLANL AALGGVAFVT FSTVLAAVGV AMVIISKKRL AGAIITASVI AIGAVSSLYV DRNGTSDESI EVAAIQGNVP RMGLDFNAQR RAVLANHARE TLKLDEQVDL VIWPENSSDV NPFSDAQARA IIDGAVEHVQ APILVGTITV DEVGPRNTMQ VFDPVEGAAE YHNKKFLQPF GEYMPFREFL RIFSPYVDSA GNFQPGDGTG VVEMNAANLG RAVTVGVMTC YEVIFDRAGR DAIANGAEFL TTPTNNATFG FTDMTYQQLA MSRMRAIEFD RAVVVAATSG VSAIVNPDGS ISQNTRIFEA ATLTESIPLK DTVTIAARVG FYVELLLVII GVLAGLFAIR MNSRSKSAKG SARPA > RXA01168 (1-720, translated) 240 residues RTATPDVHVL IVDDNSPDGT GERADKLAAD DDHIFVLHRE GKGGLCAEYM AGFQWGLERD YQVLCEMDAD GSHAPEQLHL LLAEITNGAD LVIGSRYVPG GRVVNWPKNR WLLSKGGNVY ISVALGAGLT DMTAGYRAFR REVLEALPLD ELSNAGYIFQ VEIAYRAVEA GFDVREVPIT FTEREIGESK LDGSFVKDSL LEVTKWGLKH RGGQAKELSK EMVGLLNYEW KHFKKRNTWL > RXA01185 (1-858, translated) 286 residues MTDPENSQGT PQICPTDPTT QALAVRGLTK SYGDATVVNN INLDIPKGAI YGIVGPNGAG KTTMLSMATG LLRPNKGTAW ISGFNVWEEP NDAKRSMGLL ADGLPIFDRL TGKELLTYVG ALRELDEGIV DQRSEELLEA LGLKEAAGKR VVDYSAGMTK KILLAQALIH NPKVLILDEP LEAVDPVSGR LIQQILKNFA QTGGTVVLSS HVMELVEGLC DHVAIINRGV VEIAGHVNEV RRGRSYRMSS LMRLKALLFK RGHYLGWVRP KAIAKAKIRT RIGLSK > RXA01188 (1-1104, translated) 368 residues MMNGVVQPQE HLDATLIAAD FHGNPENSGD RKERLNFQGW KYALNRTVRD VFPDGLLDLA ALLTFFSILS IAPAVLLGYS VITIFLASDS TEILNLVRDE VNQYVPEDQS HVVNGVIDSI AGSAAAGQVG VAVGVITALW TSSAYVRAFS RCANAVYGRS EGRTLIKRWA MLLFLNLALL LGIIIILVSW VLNETLVMGI FAPIAEPLHL TNVLSFLTDR FMPIWIWVRF PVIVGVLIMF VATLYYWAPN ARPWKFRWLS LGSFLAIVGI LLAGVGLNFY FTLFAAFSSY GAVGSLLAVF IALWVFNICL IIGLKIDVEI SRAKQLQAGM PAEDYSLVPP RSIEKVAKMK QRQQRLMDQA AAIREESN > RXA01245 (1-1767, translated) 589 residues ASWVTTLGLG GEHLDFWWEL ALLVTIMLLG HWLEMRALGA ASSALDALAA LLPDEAEKVV DGTTRTVAIS ELAVDDVVLV RAGARVPADG TIMDGAAEFD EAMITGESRP VYRDTGETVV AGTVATDNTV RIRVEATGGD TALAGIQRMV ADAQASSSRA QALADRAAAL LFWFALITAL ITAVVWTIIG SPDDAVVRAV TVLIIACPHA LGLAIPLVIA ISSERAAKSG VLIKDRMALE HMRTIDVVLF DKTGTLTEGA HAVTGVAPAT GIAEGELLAL AAAAEADSEH PVARAIVTAA AAHPEASQRQ LRATGFTAAS GRGIRATVDG AEILVGGPNM LREFNLTTPG ELADITGSWA QRGAGVLHVV RDGEIIGAVA VEDKIRPESR AAVRALQARG VKVAMITGDA TQVAQAVGKD LGIDEVFAEV LPQDKDTKVT QLQERGLSVA MVGDGVNDAP ALARAEVGIA IGAGTDVAME SAGVVLASDD PRAVLSMIEL SHASYRKMVQ NLVWATGYNI VAVPLAAGVL APIGVLLPPA AAAILMSLST IIVALNAQLL RRIDLDPAHL APTDGKEEKA AVSSAAPVR > RXA01247 (1-234, translated) 78 residues VAAATDATPE GPTTYQVTGM TCGHCADNVT EAVSALPQVD DVQVDLIAGG VSIVTVTGSV PLETVHRAIE ETGYTVLS > RXA01285 (1-543, translated) 181 residues PQTSIAPEGI RVYDLIARGR APYQSLIQQW RTSDEDAVAQ ALASTNLTEL AARLVDELSG GQRQRVWVAM LLAQQTPIML LDEPTTFLDI AHQYELLELL RAFNEAGKTV VTVLHDLNQA ARYADHLIVM KDGHVHATGT PEEVLTAEMV QGVFGLPCII SPDPVTGTPT VVPLSRSRAG A > RXA01289 (1-1044, translated) 348 residues MTAVAVEKQK ETSISKNLGR RRALGILGIV VALGALIVLS IAVGANPLSF SSVWQGFTAH DSSEASIIVW SMRIPRTLVG IVTGAAFGVA GALIQALTRN PLADPGILGV NAGAGFAVTV GVGFFGLSSV TGYIWFAFLG AAAATLLVYF IGASTSGSVN PVALVLAGVA LAAVLGGVTS FLTLIDPETF ESIRNWNLGS VARTDLSDTM TVLPFLAVGL AIALLLSGAL NSIALGDDLA ASLGTKVMRT RVLGIISVTL LAGGATALTG GIGFVGLMVP HVVRWVVGPD QRWIITFSAL CAPVLVLGAD ILGRIIARPG EIEVGIVTAV IGAPVLIALV RRRKASGL > RXA01290 (1-1164, translated) 388 residues VVFNIKSRTD ETPVAASEPV ESTRPVSEAS TSPALNPGYH AVSVQRRRFS FRIPARLMVV SLILFAIALC SATWAITMGD YPLSLGQVIN ALAGTGEKFQ LLVVREWRLP VAIAAVVFGA LLGTGGAIFQ SITRNPLGSP DVIGFDAGSY TAVVLVILVL GNTHYWSIAF AAIVGGIVTA FAVYVLAWRK GVQGFRLIIV GIGVSAMLSS VNAYLITRAD VEDAMVVGFW SAGSINRITW QSLLPSLVIA AVIIVAAIVL ARSLRFMEMG DDVATTLGVK TNSTRLALIV VGVATSALVT AAAGPISFIA LVAPQLARRL TKTPGVSLVA AAAMGSALLS CAHLLSLIIS SFYRTIPVGL LTVSIGGCYM IWLLLRETRR QYRTGTIR > RXA01297 (1-798, translated) 266 residues MGYVGMVLAI LEIGLPLVFI VLTSFKQQSE IYTQPVTWFP SEFNFDNYAN VFERVPFLNY FRNSIIITVI LCLVKIILGV ISAYALSILR FPGRNLVFLL VISALMVPSE VTVISNYALV SQLGWRDTYQ GIIVPLAGIA FGTFLMRNHF MSIPSELIEA ARMDHCGHFR LLWKVLLPIS MPTLVAFSMI TVVNEWNQYL WPFLMAETDN SATLPIGLTM LQNNEGVSNW GPVMAATIMT MLPVLVMFLA LQEYMIKGLI SGAVKG > RXA01298 (1-393, translated) 131 residues FVWKNLGYSF VIYLAALQGL NKDLSEAAPV DGASAWTRFW KVTLPQLRPT TFFLSITVTL NSVQVFDIIH TMTRGGPLGN GTTTLVYQVY TETFTNYRAG YGATIATILF LLLLIITVIQ VRYMDKENKQ K > RXA01303 (1-1335, translated) 445 residues VTQLNTKGVV LQGWDPEDPE HWDSKIAWRT LWITTFSMII GECVWYLVSA IAPLLNRIGF DLSAGQLYWL ASIPGLAGGL IRLIYMELPP ILGTRKLVGI SSGLFLIPMF GWFLAVQDSS TPYWWLLTLA ALTGIGGGVF SGYMPSTGYF FPKAKSGTAL GIQAGIGNLG VSIIQFMGPW VMGFGLLGIG FLTPQRTIEG TTVFVHNAAI VLVPWTILAA VLSFLFLKDV PVTANFRQQI DIFGNKNTWI LSIIYLMTFG AFAGFAAQFG LIINNNFGIA SPMAETYPAE MLHAGATFAF LGPLIGALVR AAWGPLCDRF GGAIWTFVGG IGMTIATAAA AIELSRAETP DDEWPFLWSM LALFFFTGLG NAGTFKQMPM ILPKRQAGGV IGWTGAIGAF GPEIVGVLLS FTPTVAFFWG CVVFFIIATA LTWIYYARPN APFPG > RXA01323 (1-2265, translated) 755 residues MAQTPAKIPA ALNFIDVDLG VTGMTCTSCS ARVERKLNKL DGVEATVNYA TESAQVSYDP SKVSPEQLIK TVEDTGYGAF TMASAAAESE EDNAPADSGQ SRIDAARDHE AADLKHRVIV SALLSVPVVL VSMIPALQFN NWQWAVLTLV TPIFFWGGSP FHKATWANLK RGSFTMNTLV SLGTSAADLW SLWALFIENA GHPGMKMEMH LLPSASTMDE IYLETVAVVI TFLLLGRWFE TKAKGQSSEA LRKLLDMGAK DAVVLRDGAE VRVPVNQLKL GDVFITRPGE KIATDGEVDE GSSAVDESML TGESIPVEVT KGSKVTGATL NTSGRLMVKV TRIGADTTLS QMAKLVTDAQ SKKAPVQRLV DQISQVFVPV VIVIATATLI AHLVFTDAGL APAFTAAVAV LIIACPCALG LATPTALLVG TGRGAQLGLL IKGPEILEST KKVDTIVLDK TGTVTTGTMS VTDVTAINYS ETEILEFAAA VESASERPIA QAIAKAAEHE QVTDFQNTAG QEVTGVVRGH EVRVGRPSST LIDALLHPFQ HAQKIGGTPV VVTIDGVDSG IITVRDTVKD TSAEAIRGLK ELGLTPILLT GDNEGAAKSV AAEVGIDQVI ANVLPHEKVQ NVEALQAQGK NVAMVGDGVN DAAALAQADL GLAMGAGTDV AIEASDITLM NNDLRSAVDA IRLSRKTLGT IKGNLFWAFA YNVALIPVAA IGLLNPMLAG IAMAFSSVFV VSNSLRLRGF KARSN > RXA01338 (1-1878, translated) 626 residues MLFIRSFDGI ITVAALVAIA IHLILWLALD LDGLAKNWPL IAIVIVGGIP LMWDVLKSAI KTRGGADTLA AVSIITSVLL GEWLVAAIIV LMLSGGEALE EAASRRASGT LDALARRAPS TAHRLLGATI LDGTEEIAVE EITVGDLVAV LPHELCPVDG EIVAGHGTMD ESYLTGEPYV VSKSKGSQAM SGAVNGDTPL TIVATKLAHD SRYAQIVGVL HEAENNRPEM RRMADRLGAW YTVIALALGG LGWIVSGDPV RFLAVVVVAT PCPLLIAVPV AIIGAISLAA RRGIIVKNPG MLENASGVKT VMFDKTGTLT YGRPVITDIH TAPGVEEDTV LALAASVERY SRHPLADAIR EGAKARELHL PDVVEVSERP GQGLTGTVGE HLVRITNRRS TLEIDPDSKN YIPVTSSGME SVVLVDDKYA ALIRLRDEPR ASASEFIAHL PKKHKVDKLM IISGDRASEV RYLADKVGID EVHAEASPED KLNIVNRHNE HGATMFLGDG INDAPAMAVA TVGVAMGADS DVTSEAADAV ILDSSLERLD DLLHISARMR RIALQSAGGG MALSVIGMIL AVFGFLTPLM GAIFQEVIDV LAILNSARVA LPRGAISDFD TQEKVS > RXA01395 (1-1086, translated) 362 residues MAVMAYQPAD NRYDDMIYRR VGNSGLKLPA ISLGLWHNFG DDKPLSTQRS IIHRAFDRGV THFDLANNYG PPAGSAETNF GRILREDLKS HRDELIISSK AGWDMWPGPY GFGGSRKYLV SSLDQSLTRL GLDYVDIFYH HRPDPDTPLE ETMYALRDIV ASGKALYVGI SSYGPELTAE AAEFMAEEGC PLLIHQPSYS IINRWVEEPG DDCENLLQSA ANNGLGVIAF SPLAQGLLTD KYLDGIPEGS RASQGKSXXX XXLNVNNIDX VXXXXXXSXX TGQSFXXKXF CWVVAQPRKV RRRITVTSAL IGASSVEQLD NSLDSLNNLE FSDAELEAID EISHDAGINI WAKATDSKTR EN > RXA01411 (1-327, translated) 109 residues FIAQVMLGIG AVTANCVTSV MMAEVPQEVT RGTSAGITYN VTYAIFGGSA PFISTALVSW TGSPLAPAVY MIIIALFAFT ASRFIPETSP VFVTATPAIK APKVLVNPG > RXA01454 (1-267, translated) 89 residues MMLIVAFLIA LVGHYLMGGI RAGNQMTGQK SFVSRGARTQ LAVTAGLWML VKVAGYWLDR YDLLTKENST FTGASYTDIN AQLPAKIIL > RXA01455 (1-462, translated) 154 residues VTWIFAIIAL VILIAPMSVG FYTDWLWFGE VDFRGVFSKV IVTRIVLFVI FALIAGEVTW LAGYFVTKLR PDEMSAFDTQ SPVYQYRQMI ENSLRRVMVI IPIEVALLAG LIGQRSWRTV QMWLNGQDFG VSDQQFGLDY GFYAFDLPML RLIA > RXA01625 (1-201, translated) 67 residues MAIKNYTVEG MTCGHCVSSV KEEVGEVAGV TAVDVTLETG AVQVTGEDFT DEAVKAAVVE AGYKVVA > RXA01756 (1-1308, translated) 436 residues MKELELGEAR DVAATLEAMP IQEVIDQVER TSITKGAVLL RLLSKDRSLL VFDALGPRLQ ADLIGAFQDA EVLDYEADLD PDDRVSLLDE LPASIADELL RSLDPQEKQV TELVLGYAKG SVGRWMSPQV LLLFDDMSVA EVLDEVRNHA AEAETIYALP IVNRARQVMG VVSLRKLFIA DPTLKVSEIM VRPVSVLASA DIEETARWFL QLDLVAMPVV DESNMLLGVL TFDDAQDIVE QADSEDSARS GGSEPLQQPY LSTPIRKLVK SRIVWLLVLA VSAILTVQVL DIFEATLVEA VVLALFIPLL TGTGGNTGNQ AATTVTRALA LGDVRKSDVF RVLGREIRVG LMLGALLGAV GEVIASLVYG MPVGTVIGLT LLAVCTMAAS VGGVMPIIAK AIGADPAVFS NPFISTFCDA TGLIIYFAIA KLVLGI > RXA01808 (1-1119, translated) 373 residues MRGGAPARTS KPGFRLEAAE ALIAEVPAPR DKVELMAFSK SRQGRVVIEL EDATVATPDD RILVEDLTWR LAPGERIGLV GVNGSGKTTL LRTLAGEQPL QAGKRIEGQT VKLGWLRQEL DDLDLSRRLI DCVEDVASYV MMGDKQVSAS QLAERLGFSP KRQRTPVGDL SGGERRRLQL TRVLMAEPNV LLLDEPTNDL DIDTLQELES LLDGWPGTMV VISHDRYLIE RVTDSTWALF GDGKLTNLPG GIEEYLQRRA AMAAAEDSGV LNLGAATQAG TFSAATEQAA TSVESSGISS QERHRITKEM NALERKMGKL DQQMDKLNQQ LADAAEAMDT IKLTELDTKL RAVQEEHGEL EMQWLELGEE IEG > RXA01822 (1-582, translated) 194 residues MARQNSNTGG LRLVLVGIGT GAFLGAARDE FMVRADITGA STVQLWSAGS LSGRDWNHAL LVLISCAVIV PALCIIVRRL RLMEMGDDAA GALGISVERT RLIAILLAVL LVGIATAAAG PIAFIALAAP QIARALARED GVLVAASISI GSGLLVAADC LEQHVDTELH TPVGLVTSLL GGVYLMWLLS RKEA > RXA01890 (1-720, translated) 240 residues MASIVFENVT RKYSPGARPA VDKLNLEIAD GEFLVLVGPS GCGKSTSLRM LAGLEPIDEG RLLIDGKDAT ELRPQDRDIA MVFQSYALYP NMTVRDNMGF ALKNQKVAKA EIEKRVAEAS RILQLDPYLD RKPAALSGGQ RQRVAMGRAI VREPSVFCMD EPLSNLDAKL RVSTRAEISG LQRRMGVTTV YVTHDQVEAM TMGDRVAVLL LGVLQQVDTP QNLYDYPANA FVASPIGSLP > RXA01900 (1-1299, translated) 433 residues MTTAVDQNSP PKQQLNKRVL LGSLSGSVIE WEDFLVYGTV AALVFNKMYF PSGNEFLSTI LAYASFSLTF FFRPIGGVIF AHIGDRIGRK KTLFITLMLM GGGTVAIGLL PDYNAIGIWA PILLMFLRIL QGIGIGGEWG GALLLAYEYA PKKQRGLYGA VPQMGISLGM LLAAGVISLL TLMPEDQFLT WGWRIPFVGS ILLVFIGLFI RNGLDETPEF KRIRDSGQQV KMPLKEVLTK YWPAVLVSIG AKAAETGPFY IEGTYIVAYA TNFLNIRDNI VLLAVACAAL VATIWMPLFG SFSDRVNRAV LYRICASATI VLIVPYYLVL NTGEIWALFI TTVIGFGILW GSVNAILGTV IAENFAPEVR YTGATLGYQV GAALFGGTAP IIAAWLFEIS GGQWWPIAVY VAACCLLSVI ASFFIQRVAH QEN > RXA01939 (1-603, translated) 201 residues STSGTDLTSL SHKEIFQMRR KLQVVEQNPY GSLDPMYSIY RCIEEPLTIH KVGGDRKARE ARVVELLDMV SMPRSTMRRY PNELSGGQRQ RIATARALAL NPEVIVLDEA VSALDVLVQN QILTLLAELQ QELKLTYLFI THDLAVVRQT ADDVVVMQKG RIVEKGRTDD IFNDPQQHYT RDLINAVPGL GIELGTGENL V > RXA01972 (1-594, translated) 198 residues VATGLLSAIG LFIATNIDDI IVLSLFFARG AGQKGTTLRI LAGQYLGFMG ILAAAVLVTL GAGAFLPAEA IPYFGLIPLA LGLWAAWQAW RSDDDDDDDA EIAGKKVGVL TVAGVTFANG GDNIGVYVPV FLNVDTAAVI IYCIVFLVLV AGLVLLAKFV ATRPPIAEVL ERWEHVLFPI VLIGLGIFIL VSGGAFGL > RXA01986 (1-618, translated) 206 residues MASTFIQADS PEKSKKLPPL TEGPYRKRLE YVALVATFGG LLFGYDTGVI NGALNPMTRE LGLTAFTEGV VTSSLLFGAA AGAMEFGRIS DNWGRRKTII SLAVAFFVGT MICVFAPSFA VMVVGRVLLG LAVGGASTVV PVYLAELAPE EIRGSLAGRN ELMIVVGQLA AFVINAIIGN VFGHHDGVWR YMLAIAAIPA IALFFG > RXA01995 (1-654, translated) 218 residues MDIRQTINDT AMSRYQWFIV FIAVLLNALD GFDVLAMSFT ANAVTEEFGL SGSQLGVLLS SALFGMTAGS LLFGPIGDRF GRKNALMIAL LFNVVGLVLS ATAQSAGQLG VWRLITGIGI GGILACITVV ISEFSNNKNR GMAMSIYAAG YGIGASLGGF GAAQLIPTFG WRSVFAAGAI ATGIATIATF FFLPESVDWL STRRPAGARD KINYIARR > RXA02033 (1-789, translated) 263 residues MPLSGKIGGF IVAVVFVLAA LSFIWTPFDP VQAFPQERLE GSSLRHLLGT DRYGRDVLSQ IMVGSRVTLL VGIIAVAIAA LIGTPLGIAA GMRRGMVETF VMRGADLMLA FPALLLAIIS GAVFGASTWS AMVAIGIAGI PSFARVARAG TLQVTSQDFI AAARLSKVSS ARIALRHILP NITSMLIVQA SVAFALAILA EAALSFLGLG TTPPDPSWGR MLQTAQASIG VTPMLAVWPG AAIALTVLGF NLFGDGLRDA IDP > RXA02034 (1-966, translated) 322 residues VSKTIAWTVL RYTLTFVIAS IIIFVLIRVI PGDPAAVALG ITATPEAIAA LQSQLGTDQP LFQQYFSWIG GMLTGDFGTS LSSGQDLSPI IFDRLQVSLI LVGCSIVLSL LIAIPLGVLS ARRGGVIISG ISQIGIAIPS FLAGILLVAV FAVGLGWLPA NGWIPPSENF GGFLARLILP VLALTAVQAA ILTRYVRSAV MDVMGQDFMR TARSKGMSFN RALIIHGLRN AALPVLTVTG LQLTTLVIGA VVIEQVFVIP GIGSMLLESV SNRDLIAVQS IVMLLVAFTL LVNLVVDLLY QVVDPRVGAV GVASTKVPGS VA > RXA02035 (1-1509, translated) 503 residues MKITRGLLPS LLLASTIVVS SCSAGSTAYQ QPPAVDQSSI VIATTAAAAS LDFTNAAGAA IPQAMMSNIY EGLVRIDAEG EIQPLLATSW DISDDRTEYI FHLREGVLFS NGDPFNADSA KFSIDRVKTD WTNGLKSGMD VVESTEVIDD HTLKVSLVRP SNQWLWSMGT AIGAMMTEGG VDKLATDPVG TGPYTVTHWA PGRAIGFGAR ADYWGQKPLN DAATIRYFSD ATASTNALQS GDVDVIWAMQ APEQLATLQE YTVEVGTTNG EMLLSMNNQR APFDDVRVRQ AVMFAIDRQA VIDTALEGYG TDTGGVPVPP TDPWYEKSTM YPYDPDRARA LLEEAGAEGT RITMSIPSLP YAQAASEILY SQLRDVGFDP VIESTEFPAV WLAQVMGQKD YDMSLIAHVE PRDIPTLFSP NYYLGFDDTE TQALLAEADS SANEVELMQQ AVDRIMEQAV ADNLMNVANI VVMSPEITGI DPNVVSGALE LSLIGRKESG VAQ > RXA02062 (1-1170, translated) 390 residues MRVGMMTREY PPEVYGGAGV HVTELTRFMR EIAEVDVHCM GAPRDMEGVF VHGVDPALES ANPAIKTLST GLRMAEAANN VDVVHSHTWY AGLGGHLAAR LHGIPHVATA HSLEPDRPWK REQLGGGYDV SSWSEKNAME YADAVIAVSA RMKDSILAAY PRIEPDNVRV VLNGIDTELW QPRPTFDDAE DSVLRSLGVD PQRPIVAFVG RITRQKGVEH LIKAAALFDE SVQLVLCAGA PDTPEIAART TALVEELQAK REGIFWVQDM LGKDKIQEIL TAADTFVCPS IYEPLGIVNL EAMACNTAVV ASDVGGIPEV VVDGTTGALV HYDENDVETF ERDIAEAVNK MVADRETAAK FGLAGRERAI NDFSWATIAQ QTIDVYKSLM > RXA02068 (1-1119, translated) 373 residues IFVPMLRIAA IEPKDITLVT GSVSLRTFRV RTGELQVMGD IVGAKVHTDD PELQQFHGRA VETADVELEL SRTRDWIITR VAVLGERPKF GRRPVLHTVP WSHIHGITAG GVGESNHTAE LIAGFEDMRP ADVAKQLYQL PTAQRTEVTE ELDDEKLADI LQELSEDRQA ELIEELDIER AADILEEMDP DDAADLLGEL PDDKADVLLD LMDPEESAPV RRLMDFSPDT VGALMTPEPL IMDPSTTVAE ALAMARNPDL PTSLASLIFV VRPPTATPTG KYLGCVHLQK LLREPPSSLI GGILDPDLPP LYADDEQETA ARFFATYNLV CGPVLDENRH LLGAVAVDDL LDHMLPEDWR DAGIRPGKEH THG > RXA02079 (1-615, translated) 205 residues MSEAFDATKV RKAVLTVALL NFAYFFVEFF IALSAGSVSL LADSVDFLED TSINLLIFIA LGWPLARRAV MGKLMAIVIL APAAFAAWAA IQRFSAPQAP EVFPIIVASL GAVVINGASA IIISRVRQHG GSLGQAAFLS ARNDVLINIA IIMMALITAW TTSGWPDLIL GCFIILLALH AAHEVWEVSE EERLASKALA GEAID > RXA02096 (1-1317, translated) 439 residues MGLDVSDEQI EHAARLAQAH DFIDRLPNKY EEVIGERGLT LSGGQRQRIA LARAFLARPK VLVLDDATSA IDASTEDRIF QALREELHDV TILIIAHRHS TLELGDRVGL VEDGRVTALG PLSEMRDHAR FSHLMALDFQ DSHDPEFTLD NGSLPSQEQL WPEVSTEKQY KILAPAPGRG RGMSMPATPE LLAQIEALPA ATEETRVDAG RLRTSTSGFK LLSLFKQVRW LVVAVIALLL VGVAADLAFP TLMRAAIDNG VQAQSTSTLW WIAIAGSVVV LLSWAAAAIN TIITARTGER LLYGLRLRSF VHLLRLSMSY FERTMSGRIM TRMTTDIDNL SSFLQSGLAQ TVVSVGTLIG VVTMLAITDA QLALVALSVV PIIIVLTLIF RRISSRLYTA SREQASQVNA VFHESIAGLR TAQMHRMEDQ VEDNYAGEA > RXA02119 (1-1641, translated) 547 residues MTETLVVNGL AGGYGHRTLF NDVNLTVAAG DVVGVVGVNG AGKSTELKIL AGVEKPLAGT IALSPADAFV GYLPQEHTRT SGETIAVYIA RRTGCQAATT AMDDTAEAFG ADPDNAALAD AYAEALDRWM ASGAADLDER IPIVLADLGF ELPTSTLMEG LSGGQAARVG LAALLLSRFD IVLLDEPTND LDLDGLEQLE NEVQGLRGGV VFVSHDREFL SRCVTTVLEL DLHQNSHHVY GGGYDSYLEE RAVLRQHARD QYEEFAEKKK DLVARARTQR EWSSHGVRNA IKRAPDNDKL RKKAAAESSE KQAQKVRQME SRIARLEEVE EPRKEWKLQF SVGKASRSSS VVSTLNDASF TQGDFTLGPV SIQVNAGDRI GITGPNGAGK STLLRGLLGN QEPTSGTATM GTSVAIGEID QARALLDPQL PLISAFEKHV PDLPISEVRT LLAKFGLNDN HVERDVEKLS PGERTRAGLA LLQVRGVNVL VLDEPTNHLD LEAIEQLEQA LASYDGVLLL VTHDRRMLDA VQTNRRWHVE AGEVREL > RXA02220 (1-2676, translated) 892 residues VSSPLPAAVT SKPAHALSSD EVLENLGVQD TGLTSAEATQ RLEANGPNEL PQTPPETVWQ RLFRQVNDPM IYVLIAAAVL TAELGHWTDT IVIGAVVIIN MMVGFIQEGK AADALASIRN MLSPESAALR DGVFHKIDAA ELVVGDVVKL SAGDKVPADL RMLAATNLHI EESALTGEAE AVVKGTDPVE ADAGIGDRTS MAFSGTLVLT GSGTGVVTAT GAGTEIGHIT TMLADVDSVD TPLTRSMKKF SSALAIVCVF LAILMLVVAG LVHHTPLEEL ILSAIGFAVA AIPEGLPAVI AITLALGVQK MAARNAITRR LNSVETLGSV TTICTDKTGT LTRNEMTVRA IATGTSLYDV SGAGYEPLGE IRLKDGEQVS KQDFPDLYAM ALVAANVNDA EIYQEDGMWR LSGEPTDGGI RAFAMKTNAE ILTRTAEVPF DSAYKYMATL HTIDGANTML VKGAPDRLLD RSAQQRNGEP LDRPYWEQLI EDLASQGLRV LAAAYKELPH STSTITPEDV DQGELTFLGL YGIMDPPREE VIEAMKVVQS AGVRVRMITG DHSSTARAIA REVGIRGQNV LTGAEITAAT DEELQGLVDN ADLFVRTSPE HKLRVVRALQ ANGEVASMTG DGVNDAPALK QADVGVAMGI KGTEATKDAA DIVLADDNFA TIAGAVEMGR TIYDNLRKAV VFMLPTNGAQ GLVIFIAMLL GWELPITALQ VLWINLITAI TLSLALSFEP AEPGIMNRKP RNPKSGLIDA PSVLRIVYVS LLLGGATFWA FLGARDAGID IDTARTIAVT TLAVSQVFYL LSSRYFEVSA LRKELFTTNP ISWLCIALML ILQLAFVYLP FMQSTFDTAA LTLRDWVMPL VFGVVVFAVV ETEKFIRRLK AS > RXA02222 (1-375, translated) 125 residues LGRPPPGDVH TLLDDIGAEE SEADKVPIEW QNALTKADRY ANRQHMSQAR LYRQLTSDVG EGFTEEAAQY AIENVNADWN ANALVKARNY QERQANSVDR IYRQLTSEHG EGFTPEQAQY AIDNL > RXA02312 (1-1359, translated) 453 residues LSNRHLQLIA IGGAIGTGLF MGSGKTISVA GPSVILVYAI IGFMLFFVMR AMGELLLANL NYKSLRDAVS DILGPGAGFV TGWTYWFCWI ATGMADIVAI TGYTQYWWPE IPLWLPGVLT IALLFALNLA AVRLFGEMEF WFAIIKIVAI VSLIVVGLFM VVTAFESPNG TTAQFNNLIE HGGFFPNGIT GFLAGFQIAI FAFVGIELAG TAAAETENPT KTLPRAINSI PIRIVVFYVL ALAVIMMVTP WDQVRADNSP FVQMFALAGI PAAAGIINFV VITSAASSAN SGIFSTSRML YGLSLEGAAP KRWSRLSKNL VPARGLTFSV ICLIPAVGLL YAGGTVIEAF TLITTVSSVL FMVVWSYILV AYIVYRRNSP ELHKKSIFKM PGGVVMAVVV LVFFAAMLVV LSLEPDTRAA LIATPVWFII LGIGWLSIGG AKGAKHRSQI TSH > RXA02313 (1-1221, translated) 407 residues MRVAIVAESF LPNVNGVTNS VLRVLEHLKA NGHDALVIAP GARDFEEEIG HYLGFEIVRV PTVRVPLIDS LPIGVPLPSV TSVLREYNPD IIHLASPFVL GGAAAFAARQ LRIPAIAIYQ TDVAGFSQRY HLAPLATASW EWIKTVHNMC QRTLAPSSMS IDELRDHGIN DIFHWARGVD SKREHPGKRS VALRKSWDPS GAKKIVGFVG RLASEKGVER LAGLSGRSDI QLVIVGDGPE AKYLQEMMPD AIFTGALGGE ELATTYASLD LFVHPGEFET FCQAIQEAQA SGVPTIGPRA GGPIDLINEG VNGLLLDVVD FKETLPAAAE WILDDSRHSE MCAAAWEGVK DKTWEALCTQ LLQHYADVIA LSQRIPLTFF GPSAEVAKLP LWVARALGVR TRISIEA > RXA02344 (1-678, translated) 226 residues MLNRMKSARP KSVAPKSGQA LLTLGALGVV EGDIGTSPLY SLHTAFSMQH NKVEVTQENV YGIISMVLWT ITLIVTVKYV MLVTRADNQG QGGILALVAL LKNRGHWGKF VAVAGMLGAA LFYGDVVITP AISVLSATEG LTVISPSFER FILPVSLAVL IAIFAIQPLG TEKVGKAEGP IMLLWFVTLA GLGIPQIIGH PEILQSLSPH WALRLIVAEP FQAEVL > RXA02348 (1-1134, translated) 378 residues PIRVAWFCVV MPALILTYLG QGALVINQPE AVRNPMFYLA PEGLRIPLVI LATIATVIAS QAVISGAYSL TKQAVNLKLL PRMVIRHTSR KEEGQIYMPL VNGLLEVSVM VVVLVFRSSE SLASAYGLAV TGTLVLVSVL YLIYVHTTWW KTALFIVLIG IPEVLLFASN TTKIHDGGWL PLLIAAVLIV VMRTWEWGSD RVNQERAELE LPMDKFLEKL DQPHNIGLRK VAEVAVEPHG TSDTVPLSLV RCVKDLKLLY REIVIVRIVQ EHVPHVPPEE RAEMEVLHHA PIRVVRVDLH LGYFDEQNLP EHLHAIDPTW DNATYFLSAL TLRSRLPGKI AGWRDRLYLS MERNQASRTE SFKLQPSKTI TVGTELHL > RXA02353 (1-468, translated) 156 residues MALLILAGLQ MIPKETYEAA RVDGATAWQQ FTKITLPLVR PALMVAVLFR TLDALRMYDL PVIMISSSSN SPTAVISQLV VEDMRQNNFN SASALSTLIF LLIFFVAFIM IRFLGADVSG QRGIKKKKLG GTKDEKPTAK DAVVKADSAV KEAAKP > RXA02354 (1-789, translated) 263 residues MTKRTKGLIL NYAGVVFILF WGLAPEYWMV ITALRDSKHT FDTTPWPTHV TLDNFRDALA TDKGNNFLAA IGNSLVISVT TTAIAVLVGV FTAYALARLE FPGKGIVTGI ILAASMFPGI ALVTPLFQLF GDLNWIGTYQ ALIIPNISFA LPLTIYTLVS FFRQLPWELE ESARVDGATR GQAFRMILLP LAAPALFTTA ILAFIATWNE FMLARQLSNT STEPVTVAIA RFTGPSSFEY PYASVMAAGA LVTIPLIIMV LIF > RXA02394 (1-1311, translated) 437 residues MLSPAAVAAL ILVIGIVVLI IASVPVAIAI GLPSLFAAMA VLGPENAAQA VAQRMFTGTN SFTLLAIPFF VLAGLLMNSG GIATRLIDAA KVLVGRMPAS MANTNIAANG LFGAVSGAAV ASASAVGTVM TPKMKEEGYS RAYAAAVNVA SAPAGMLIPP SNTFIVYSLV SSTSIAALFM AGVGPGLLWI LACVIVGTWL ARKENYKREQ IHPTFKQSLV VLWRALPSLL MIVIVVGGIL LGWFTPTESA AIAVVYCLVL GFIYRTIKVG DLADILLKAT RTTSIVMLLI AVSAALSWVM AFAKIPQMIS DALLSVSDSK VVILLIMMFI LLLIGTVMDP TPAILIFVPI FLPVVTELGV DPVHFGAMVV MNLSVGVITP PVGNVLFVGS QVAGLRVETV IRRLWPYLIA ITVALFVVVF VPQISIWLPT TMGLMGG > RXA02402 (1-744, translated) 248 residues VSKTEEGRSA AIIIYAFPTF ILLGATIAFI FPEPFIPLTN YTNIFLTIIM FTMGLTLTVP DFQMVLKRPL PILIGVVAQF VIMPFLAIVV AKMFNLNPAL AVGLLMLGSV PGGTSSNVIA FLARGDVALS VTMTSVSTIV SPIMTPFLML MLAGTETAVD GGGMAWTLVQ TVLLPVIIGL VLRVFLNKWI DKILPILPYL SILGIGGVVF GAVAANAERL VSVGLIVFVA VIVHNVLGYV VGYLTGRV > RXA02422 (1-435, translated) 145 residues VSTLISEPEV DKLRKRAKRS RRTEWWLAAA LLAPNLLLLA IFTYRPLLDN FRLSFFNWNI SSPTSTFIGF DNYVEFFTRS DTLQVVLNTV IFTACAVIGS MVLGLLLAML LDQKLFGRNF VRSMVFAPFV ISGAAIGGAF QFVFD > RXA02438 (1-759, translated) 253 residues MTDLIQLREV SKKYGAFQAL NDINLNVRAG EVTCVLGDNG AGKSTLIKIL SGLHPATSGE VIVAGDVVNF GSPRDALDAG IATVYQDLAV VGQMSVWRNF FLGQELTGRF GVLKQEEMRR ITDEQLREMG IELRDVDVPV ASLSGGQRQV VAIARAIYFG ARVLILDEPT AALGVKQSGM VLRFIAAARD RGIGVIFITH NPHHAYLVGD HFILLNLGKQ VMDKSRAEVE LEELTLAMSG GGELDSLSHE LKR > RXA02439 (1-1023, translated) 341 residues MTKIKSGEAS TSIVERALKR PELTSLLGAV LVFTLFMVVA PAFRSWDSMA TVLYASSTIG IMAVAVGLLM IADEFDLSTG VAVTTAALAA SMFSYNLWLN TWVGALIALV ISLAIGFFNG FLVVKTKIAS ELITLATFLM LQGINLAVTK LISGTVATPT IADMEGFPSA RAVFASSIPI FGVNIRITVF WWLLFVIVGT FVLEKTRIGN WIFAVGGDEE AARAVGVPVR GVKIGLFMFV GFAAWFVGMH NLFLFDSIQA GQGVGNEELY IIAAVIGGIS MTGGRGTVVG TMIGALIEGM TNQGIVYAGW NPDWEMFFLG GTLLLAVLLN HRFERENKER S > RXA02441 (1-657, translated) 219 residues MAELSVRNLT CTYGNHIALN NITARFPTGK ITALIGSNGS GKSTLLETLA GMLAPRSGSI NNLVPEIAFV PQRSHVSHNL PITIRQTVSM GRWSAKKNWQ RLTAADCNIV DSCLDRLEIS GLADRPLGEV SGGQRQRALI AQGLAQQAPL LLLDEPLAAV DSHAASLIED VINQQRNQGT TIILATHDLD QAHQADQIIA LEKGIIKPQR KATESIKKR > RXA02442 (1-849, translated) 283 residues MKFFTDALIV PFDVSFISRA LVAGCLAAIL CSLIGTWVIL RRLTFFGDAM SHGLLPGVAT ASLLGGNLMF GAAISALIMS AGVVWTSRKS SLSQDVSIGL QFITMLSLGV VIVSHSDSHA VDLTSFLFGD ILGVRPSDIF IIAIATVLGG LTIFLEHRQF TALAFDERKA HTLGLNPRFA HLLMLALIAL ATVVSEQVVG TLLVFGLLIG PPATAALLVQ DKASISLIMI VASLLGCAEI YLGLLISWHA STAAGATITL LSAAIFFATL LTKSAISRLN FTA > RXA02447 (1-270, translated) 90 residues WVWLAEIFPV RMKGIGTGIS VFCGWGINGV LALFFPALVS GVGITFSFLI FAVVGVIALA FVTKEVPETR GRSLEELDHA AFTGQIFKKA > RXA02451 (1-1524, translated) 508 residues MNTDTTQDGV SPEPSDPHLG SEVAETHREK KFFGQPWGLA NLFGVEMWER FSFYGMQSIL AFYLYYSVTD GGLGMNQTAA LSIVGAYGGF VYMTSLVASF IADRVLGSER TLFYSAIIVM LGHIALALIP GYTGLSIGLV LIGLGSGGVK TAAQVVLGQL YSRTDTRRDA GFSIFYMGVN LGGLFGPLIT NALWGWGGFH WGFGIAAVGM ALGLIQYVAM RKTTIGAAGH TVPNPLPKNE YARWIIGAVV VVAAVVALIA TGIIKLEWLS NITAAIALIA AIALLAQMYV SPLTTAAEKS RLLGFIPMFI GGVLFFAIFQ TQFTVLAVYS DTRLDRNFFG IDLPPGLINS FNPIFIIIFS GIFATLWTKL GAKQWSTAVK FGVANIVIGC ALFFFLPFAG GAENSTPMAL IIWVYFLFTI AELLLSPVGN SLATKVAPEA FQSRMFAVWL MAVSMGTSLS GTLGGYYDPT DAGSEKVFFI TVGVAAIVLG AIVIAAKGWV LKKFIDVR > RXA02491 (1-1254, translated) 418 residues MRVAMISMHT SPLQQPGTGD SGGMNVYILS TATELAKQGI EVDIYTRATR PSQGEIVRVA ENLRVINIAA GPYEGLSKEE LPTQLAAFTG GMLSFTRREK VTYDLIHSHY WLSGQVGWLL RDLWRIPLIH TAHTLAAVKN SYRDDSDTPE SEARRICEQQ LVDNADVLAV NTQEEMQDLM HHYDADPDRI SVVSPGADVE LYSPGNDRAT ERSRRELGIP LHTKVVAFVG RLQPFKGPQV LIKAVAALFD RDPDRNLRVI ICGGPSGPNA TPDTYRHMAE ELGVEKRIRF LDPRPPSELV AVYRAADIVA VPSFNESFGL VAMEAQASGT PVIAARVGGL PIAVAEGETG LLVDGHSPHA WADALATLLD DDETRIRMGE DAVEHARTFS WAATAAQLSS LYNDAIANEN VDGETHHG > RXA02507 (1-1401, translated) 467 residues MSEQLQGVTH SESTPGKTPK RAALSSWIGS ALEYYDFAVY GTAAALVLNH LFFPADTSPG IAILAAMGTV GVAYVVRPLG ALIMGPLGDR YGRKFVLMLC LFLIGASTFA VGCLPTFDQV GYLAPALLVL CRVIQGLSAS GEQSSAISVS LEHADERHRA FTASWTLHGT QFGTLLATGV FIPFTLFLSE DALMSWGWRV PFWLSAAVVL VAFLIRRGLE EPPAFRENKE AVAGAASPLA MTLRYHKAAV ARVAIAAMIN SVNIVFTVWA LSFATNIVGL DRSTVLLVPV VANLVALIAI PLSGMLADRI GRRPVFIMGA IGGGLAMNGY LGAIYSGNWT MIFFMGVLMS GLLYSMGNAV WPAFYAEMFP TSVRVTGLAL GTQIGFAVSG GFVPVIASAL AGDQGDQWMK VSIFVGVVCV ISALVAMTAK ETKALTLDEI DALHTAGGEA ADLAAASKAS EAQLAAQ > RXA02515 (1-756, translated) 252 residues MSTLEIRNLH AQVLPSDESA EPKEILKGVN LTINSGEIHA IMGPNGSGKS TLAYTLGGHP RYEVTAGEVL LDGENILEME VDERARAGLF LAMQYPTEIP GVSVANELRS AATAIRGEAP KLREWVKEVR TAQEALAIDP EFSNRSVNEG FSGGEKKRHE VLQLDLLKPK FAIMDETDSG LDVDALRIVS EGINSYKQET EGGILMITHY KRILNYVKPD FIHVFANGQI VTTGGAELAD KLEADGYDQF IK > RXA02562 (1-720, translated) 240 residues MFLTKVSLLD HPESLPGYLS SLAIVEYLHE QPLEFRAPIT VITGENGVGK STLVEALAVG MRLNPSGGSR HANFGREGDI VSSLHQSLKL VRRENPRDAF FFRGETMYNV ASYYEELMGE KNMHDLHKMS HGESVFAVID RRFNNQGFFV LDEPEAGLSM LRQLELLGKL GNLARGGAQI IMATHSPILL AIPGAEILEI TSSGVAKVNF EDAEAVRAAR EFVADPRGTA AFLTAEEDHQ > RXA02595 (1-651, translated) 217 residues VIVVAMASIM ACLKAARLNN PMKILLLCWR DTTHPQGGGS ERYLERVGEF LADQGHEVVF RTAGHTDAPR RSFRDGVRYS RSGGKESVYP KAWVAMMLGR VGIGTFSKVD VVVDTQNGIP FFGKFFSGKP TVLLTHHCHK EQWPVVGRVL AKVGWLIESQ IAPRAYKTAP YVTVSEPSAE ELIALGVDQQ RIHIVRNGVD PVPLHTPKLD RDGQHAV > RXA02597 (1-1788, translated) 596 residues LPEQDLTTLA NDWLQAFEKA TASSSPDEAA TAVVQLFEDE GYWRDLLAFT WNLTTAEGAD EIAEMIRNTW PSSIFRNVEL KGEPADEGDG VTRVHFSCES ADFKCTGIVR LRNGKAWTLL TSARELLEHP EPKGRNREMG VVHGQNEDTR NWTDRKNDRQ AALGVTEQPY TLIIGGGQGG IALGARLKRL GVPALIIDKA SRPGDQWRSR YHSLCLHDPV WYDHLPYIPF PDHWPVFTPK DKMGDWLEHY VGIMDLDYWT NTECLRASYN EDTKQWDVTV NRDGAESTLH PTQLVMATGM SGSPNKPTLP GQDKFQGEIR HSSEHPGGDV DRDKNVVVLG ANNSAHDICA DLYSNGAKPV MIQRSSTHIV RSDSLMREVF GPLYSEDAVE AGIDTDTADL LFASWPYKVL PGVQKQAFDK IREDDKEFYD KLENAGFLLD FGDDDSGLFL KYLRRGSGYY IDVGASELVA DGKIPVRSNV SIEDVKENSV VLTDGTELPA DVIVLATGYG NMNNWVAQLV DQETADKVGP CWGLGSETTK DPGPWEGELR NMWKPTNVDS LWFHGGNLHQ SRHYSRYLSM QLKARYEGMN TPVYSK > RXA02605 (1-495, translated) 165 residues VACPWAGTAA LNLAAKHPDQ FRQAMSWSGY LNTTAPGMQT LLRVAMLDTG GFNVNANYGS IINPRRFEND PFWNMGGLAN TDVYISAASG LWSPQDDGVR VDHRLTGSVL EFVAMTSTRI WEAKARLQGL NPTADYPMYG IHGWAQFNSQ LERTQGRVLD VMNAW > RXA02614 (1-729, translated) 243 residues MTATLSLKPA ATVRGLRKSY GTKEVLQGID LTINCGEVTA LIGRSGSGKS TILRVLAGLS KEHSGSVEIS GNPAVAFQEP RLLPWKTVLD NVTFGLNRTD ISWSEAQERA SALLAEVKLP DSDAAWPLTL SGGQAQRVSL ARALISEPEL LLLDEPFGAL DALTRLTAQD LLLKTVNTRN LGVLLVTHDV SEAIALADHV LLLDDGAITH SLTVDIPGDR RTHPSFASYT AQLLEWLEIT TPA > RXA02616 (1-711, translated) 237 residues LQKHTRGGKH RKQTTSPVTK GGVAFVAVAT GAVSTAGAGG AVAAQASNQP VEVNFELTAN DTTDLVAGSS APQILSIAEF KPVVNLGDQI VKTIQYNADR IQADLDARGP SVVRPAEGSY TSGFGARWGT NHNGVDIANA IGTPILAAMD GTVIDAGPAS GFGNWVRLQH EDGTITVYGH METVEVTVGQ TVKAGERIAG MGSRGFSTGS HLHFEVYPAG GGAVDPAPWL AERGITL > RXA02627 (1-843, translated) 281 residues DVTVESQPER VVALGWGDAE AALEFGVQPV GASDWLAFGG EGVGPWIEDS AYDEAPEIIG TMEPEYEKIA ALEPDLTLDV RSSGDQERYD KLSSIALTIG VPEGGDSYLT PRAEQVTMIA TALGQAERGE EVNAEYEQLT ADIRAAHPGW PEKTAAAVSA TATSWGAYIK GSNRVDTLLD LGFQENPELA KQQPGDTGFS IKFSEETFGV VDSDLVVGFA IGMTPEEMAE QVPWQMLTAT RDGRSFVMPR EISNAFSLGS PQSTRFALDA LVPLLEEHAG E > RXA02628 (1-405, translated) 135 residues MLEGFRDFVL RGNVIELAVA VVTGTAFTAI VTAFSESIIN PLIASIGSTE VEGLGFHIRA GNAATFVDFG AVITAAINFL IIAAIVYFVL VAPMNKLSET LAKRKGVEED ETPASIEAEL LTEIRDLLQE QKRLQ > RXA02650 (1-579, translated) 193 residues MVNVTSKDAG ANVTPMSKKE KRTTVKQVVA LMAAIVVVIA SLDQIVKQIM LSWLEPGVPV PIIGDWFRFY LLENPGAAFS MGGENSTWIF TTIQLSFVIG IAIYAPRIKH KWIAAGLALV AGGALGNVLD RLFRDPSFFF GHVVDYISVG NFAVFNIADA SISCGVVVFL IGMFLEDREN AQHAKATDEK DEA > RXA02660 (1-639, translated) 213 residues MIIGVTLLVF IVMSFSPADP ARLALGESAS PEALEAYREA NGLNDPMMVR YFDFILGMLK GDLGTSSGGV AVTDIVARAF PITLQLTFWG LIIAVVVALI LGVIAALYRD RWPDQLIRVV SIAALATPSF WLAILLIQWL GTIPGAWGFF PALVTRWVPF SEDPATYFNN IALQRLRWQS PLQVLWPALF VPPWWKNWTR TTSAQQSVQD PQN > RXA02661 (1-219, translated) 73 residues VIGLRVGSLM GGAVIIEIIF NIQAMGQLIL DGVTRNDVYL VQGVTLTVAI AFIIVNIAVD LLYVLVNPRI RSI > RXA02663 (1-1395, translated) 465 residues MAPILVFATV LVADAIVFEA SLSFINAGVK PPSPSWGNIL ADGKALLLSG AWWPTFFPGL MILLTVLCLN ILSEGLTDTL ASPKPKPVSA SAKKALKKEE SGEKEGSGIV LGHTTREEAN ASLLASLAAL STSENNSNNR LIFDGNPTPL LEVRDLKISF PNAHGDINIV DGVNFTVAPG QTMGLVGESG CGKSITAMSI MGLLPPTAKI EGEILFDGKN LLDLKPDELN ALRGHEIAMI YQDALSSLNP SMLISAQMKQ LTRRGGKRSA EELLELVGLD PKRTLQSYPH ELSGGQRQRV LIAMALTRNP RLLIADEPTT ALDVTVQQQV VDLLNELREK LGFAMIFVSH DLALVARLVH KLTVMYAGQV VEQGTTREIL IDPRHEYTRG LLGSVLSIEA GVDRLYQVPG TVPSPKEFVA GDRFAPRSEF PELGLDQKPV LRPITGTEHA YAATDELLAA KGEQR > RXA02664 (1-660, translated) 220 residues VGESGCGKST LARVMVGLQP VTSGEVLFKG KPMKPRGAQR KELGSSVSVV FQDPATSLNP RMTVREQLLD PLRVHKVGDE ASRNQWVSEL ISMVGLPQSA LEVLPRQVSG GQRQRVAIAR ALALKPDIIV ADEPTSALDV SVRAQVLNLL LDLKTELGLG LVFISHDINT VRYVSDRIAV MLAGEIIEEN TTSEIFNNAQ QDYTRTLLEA TPSLLNKTRL > RXA02684 (1-864, translated) 288 residues VLAVGLVLVF VVTLWADSKL NRVDATPATQ VANTAGTNWL LVGSDSRQGL SDEDIERLGT GGDIGVGRTD TIMVLHMPRT GEPTLLSIPR DSYVNVPGWG MDKANAAFTV GGPELLTQTV EEATGLRIDH YAEIGMGGLA NMVDAVGGVE MCPAEPMYDP LANLDIQAGC QEFDGAAALG YVRTRATALG DLDRVVRQRE FFSALLSTAT SPGTLLNPFR TFPMISNAVG TFTVGEGDHV WHLARLALAM RGGIVTETVP IASFADYDVG NVAIWDEAGA EALFSSMR > RXA02728 (1-813, translated) 271 residues MAIVSLDNVT VSIEGKKLLD AVSLKAYPGE VLGLIGPNGA GKSTLLSVLS GDRLPDSGEV NVGGLDPATA AASDMARVRA VMLQDVSVAF SFLVWDVVEM GRRPWQKAST PEEDHEIIEA ALAATSVSHL AEREITTLSG GERARVALSR VLAQQTPIVL LDEPTAAMDI SHQEQTLGTA RALAAAGAAV IVVLHDLNAA AAYCDSIVCL SDGRVIASGS VDQVYSTETL SRVYGWPIRV DHSGKYVRVE PDRSEANLPS VLQVKNTVSP A > RXA02750 (1-816, translated) 272 residues MAVLFSIMGA LILLVLYVLF LGKLQIDGLM VDLPDSARDD VEGFVFNWVF SGILITSAIT VPQAALGVLV EDRTRGGIKD FLVAPVSRTT LTVSYIEAAV IVAMTILIFE IVVGSIGLAI LGHFSMSIAR VLELVVALLL LTLVFSAIAA FLITLVKSQG GMSALSSLVG TLAGFLSAAY IPPIALPEAV TNVLNFLPFT PAGMLIRQIV VAPALDAISL PPEAFDIFQF GYGLKLEMFG EPVSTWVAVG IVASWGVVFG LIAAFKMKSV VR > RXA02761 (1-201, translated) 67 residues MMDGINRRTT LITGYSLTTI SHVLIGIASV AFPVGDPLRP YVILTLVVVF VGSMQTFLNG SYLGYAL > RXA02762 (1-285, translated) 95 residues MLSELFPLAM RGFAIGISVF FLWIANAFLG LFFPTIMEAV GLTGTFFMFA GIGVVALIFI YTQVPETRGR TLEEIDEDVT SGVIFNKDIR KGKVH > RXA02769 (1-711, translated) 237 residues TVVPVYLAEL APLEIRGSLT GRNELAIVTG QLLAFVINAL IAVTLHGVID GIWRIMFAVC ALPAVALFLG MLRMPESPRW LVNQGRYDDA RRVMETVRTP ERAKAEMDEI IAVHSENNAA LPGVKQSSGQ ASGQVSSKHT HMSIGEVLSN KWLVRLLIAG IGVAVAQQLT GINAIMYYGT RVLEESGMSA EMAVVANIAF GAVAVIGGLI ALRNMDRLDR RTTFIIGLSL TTTFHLL > RXA02795 (1-1095, translated) 365 residues IDVSLPERTA SAYPHELSGG QRQRALIAMA LANDPDLLIC DEPTTALDVV VQKQIVDLLL RLTKERGTAL LFITHDLGLI ARTCERLLVM KSGETVERGD TEAILRSPAH SYTQQLLDAS ILDQPEIASD SGAPVVIDVE EASKSEKETT ALHKVSLAVR KGDLLGIVGG SGSGKTTLLK LIAGLDKPTT GTVAVTGGVQ MVFQDPQSSL NPRMKIKDIV AEPLLGWNAA EKTTRVAEVI TQVGLSPDVL DRYPHEFSGG QRQRISIARA LAIKPAILLA DEPVSALDVS VRKQVLDLLQ QLVEEYGITL VFVSHDLAVV RHLCTTVWVM EQGRVLEQGP IDSVYDHPQT EYTKELLDAV PRLSL > RXA02808 (1-258, translated) 86 residues FYEGILPVLA ESASHFGIEP VEMARASITG QPVHMQSPLV PAILLLVSLA NVNLGDHHKK VLWRACIVSI AMLAVALFIG VVPLSA > RXA02863 (1-975, translated) 325 residues MKKSLIAIVA SALVLSGCTS DSSDSSGTSG TVETTSITTS VAAADGAFPR TVTLDDSSIT LESKPERIAV LTPEAASLVL PITGADRVVM TAEMDTADEE TAALASQVEY QVKNGGSLDP EQVVAGDPDL VIVSARFDTE QGTIDILEGL NVPVVNFDSD AWGDIDAITK HLEIVGELVG EEDKAAEAIA EIDANRIDID KPATSPTVLT LMQRGPRQMV MPESAMLNGL IREAGGTPVV DSLGAVGTIT ADPEQVVAMA PEIIIIQDFQ GKGRENFANF LSNPALANVP AIENDKIFYA DTVTTGVTAG TDITTGLQQV AEMLS > RXA02864 (1-780, translated) 260 residues MPQLVEIRDL NVEFPSRHAV KNVSFSAPAG KVTALIGPNG AGKSTALSAI AGLVESTGEV MVGGSGVASK SAKARARLLS LVPQNTELRI GFSARDVVAM GRYPHRGRFA VETDADRRAT DDALRAINAL DIAEQPVNEL SGGQQQLIHI GRALAQDTAV VLLDEPVSAL DLRHQVEVLQ LLRARANSGT TVIVVLHDLN HVARWCDHAV LMADGEVVSQ GDIREVLEPA TLSTVYGLPI AVRDDPETSS LRVIPHPNPF >RXN00001 TRANSLATE of: rxn00001.seq check: 7420 from: 1 to: 1128 MATVTFKDASLSYPGAKEPTVKKFNLEIADGEFLVLVGPSGCGKSTTLRMLAGLENVTDG AIFIGDKDVTHVAPRDRDIAMVFQNYALYPHMTVGENMGFALKIAGKSQDEINKRVDEAA ATLGLTEFLERKPKALSGGQRQRVAMGRAIVRNPQVFLMDEPLSNLDAKLRVQTRTQIAA LQRKLGVTTVYVTHDQTEALTMGDRIAVLKDGYLQQVGAPRELYDRPANVFVAGFIGSPA MNLGTFSVKDGDATSGHARIKLSPETLAAMTPEDNGRITIGFRPEALEIIPEGESTDLSI PIKLDFVEELGSDSFLYGKLVGEGDLGSSSEDVPESGQIVVRAAPNAAPAPGSVFHARIV EGGQHNFSASTGKRLP >RXN00099 TRANSLATE of: rxn00099.seq check: 3872 from: 1 to: 1173 VKNPRLIALAAIILTSFNLRTAITALAPLVSEIRDDLGVSASLIGVLGMIPTAMFADAAF ALPSLKRKFTTSQLLMFAMLLTAAGQIIRVAGPASLLMVGTVFAMFAIGVTNVLLPIAVR EYFPRHVGGMSTTYLVSFQIVQALAPTLAVPISQWATHVGLTGWRVSLGSWALLGLVAAI SWIPLLSLQGARVVAAPSKVSLPVWKSSVGVGLGLMFGFTSFATYILMGFMPQMVGDPQL GAVLLGWWSILGLPLNILGPWLVTRFTNCFPMVVIASVMFLIGNGGFCLAPDVAPWLWAT LSGLGPLAFPMALTLINIRAETSAGASALSSFGQGLGYTIACFGPLLTGFIVDATGSFRT IFVLFAVATLFVIRGGYFATRQVYVEKLLNR >RXN00193 TRANSLATE of: rxn00193.seq check: 1918 from: 1 to: 594 KAFXQREGFISAFGFTVLVVIVSVITVNIFAFLLAWLLTRKLRGTNFFRTVFFMPNLIGG IVLGYTWQTMINAVLSHYATTTSADWKFGYAGLIMLLNWQLIGYMMIIYIAGLQNVPPEL IEAAELDGVNKWEMLRHVTIPMVMPSITICLFLTLSNSFKLFDQNLALTNGAPGGQTEMV ALNIINTLFNRMNVEGVG >RXN00378 TRANSLATE of: rxn00378.seq check: 9591 from: 1 to: 2610 VDKAVNTAISDAKTAALKAGVGLNRATASEEEEDLSSSIKVSLAFELEGLSNAPSLMVVE KALEKIPGVSADLIYPSQTAWITATDRVHPETLIEVFEQFGIKAHLSNSSLLRRHQQLSA EVNREARLDRYRSRMDAKRISPRVRRHNRQEMVHAVRARESGWIKRRNHTTSQHEDPMSG DVLFTARALITPKRLWVSLPFALIVLALSLNPSWQFDYWQWLSAVLAIPVVVWGAWPFHR AAAGGIRRGISALDATSSIAIAAAYAWSIAMLLFETPGGKSWRSYPSWFAFDHGTLTQNE IYFDVACGITVLLLAGRLLTRRRSQSSLLAELGRLQIDPQRIVTVVRKHRLKRVVQELNI PVQEVRVNDDVKVPPNTTIPVDGTVIGGGSRIAASIIMGQDQRDVKVNDKVFAGSLNLES EIKVRVIRTGHRTRIAAVHRWVKEATLKENRHNRAAIRSAGNLVPITFTLAVVDFCLWAL ISGNINAAFTTTLAVLACVAPVALALSAPLATRNSIEAAARHGILVRSGEIFRVLDDVDT AVFNRVGTLTDGEMTVETVTADKGEDPELVLRVAGALAMESHHAISKALVKASREARDTG AGGEDVPHWIEVGNVEITEAGSEQATIELPLIKPSGEKIMRTTEALLWRPRSMTEVREHL SPRLVAAATSGGAPLIVRWKGKDRGVITLSDHVRSDSSDAIIAIEEQGIETMMLSRDTYP VARRYADSLGITHVLAGIAPGKKAQVVRAVHTRGSTVAMIGDESVMDCLKVADVGVLMGV DRPSDLRDDSDDPAADVVVMREEVMSVPTLFKLARRYAKLVNGNIALAWIYNGVAMVLAV SGLLHPMAATVAMLASSLLIEWRSGRARKY >RXN00412 TRANSLATE of: rxn00412.seq check: 7568 from: 1 to: 1080 VSHTASTPTPEEYSAQQPSTQGTRVEFRGITKVFSNNKSAKTTALDNVTLTVEPGEVIGI IGYSGAGKSTLVRLINGLDSPTSGSLLLNGTDIVGMPESKLRKLRSNIGMIEQQFNLFQS RTAAGNVEYPLEVAKMDKAARKARVQEMLEFVGLGDKGKNYPEQLSGGQKQRVGIARALA TNPTLLLADEATSALDPETTHEVLELLRKVNRELGITIVVITHEMEVVRSIADKVAVMES GKVVEYGSVYEVFSNPQTQVAQKFVATALRNTPDQVESEDLLSHEGRLETIDLTETSGFF AATARAAEQGAFVNIVHGGVTTLQRQSFGKMTVRLTGNTAAIEEFYQTLTKTTTIKEITR >RXN00431 TRANSLATE of: rxn00431.seq check: 340 from: 1 to: 789 MVSIDTYNACVDFPIEDAKSRSMKKAFLGAAGGAIGRNQDNVVVVEALKNVNLHLREGDR VGLVGHNGAGKSTLLRLLSGIYEPTRGSADIRGRVAPVFDLGVGMDPEISGYENIIIRGL FLGQTRKQMKAKMEEIADFTELGEYLSMPLRTYSTGMRIRLALGVVTSIEPEILLLDEGI GAVDAAFMAKARDRLQALVERSGILVFASHSNDFLAQLCNTALWVDHGQIREAGLVPDVV EAYEGKGAGDHVRRLLTRMEEEK >RXN00444 TRANSLATE of: rxn00444.seq check: 7535 from: 1 to: 837 MVLAQTKKARRSENHILPGWLLIPATLAMLLIIGPIEALLLQIPWDRSWELLTAPESLGT ARLSIGTALFSTALCAIVGFPLALALHLYERSHPRVTSVLTVLVYAPLVLSPVVSGLALT FLWGRRGFLGSWLDQVGLPIAFTTTAVVEAQVFVALPFFISTVTTALRGIPKQFEEIAAT EGATRWEIMHKMIIPLAMPGIFTGMILGFARALGEYGATLTFAGNIAGVTRTIPLHIELG LSSNDMDKALGAVIMLLAVYVLIIGAIGALRLFSKVRKV >RXN00466 TRANSLATE of: rxn00466.seq check: 8825 from: 1 to: 996 VQSRLSKILRSSVVGVAVLALLAGCSNNADDTDADSTSTGNSAFPVSIEHEFGTTTIDDV PERVVTLGVTDADIVLALGTVPVGNTGYKFFENGLGPWTDELVEGKELTLLDSDSTPDLE QVAALEPDLIIGVSAGFDDVVYEQLSDIAPVVARPAGTAAYAVAREEATNLVARAMGQSE KGQELNEETDALIQAARDENPSFDGKTGTVILPYQGKYGAYLPGDARGQFLDSLGISLPE AVLSRDTGDSFFVDVPAESVKDVDGDVLLVLSNDENLDITAENPLFETLNVVQKDAVIVA TTEERGAITYNSVLSVPFALEHLAPRIAEALK >RXN00523 TRANSLATE of: rxn00523.seq check: 9218 from: 1 to: 1026 MSLSHQLKRQRASRNSRRWLIVAALGVVTLGIFAFSLMWGEVFYGPAQVLKVLSGQQVPG ASYSVGVLRLPRAVMGLTAGLAFGAAGVIFQTVLRNQLASPDIIGISSGASAAGVICIVF FGMSQSAVSAISLCASLAVALLIYLVAYRGGFSATRLILTGIGIAAIMLNSLVSYSLSKAD SWDLPTATRWLTGSLNGATWDRAMPLIVTTVVLIPLLVANARNVDLMRLGNDSAVGLGVA TNRTRVIAIIAAVALIAVATAACGPIAFVAFVSGPIAARILGSGGSLIIPSALIGGLIVL IADLIGQYFLGTRYPVGVVTGAFGAPFLIYLLIRSNRAGVTL >RXN00525 TRANSLATE of: rxn00525.seq check: 5915 from: 1 to: 1263 MSLAESILLALTSLRSNKMRALLTLLGVIIGIASVIGILTIGKALQDQTLNSLESLGAND LSAQVEERPDEDSPEPDMFAFSGAANSSGNLIPEETVDTLRDRFAGSITGISVGGMGTQG TLIGDTADLKSDLLGVNEDYMWMNGVEMNYGRAITQDDVAAQRPVAVIAPDTFNTLFDAN PNLALGSEVAFELNGQETFLRVIGVYKEAAAGGLVGSNPTVHTYTPYTVANDITHTEDGL NTLSIRAAQGVDQDSLKGSLQTYEDALYANNDSHHVAMLDFRKQIEEFNTILGAMSLGIS AIGGISLLVGGIGVMNIMLVSVTERTREIGVRKALGARRRDIRLQFVVEAMIICFIGGIL GVLLGGILGLIMSSAIGYISLPPLSGIVIALVFSMAIGLFFGYYPANKAAKLDPIDALRY E >RXN00702 TRANSLATE of: rxn00702.seq check: 9529 from: 1 to: 1707 MSAPFSARTAWSTDPVLELESVAASYYDDERTLAAPQISDVNLTLFEGEILLVVGRTGSG KSTLLNAMSGAMPHATGGRLDGRVRVVGRDTRDFPPRMLSDVVGVVGQDPAASFITNTVE EELAYSMEQLGLPPAVMRKRVEETLDLLGIAELRYVPLAELSGGEQQRVAIGAVLTTRPA LIILDEPTSALDPNGAEDVLATVTKLAHDLAMTVVLAEHRIERVLQYVDRVAHVGADGHV TVGTPEEIMADSDVAPPIVELGRWAGWAPLPLSIRDARAHSADMRKRLYQRGLVVNKLHN HAVQPLLIAEDIMVDFPEIRAVDGVNLNLNSGEITVLMGRNGCGKSSLLWALQGSGTRNQ GSVQVLDEAAGFSWTDPKTLKPAKRRNLVSMVPQTPTDILYESTVHAELARSDKDAAAPA GTTREILDSLVPNIPDHLHPRDLSEGQKLSLALSIQLAAKPRVVFFDEPTRGLDYDGKKS LARSFQQLADDGHAILVVTHDVEFSALCADRVLFMASGKIISDGTAVEILPASPAYAPQV AKITAGIQEESHWLTVSAVKAALGHGEIS >RXN00726 TRANSLATE of: rxn00726.seq check: 2288 from: 1 to: 591 NAGRLYVDGDLIGYRERDGVLYEISEKDAAKQRSDIGMVFQNFNLFPHRTVIENIIEAPI HVKKQPESKARARAMELLEQVGLAHKADAYPVQLSGGQQQRVAIARAVAMEPKLMLFDEP TSALDPELVGEVLRVMKQLADDGMTMLVVTHEMGFAHEVADQVVFMADGVVVEAGTPEQV LDNPKEQRTKDFLSSLL >RXN00732 TRANSLATE of: rxn00732.seq check: 6509 from: 1 to: 1647 NHLLLLPTVKADIIDNGVVTGDIGYIWHTGGIMLALTLVQVACAIAGVYFGSKLSMRVGR DLRSAIFGKVVNFSEREMGQFGAPSLITRNTNDVQQVQMLVQMTSTLMISAPMLAIGGII MAVRQDLGLSWLMVVSIPVLIIVVALIIVRMVPLFQTMQKRIDRINQIIREQLTGIRVIR AFVREDVERERFTTASKDVADIGVRTGNLMALMFPAVMLIMNLSAVAVIWFGAFQVESGE TQIGTLFAFLQYIMQILMGVMMAAFMFVMVPRAAVSADRIGEVLETTPSVQAPETPAQPS TSAGEIVFNNATFAYPGADDPVLNNVSFRVAPGSTTAIIGSTGSGKTTLIGLVPRLFDVT EGDVTVDGTDVREFEPLKLWDRIGLVPQKSFLFSGTIASNLRYGNEDATETQLWQALAIA QAADFVREMPEGLDSEIAQGGTNVSGGQRQRLAIARALLKQPEIYIFDDSFSALDVSTDA ALRRALSTNLPDATKLIVAQRVSTIRDADQIVVLDNGEVVGIGTHTNLLNTCGTYREIVE SQETAQAQS >RXN00759 TRANSLATE of: rxn00759.seq check: 3116 from: 1 to: 924 MLRYVGRRLLQMIPVFFGATLLIYALVFLMPGDPVQALGGDRGLTEAAAEKIRQEYNLDK PFTVQYLLYIKGIFVLDFGTTFSGQPVIDVMARAFPVTIKLAIMALLFESILGIIFGVIA GIRRGGIFDSTVLVLSLIVIAVPTFVIGFVLQFLVGVKWGLLPVTVGSNTSITALIMPAV VLGAVSFAYVLRLTRQSVSENLRADYVRTARAKGMSGFNVMNRHVLRNSLIPVATFLGAD LGALMGGAIVTEGIFGINGVGGTLYQAILKGEPTTVVSIVTVLVIVYIIANLLVDLIYAV LDPRIRYA >RXN00808 TRANSLATE of: rxn00808.seq check: 7354 from: 1 to: 1458 VLGTNVFGALAVMLFVRFLIPQPDASNFNAEISYLPAVGFAYLAFAIVAGMLVTFLMFRP VLDWQRSPEDHDRNMVRNLVMRIPIYQAILCAVVWLIGIAIATLISASVSTSLALVVAFS TLMAAAIVVLLTYLEAERLVRPVAASALARRFEDSTLEPPVSQRLRMTWLLTLGIPVMGI LLLIWGYSQGIFGSDASGIMPAIAALAFASLVTGYLGNRLVVSSVVDPIRELQEAINRVR RGENDVQVDIYDGSEIGVLQAGFNEMMRGLRERQRVRDLFGRYVGAEVAKRALEERPTLG GEDRKVAVLFVDVIGSTTFAVNHTPEEVVEALNEFFEHVVEVVHRNKGVINKFQGDAALA IFGAPLPLSDATGHALAAARELRAELKDLQLKAGIGVAAGHVVAGHIGGHARFEYTVIGD AVNQAARLTEIAKTTPGRTVTNASTLREANEAEQARWTLMKSVELRGRSQMTQIARPIRP TLADRS >RXN00828 TRANSLATE of: rxn00828.seq check: 8544 from: 1 to: 453 VRGGLNTPPHKWRSADLAARIGTVFQDPEHQFVARTVRDELEIGPKIMKVDASERIEELL DRLRLRHLENANPFTLSGGEKRRLSVATALVAAPKLLILDEPTFGQDPETFTELVTMLRE LTDNGISIVSVTHDPDFIAALGDHHIEVSAK >RXN00832 TRANSLATE of: rxn00832.seq check: 2297 from: 1 to: 1050 MPFSWLKPIDYARIFVGWASIFIIPLITLPSIIELALIVAVILFCAFGVVKMAERLAHIL GDPFGSLILTLSIVIIEVILICAVMLGPADSTTAGRDSVMAVSMIIMGLVVGLCLLIGGL RHGSMPHNGVGTPTYLVLIATFSVIAFAVPAFRGEYSTGQALVISTLTAVVYGFFLFRQM GAQAGEFQEVEVAEKADDAAKWEVPFRGLILIITVLPIVLLSHDMATVMDEVLASLGAPV AMAGLIIATIVFLPETITSLKAAWTGEIQRVSNLAHGAQVSTVGLTIPAVLVIGVITGQD VVLGETPINLLLLGTTIAVTAIAFSSKKVSAVHGSVLLMLFGVYMMSMFA >RXN00934 TRANSLATE of: rxn00934.seq check: 9723 from: 1 to: 1083 VRIGMVCPYSFDEPGGVQAHILDLARTFIAQGHEVQVLGPCSADTQVPDFVVRGGGSIPI PYNGSVARLSFGPKMFKAVRTFLREGNFDVLHIHEPNSPSFSMAALRFAEGPIVATYHAS SSGSKLLKAFLPVLSPMLEKVRAGIAVSEMARRWQVEQVGGDPVLIPNGVETSMFKAARQ IEPNDPVEIVFLGRLDESRKGLDILLRALTRLDRPFTCTVIGGGTPREVAGINEVGRVSD EEKAAILGRADIYVAPNTGGESFGIVLVEAMAAGCAVVASDLEAFSLVTDSEAAQPAGVL EKTGSDADLAKKLQALIDDPSSRSTLIAAGLKRANAYDWSTVSTQVMAVYETIAIDKVRL G >RXN00939 TRANSLATE of: rxn00939.seq check: 3908 from: 1 to: 1236 MTRQKTQPFLEKESKYYTPGVMIAALAVGLITLNVELALTLLVIACPGALVISIPVSIVA GIGRSAKDGVLIKGGEYLETSAKVDTVVVDKTGTLTNGRPELTNVDVLDPAYSDDEVLTL AARAETASEHPLAEAIIRGAENRGLTVAMVEKAEPVAGRGIRADVDGATVAVGSADLLDH TPDNTRILELNEQGRTAMYVGINGKAVGIVAVADTIRDDAPAAIRSLHNKGIRVVMATGD AERVARNVAAELGVDEVRAELMPEDKLEIVKELQAQGRVVAMVGDGVNDTPALATADIGV AMGAAGSPAAIETADTALMADKLPRLPYALGLAQRTVRTMRVNIGIALLTVTILLAGVLL GGVTMSIGMLVHEASVLLVIAIAMLLLRPTLKEDKDKADVSTADAAKETLSA >RXN00960 TRANSLATE of: rxn00960.seq check: 4118 from: 1 to: 1035 MARHCCSNRYASTVFSGLIAYGASQALYPWLLKDHQSVTEIDLDAGALQPYPNIENPPPF EVMTALLLAECLGLGMAVIKSDTLFKVTRELERVVMKTITAFVIPLLPLFIFGIFLGMGM NGGLLEIMSAFGKVLILAVVGTLLFLAIQFIIAGAVSKKNPWKLFKNNLPAYFTALGTSS SAATIPVTYQQTLKNDVDVNVAGFVVPLCATIHLAGSMMKIGLFTFAVVFMYDMEVGVGL SIGFLLMLGITMIAAPGVPGGAIMAATGMLASMLGFNTEQVALMIAAYIAIDSFGTAANV TGDGAIAVIVNKFAKGQLHTTSPDEIEEDDRVAFDITPSDVEHHK >RXN00980 TRANSLATE of: rxn00980.seq check: 2367 from: 1 to: 1794 MLADAFMIAAAIVAGWPIAQSAYQALRIRMVSIDLLVVVAAVGAMFINNYWESAAVTFLF ALGKALERATMNRTRKALSDLVDAAPETATRLNADDSTEVVELWELEPGDIVLVRNGEQI PVDGNVIAGVGGIDESNITGESMPAEKGQGSDVYAGTWLRSGVLRVEATGIGSDSTLAKI IHRVEDAQDDKARTQTFLEKFSKWYTPGVMIAAAVVGLITWDVELALTLLVIGCPGALVI SIPVSIVAGIGRAARDGVLIKGGEYLETAAKVDVVVVDKTGTLTTGRPELTDVEVIEPAY SQGEVLELAARAETASEHPLADAIIRGAQDRGLSTTLVEAAENITGRGIIANVDGQAVAV GSAELLDHEPDSTRILELNAEGKTAMFVGVNGHAIGIVAVADAVRSDSASAIESLHKAGI QVVMATGDAHRVAQNVASKLGVDEVYSELLPEQKLELVRDLQAAGKTVAMVGDGVNDTPA LAAADIGVAMGVAGSPAAIETADIALMADRLPRLAHAVTLAKRTVRTMRINILIALATVM VLLAGVLFGGVTMSVGMLVHEASVLLVISIAMLLLRPTLKEDAAQASDIKRSEIQQIA >RXN01000 TRANSLATE of: rxn01000.seq check: 4854 from: 1 to: 846 MSTLTSHRTVPAPSSPPARPNKLARNIVAIVAALIVLIATGTLKIEWNELPQMPAQVWHY LELMFSDPDWSKFGRAVQEMWRSIAMAWLGAILCVVVSVPLGMLAARGVGPYWLRTVLRF VFAVIRAFPEVVIAIILLTVTGLTPFTGALALGISGIGQQAKWTYEAIESTPTGPSEAVR AAGGTTPEVLRWALWPQVAPSIASFALYRFEINIRTSAVLGIVGAGGIGSMLANYTNYRQ WDTVGMLLIVVVVATMIVDLISGTIRRRIMKGASDRVVAPSN >RXN01002 TRANSLATE of: rxn01002.seq check: 1757 from: 1 to: 804 MNSDASATTNSWATNPDHVSVTYPNGTKALDDVSLTINPGEMVAIVGLSGSGKSTLIRTI NGLVRATEGTVTVGPHQINTLKGKALRDARGQIGMIFQGFNLSERSSVFQNVLVGRFAHT AWWRNLLGFPTEHDKQIAFHALESVGILHKVWTRAGALSGGQKQRVAIARALSQDPSVML ADEPVASLDPPTAHSVMRDLENINNVEGLTVLVNLHLIDLARQYTTRLVGLRAGKLVYDG PTSEATDKDFEATYGRPIQAKDLLGDRA >RXN01141 TRANSLATE of: rxn01141.seq check: 9956 from: 1 to: 825 LSTALAGAARYVTSTSNNEPADNTPLTIGYVPIAGSAPIAIADALGLFKKHGVNVTLKKY SGWSDLWTAYATEQLDVAHMLSPMTVAINAGVTNASRPTELSFTQNTNGQAITLASKHYG SVNSAADLKGMVLGIPEEYSVHALLLRDYLVSNAVDPIADLELRLLRPADMVAQLTVEGI DGFIGPGPFNERAISNGSGRIWLLTKQLWDKHPCCAVAMAKEWKAEHPTAAQGVLNALEE ASATLSNPAQFDSSARTLSQEKYLNQPATLLDGPS >RXN01142 TRANSLATE of: rxn01142.seq check: 3960 from: 1 to: 498 LTARGNIDFGLRSARPSLSKTERADITRTHLEQVGLTDAAERRPARLSGGMQQRVGIARA FAIDPPIMLLDEPFGALDALTRRELQLQLLNIWEASRRTVVMVTHDVDEAILLSDRVLVM SKSPEATIITDTPVNLPRPRHELSEDASVEAETTALRKRMLHLLEH >RXN01164 TRANSLATE of: rxn01164.seq check: 868 from: 1 to: 1635 VTLFVRLALAAVGGLFVFASNEPIGWFVAGIVGTALFFISLAPWDLGVPQKRRKKNEPVP FLQQMSTGPTVVQGMLLGFVHGLVTYLQLLPWIGEFVGSLPYVALSVVEALYSIALGAFG VLIARWRDWKVLLFPAMYVAVEYLRSSWPFDGFAWVRLAWGQINGPLANLAALGGVAFVT FSTVLAAVGVAMVIISKKRLAGAIITASVIAIGAVSSLYVDRNGTSDESIEVAAIQGNVP RMGLDFNAQRRAVLANHARETLKLDEQVDLVIWPENSSDVNPFSDAQARAIIDGAVEHVQ APILVGTITVDEVGPRNTMQVFDPVEGAAEYHNKKFLQPFGEYMPFREFLRIFSPYVDSA GNFQPGDGTGVVEMNAANLGRAVTVGVMTCYEVIEDRAGRDAIANGAEFLTTPTNNATFG FTDMTYQQLAMSRMRAIEFDRAVVVAATSGVSAIVNPDGSISQNTRIFEAATLTESIPLK DTVTIAARVGEYVELLLVIIGVLAGLFAIRMNSRSKSAKGSARPAQVRVKKVPAKKAATN RRKVK >RXN01168 TRANSLATE of: rxn01168.seq check: 6703 from: 1 to: 810 MSSEAVDATTLVIIPTYNELENLPLIVDRVRTATPDVHVLIVDDNSPDGTGERADKLAAD DDHIEVLHREGKGGLCAEYMAGFQWGLERDYQVLCEMDADGSHAPEQLHLLLAEITNGAD LVIGSRYVPGGRVVNWPKNRWLLSKGGNVYISVALGAGLTDMTAGYRAFRREVLEALPLD ELSNAGYIFQVEIAYRAVEAGFDVREVPITFTEREIGESKLDGSFVKDSLLEVTKWGLKH RGGQAKELSKEMVGLLNYEWKHFKKRNTWL >RXN01285 TRANSLATE of: rxn01285.seq check: 1049 from: 1 to: 726 LNVTIPDNTFTAIIGPNGCGKSTLLRGESRVLNPQHGKVLLDGRQLDSFKPKEIARELGL LPQTSIAPEGIRVYDLIARGRAPYQSLIQQWRTSDEDAVAQALASTNLTELAARLVDELS GGQRQRVWVAMLLAQQTPIMLLDEPTTFLDIAHQYELLELLRAFNEAGKTVVTVLHDLNQ AARYADHLIVMKDGHVHATGTPEEVLTAEMVQGVFGLPCIISPDPVTGTPTVVPLSRSRA GA >RXN01298 TRANSLATE of: rxn01298.seq check: 8940 from: 1 to: 930 VSTLISEPEVDKLRKRAKRSRRTEWWLAAALLAPNLLLLAIFTYRPLLDNFRLSFFNWNI SSPTSTFIGFDNYVEEFTRSDTLQVVLNTVIFTACAVIGSMVLGLLLAMLLDQKLFGRNF VRSMVFAPEVISGAAIGVAFQFVFDPNFGLVQDLLGRIGVDSPQEYQNPNWALFMVTFTF VWKNLGYSPVIYLAALQGLNKDLSEAAPVDGASAWTRFWKVTLPQLRPTTFFLSITVTLN SVQVFDIIHTMTRGGPLGNGTTTLVYQVYTETFTNYRAGYGATIATILFLLLLIITVIQV RYMDKENKQK >RXN01323 TRANSLATE of: rxn01323.seq check: 658 from: 1 to: 2265 MAQTPAKIPAALNFIDVDLGVTGMTCTSCSARVERKLNKLDGVEATVNYATESAQVSYDP SKVSPEQLIKTVEDTGYGAFTMASAAAESEEDNAPADSGQSRIDAARDHEAADLKHRVIV SALLSVPVVLVSMIPALQFNNWQWAVLTLVTPIFFWGGSPFHKATWANLKRGSFTMNTLV SLGTSAADLWSLWALFIENAGHPGMKMEMHLLPSASTMDEIYLETVAVVITELLLGRWFE TKAKGQSSEALRKLLDMGAKDAVVLRDGAEVRVPVNQLKLGDVFITRPGEKIATDGEVDE GSSAVDESMLTGESIPVEVTKGSKVTGATLNTSGRLMVKVTRIGADTTLSQMAKLVTDAQ SKKAPVQRLVDQISQVFVPVVIVIAIATLIAHLVFTDAGLAPAFTAAVAVLIIAGPCALG LATPTALLVGTGRGAQLGLLIKGPEILESTKKVDTIVLDKTGTVTTGTMSVTDVTAINYS ETEILEFAAAVESASEHPIAQAIAKAAEHEQVTDFQNTAGQEVTGVVRGHEVRVGRPSST LIDALLHPFQHAQKIGGTPVVVTIDGVDSGIITVRDTVKDTSAEAIRGLKELGLTPILLT GDNEGAAKSVAAEVGIDQVIANVLPHEKVQNVEALQAQGKNVAMVGDGVNDAAALAQADL GLAMGAGTDVAIEASDITLMNNDLRSAVDAIRLSRKTLGTTKGNLFWAFAYNVALIPVAA IGLLNPMLAGIAMAFSSVFVVSNSLRLRGFKARSN >RXN01338 TRANSLATE of: rxn01338.seq check: 9102 from: 1 to: 1902 KTYTPNPWMLFIRSFDGIITVAALVAIAIHLILWLALDLDGLAKNWPLIAIVIVGGIPLM WDVLKSAIKTRGGADTLAAVSIITSVLLGEWLVAAIIVLMLSGGEALEEAASRRASGTLD ALARRAPSTAHRLLGATILDGTEEIAVEEITVGDLVAVLPHELCPVDGEIVAGHGTMDES YLTGEPYVVSKSKGSQAMSGAVNGDTPLTIVATKLAHDSRYAQIVGVLHEAENNRPEMRR MADRLGAWYTVIALALGGLGWIVSGDPVRFLAVVVVATPCPLLIAVPVAIIGAISLAARR GIIVKNPGMLENASGVKTVMFDKTGTLTYGRPVITDIHTAPGVEEDTVLALAASVERYSR HPLADAIREGAKARELHLPDVVEVSERPGQGLTGTVGEHLVRITNRRSTLEIDPDSKNYI PVTSSGMESVVLVDDKYAALIRLRDEPRASASEFIAHLPKKHKVDKLMIISGDRASEVRY LADKVGIDEVHAEASPEDKLNIVNRHNEHGATMFLGDGINDAPAMAVATVGVAMGADSDV TSEAADAVILDSSLERLDDLLHISARMRRIALQSAGGGMALSVIGMILAVFGFLTPLMGA IFQEVIDVLAILNSARVALPRGAISDFDTQEKVS >RXN01411 TRANSLATE of: rxn01411.seq check: 3735 from: 1 to: 765 MLGVGWRIPFLMAVPLGLIGWWIRTGAQENVRPASERPEAPIKQALRTEWKMMLRVGGFI SCTGLSFYIFTTYMTTFLRSTVGLEGTLVLAGNIIALSMAAIVAPFVGRAIDKFPRRNIM AFATLSTVIMAIPAYIIAGQGTLTASLIAQVMLGIGAVTANCVTSVMMAEVFQEVTRGTS AGITYNVTYAIFGGSAPFISTALVSWTGSPLAPAVYMIIIALFAFTASRFIPETSPVFVT ATPATKAPKVLVNPG >RXN01808 TRANSLATE of: rxn01808.seq check: 4151 from: 1 to: 1149 QSLACKELAWMRGGAPARTSKPGFRLEAAEALIAEVPAPRDKVELMAFSKSRQGRVVIEL EDATVATPDDRILVEDLTWRLAPGERIGLVGVNGSGKTTLLRTLAGEQPLQAGKRIEGQT VKLGWLRQELDDLDLSRRLIDCVEDVASYVMMGDKQVSASQLAERLGESPKRQRTPVGDL SGGERRRLQLTRVLMAEPNVLLLDEPTNDLDIDTLQELESLLDGWPGTMVVISHDRYLIE RVTDSTWALFGDGKLTNLPGGIEEYLQRRAAMAAAEDSGVLNLGAATQAGTFSAATEQAA TSVESSGISSQERHRITKEMNALERKMGKLDQQMDKLNQQLADAAEAMDTIKLTELDTKL RAVQEEHGELEMQWLELGEEIEG >RXN01939 TRANSLATE of: rxn01939.seq check: 574 from: 1 to: 1731 MTTNIPQTPNHEGEQPLLELKDLKISFTSSTGVVDAVRGANLTIYPGQSVAIVGESGSGK STTAMSIIGLLPGTGKVTEGSIMFDGQDITGLSNKQMEKYRGSEIGLVPQDPMTNLNPVW RIGTQVKESLRANHVVPGSEMDKRVAEVLAEAGLPDAERRAKQYPHEFSGGMRQRALIAI GLAARPKLLIADEPTSALDVTVQRQILDHLETLTKDLGTAVLFITHDLGLAAERAEHLVV MHRGRIVESGPSLKILRNPQHPYTQRLVKAAPSLASARIQSAQEQGIESAELLSATAVAE GTIPEMEEKVIEVKNLTREFDIRGARGDKKKLKAVDDVSFFVRKGTTTALVGESGSGKST VANMVLNLLEPTSGEVLYNGTDLTSLSHKEIFQMRRKLQVVFQNPYGSLDPMYSIYRCIE EPLTIHKVGGDRKAREARVAELLDMVSMPRSTMRRYPNELSGGQRQRIAIARALALNPEV IVLDEAVSALDVLVQNQILTLLAELQQELKLTYLFITHDLAVVRQTADDVVVMQKGRIVE KGRTDDIFNDPQQHYTRDLINAVPGLGIELGTGENLV >RXN01995 TRANSLATE of: rxn01995.seq check: 3763 from: 1 to: 1338 MDIRQTINDTAMSRYQWFIVFIAVLLNALDGFDVLAMSFTANAVTEEFGLSGSQLGVLLS SALFGMTAGSLLFGPIGDRFGRKNALMIALLFNVVGLVLSATAQSAGQLGVWRLITGIGI GGILACITVVISEFSNNKNRGMAMSIYAAGYGIGASLGGFGAAQLIPTFGWRSVFAAGAI ATGIATIATFFFLPESVDWLSTRRPAGARDKINYIARRLGKVGTFELPGEQSLSTKKAGL QSYAVLVNKENRGTSIKLWVAFGIVMFGFYFANTWTPKLLVETGMSEQQGIIGGLMLSMG GAFGSLLYGFLTTKFSSRNTLMTFMVLSGLTLILFISSTSVPSIAFASGVVVGMLINGCV AGLYTLSPQLYSAEVRTTGVGAAIGMGRVGAISAPLLVGGLLDSGWSPTQLYVGVAVIVI AGATALIGMRTQAVAVEKQPEALATK >RXN02062 TRANSLATE of: rxn02062.seq check: 5414 from: 1 to: 1170 MRVGMMTREYPPEVYGGAGVHVTELTRFMREIAEVDVHCMGAPRDMEGVFVHGVDPALES ANPAIKTLSTGLRMAEAANNVDVVHSHTWYAGLGGHLAARLHGIPHVATAHSLEPDRPWK REQLGGGYDVSSWSEKNAMEYADAVIAVSARMKDSILAAYPRIEPDNVRVVLNGIDTELW QPRPTFDDAEDSVLRSLGVDPQRPIVAFVGRITRQKGVEHLIKAAALFDESVQLVLCAGA PDTPEIAARTTALVEELQAKREGIFWVQDMLGKDKIQEILTAADTFVCPSIYEPLGIVNL EAMACNTAVVASDVGGIPEVVVDGTTGALVHYDENDVETFERDIAEAVNKMVADRETAAK FGLAGRERAINDFSWATIAQQTIDVYKSLM >RXN02096 TRANSLATE of: rxn02096.seq check: 3261 from: 1 to: 1692 MGLDVSDEQIEHAARLAQAHDFIDRLPNKYEEVIGERGLTLSGGQRQRIALARAFLAHPK VLVLDDATSAIDASTEDRIFQALREELHDVTILIIAHRHSTLELGDRVGLVEDGRVTALG PLSEMRDHARFSHLMALDFQDSHDPEFTLDNGSLPSQEQLWPEVSTEKQYKILAPAPGRG RGMSMPATPELLAQIEALPAATEETRVDAGRLRTSTSGFKLLSLFKQVRWLVVAVIALLL VGVAADLAFPTLMRAAIDNGVQAQSTSTLWWIAIAGSVVVLLSWAAAAINTIITARTGER LLYGLRLRSFVHLLRLSMSYFERTMSGRIMTRMTTDIDNLSSELQSGLAQTVVSVGTLIG VVTMLAITDAQLALVALSVVPIIIVLTLIFRRISSRLYTASREQASQVNAVFHESIAGLR TAQMHRMEDQVFDNYAGEAEEFRRLRVKSQTAIAIYFPGLGALSEIAQALVLGFGALQVT RGDISTGVLVAFVLYMGLMFGPIQQLSQIFDSYQQAAVGFRRITELLATQPSVQIWAPTG TLGRLPRSLYCLTTSPSAIQTIRS >RXN02348 TRANSLATE of: rxn02348.seq check: 8038 from: 1 to: 1884 MLNRMKSARPKSVAPKSGQALLTLGALGVVFGDIGTSPLYSLHTAFSMQHNKVEVTQENV YGIISMVLWTITLIVTVKYVMLVTRADNQGQGGILALVALLKNRGHWGKFVAVAGMLGAA LFYGDVVITPAISVLSATEGLTVISPSFERFILPVSLAVLIAIFAIQPLGTEKVGKAFGP IMLLWFVTLAGLGIPQIIGHPEILQSLSPHWALRLIVAEPFQAFVLLGAVVLTVTGAEAL YADMGHFGARPIRVAWFCVVMPALILTYLGQGALVINQPEAVRNPMFYLAPEGLRIPLVI LATIATVIASQAVISGAYSLTKQAVNLKLLPRMVIRHTSRKEEGQIYMPLVNGLLFVSVM VVVLVFRSSESLASAYGLAVTGTLVLVSVLYLIYVHTTWWKTALFIVLIGIPEVLLFASN TTKIHDGGWLPLLIAAVLIVVMRTWEWGSDRVNQERAELELPMDKFLEKLDQPHNIGLRK VAEVAVFPHGTSDTVPLSLVRCVKDLKLLYREIVIVRIVQEHVPHVPPEERAEMEVLHHA PIRVVRVDLHLGYFDEQNLPEHLHAIDPTWDNATYFLSALTLRSRLPGKIAGWRDRLYLS MERNQASRTESFKLQPSKTITVGTELHL >RXN02354 TRANSLATE of: rxn02354.seq check: 8723 from: 1 to: 834 MTKRTKGLILNYAGVVFILFWGLAPFYWMVITALRDSKHTFDTTPWPTHVTLDNFRDALA TDKGNNFLAAIGNSLVISVTTTAIAVLVGVFTAYALARLEFPGKGIVTGIILAASMFPGI ALVTPLFQLFGDLNWIGTYQALIIPNISFALPLTIYTLVSFFRQLPWELEESARVDGATR GQAFRMILLPLAAPALFTTAILAFIATWNEFMLARQLSNTSTEPVTVAIARFTGPSSFEY PYASVMAAGALVTIPLIIMVLIFQRRTVSGLTAGGVKA >RXN02356 TRANSLATE of: rxn02356.seq check: 7192 from: 1 to: 996 MATVTFDKVTTRYPGAERATVHELDLDIADGEFLVLVGPSGCGKSTTLRALAGLEGVESG VIKIDGKDVTGQEPADRDIAMVFQNYALYPHMTVAKNMGFALKLAKLPQAQIDAKVNEAA EILGLTEFLDRKPKDLSGGQRQRVAMGRALVRDPKVFLMDEPLSNLDAKLRVQTRAEVAA LQRRLGTTTVYVTHDQVEAMTMGDRVAVLKDGLLQQVAPPRELYDAPVNEFVAGFIGSPS MNLFPANGHKMGVRPEKMLVNETPEGFTSIDAVVDIVEELGSESYVYATWEGHRLVARWV EGPVPAPGTPVTFSYDAAQAHHFDLESGERIA >RXN02391 TRANSLATE of: rxn02391.seq check: 7541 from: 1 to: 399 MTQSDLPDDVQELVTKIFGLARDGGAESAATLGAYVDNGVDVNLSNQDGNTLLMLAAYAG HADVVQALIERGADVDRVNNRNQTPLAGAIFKKEEAVIEALLAGGADPYAGTPTAVDTAK MEGREDLVARFES >RXN02442 TRANSLATE of: rxn02442.seq check: 5164 from: 1 to: 849 MKFFTDALIVPFDVSFISRALVAGCLAAILCSLIGTWVILRRLTFFGDAMSHGLLPGVAT ASLLGGNLMFGAAISALIMSAGVVWTSRKSSLSQDVSTGLQFITMLSLGVVIVSHSDSHA VDLTSFLFGDILGVRPSDIFIIAIATVLGGLTIFLFHRQFTALAFDERKAHTLGLNPRFA HLLMLALIALATVVSFQVVGTLLVFGLLIGPPATAALLVQDKASISLIMIVASLLGCAEI YLGLLISWHASTAAGATITLLSAAIFFATLLTKSAISRLNFTA >RXN02447 TRANSLATE of: rxn02447.seq check: 8454 from: 1 to: 1095 TVVPVYLAELAPLEIRGSLTGRNELAIVTGQLLAFVINALIAVTLHGVIDGIWRIMFAVG ALPAVALFLGMLRMPESPRWLVNQGRYDDARRVMETVRTPERAKAEMDEIIAVHSENNAA LPGVKQSSGQASGQVSSKHTHMSIGEVLSNKWLVRLLIAGIGVAVAQQLTGINAIMYYGT RVLEESGMSAEMAVVANIAFGAVAVTGGLIALRNMDRLDRRTTFIIGLSLTTTFHLLIAA AGTLLPEGNSIRPFAIMILVVGFVLSMQTFLNVAVWVWLAEIFPVRMKGIGTGISVFCGW GINGVLALFFPALVSGVGITFSFLIFAVVGVIALAFVTKFVPETRGRSLEELDHAAETGQ IFRKA >RXN02455 TRANSLATE of: rxn02455.seq check: 2559 from: 1 to: 1269 LKRLTRIASISMASMLAAASLVACSGSTDEEGDVYFLNFKPEQDVAYQEIAKAYTEETGV KVKVVTAASGSYEQTLKAEIGKDEAPTLFQVNGPAGFITWQDYMADMSDTEVAKQLTDDI PPLTTEDGEVRGVPFAVEGFGTTYNDEIFDKYIATSGAKIKSTDEITSYQKLKEVAEDMQ AKKDELGIEGAFASTSLTSSEDWRWQTHLANAPIWQEYQDKGVEDTNEIEFSYNKEYKNL FDLYLENSTVEKSLAPSKTVSDSMAEFAQGKAANVQNGNWAWSQISETSGNVVKEDKIKF LPMYMGLPDEEKHGINVGTENYLGVNSEASEVDQQATKDFVDWLFTSEAGKEHVVKDLGF IAPFESYTAENTPNDPLSEQVAEAIANKDLTTYPWNFQYFPSQQFKDDFGQDLSQYASGK LKW >RXN02515 TRANSLATE of: rxn02515.seq check: 4857 from: 1 to: 756 MSTLEIRNLHAQVLPSDESAEPKEILKGVNLTINSGEIHAIMGPNGSGKSTLAYTLGGHP RYEVTAGEVLLDGENILEMEVDERARAGLFLAMQYPTEIPGVSVANFLRSAATAIRGEAP KLREWVKEVRTAQEALAIDPEFSNRSVNEGFSGGEKKRHEVLQLDLLKPKFAIMDETDSG LDVDALRIVSEGINSYKQETEGGILMITHYKRILNYVKPDFIHVFANGQIVTTGGAELAD KLEADGYDQFIK >RXN02549 TRANSLATE of: rxn02549.seq check: 8075 from: 1 to: 2703 MVHAKQTKKPLPRFLHSAHFYVWIVLGFVVFAQPYGQVAADTKLDLLLNPAGFLTGALHA WTDTFTLGQLQNQAYGYLFPQGFFFLITDFLPDWIAQRLWWWLVLGLGFSGFYALVARLG IGNPAFRVIAALLFALSPRTLTTLTAISSETWPIMLAPWVCLPLLSRNVDARAIALSLLP AACMGAVNATATMAALIPAALILLYRGLFLRLLLWGMGVLAVNSWWIGPLLVLGKYAPPF TEFIESSSVTTSWLNPVEILRGTTSWTPFVDTERQAGYLLVNDALFVTLSVLVAALGLIG LTLMKHRGLWAFMLAIGLLILGSAHLTAVQEFLDGPGAALRNIHKFDLLVRNPLMVGVAA LGSHISLPLLGTTALTSGQGKHHTIPLPLQKRQAAGLLVVIIAVGALAPAWSARLLPQGT WDEVPDYWYEATEFLNQNATGTRTLIWPSSPFARQDWGWTRDEPAQPLLDVPWAVRDAIP LVPPEAIRGLDGLDDLGTLGTGLNDEALKRLGIGAVLVRHDLEADPDIEVDLPGEKHTFG SQGQVDVYLTDPDRNMWITSGTSKQLPTVAGGGEILSLLDTINGYSPRTLVSENAQIVTD TPQLVGTNYGDGTSSAALASLDETEVKNRIVDYPSAGPMTQVVQEGSITASSSGSDATSF GGADPDRSLNSLLDHRYNTAWYPTPGDTSPWLEVSGTGTTLSISPRSTVTATITSGDSVM VREFEKGRTTTVTLAEPEARIEFDGFVGISELSLEGLSRTITVPETSPDVQQFVPQRLTV PTSFLDRTFTVPRHMSVTVEAQSCVTLELDGDRIDCGPSNSPPEPTRCAPNRNGSPSPNP LRSPLFSQQQTSRQHPPTACSSPRALSIQVPARLSTPPPFPQSNSTPPPKVSSSPRTPPA S >RXN02570 TRANSLATE of: rxn02570.seq check: 2673 from: 1 to: 642 MNPLTWITGAFSMWTVVLGVNKLGLSIAVIIIAQVVAMTRVRNVSVLASTALLSVPALAS MALIHMPYSSDGWLIALTLTARFSALMSIFLLAATAITIPELVKSLYRWPKLAYIVGSAL QMIPQGKQTLALVRDANALRGRSVKGPVRAVKYVGLPLITHLLSAGAARAIPLEVAGLDR PGPRTVLVEVVEGRVEKHCRWLLPLLAVGMAWWL >RXN02595 TRANSLATE of: rxn02595.seq check: 5016 from: 1 to: 1164 VIVVAMASIMACLKAARLNNPMKILLLCWRDTTHPQGGGSERYLERVGEFLADQGHEVVF RTAGHTDAPRRSFRDGVRYSRSGGKFSVYPKAWVAMMLGRVGIGTFSKVDVVVDTQNGIP FFGKFFSGKPTVLLTHHCHKEQWPVVGRVLAKVGWLIESQIAPRAYKTAPYVTVSEPSAE ELIALGVDQQRIHIVRNGVDPVPLHTPKLDRDGQHAVTLSRLVPHKQIEHAMDVVAALDG VVLDVVESGWWQKELVDYARTLGVSDRVVFHGQVAEDHKHALLERATIHLMPSRKEGWGL AVTEAAQHGVPTIGYRSSGGLRDSVVDGETGLLVDSKAELISATKTLLIDASLRSKLGAS AKQRAENYKWDTAGAQFEELLLGLASKK >RXN02614 TRANSLATE of: rxn02614.seq check: 5216 from: 1 to: 729 MTATLSLKPAATVRGLRKSYGTKEVLQGIDLTINCGEVTALIGRSGSGKSTILRVLAGLS KEHSGSVEISGNPAVAFQEPRLLPWKTVLDNVTFGLNRTDISWSEAQERASALLAEVKLP DSDAAWPLTLSGGQAQRVSLARALISEPELLLLDEPFGALDALTRLTAQDLLLKTVNTRN LGVLLVTHDVSEAIALADHVLLLDDGAITHSLTVDIPGDRRTHPSFASYTAQLLEWLEIT TPA >RXN02795 TRANSLATE of: rxn02795.seq check: 7318 from: 1 to: 1437 VLKVSDLTVGNNFVHNVSFEVNPGERVGIIGESGSGKSLTALSIMGLTDLPTTGQITFNG KPSATFRGTRIANVFQEPMSALNPLMRIGRQIEEMMTLHGASKKDARARLKSLLIDVSLP ERTASAYPHELSGGQRQRALIAMALANDPDLLICDEPTTALDVVVQKQIVDLLLRLTKER GTALLFITHDLGLIARTCERLLVMKSGETVERGDTEAILRSPAHSYTQQLLDASILDQPE IASDSGAPVVIDVEEASKSFKETTALHKVSLAVRKGDLLGIVGGSGSGKTTLLKLIAGLD KPTTGTVAVTGGVQMVFQDPQSSLNPRMKIKDIVAEPLLGWNAAEKTTRVAEVITQVGLS PDVLDRYPHEFSGGQRQRISIARALATKPAILLADEPVSALDVSVRKQVLDLLQQLVEEY GITLVFVSHDLAVVRHLCTTVWVMEQGRVLEQGPIDSVYDHPQTEYTKELLDAVPRLSL >RXN02925 TRANSLATE of: rxn02925.seq check: 5237 from: 1 to: 2217 MSTPHHHGDHPAPETDHTHHPNHAGHEHHADAATHGQAMPHDRPHSTVDEEHQVHSHGEH AGHSAANFRDRFWWSLILSVPVVFFSPMPADLLGYNIPEIPGAYWIPPVLGTIIFLYGGT PFLKGAMTELKSRQPGMMLLIAMAITVAFIASWVTTLGLGGFHLDFWWELALLVTIMLLG HWLEMRALGAASSALDALAALLPDEAEKVVDGTTRTVAISELAVDDVVLVRAGARVPADG TIIDGAAEFDEAMITGESRPVYRDTGETVVAGTVATDNTVRIRVEATGGDTALAGIQRMV ADAQASSSRAQALADRAAALLFWFALITALITAVVWTIIGSPDDAVVRAVTVLIIACPHA LGLAIPLVIAISSERAAKSGVLIKDRMALEHMRTIDVVLPDKTGTLTEGAHAVTGVAPAT GIAEGELLALAAAAEADSEHPVARAIVTAAAAHPEASQRQLRATGFTAASGRGIRATVDG AEILVGGPNMLREENLTTPGELADITGSWAQRGAGVLHVVRDGEIIGAVAVEDKIRPESR AAVRALQARGVKVAMITGDATQVAQAVGKDLGIDEVFAEVLPQDKDTKVTQLQERGLSVA MVGDGVNDAPALARAEVGIAIGAGTDVAMESAGVVLASDDPRAVLSMIELSHASYRKMVQ NLVWATGYNIVAVPLAAGVLAPIGVLLPPAAAAILMSLSTIIVALNAQLLRRIDLDPAHL APTDGKEEKAAVSSAAPVR >RXN02933 TRANSLATE of: rxn02933.seq check: 4913 from: 1 to: 810 MPLSGKIGGFIVAVVFVLAALSFIWTPFDPVQAFPQERLEGSSLRHLLGTDRYGRDVLSQ IMVGSRVTLLVGIIAVAIAALIGTPLGIAAGMRRGMVETFVMRGADLMLAFPALLLAIIS GAVFGASTWSAMVAIGIAGIPSFARVARAGTLQVTSQDFIAAARLSKVSSARIALRHILP NITSMLIVQASVAFALAILAEAALSFLGLGTTPPDPSWGRMLQTAQASIGVTPMLAVWPG AAIALTVLGFNLFGDGLRDAIDPKREVGRA >RXN02945 TRANSLATE of: rxn02945.seq check: 2147 from: 1 to: 933 MTTALGTRVVARNFGYRHASRENPALKDINFEIAPGERILLTGASGAGKSTLLAALAGVL GGSDEGVSTGELLVDAPSIGLVLQDPDSQVIASRIGDDVAFGCENLQIPREEIWPRVERA LELVGLDLPLSHPTKYLSGGQKQRLALAGVIAMGARLILLDEPTANLDPQGQKNVVAAVD RVVQETGATLIVVEHRHELWVNIIDRIISITDGEDVQPAELIKVGQLPGAQPSTSKPILW ANDLLCTWGGLRSFEVPEGASTVITGPNGAGKSTLALTMGGLLPRKVGSWNSLTRCAAAL TRPRTSGVQLI >RXN02975 TRANSLATE of: rxn02975.seq check: 5313 from: 1 to: 249 VIVTNDLEVRVGARTLLDAPGQLLRVQPGDRIGLVGRNGAGKTTTMRILSGETKPYGGSV TTSGEIGYLPQDSREGNIEQTAR >RXN02994 TRANSLATE of: rxn02994.seq check: 4127 from: 1 to: 723 IKMTGVQKYFGDFHALTDIDLEIPRGQVVVVLGPSGSGKSTLCRTINRLETIEEGTIEID GKVLPEEGKGLANLRADVGMVFQSFNLFPHLTIKDNVTLAPIKVRKMKKSEAEKLAMSLL ERVGIANQADKYPAQLSGGQQQRVAIARALAMNPKIMLFDEPTSALDPEMVNEVLDVMAS LAKEGMTMVCVTHEMGFARKAADRVLFMADGLIVEDTEPDSFFTNPKSDRAKDFLGKILA H >RXN03020 TRANSLATE of: rxn03020.seq check: 1931 from: 1 to: 603 MTLHVSNLNLTVADGSTSRTLLNNIHFWMSNQAKSSVSPAHPAPENPPYSPSSAASKAPD SGTATLGDIDLLNPQNRAALRRNHLGIVFQQPNLLPSLTVLDQLLLIPRLGRILPPSRSA RTQHKDKALSLLNSIGLGDLAKRKVSELSGGQQARVNLARALMNSPKLLLVDEPTAALDQ HSASEVTELIVSMAHQYNAPT >RXN03080 TRANSLATE of: rxn03080.seq check: 3725 from: 1 to: 780 MPQLVEIRDLNVEFPSRHAVKNVSFSAPAGKVTALIGPNGAGKSTALSAIAGLVESTGEV MVGGSGVASKSAKARARLLSLVPQNTELRIGFSARDVVAMGRYPHRGRFAVETDADRRAT DDALRAINALDIAEQPVNELSGGQQQLIHIGRALAQDTAVVLLDEPVSALDLRHQVEVLQ LLRARANSGTTVIVVLHDLNHVARWCDHAVLMADGEVVSQGDIREVLEPATLSTVYGLPI AVRDDPETSSLRVIPHPNPF >RXN03081 TRANSLATE of: rxn03081.seq check: 3848 from: 1 to: 459 MKKSLIAIVASALVLSGCTSDSSDSSGTSGTVETTSITTSVAAADGAFPRTVTLDDSSIT LESKPERIAVLTPEAASLVLPITGADRVVMTAEMDTADEETAALASQVEYQVKNGGRLDP EQVVAGDPDLVIVSARFDTEQGTIDILEGLNVP >RXN03108 TRANSLATE of: rxn03108.seq check: 138 from: 1 to: 267 MTKPNASVELNTITKSYGSTTIIGDTSITINDGEFVSLLDPSGCGKSTILKMIAGLASPS TGTVSAGNEEIKGPGPDRGMVFQDHALLP >RXN03116 TRANSLATE of: rxn03116.seq check: 7423 from: 1 to: 609 MGEGDVEKHFAFGLKAAKQRRFFARTVALMPQNPTIPAGLSVFDYVLLGRHPHSYAPGRA DDEIVKRCLADLKLEHFSDRGLDELSGGERQRVSLARALAQEPRIVLLDEPTSALDIGHA QETLELIDAIRHRLGLTVIAAMHDLTLTAQYGDRVLMMNGGRKVFEGTAAEVLTAQRISE IYDATVIVEVIDGRPVVIPQRSH >RXN03129 TRANSLATE of: rxn03129.seq check: 210 from: 1 to: 1224 MASIVFENVTRKYSPGARPAVDKLNLEIADGEFLVLVGPSGCGKSTSLRMLAGLEPIDEG RLLIDGKDATELRPQDRDIAMVFQSYALYPNMTVRDNMGFALKNQKVAKAEIEKRVAEAS RILQLDPYLDRKPAALSGGQRQRVAMGRAIVREPSVFCMDEPLSNLDAKLRVSTRAEISG LQRRMGVTTVYVTHDQVEAMTMGDRVAVLLLGVLQQVDTPQNLYDYPANAFVASFIGSPS MNLIEGTIRGDKVTLGTGIQISVPDEVAAEVRNNPDRFEGRPVIVGARPEHMYLTTANES GAVLGEVSHIDELGADSMVYVLASGVKNPNTDLLGEGIPEDMRVTVVGAEETDKARLGIR VERHHGLKAGDKVHVVAAPKDVHLFDGLDGRRIGASVLAPAHTVQSGH >RXN03164 TRANSLATE of: rxn03164.seq check: 9986 from: 1 to: 870 MIYRRVGNSGLKLPAISLGLWHNFGDDKPLSTQRSIIHRAFDRGVTHFDLANNYGPPAGS AETNFGRILREDLKSHRDELIISSKAGWDMWPGPYGFGGSRKYLVSSLDQSLTRLGLDYV DIFYHHRPDPDTPLEETMYALRDIVASGKALYVGISSYGPELTAEAAEFMAEEGCPLLIH QPSYSIINRWVEEPGDDGENLLQSAANNGLGVIAFSPLAQGLLTDKYLDGIPEGSRASQG KSLSEGMLNVNNIDMVRKLNDIAQERGQSLAQNALAWVLREQREYGAGLP >RXS00088 TRANSLATE OF: RXS00088.seq check: 1389 from: 1 to: 876 IEDNHGTEGISLPIEGVAATDNRAFELLDRWGVELVAAPLQLVPFTVTGYTEEGGVANLGSHREPDLEA LAAAQPSLIINGQRFAQYYDDIIALNPDATVVELDPRDGEPLDQELIRQAETLGEIFGEEEDAAKIVAD FESALERAKTAYAAISDQTVMAVNVSGGNIGYIAPSVGRTYGPIFDLVGLTPALEVGNASSDHEGDDIN VEAIAAANPDLILVMDRDGGTSTRNEADYVPAEQIVSDNEALANVKAVTDGYVYYAPADTYTNENIITY TEILNGMADMFEKAAQ >RXS00372 TRANSLATE OF: RXS00372.seq check: 2326 from: 1 to: 1077 MSSKHPLKRTAVTVFALGASAALLVACSEPSEDVSTAETTTASSSANASDAAGEKVTITVYTSEPEEKV DEINKAFMEANPDIEVEVYRAGTGDLTARIEAEKASGSIEADVLWAADAATFETYAAQGDLAELEDVET SDIIEEALDAENFYVGTRIIPTVIAYNTEVVDQAELPTSWADLTDPKYAGQLVMPDPAVSGAAAFNASV WKNDPALGEAWITALGENQPMIAQSNGPTSQEIAGGGHPVGIVVDYLVRDLAAAGSPIDTIYASEGSPY ITEPAGVFADSEKKEAAERYINFLLSVEGQEIAVEQAYLPVREDVGTPEGTPELADIELMTPDLEVVTA DKAAAVEFFQNAMN >RXS00453 TRANSLATE OF: RXS00453.seq check: 3260 from: 1 to: 2349 VISAWLLILAIVGGLALTMQKGFSNSFTIEDTPSIDATVSLVENFPDQTNPVTAAGVNVVFQSPEGTTL DDPQMMTAMDAVVDYIEDNLPDFGGGERFGNPVEVSPALEEMVIEQMTSMGLPEETAAKDAANLAVLSE DKTIGYTSFNIDVEAAEYVEQKHRDVINEAMQIGEDLGVRVEAGGPAFGDPIQIETTSEIIGIGIAFIV LIFTFGSLIAAGLPLITAVIGVGIGALAIVLATAFTDLNNVTPVLAVMIGLAVGIDYALFILSRYRAEY KRMPRADAAGMAVGTAGSAVVFAGATVIIALVALIIADIGFLTAMGISAAFTVFVAVLIALTFIPALLG VFGGHAFKGKIPGIGGNPTPKQTWEQALNRRSKGRSWVKLVQKAPGLVVAVVVLGLGALTIPAMNLQLS LPSDSTSNIDTTQRQSADLMAEGFGAGVNAPFLVIVDTHEVNADSTALQPLIEAQEPEEGEFDREQAAR FATYMYVTQTYNSNIDVKNAQIISVNDDFTAAQILVTPYTGPADKETPELMHVLRAQEAQIEDVTGTEL GTTGFTAVQLDITEQLEDAMPVYLAVVVGLAIFLLILVFRSLLVPLVAGLGFLLSVGAAFGATVLVWQE GFGGFVNTPGPLISFMPIFLIGVTFGLAMDYQVFLVTRMREHYTHHNGKGQPGSKYTPVEQSVIEGFTQ GSRVVTAAALIMIAVFVAFIDQPLPFIKIFGFALGAGVFFDAFFIRMGLVPASMFLMGKATWWMPKWLD RILPSLDIEGTALEKEWEEKQAAR >RXS00479 TRANSLATE OF: RXS00479.seq check: 9191 from: 1 to: 2190 MSTSITTENKKKSGPPRLMRIFLPALLILVWLVGAGVGGPYFGKVSEVSSNSQTTYLPESADATQVQEQ LGDFTDSESIPAIVVMVSDEPLTQQDITQLNEVVAGLSELDIVSDEVSPAIPSEDGRAVQVFVPLNPSA ELTESVEKLSETLTQQTPDYVSTYVTGPAGFTADLSAAFAGIDGLLLAVALAAVLVILVIVYRSFILPI AVLATSLFALTVALLVVWWLAKWDILLLSGQTQGILFILVIGAATDYSLLYVARFREELRVQQDKGIAT GKAIRASVEPILASGSTVIAGLLCLLFSDLKSNSTLGPVASVGIIFAMLSALTLLPALLFVFGRVAFWP KRPKYEPEKARAKNDIPASGIWSKVADLVEQHPRAIWVSTLIVLLLGAAFVPTLKADGVSQSDLVLGSS EARDGQQALGEHFPGGSGSPAYIIVDETQAAQAADVVLNNDNFETVTVTSADSPSGSAPITADGIVPLG SGTAPGPVVVEGQVLLQATLVEAPDSEEAQKAIRSIRQTFADENISAVVGGVTATSVDTNDASIHDRNL IIPIVLLVILVILMLLLRSIVAPLLLVVTTVVSFATALGVAALLFNHVFSFPGADPAVPLYGFVFLVAL GIDYNIFLVTRIREETKTHGTRLGILRGLTVTGGVITSAGVVLAATFAALYVIPILFLAQIAFIVAFGV LIDTLLVRAFLVPALFYDIGPKIWWPSKLSNQKYQKQPQL >RXS00654 TRANSLATE OF: RXS00654.seq check: 6625 from: 1 to: 1266 VLDILIYPVSGVMKLWHLLLHNVAGLDDSLAWFFSLFGLVITIRAIIAPFTWQMYKSGRTAAHIRPHRA ALREEYKGKYDEASIRELQKRQNDLNKEYGINPLAGCVPGLIQIPIVLGLYWALLRMARPEGGLENPVF QSIGFLTPEEVESFLAGRVSNVPLPAYVSMPTEQLKYLSTTQAEVLSFVLPLFITAAILTAINMAMSMY RSFQTNDYASGFSNGMLKFMIVMSILAPIFPLSLGLTGPFPTAIALYWVSNNLWTLLQTIIMMVILERK YPLTDDFKVHHLEQRDIYRAKQKEKRIFLWTRRKNRALMILTPWNASTLHATNVELTKTRTAEINEAKQ ARKEIANKRRETQREMNRAAMQRLKQRRAEVKAKKKGLIDASPNEDTPSENEETKLSSPQVEPTTTAEP NREPSQED >RXS00758 TRANSLATE OF: RXS00758.seq check: 161 from: 1 to: 1602 MTLKKSLAVTTAAALALSLAACSSDSSSDSSSSSSGSEGGDNYVLVNGTEPQNPLVPGNTNEVGGGRIV DSIFSGLVYYDVDGSPVNDVAESIELEGDKTYRITIKDGQTFTDGTPVTAESFVNAWNYNVANSTLSSY FFESILGYEEGVESMEGLQVVDDTTFTVELTQPESDFPLRLGYSAFFPLPESAFDDMDAFGENPIGNGP YKLQEWNHNQDATIVPNADYTGGRQAQNDGVKFIFYPTFDSAYADLLSDNLDVLDAIPDSAFSSFEDEL SGRSINQPSAVFQSFTIPESLEHFSGEEGVLRRQAISLAVNRDEITQTIFEGTRTPATDFTSPVIDGHS DSLQGADVLTYDPERAQELWAQADEISPWSGEFSISYNADGGHQAWVDATANSIRNTLGIDAIGNPYPD FKSLRDDVTNRTINGAFRTGWQADYPSLGNFLGPLYGTGAGSNDGDYSNPDFDAKLAEAANAADVDAST PLYNEAQEILLQDLPAIPTWYSNAVGGYSTNVDNVEFQWNSQPAYYQITKN >RXS00912 TRANSLATE OF: RXS00912.seq check: 8141 from: 1 to: 273 MDNTLYTAGLTIAAAFFMLSFIFTIYRIIVGPNSIDRLLGLDGTVSMIQCSMATYICWTLDTTVTNFMM VIALLGFISSVSVARFRKRDGA >RXS00932 TRANSLATE OF: RXS00932.seq check: 6704 from: 1 to: 474 MTPQKLHRFAALLEMGTWTLLIIGMILKYSGVTDAVTPIAGGIHGFGFLCFAAITITVWINNKWTFPQG IAGLIVSVIPWAALPFALWADKKGLVAGGWRFSDPSEKPHTFFDKILAQLVRHPIRSILILLVIIAVVF STLLAMGPPYDPDAIANTVD >RXS01346 TRANSLATE OF: RXS01346.seq check: 3214 from: 1 to: 1575 MRTATKVIATVMASTLAIGLASCSSSSGTPDVNYVSVNGTEPQRGLIPGDTNENGGGRVVDMLYSGLVY FDEAGVAQNDLAASIDQETDTTYKITLRDGIKFSDGSDITATDFVDTWNFVVENGLLNTSFFSPIKGYE EGVETLEGLNVVDDRTFTIELAQPDSEFTQRIGYYGFAPMPASARDDIDAFGENPVSSGPYKLEQWDHN AELKVVANEHYDGPRAANNDGLKYVFYAQNDAAYSDLLAGNLDVLDLIPPSAYTTYEEELSGRSINQPA ASYLELSIRMESPNFEGQQGQLRRQAISMAINREEIAEQIFAGTYTPALDFTAPVLDGWRDDLNGNDVL TFQPDKARELWEDAEEIAPFEGELQISYNADVPNREWVDAVANSISNELDVNATGNPFPDFKSFRDTYR TTGLDGAYRTAWFADYPSIGNFLGPNYTSGVASNDAKYENPEFDQLIADAAAASTKEETFQAYAQAQEM LLRDLPAIPLWYPNVVGGYSESVDNVSVNWKAIPVYWAITKQ >RXS01425 TRANSLATE OF: RXS01425.seq check: 9957 from: 1 to: 885 VLSPDSGITWALSIMFLTFTVRMVLVKPMVNTMRSQRKMQDMAPKMQAIREKYKNDQQKMMEETRKLQK EVGVNPIAGCLPMLVQIPVFLGLFHVLRSFNRTGSGVGQLEMTVEQNANTPNYIFGVDEVQSFLRADLF GAPLSSYITMPADAFDAFLGLDVSRLNIALVAAPMILIIVVATHMNARLSVNRQEARKAAGKQQAASSD QMAMQMQMMNKMMLWFMPATILFTGFIWTIGLLVYMMSNNVWTFFQQRYIFAKMDAEEAAEEEEKRAAK RTTAPKPGVKPENPKKRKK >RXS01658 TRANSLATE OF: RXS01658.seq check: 7999 from: 1 to: 1833 DPQILSPTFTQQQQLRNFYGFPDQLAMDRFEVDGKLRDFVVAARELDPNALQQNQQDWINRHTVYTHGN GFIAAQANQVDEVARDVGSTRGGYPVYTVSDLQSNARAAESEDAEELGIKVDEPRVYYGPLIASATDGA DYAIVGDTGDGPVEYDTDTSSYTYEGAGGVDIGNMVNRAMFALRYQEMNMLLSDRVGSESKILFERDPR SRVEKVAPWLTTDSKTYPTVIDGRIKWIVDGYTTLDSLPYSTRTSLTEATQDAVMPDGTPQPLITDRVG YIRNSVKAVVDAYDGTVELYEFDTEDPVLKAWRGVFPDTVKDGSEISDELRAHLRYPEDLFKVQRDMLA KYNVDDSGTFFTNDAFWSVPGDPTAAEGRQELKQPPYYVVAADPETGESSFQLITPFRGLQREYLSAHM SASSDPVTYGEITVRVLPTDSVTQGPKQAQDAMMSSDQVAQDQTLWRGSNDLHNGNLLTLPVGGGEILY VEPIYSQRKDQASAFPKLLRVLVFYKGQVGYAPTIAEALSQVGIDPKEAQDIEEVDGTATTPSTDETDT DTDQPATETPTAPVSEAEGIAAINDALSNLEAARDSSFEEYGRALDALDRAVDSYQSAQ >RXS01677 TRANSLATE OF: RXS01677.seq check: 5194 from: 1 to: 744 VNQQSKKWLVPTLVVIIAVLLIAVVLLMYRGNASDTAEGVSAAATSDSAAASTAASGSASGAADSDLTS VEARDPSDPVAVGDVDAPVGLVVFSDYQCPFCAKWSDETLPQMMKHVEDGNLRIEWREVNIFGEPSERG ARAAYAAGLQDAYLEYHNALFANGEKPSEDLLSEEGLIKLAGDLGLDESKFTADFQSPETAVAIAQHQQ LGIDLGAYSTPAFLLGGQPIMGAQPASVFEAAFEQALAAKE >RXS02586 TRANSLATE OF: RXS02586.seq check: 4914 from: 1 to: 270 MHLLRDDNWWAPGFVKKAYTVMGHGSEVEEAPRPTTRRLNDDEEVTVHEAVVAGDTVASRGGLSTQENR DLVSFVELKARLEKRRLEDLD >RXS02587 TRANSLATE OF: RXS02587.seq check: 637 from: 1 to: 2091 VFSKWGHFAYRFRRIVPLVVIAAILALFVIFGTKLGDRMSQEGWDDPGSSSTAAARIELETFGRDNDGD VVLLFTAPEGTSFDDAEVFSSISGYLDGLIENNPDEVSHINSYFDTRNQNLLSKDGTQTFAALGLKGDG EQTLKDFREIEDQLHPDNLAGGVTTEVAGATAVADALDEGMAGDISRAEVFALPFVAILLLIVFGSVVA AAMPLIVGILSILGSLGILAILAGFFQVNVFAQSVVTLLGLGLAIDYGLFMVSRFREEMDKGTPVEQAV ATTTATAGKTVVFSAAMVAVALSGLFVFPQAFLKSVAFGAISAVGLAALMSVTVLPSLFSMLGKNIDKW SLRRTARTARRLEDTIWYRVPAWAMRHAKAVTVGVVLLLLALTVPLTGVKFGGINETYLPPANDTRVAQ ERFDEAFPAFRTEPVKLVVTGADNNQLIDIYVQANEVEGLTDRFTAGATTDDGTTVLSTGIQDRSLNEQ VVEQLRAISVPEGVEVQIGGTPAMEIESIEALFEKLLWMALYIVLATFILMALVFGSVILPAKAIIMTI LGMGATLGILTLMFVDGVGASALNFSPGPLMSPVLVLIMAIIYGLSTDYEVFLVSRMVEARDKGESTDD AIRYGTAHTGSIITAAALIMIVVCGAFGFSEIVMMKYIAFGMIAALILDATIIRMLLVPRRDAPASRRQ LVGTRLR >RXS02590 TRANSLATE OF: RXS02590.seq check: 3473 from: 1 to: 936 MGISLLSSLLKIHGFPVVADFFFALAVVVAIVIIGGWLIYRSPSFKTEVMPAWAMLSMGLIALGTASPV VLGDDLWGFMFVCWSIGTAVGLVAYSLYITAILRSKAGTPTFAWGLPLVTPMVASTSAAQLHEHFELPA MLWVSFGLFLLTLASAPAVFTRVYFYYFGPKAQGIPLMATPTSWIPLGMVGQSTAAAQLIGASFGSKTA ITMGIIYGIIMGIFTIPLGAIAHFVFYRAVFKGATYSPTWWASTFPVGTLSLGAHFLSQSTGVEWFNYF SLYLIALMLFHVIVSTIAGTIAVMRRIVGKLKSQLA >RXS02932 TRANSLATE OF: RXS02932.seq check: 938 from: 1 to: 972 VSKTEEGRSAAIIIYAFPTFILLGAIIAFIFPEPFIPLTNYINIFLTIIMFTMGLTLTVPDFQMVLKRP LPILIGVVAQFVIMPFLAIVVAKMFNLNPALAVGLLMLGSVPGGTSSNVIAFLARGDVALSVTMTSVST IVSPIMTPFLMLMLAGTETAVDGGGMAWTLVQTVLLPVIIGLVLRVFLNKWIDKILPILPYLSILGIGG VVFGAVAANAERLVSVGLIVFVAVIVHNVLGYVVGYLTGRVFKFPEAANRTMAIEIGTQSAGLASGMAG RFFTPEAALPGAVAALVHNITGAVYVGLVRNRPLTKASRKKESVAVSS >RXS03042 TRANSLATE OF: RXS03042.seq check: 1569 from: 1 to: 606 LVLAFLVLLLVFRSIWVPLIAALGFGLSVLATFGATVAIFQEGAFGIIDDPQPLLSFLPIMLIGLVFGL ANDYQIFLVTRMREGFTKGKTAGNATSNGFKHGARVVTAAALIMVSVFAAFIAQDMAFIKTMGFALAVA VFFDAFVVRMMIIPATMFLLDDKAWWLPKWLDKILPNVDVEGEGLSELHEARTEELKENVGVGA >RXS03075 TRANSLATE OF: RXS03075.seq check: 8649 from: 1 to: 726 VAKFLYKLGSTAYQKKWPFLAVWLVILIGITTLAGLYAKPTSSSFSIPGLDSVTTMEKMQERFPGSDDA TSAPTGSVVIQAPEGKTLTDPEVGAEVNQMLDEVRATGVLKDADSVVDPVLAAQGVAAQMTPALEAQGV PAEKIAADIESISPLSADETTGIISMTFDADSAMDISAEDREKVTNILDEYDDGDLTVVYNGNVFGAAA TSLDMTSELIGLLVAAVVLIVTFGSFIAAGMPLIS >RXS03124 TRANSLATE OF: RXS03124.seq check: 3878 from: 1 to: 960 MTPTLASMIGLAVGIDYALFIVSRFRNELISQTGANDLEPKELAERLRTMPLAARAHAMGMAVGTAGSA VVFAGTTVLIALVALSIINIPFLTVMAIAAAITVAIAVLVALSFLPALLGLLGTRIFAARVPGPKVPDP EDEKPTMGLKWVRLVRKMPVAYLLVGVVLLGAIAIPATNMRLAMPTDGTSTLGTAPRTGYDMTADAFGP GRNAPMIALIDATDVPEEERPLVFGQAVEQFLNTDGVKNAQITQTTENFDTAQILLPQNLMRSMSAPLR LSQLFVQMLRPSLMTPARRMALLASPQFTMTSLLASATSWFLTF >RXS03125 TRANSLATE OF: RXS03125.seq check: 4701 from: 1 to: 171 LVLAFLVLLLVFRSIWVPLIAALGFGLSVLATFGATVAIFQEGAFGIIDDPQPLLCF >RXS03220 TRANSLATE OF: RXS03220.seq check: 3878 from: 1 to: 960 MGLREILSSKWLVRILLVGIGLGVAQQLTGINSIMYYGQVVLIEAGFSENAALIANVAPGVIAVVGAFI ALWMMDGINRRTTLITGYSLTTISHVLIGIASVAFPVGDPLRPYVILTLVVVFVGSMQTFLNVATWVML SELFPLAMRGFAIGISVFFLWIANAFLGLFFPTIMEAVGLTGTFFMFAGIGVVALIFIYTQVPETRGRT LEEIDEDVTSGVIFNKDIRKGKVH >RXS03221 TRANSLATE OF: RXS03221.seq check: 3878 from: 1 to: 960 MFRDPAPPSKGTTNLGDKMASTFIQADSPEKSKKLPPLTEGPYRKRLFYVALVATFGGLLFGYDTGVIN GALNPMTRELGLTAFTEGVVTSSLLFGAAAGAMFFGRISDNWGRRKTIISLAVAFFVGTMICVFAPSFA VMVVGRVLLGLAVGGASTVVPVYLAELAPFEIRGSLAGRNELMIVVGQLAAFVINAIIGNVFGHHDGVW RYMLAIAAIPAIALFFG

Appendix A: DNA Sequences

>RXA00001-upstream TGTCATAGGCAGCACTCTAGATGGCGCACAGTGACTCACTTCACTGTTTCTCACAGTACG GATCGTTCGGCACGTACCTGCCGATGGAGGAGATTCTGCA >RXA00001 ATGGCAACCGTAACGTTCAAAGATGCTTCCCTAAGCTACCCGGGAGCAAAGGAACCCACC GTCAAGAAATTCAACCTGGAAATCGCCGATGGCGAGTTCCTCGTCCTCGTCGGCCCTTCC GGCTGTGGTAAATCCACCACGCTGCGCATGCTGGCCGGTTTGGAAAACGTTACTGACGGT GCCATTTTCATCGGAGACAAGGACGTTACCCACGTTGCACCGCGTGACCGTGACATCGCC ATGGTTTTCCAGAACTATGCTCTCTACCCCCACATGACCGTGGGCGAGAACATGGGCTTC GCACTGAAGATCGCCGGCAAGTCCCAAGACGAGATCAATAAGCGCGTCGACGAAGCCGCC GCCACTTTGGGCCTGACCGAATTCTTGGAGCGCAAGCCGAAGGCCCTGTCCGGTGGTCAG CGTCAGCGTGTGGCCATGGGCCGCGCCATTGTTCGCAACCCGCAGGTCTTTCTCATGGAT GAGCCGCTGTCTAACCTCGATGCCAAGCTGCGTGTTCAGACCCGTACCCAGATTGCAGCC CTGCAGCGCAAGCTTGGGGTTACCACCGTTTACGTCACCCACGACCAGACGGAGGCCTTG ACCATGGGTGACCGCATCGCGGTGCTGAAGGATGGCTACCTGCAGCAGGTTGGCGCGCCC CGAGAGCTTTATGACCGCCCCGCCAACGTCTTCGTCGCCGGCTTCATCGGCTCCCCAGCC ATGAACTTGGGCACCTTCTCGGTCAAGGATGGTGACGCTACCTCTGGTCACGCTCGCATC AAGCTTTCCCCGGAAACCCTCGCGGCCATGACGCGGGAGGATAATGGCCGCATCACCATT GGTTTCCGCCCGGAGGCACTGGAGATCATTCCGGAAGGCGAGTCCACCGATCTTTCCATC CCAATCAAGCTCGACTTCGTGGAGGAACTCGGTTCCGATTCCTTCCTCTACGGCAAGCTG GTAGGCGAGGGCGACCTTGGATCGTCCAGCGAGGATGTCGCCGAGTCCGGCCAAATCGTC GTCCGCGCTGCTCCGAACGCCGCGCCTGCTCCGGGCAGTGTTTTCCACGCACGCATCGTG GAGGGCGGCCAGCACAACTTCTCGGCGTCGACTGGCAAGCGCCTCCCT >RXA00001-downstream TAAGCCCGCGTACCGGCTACCCC >RXA00002-upstream CTGACTTCTTGGGCTTCGGTGCTGCAATATCTAGGTTCACGCCCCGGATGGCACCGGAGA GGCTGCAGACAAGCTCGCTGCTGAGGATTCTCACCTGCAC >RXA00002 GTGCTGCACCGCGAAGGCAAGGGTGGCCTTCTTGGCGCTTATATCGCCGGCTTCGAGTGG GGCCTAGAGAAGGATTACCATGTTCTGTGCGAAATGGATGCCGACGGCTCCCACGCACCA GAACAGCTCCACCTCTTGCTTGAGGAAATTGAAAAGGGCGCAGATCTGGTCATTGGCTCC CGCTACGTACCGGGTGGAGAGACAGTGAACTGGCCTGCCAACCGCGAACTGCTGTCCCGC TTGGGCAACAAGTACATTTCTGTTGCCCTGGGTGCCGGCATCAATGACATGACTGCGGGC TACCGTGCTTTCCGGCGTGAGCTGCTTGAGCACCTCGACTTTGAGGAGCTTTCCAACGCC GGATACATCTTCCAGGTGGACGTTGCCTTCCGCGCCATCAAGGATGGCTTCGATGTCCGC GAGGTTCCGATCACCTTCACCGAGCGCGAGCTTGGTGAATCCAAGCTGGACGGCTCCTTT GTCAAGGATTCCCTGCTCGAAGTAACCAAGTGGGGAGTGGCTCACCGCTCCGAGCAGATC AGCGATTTCACATCGGAAGTATCCAAGATCGCCTCCCGCACGGTCAAGGACATGGAGCTT GGGCCTAAGGCCACCACGGCCAAGAACGGTGTACCGGACTTCGTTTGCGAAGTCTCTAAC CTAGCTAAAGGCACCTTCAAGAAG >RXA00002-downstream TAACTCGATGCCCGCGGCGTCTC >RXA00089-upstream ACCTCGTTTTGGCCGCAAGTTCTCGTTAGTTAAAAACTGTAGGAAACCAGGTTCCACACA TGACACACAATCGGTTTAACAGGGAAGGGGATCGGCACTG >RXA00089 ATGGCAACACCAGCATCGGCTCCCACTTCCGAACCACGTCTCAAACGCACCAGAGCCAAG CTTTTTGATTGGAAGCTTCTCATCGGCATCATTTTCGTCGCCGGCCTCGTGGTGCTTTCC CTCCTCACCGGCCAATACGACATTTTCGGTGGCGATGATGGCCAACTGATGTTCGAGGCA GTTCGCATCCCGCGTACCGTTTCCCTCATTTTGTCCGGTGCAGCAATGGCGATGTGTGGC TTAGTCATGCAGCTGTTGACCCAAAAGAAATTCGTGGAACCCAGCACCACAGGAACAACC GAATGGGCAGGTCTTGGCCTGCTCTTCGTGATTTACTTCGTGCCAGCCGCGACCGTTTTG GATCGCATGCTCGGTGCCGTGGTGTTTTCCTTCATCGGAACCATGGTGTTCTTCCTCTTT CTACGCCGAGTAACACTGCGTTCCTCATTGATCGTCCCGATTATCGGCATCATGCTCGGT GCCGTGGTGTCATCGATCTCCAGCTTCTTCGCCTTGCAATTCGACATGCTCCAGCAATTG GGAACATGGTTTGCGGGTTCCTTTAATACAGTGTTCCGCGGACAGTACGAAGTGCTGTGG ATCGTTGTCATCGTCGTTATTGGAGTGTTCTTCTTCGCAGACCGGCTCAGCGTAGCTGGC CTTGGCGAGGAAATCGCGACAAACGTGGGTCTCAATTACAACCGCATGGTCCTTATCGGA ACTGGCCTCATCGCCATCGCAACAGGTGTGGTCACCGTCGTGGTTGGTAGCCTGCCATTC CTCGGACTCATCGTGCCCAACGTTGTGTCCATGTTCCGTGGCGATGACCTGCGCTCGAAC CTGCCATGGGTATGCCTAACCGGCATCGCGATCGTAACCATTTGTGACTTGATCAGCCGA ACCATCATCGCGCCTTTCGAAATTCCAGTTTCAGTAATCCTGGGCATCATCGGCGCAGTG GTCTTCGTGATCATGATTGTGAGGCAACGTGGCCGTGGA >RXA00089-downstream TAAAGATATTGAAAACCGCACCT >RXA00090-upstream TTGATGAGCCGAACCATCATCGCGCCTTTCGAAATTCCAGTTTCAGTAATCCTGGGCATC ATCGGCGCAGTGGTCTTCGTGATGATGATTGTGAGGCAAC >RXA00090 GTGGCCGTGGATAAAGATATTGAAAACCGCACCTCAGACCTTTCTCGATGGGAAACTATG GAGGAATCAGCAACGGTCGAGGGACGCACCGATGTCGAACTAGCATCAGCGCCGAGCAAA CGACGCAGCTCAGGTGCATTCCAAAGAGCGCGCGGGAAGCGCCGCTACTGGATCATCATG GCCGCGCTGCTGGTCACCGCGCTTGCCTTCACCTGGGGCCTCATTTGGTACAAGAACGCG ATGCCCGTTGGGCATCCGGCCTTCGCGCTGATTGCAGAACGAGGCATGGAGTCGGTCTTT GTCATGCTGATTGTTGCGGTTTGCCAAGGCTTTGCGACGGTTGCGTTCCAGACCGTCACC AACAACCGCATTATCACGCCGTCGATCATGGGCTTTGAATCTCTCTACACACTGATTCAT ACCTCCACAGTGTTCTTCTTCGGCGCAACTGCACTGCTGGCCACCAGAAATCTCGAAATG TTTGTCGGCCAGCTGGTGATCATGGTTCTTTTGACCTTGGTCCTCTACACCTGGCTGCTT TCCGGAAAACGCGGCGATATGCACGCCATGCTGCTTGTCGGCATCATCATTGGTGGCGGA CTCGGATCCATCTCCACCTTTATGCAGCGCATTCTGACCCCATCAGAATTCGATATTCTT TCCGCCCGACTTTTCGGATCAGTAAACAACGCGGAAACCGAATACTTCCCAATTGCTGTT CCACTAGTAGTAGTGGCGTCCGTCTTGTTGCTGCTAAGCTCTCGACGCCTCAACGTTGTA GGGCTTGGCAAAGATGCCGCAACCAACCTTGGAATTAATCACCGACGATCCTCCATTTAC ACACTGGTTCTCGTCTCTGTATTAATGGCAGTATCCACCGCACTTGTCGGACCGATGACA TTCCTCGGATTCTTGGTCGCGACCTTGGCATATCAATTCGCCGACACTTACGACCACCGA TACATCCTTCCGATGTCCGCACTCATCGGATTCGTCGTACTCAGCGGCGCTTACTTTGTC ATGAACCAGGTGTTGGGCGCAGAAGGCGTCGTGTCCATCATTATTGAGATGGTCGGCGGT ACCGTGTTCCTCATCGTCATCCTCAGAAAGGGGAGACTG >RXA00090-downstream TGATTACGTTAAGTAATGTCGGC >RXA00099-upstream CTCTGGTGAAGAGGATGTTGAGTCGGGAGATTCTTCCACTGATTCACTGATTAAGTGGTA CCGCGCAAATAGGTAGTCGCTTGCTTATAGGGTCAGGGGC >RXA00099 GTGAAGAATCCTCGCGTCATAGCACTGGCCGCTATCATGCTGACCTCGTTCAATCTGCGA ACAGCTATTACTGCTTTAGCTCCGCTGGTTTCTGAGATTCGGGATGATTTAGGGGTTAGT GCTTCTCTTATTGGTGTGTTGGGCATGATCCCGACTGCTATGTTCGCGGATGCTGCGTTT GCGCTTCCGTCGTTGAAGAGGAAGTTCACTACTTGCCAACTGTTGATGTTTGCCATGCTG TTGACTGCTGCCGGTCAGATTATTCGTGTCGCTGGACGTGCTTCGCTGTTGATGGTCGGT ACTGTGTTCGCGATGTTTGCGATCGGAGTTACCAATGTGTTGCTTCCGATTGCTGTTAGG GAGTATTTTCCGCGTCACGTCGGTGGAATGTCGACAACTTATCTGGTGTCGTTCCAGATT GTTCAGGCACTTGCTCCGACGCTTGCCGTGCCGATTTCTCAGTGGGCTACACATGTGGGG TTGACCGGTTGGAGGGTGTCGCTCGGTTCGTGGGCGCTGCTGGGGTTGGTTGCGGCGATT TCGTGGATTCCGCTGTTGAGTTTGCAGGGTGCCAGGGTTGTTGGGGGGCCGTCGAAGGTT TCTCTTCCTGTGTGGAAGTCTTCGGTTGGTGTGGGGCTCGGGTTGATGTTTGGGTTTACT TCGTTTGCGACGTATATCCTCATGGGTTTTATGCCGCAGATGGTAGGTGATCCTCAGCTC GGTGCGGTGTTGTTAGGCTGGTGGTCAATTTTGGGATTGCCGCTGAACATTCTGGGACCG TGGTTGGTGACGCGTTTCACTAACTGCTTCCCGATGGTTGTTATCGCCAGTGTCATGTTT CTCATCGGTAATGGTGGGTTTTGTTTGGCTCCGGATGTTGCGCCGTGGTTGTGGGCGACG TTGTCTGGTCTTGGTCCCCTTGCGTTCCCGATGGCGTTGACGCTCATTAATATTGGTGCT GAAACTAGTGCTGGTGCTTCTGCGTTGAGTTCCTTCGGGCAGGGTTTGGGTTATACGATT GCGTGTTTCGGTCCCTTGTTGACTGGTTTCATTGTCGATGCAACAGGCAGCTTCCGAACA ATCTTTTTGCTTTTTGCGCGTGCAACACTCTTCGTTATTAGAGGCGGTTACTTTGCGACA AGGCAGGTTTACGTCGAAAAGCTTTTAAATCGC >RXA00099-downstream TAGGATGGCGCTATGCCGCAAAG >RXA00123-upstream GAAGGATCGTCAGAATAGCTCTCGAATAGGCCATTTCTTACTTCATCGGCAATACTGACT TAGTAGAAATTGCTGTCCAGAACTGTTGAAGGAGTTGAAA >RXA00123 ATGCCAAAGAATTACGACATCAACGGGGCGATCCGCAGACGGGATATGCTCAGACGTCGG TACCTTCCTGATTCGGCAAATTCAACTCCTCTACCTGAAGACGTTTCTCCGCTGACCCGC TATGTCACCGACGGCATCCCGAAGCGCCCACCGCTGGGTGCCACTGTTGCTGACGGTTTA AAATTCGCGGAAGGCGCCTCCAACCGCATGGTCATGTCGCTGTACCCTGCGGCATCCAAG CCCGCAATCGAGGAATTGGCAGAGGCCTGGGACCTCCACCCCACCATCGTAGAAGACTTG CTCCTTGGTCAGCAGCGCCCAAAACTAGACCGCTACGAAGACATCATTTTTATCGCGATC CGCTCCGCGCGCTACATCGACTCCCGCGAAGAGGTGGACTTCTCCGAATTCCACATCCTC ATGAAGCCTCAGGCCATAGCCATTTTGTGCCAGGATAACCAATGGATTGACGGCACCAGC GCCGCCAGCTTCAGCAACCCCGAGGAGATCGATAAGCGCATAAAAACATTGCTTGCCGAC GCCGAGTTACTCTCGTCCGGCCCCCGCGCCGCGGCCTATAGGCTTCTCGACGCCATCGTC GACGGCTTCTCCCCCGTTCTTAGAGGCATCGCCATCGACCAGGAACAGATTGAGCGCCAG GTGTTCTCCGGCGACGCCGCCGTCGCCGAACGTATTTACAACCTGTCCCAAGAAATCATC GACATGCAGCACACCACCAGCTCAGTTACCGAAGTGGTGCAACGCCTCAACAAAGACTTC ATCCGAAGTGGCATGTCCGAAGAACTCCGCGCCTACCTCGACGACGTCGCCGACCACCTC ACCCGCGACAACACCCGCGTCTCCGAATACCGCGAATCCCTATCCCAAATTTTGAACGTC AACGCCACCCTTGTAGCCCAACGCCAAAACGAAGACATGAAGAAAATCTCCGGATGGGCC GCCATCATCTTCGCCCCAACCCTCGTGTCCTCCATCTACGGCATCAACTTCGACATCATG CCAGAACTTCACTGGGCGTTTGGCTACCCGTTGGCTCTCTTAGCAATGCTCGGATTCACC CTCCTTTTGTACTGGATCTTCAAACGCAGTAAGTGGATG >RXA00123-downstream TGAGACAAAAACCGAAAAACCAA >RXA00160-upstream TACAGGGGTGGGGTTACCCCCTAAGGTGGTCACAACTTGATAACGGACTGGTTAATAAAT GGCCAATCTGACCATTTTAACCTCCATAAAAAGGATTCTC >RXA00160 ATGCTAAACATCGCACGCAACCGCAACATGAAGCGTCGACTAGCAATTGCTGCTTTCGTC GCCACCGCAACCGCTACCGCCACCATGGCACCAGCATCCGCGCAAACCGACTACGCAGGC CTTTCCTCCGGCGTTGCCGACACCGTCGCAGAAGCTGCAGGAGTCGCAACCACCGCCGTC GCACCAGCCGCCACCGTAGCGCGCCCAGCAAACGGCACCTTCACCTCAGGATTCGGACCA CGTTGGGGAACCTTCCACAACGGCATCGACATCGCAAACTCAATCGGCACCCCAATCTAC GCCGTCATGGCCGGCACTGTCATCAGCTCTGGCCCAGCATCCGGCTATGGACAGTGGATC CGCATCCAGCACGACGAGGGATCCATCTCCATCTACGGACACATCGAATACCTCTACGTC TCCGTCGGCGAACGCGTCGCAGCAGGGCAGGAAATCGCACGAATGGGCAGCCAAGGATTC TCCACCGGCTCCCACCTCCACTTCGAGATCCACCCAGACGGCGTCACGCGAGTCGAGCCA CAGGCATGGCTCGCAAACCACGGCATCTACGTT >RXA00160-downstream TAAGCGCTAGCCGTTCGTGGGAT >RXA00193-upstream CCTCAGCGTCCTCTCCTCAGCGCCTTCCCCGCTGGGAAACGTGTGGCAGCACCTGAAATT AAGGTTTCACCACC >RXA00193 ATGCAAGGAACGCTGAAGAAGTAGTTCCCAGTCTTTGTCTTGCCCACCCTTCTGGGATTC ATGATTGCGTTCTTGGTGCCGTTCATCGTGGGTTTCTTCCTCTCCTTTACGAAGTTCACC ACTATCACCAACGCCAAGTGGGTTGGCATAGACAACTACGTCAAAGCTTTCTCCCAACGC GAAGGTTTCATCTCAGCCTTCGGTTTCACCGTCCTCGTGGTCATCGTCTCCGTGATCACA GTCAACATCTTCGCCTTCCTCTTGGCGTGGTTGCTGACCCGCAAACTCCGCGGTACCAAC TTTTTCCGCACAGTCTTCTTTATGCCGAACCTTATCGGCGGCATTGTGCTGGGTTATACC TGGCAGACCATGATCAACGCCGTGCTTTCGCACTATGCCACGACTATTAGCGCGGACTGG AAATTCGGCTACGCCGGCCTCATCATGCTACTTAACTGGCAGCTCATCGGCTACATGATG ATCATTTACATCGCCGGCCTGCAAAACGTCCCACCAGAGCTCATTGAGGCTGCCGAACTC GACGGCGTCAACAAGTGGGAGATGCTGCGGCACGTCACTATTCCGATGGTGATGCCATCC ATCACCATCTGCCTCTTTTTGACTTTGTCGAACTCCTTTAAGCTCTTCGACCAGAACCTG GCGCTGACCAACGGCGCTCCTGGCGGGCAAACTGAGATGGTGGCGCTCAACATCATCAAC ACGCTGTTTAACCGTATGAATGTCGAGGGCGTCGGTCAGGCCAAGGCCGTTATCTTCGTC GTCGTTGTGGTCGTCATCGCGTACTTCCAGCTGCGCGCGACCCGCTCCAAGGAAATCGAG GCT >RXA00193-downstream TAAGTTATGACTACCAGCAGTTC >RXA00203-upstream AGGAAGCTGCTGCAGAAATCGAAAACACAAAGGAGGACCGTTGAGCACCGCCGTAGTTTC ACAGAAGAAGTCGACAACGGCATCCAAAATTGGACATTGG >RXA00203 ATGCTCAATAACGGTGCGTTGGTGGGGCTGATTGCACTGTGTGTTGGACTTTTTATTGCA ACACCCCACTTTCTCACCATTCCTAACCTGATCAACATCGGTATCCAATCGGCGACGGTG GCGATCCTGGCGTTCGGCATGACCTTCGTCATCGTTACCGCAGGCATTGATTTGTCTGTG GGATCAGTGGCTGCGTTGGGTGCGATGACCTCGGCGTATTTCTTCGCGGAAGTTGGTTTG CCGGGCTGGATCACGCTGCTGATTGGCCTGTTCATCGGATTGTTGGCGGGTGCGATCTCT GGCATTTCTATTGCTTATGGCAAGTTGCCTGCGTTTATTGCCACCTTGGCCATGATGTCG ATCGCCAGGGGAATCACCTTGGTCATTTCCCAAGGCTCACCAATTCCCAGTGCACCAGCT GTGAACGCTTTGGGGCGCACCTAGTTTGGCATCCCGATGCCGATTCTGATGATGGCACTG GCTGGCATTGTGTGTTGGTTTATTTTGAGCCGCACCGTGCTGGGACGGTCCATGTACGCC ATTGGCGGAAACATGGAAGCAGCGCGACTATCTGGTCTGCGAGTGAAGAAAATCCTGGTC ATGGTCTATGCACTGGCTGGTGTGTATGCAGCACTTGCGGGTCTGGTCATGACGGGACGC TTGTCGTCCGCGCAGCCGCAGGCAGGCGTGGGATAGGAACTCGATGCGATTGCCGCCGTG GTCATTGGTGGTGCGTCACTTGCTGGCGGAACCGGAAAAGCAACGGGCACTTTGATTGGT GCCATCTTGTTGGCCGTGATGCGGAATGGCTTGAACATTTTGAACGTGTCCTCGTTCTGG CAGCAGATTGTCATCGGTTGTGTCATCGGGCTTGCGGTGGGCTTGGATGTCATGCGAAAC AAAACCTCTAAG >RXA00203-downstream TAATTCCTGAAAGGAAATTTTCA >RXA00204-upstream TCAACGGCGGTTTCCCAAAAGGCGGCCGCAAAGGCAGCAAAAGCAGCCCAAAAAGCAGCC GCGAAAGCCGCACAGAACACGCAACACGAGGTGAGCCTAG >RXA00204 ATGGTGAACTCTGAACAAGCGCTTCATCAGGATGATCCTGGACCAATCCTTCAGTTGGAT AAAGTCTCCAAGTCGTTTGGCCCAGTCAACGTGATTAATCAAGTGAGCATCGATGTTCGC CCTGGCAGGGTGCTTGCGCTGTTGGGTGAAAATGGTGCGGGTAAATCTACGCTGATCAAG ATGATGTCGGGTGTGTATCAGCCTGATGGCGGGCAGATTTTGGTGGATGGAAAGCCCACG ACTTTGCCTGATACGAAAACTGCTGAGTCTTTTGGCATCGCTACGATTCACCAGGAATTG AATCTGGTGCCCACGATGACGGTGGCGGAAAACGTCATGCTGGGCCGCACTCCTCGGAAG TGGGGTTTGGTCAATTTGAAACATTTGCGCAGGGAGGCACAGGCGGCGCTGGATCTCATC GGCGTGGATGTGGATCTGAATGCTCAGGTGGGTTCTTTAGGAATCGCTAGGCAGCAGATG GTGGAGATCGCGAAGGCGTTGTCCATGAATGGGCGGATATTGATTTTGGATGAGCCCACT GCAGCGTTGACTGGTCGTGAAATTGATCAGTTATTCAAAGTGGTGGATGAGGTGAAAGAA AAAGGCGTGGCCATGGTGTTTATTTCGCACCACTTGGATGAGATCGCGCGCATCGGCGAT AGCGTCTCTGTGCTGCGTGATGGCGAGTTCATCGCGGAGCTGCCAGCGGATACTGATGAA GATGAGCTGGTGCGGCTGATGGTGGGTCGTAGCATTGAAAACGAGTATCCGCGTAGTGCG CGAGAGATCGGGCAGCCACTGTTGGAGGTGAAAAACCTCAACGCGGAGGGCCGGTTCACG GATATTTCCTTGACTGTTCGCGCTGGTGAAGTCGTAGGCCTTGCCGGTCTTGTGGGTGCT GGTCGCACGGAAGTGGTTCGCTCGATTGCTGGCGTGGACAAAGTTGATTCCGGTGAGGTG ATCGTTGCTGGCAAGAAATTGCGCGGCGGCGATATTTCCGAGGCTATTAAAAACGGCATC GGGCACATTCCGGAAGATCGAAAAGCCCAGGGCCTGGTGCTGGGGTCGTCTGTGGAGGAC AACCTGGGATTGGCGACTTTGGCGTCGACAGCCCGCGCAGGTTTGGTCGATCGATCAGGA CAGCACAAACGAGCCGCCGAGGTCGCGGAAAAACTCCGCATCCGGATGGCAAGCCTCAAA CAACCGATTAGCGATTTATCGGGCGGCAATCAGCAAAAGGCCGTGTTCGGCCGCTGGGTG CTTGCCGGGTCAAACGTGCTGCTTCTCGACGAACCGACCCGTGGCGTTGACGTCGGCGCG AAGGTGGAAATTTACAACATCATTAATGAGATGACGGAAAAAGGTGGCGCTGTGCTCATG GTGTCATCGGAGCTTCCCGAAGTCTTGGGCATGGCTGATCGCATTTTGGTCATGTCTGGT GGACGCATCGCAGGCGAACTGCCAGCGAAGGGAACAACCCAGGACGATGTCATGGCTCTA GCTGTTTCCCAGGTGGATGATTCCATCACCGAGGAAGCTGCTGCAGAAATCGAAAACACA AAGGAGGACCGT >RXA00204-downstream TGAGCACGGCCGTAGTTTCACAG >RXA00270-upstream TGGAGACTGCAACTGAGTTCACCTACGTGATCAACGAAGATGCAGGAGAGCGCCAGGGGG TGGAGATCCCTCAAGAGATTTTGGATAAGGCCGAACGCGT >RXA00270 ATGATCGGCGCTTTTGAGTTCGGATTGTTGTACGGAGTTGTCGCATTGGGCGTCTATTTG ACGTTCCGTGTGCTCAACTTTCCCGACCTCACCGTTGACGGCAGCCTGACCACTGGCGCG GCAACAGCTGCGACAGCTCTTATGTCTGGCTGGCCTCCCCTTATGGCTACTGCCGCTGGT TTCGTTACTGGCTTTATCGCTGGCATGATCACCGGTTTGCTGCACACCAAGGGCAAGATC GATGGTTTGCTCGCAGGTATTTTGACCATGATTGCGTTGTGGTCGGTTAACTTGCGCATC ATGGGTGGCGCGAACGTGCCATTGTTGCGCACCGATAACCTCTTCACCCCGCTTCGCGAC GCCGGCCTCCTCGGCACATGGGCAGGCCCGGCGATCCTCGCCGTTGCAGTGGGAATTTTG GGACTCATCGTCATCTGGTTCCTCAACACTGATATCGGACTGTCGCTGCGATCCACCGGC GACAACGGGCCGATGGTGCAGTCCTTTGGTGTTTCAACGGATTTCACCAAAATCCTCACC ATCTCCCTGTCCAATGGTTTTGTTGGTCTTGCCGGTGCACTCATCGCTCAGTACCAGGGC TTCGCAGATATTTCGATGGGTATTGGCCTCATCGTGATCGGTCTCGCATCGGTTATTTTG GGCCAGGCCATCTTCGGTCAGCGTCGCGTGTGGTTGGCTGTGTTGGCTGTCATCGTCGGT GCCATCGCGTACCGCCTGATCATTTTCGCAGCACTGCGCGTTGGCCTTGACCCCAACGAT ATGAAGGCAATTTCTGCGATCTTGGTGGTTGTCGCCATGCTGCTGCCGAGGTGGCGTGCG AAGTTCTCCAAGGCACCGAAGCGTAAGCAACCAGTAGCAGTGGAGGCT >RXA00270-downstream TAAGACATGTTATCCATCAACGG >RXA00311-upstream CGGAGAGATCGGCATTTGGGCGACCGTGCTGTTGATGATCGCCCGCATCGCATAGGGATT CTGTGCAGTGGCAGAAGCTGCAGGTGCATCCACACTGACC >RXA00311 ATGGAACATTCTCGTGAAGGCAAGCGTGGATTCTTCACCTCATCGGTGATGGCGGGTTGC TCAGTTGGAAACGTCGTGGCTGGCTTGGTATTTATCCCGTTCTTGATGCTGCCGGAAGAA CACCTCATGTCATGGGGCTGGCGCGTACCTTTGCTGCTTTCCGCACTGGTTTTAGTTGTC GCATACTTCGTGCGCACCCGACTGGAGGAAGCATGAACTGAGAAGGCGGAAGAGGACGCA GGCGCTCCGGCTTTGGCTGTGCTGCGCACCCAGGGCATTGATGTCGCACGAGTTTTCCTG ATCACCTTCTTCGCCGTTGTTCAGACCACTTTGAACGTTTACGCACTGGCATACGCCGCC AACGAAATCGGCATCGATCGTTCCTTCATGGTGATGGTGAACACGATCGCGCTGGGGCTT TCCATCGGAAGGATTCCTTTGGCCGCGTGGGTCTCTGACCGCATTGGCCGCAAGCCAGTC TTGCTGTTCGGGGCCATCACCTGTGCAATCACCACCTACTTCTACTTCCAGGCAATCTCT GAAGCTGACCTTGTGCTGATCTTCGCACTGTGCTTGGTCAACCAAGGTTTGTTCTACTCC TGCTGGAACGGCGTGTGGACCATTTTCTTCCCAGAAATGTTCGCATCTTCCGTGCGCTAC ACCGGCATGGCTATGGGCAACCAGCTCGGTCTGATCATCGTTGGTTTCGCACCAACCATC GCCACCGCCCTGTACGCATGGAACGGTTGGGAAGCTGTTGCGGGATTCATCATCGGCGCA ATCGCACTGTCTGCCGCAGTTATTTTGACCACCAAGGAAACCGCCTTCACCAAGCTTGAA GATCTAGGGAAGAAA >RXA00311-downstream TAATGTCTGACAAGATCTGGAAA >RXA00312-upstream CCATTGAATGGGAAGAACTTGGTTGTGTGTTTGTGACACCTATTCTAAAGAACATTAAAC GTGATTAAGTTCATGATTCTTAATGAGAAAGGGTGATCAC >RXA00312 ATGGAAACCGTGAGGACCGCAACCGCCGCTCCTGAAACTGCATCTTTGAAGCTGCGTGAG GCAGAAAGCCCAGCAAAGTCCCCAAAGAAAGCCGCCTTGGCGTCACTTTTGGGTTCGACT CTGGAGTACTACGACTTTGTCATTTACGGCACCGCCTCCGCGCTGCTGTTCAATCACCTC TTCTTCCCACAGGGCGACCCAGTCGTCGCGACGATCGGCTCTCTCGCCTCATTCGGTGTT GCGTACATTGCGCGCCCCATCGGTGGTCTGGTGATGGGACATGTTGGCGATAAGATCAGT CGCAAAACCGCCCTCATGGTGACGTTGATGATCATGGGTATCGCCTCCATTTCCATCGGA CTTCTGCGCACCTACGGACAGATCGGCATTTGGGCGACCGTGCTGTTGATGATCGCCCGC ATCGCA >RXA00312-downstream TAGGGATTCTCTGCAGTCGCAGA >RXA00345-upstream AGTGACCCATATGGCGTATCCGAGGTCTAACGCGATTTTGCGATTTTCAATAAGTTTTCA TGTTGACATCCTTTTTCAATAAGCATTTA >RXA00345 ATGGCAGGTATGAAAAAGCTTCTTTGGACACTCCCCATCCTCCCACTGGTACTAGCTGGC TGCTCAACTGGATCAGCAGATTCCGCGGATTCCACCAACGCTGCCGGATCCAATTCCCTT AAAGTGGTCACCTCCACCCAGGTGTGGGCTGACGTCGCCGAAGCTGTCGCCCCAGATGTA GACATTGAAGCAATTATTACCGGTGGCGACATCGACCCTCATTCCTTCGAGCCTTCCGCT ACCGATATGGCTAAAGTTTCCGAAGCTGACATCATTATCGTCGGTGGCGGCGGCTATGAT TCCTGGCTCTACGGCACCTTGGAAGAGGATGATCGCATCATCCACGCATTGGATCTCTCA GAGCATGACCACAGCGAGCATGATGATCACGAGCACGAAGCCGAAGAAGCCGACGAACAC GACCACGATGAAGAGGGCCACGATCATGACGTCGACAACGAGCACGTCTGGTACTCCACT GAATACGTCTCTGAGGTAGCTGAAGAGTTCGCAGAAAAAGTCACCGAGCTTGATCCCGAG GCACAGGCCGATGCAACGGCTGTGACCACCAAGATGGACGAGCTGCACAATCAGATTCAC GATCTTCCAGCAGTTCGCATTGCTCAGACCGAGCCGATCGCCGATCACATTTTGTCCCAC TCCGACATGGTGGAATCCACCGGTGAGGGTTACCGCGCAACCACGTTGAGCGAGAGCGAG GCAACGGCAGCAGATGTTGCGTCGTTCCAGGATGCAATTAACAACGGTGACCTGGATGTT TTGATGTACAACCCACAGTCCGCGTCGACTGTCGCGACCAGCTTGAAGGATTTGGCAGAA GAAAAAGGCATCCCAGTTGTTGAGATCTATGAGACCCCTCAAAACACCGAGAATTTCCTC GATGCATTCACCAAGGCAGTTGATGATCTCACCGCTGCCACTAACCAGGTT >RXA00345-downstream TAGAATTATTTAAATGGTGTTGA >RXA00378 AAATCCTGGCGGTCATATCCGTCCTGGTTCGCTTTTGACCACGGCACGTTGACCCAAAAC GAGATTTATTTTGATGTGGCCTGCGGAATCACCGTGTTGCTTCTTGCCGGACGGCTGCTG ACAAGGCGTCGAAGCCAATCCAGTTTGTTAGCGGAACTTGGTCGCCTCCAAATCGATCCA CAGCGCATTGTCACTGTGGTGCGTAAACACCGATTGAAGCGCGTAGTCCAGGAACTGAAC ATTCCAGTGCAGGAAGTCCGTGTCAATGACGATGTGAAAGTTGCACCTAATACCACGATC CCTGTGGATGGCACTGTCATCGGTGGCGGTTCGCGGATCGCAGCTAGCATCATCATGGGA CAAGACCAGCGTGATGTAAAAGTAAATGACAAAGTTTTCGCCGGCAGCCTCAACCTCGAA TCCGAAATCAAGGTTGGTGTTATTCGCACTGGTCACCGCACCCGCATCGCCGCGGTACAT AGGTGGGTTAAAGAAGCGACGTTGAAGGAAAACCGCCACAATAGGGCAGCGATCCGTTCG GCCGGTAACCTTGTGCCCATCACGTTCACCCTTGCTGTGGTGGACTTCTGTCTGTGGGCA CTGATCTCTGGAAACATCAACGCTGCATTTACCACTACCTTGGCTGTCCTTGCGTGGGTG GCTCCGGTGGCCTTAGCGTTGTCTGCTCCACTTGGCACGAGGAATTCGATCGAAGCTGCA GCACGACACGGTATTTTGGTCCGCTCTGGTGAAATTTTCCGAGTTCTCGATGATGTGGAT ACTGCCGTATTTAATCGTGTGGGCACACTkACCGATGGCGAAATGACAGTGGAAACCGTC ACAGCAGACAAAGGCGAGGACCCAGAACTAGTGCTGCGTGTCGCCGGGGCGTTGGCGATG GAATCCCACCACGCGATTTCCAAAGCACTGGTGAAAGCATCCCGTGAAGCTCGTGATACC GGCGCGGGTGGTGAAGATGTCCCACACTGGATTGAAGTAGGCAACGTGGAAATCACGGAA GCCGGCTCATTCCAAGCAACCATCGAGCTGCCACTGATCAAACCATCTGGCGAAAAAATC ATGCGCACCACAGAAGCACTCCTGTGGCGACCACGATCCATGACAGAAGTCCGTGAGCAC TTAAGCCCCCGACTAGTGGCAGCAGCAACCTCAGGTGGCGCACCACTGATCGTGCGATGG AAAGGCAAAGACCGCGGAGTTATCACTCTAAGTGACCACGTGAGATCAGATTCCTCCGAT GCGATTATTGCGATTGAAGAACAAGGCATCGAGACCATGATGCTTTCACGTGATACTTAC CCGGTGGCACGTCGATACGCAGACAGCTTAGGCATCACCCACGTCTTGGCCGGCATCGCG CCGGGCAAGAAAGCCCAGGTCGTCCGTGCAGTCCACACCCGCGGATCCACTGTCGCGATG ATCGGCGATGAATCAGTAATGGACTGTTTGAAAGTCGCTGACGTGGGTGTACTGATGGGC GTCGATCGTCCCTCAGATCTGCGTGATGATTCCGATGACCCGGCAGCTGACGTTGTGGTC ATGCGCGAAGAGGTCATGAGCGTGCCGACGCTGTTTAAACTGGCTCGACGCTACGCCAAG TTGGTCAATGGCAATATTGCTCTGGCCTGGATCTATAACGGTGTTGCCATGGTGGTTGCA GTGTCTGGCTTGCTGCATCCAATGGCTGCGACCGTGGCTATGCTGGCGTCTTCGCTGCTT ATTGAATGGCGCTCGGGCAGGGCGCGCAAGTAC >RXA00378-downstream TAACCAGCAATTCCCAAGCCCAA >RXA00412-upstream CTTTTGACGAACACCACGTCGCGTACGCTTCCTCGGGGCGTTAAACTATTTGTCTTCCAG CTTTTGTCCCCCGACTTTTGTACGAATCGAGGACACCGTC >RXA00412 GTGTCACACACCGCGTCGACACCGACGCCAGAGGAATACTCCGCGCAGCAACCCAGCACC CAGGGCACTCGCGTTGAGTTCCGCGGCATAACCAAAGTCTTTAGCAACAATAAATCTGCT AAAACCACCGCGCTTGATAATGTCACTCTCACCGTAGAACCCGGTGAGGTAATCGGCATC ATCGGTTACTCTGGCGCCGGCAAGTCCACTCTTGTCCGCCTCATCAATGGGCTTGACTCC CCCACGAGCGGTTCGTTGCTGCTCAACGGCACCGAGATCGTCGGAATGCCGGAGTCTAAG CTGCGTAAACTGCGCAGTAATATCGGCATGATTTTCCAGCAGTTCAACCTGTTCCAGTCG CGTACTGCGGCTGGAAATGTGGAGTACCCGCTGGAAGTTGCCAAGATGGAGAAGGCAGCT CGTAAAGCTCGCGTGCAAGAAATGCTCGAGTTCGTCGGCCTGGGCGACAAAGGCAAAAAC TACCCCGAGCAGCTGTCGGGCGGCCAGAAGCAGCGCGTCGGCATTGCCCGTGCACTGGCC ACCAATCCAACGCTTTTGCTTGGCGACGAAGCCACGTCCGCTTTGGACCCAGAAACCACG CATGAAGTTCTGGAGCTGCTGCGCAAGGTAAAGCGCGAACTGGGCATCACCATCGTTGTG ATCACCCACGAAATGGAAGTTGTGCGTTCCATCGCAGACAAGGTTGCTGTGATGGAATCC GGCAAAGTTGTGGAATACGGCAGCGTCTACGAGGTGTTCTCCAATCCACAAACACAGGTT GCTCAAAAGTTCGTGGCCACCGCGCTGCGTAACACCGGAGACCAAGTGGAATCGGAAGAT CTGCTTAGCCATGAGGGACGTCTGTTCACCATTGATCTGACTGAAACGTGCGGCTTCTTT GCAGCAAGCGCTGGTGCTGGCGAACAAGGTGCTTTTGTCAACATCGTTCACGGTGGCGTG ACCACCTTGCAAGGCCAATCATTTGGCAAAATGACTGTTCGACTCAGCGGCAACACCGCT GCGATTGAAGAGTTCTATCAAACCTTGACCAAGACCACGACCATGAAGGAGATCACCCGA >RXA00412-downstream TGAACGAGATGATCCTCGCAGCT >RXA00413-upstream CTGTACAGATCGCGGTCTATGGTGCTAATCTCCTAAATACTTGAATGACCATTTCATGAT CCATTCACAAAAACTTTCCCAAACAAGGACGTATTTGAAA >RXA00413 ATGAAACTTCGTCGCATCACAACCACCGCCATCGCTGGCCTCTTCGCCGCAACCGCACTT GTTGCCTGTGGCTCCGATTCCGATGGAAGCAGCACCACTGTTGCTGAAGGCACCGAAGGC GTGACCATGCGCATCGGCACCACCGACGCTGCGAAGGAAGCATGGACCGTATTGGAAGAC AAGGCAGCTGAAGAGGGCATCACGCTGGACATCGTTCCTTTCTCTGACTACTCCACCCCA AATGAGGCTCTTGCCCAGGATCAGCTGGACGTTAACCTCTTCCAGCACCTGAAGTTCCTG GCTGAGTAGAACGTCGGCTCCGGCGCAGACCTCACCGCAGTTGGCTCCAGCGAAATCGTG CCACTGGCACTATTCTGGAAGGACCACGACTCCATCGACGGCATTGACGGCGAGTCCGTT GCCATCCCTAACGATCCTTCCAACCAGGGCCGCGCCATCAACGTTCTCGTTCAGGCAGGT CTGGTCACCCTGAAGACCCCAGGTCTGGTCACCCCAGCTCCAGTCGATATCGACGAGGCA GCTTCCAAGGTTTCCGTCATCCCAGTCGACGCAGCTCAGGCACCAACCGCTTACCAGGAG GGTCGCCCAGCGATCATCAACAACTCCTTCCTTGACCGCGCAGGCATCGATCCAAACCTC GCGGTCTTCGAAGATGATCCTGAGTCTGAAGAAGCAGAGCCATACATCAACGTCTTCGTC ACCAAGGCTGAGGACAAGGACGATGCCAACATCGCCCGCCTCGTTGAGCTGTGGCACGAC CCAGAGGTTCTGGCTGCAGTAGACCGCGACTCTGAGGGCACCTCCGTCCCAGTTGATCGT CCAGGAGCTGACCTTCAGGAAATCCTTGATCGCCTTGAGGCTGATCAGGAAAACGCA >RXA00413-downstream TAATCTCTTTTGAGTTCTTTGCA >RXA00431-upstream TGGATCGTCCTCGCCTTCACATTCGTCGGCCTTGGCCTTGCTCTCCTCGCGATGAAGCAA TGGCGATTCCGCGTCAGCTACTGGGTATAAGGAGCACCAC >RXA00431 ATGGTATCGATCGATACATAGAACGCCTGCGTCGACTTGCCCATCTTCGACGCCAAATCC GGCTCCATGAAGAAAGCCTTCCTCGGCGCAGCCGGCGGAGCAATCGGGCGCAATCAAGAC AACGTCGTAGTCGTCGAAGCGCTGAAGAACGTCAACCTGCACTTGCGCGAAGGTGACGGG GTCGGACTCGTCGGGGAGAACGGCGCCGGCAAATCCACCCTCCTGCGACTCCTCTCCGGC ATCTACGAACCCACCCGCGGAAGCGCTGACATCCGTGGACGCGTCGCCCCCGTCTTCGAC CTCGGCGTCGGCATGGATCCAGAAATCTCCGGCTACGAAAATATCATCATCGGCGGCCTG TTCGTCGGTCAAACCCGCAAACAGATGAAAGGCAAAATGGAAGAAATCGCCGACTTCACG GAACTCGGGGAATACCTCTGCATGCCTCTCCGAACCTACTCCACCGGCATGCGCATGCGC GTAGCCCTCGGCGTGGTCACCTCCATCGAGCCCGAAATTCTGCTTCTTGATGAAGGCATC GGCGCGGTCGACGCCGCGTTCATGGCCAAAGCCCGCGACCGGCTCCAAGCCCTCGTCGAA CGATCCGGCATCCTCGTCTTCGCCTCCACTCAACGACTTTCTTGCCAACTCTGCAACACC GCACTCTGGGTCGAC >RXA00444-upstream GATCGTGCCAAGGAGATCCTTGCCAGCnnnnnnnnTnnnAnTGGTTTTGGCACAAACTAA AAAGGCTCGTCGAAGCGAGAATGATATCCTCCCAGGGTGG >RXA00444 TTGCTGATCCCAGCCACCCTGGCCATGCTGCTGATCATTGGACCTATTTTTGCTTTGCTG TTGCAGATCCCCTGGGATCGGTCTTGGGAGTTGGTTACCGCGCCGGAATCTTTAGGAACC GCACGGTTATCTATCGGAACTGCTCTGTTTTCTACCGCGCTATGCGCAATTGTGGGTTTC CCGCTAGCGTTGGCGCTGCATTTATATGAGGGTTCGCACCCCAGGGTGACATCAGTTTTG ACGGTGCTGGTTTATGCGCCTTTGGTGTTGTCGCCGGTGGTGTCTGGTTTGGCGCTGACT TTTCTGTGGGGCAGGCGTGGTTTTTTAGGTTCTTGGCTTGATCAGGTTGGATTGCCGATT GCATTTACCACGACGGCTGTGGTGTTTGCCCAGGTGTTTGTAGCGTTGCCATTTTTCATT TCCACTGTGACTACTGCACTGCGTGGGATTCCAAAACAGTTTGAGGAAATCGCAGCTACT GAAGGCGGAACCGGCTGGGAGATCATGCACAAGATGATCATTCCGGTGGCGATGCCTGGA ATTTTCACCGGTATGATTTTGGGATTCGCGAGGGCCTTGGGCGAGTATGGTGCGACACTG ACTTTTGCTGGAAATATTGCAGGTGTTAGCCGCACCATTCCGTTGCATATTGAGCTTGGT TTGAGTTCCAATGACATGGATAAAGCCTTGGGAGCGGTGATTATGCTTTTGGCTGTCTAT GTCCTCATCATTGGAGCCATCGGAGCGTTACGATTGTTTTCCAAGGTGAGAAAGGTT >RXA00444-downstream TAATTGATGTGTCGTTCGCCGGA >RXA00445-upstream GGTGCAAAAAAGGACTAACC >RXA00445 ATGGCGGATCTGAGCATTGAACACGTATCAAGGTTTTTCGGCGATGCCATCGCCTTGAAC GATCTGTCATTGACCGTCCCCTCAGGCTCCATCACCGCCATCATCGGGCCGTCCGGGAGC GGTAAAACCACGTTACTGCGTTTGGTGGCAGGCCTTGATTCACCCGATGAAGGCACCGTG AGCATTGGGAATAAGATCGCCAAGCTGGGTGACACTGCGCTGTGTTTCCAGGATTCGCCT TTGTATCCGCACCTTAATGTGTGGGAAAACGTGGCATTTCCGCTCAAGCTCAAAGCCACC AATACTGCAGATGAGGTGGTGAAAAAGCGGGTGAGTGATGTTTTGGAAATGCTCGAAATT GCTCCCCTCGCCCGCCGGAAAATTACCGAACTCTCCGGCGGGCAAAAACAGCGCGTCGGC ATTGCTCGAGCACTGGTCAGAGACGTAGAGGTTTACCTTTTCGACGAACCGATGGCCCAC CTCGACCAAGCCTTAGCCCGCGATATTGTGGCCGATCTGCGCAAAATTCAACAATCGTTG GGACTGACGTTTGTATACGTCACCCACAGCAAATCCGAGGCATTCGCGCTCGCCGACCAA ATTGTCGTGCTGGTAGATGGCCAAGTCGCGCAGGTTGGTGAGGCGGAGGACCTCGTCGAA AAGCCAAAAACCCTAGAAATAGCCGAGTTCCTCTCCCCCACCGAGCTCAATGTGCGCCGG CGTGGGGACGCCGTGGAGGCATGGCGACCCGAAGACACCCAGCTCGCCCGCGGTGGCACT GCGACCGTGGAAGCCGTGACGTATTTGGGCCGCGAGTGGCTTGTACAAACCACCGAGGGG CACGCCGTGTCGGAGGAAAAATTCGACGTCGGCGAAAGCGTCACGCTAACCCAGAAGAAG GTGTTTAGTTTC >RXA00445-downstream TAGCCGCCTGCAAAAGGAGGGAG >RXA00466-upstream TTTAAAAGCGCACTAAGAGCTCGTCAATTCTTTAAAACAAGCTGAGAATGTGAATAATAG GATAGGTTAACCTGATTCGATTAGAAAACGGAGATTTGTC >RXA00466 GTGCAATCCCGCCTGTCCAAAATCCTGCGCAGTAGCGTCGTAGGCGTTGCTGTCCTAGCC CTGTTAGCTGGGTGTTCTAACAATGCAGATGACACCGACGCTGATTCAACATCCACGGGA AACTCCGCTTTTCCTGTTTCGATTGAACACGAGTTCGGAACCACCACAATCGATGATGTA CCCGAAAGAGTTGTCACCCTTGGCGTTACCGACGCCGATATTGTCCTCGCATTGGGGACC GTCCCAGTAGGCAACACCGGATACAAATTCTTCGAAAACGGATTGGGACCGTGGACTGAT GAGTTAGTGGAAGGCAAAGAATTAACACTGCTTGACTCTGATTCCACACCAGATCTTGAA CAAGTAGCAGCCCTGGAGCCAGACCTGATTATTGGAGTCTCTGCGGGGTTTGACGACGTT GTATACGAGCAACTATCTGATATCGCACCGGTGGTCGCCCGTCCAGCGGGAACAGCTGCA TACGCAGTAGCTCGCGAGGAAGCTACCAACCTTGTTGCCCGTGCGATGGGGCAATCAGAA AAAGGACAAGAGCTCAATGAGGAAACAGATGCTCTGATCCAAGCTGCGCGTGATGAAAAT CCTTCTTTTGACGGTAAAACAGGAACCGTCATCTTGCCATACCAGGGTAAATACGGTGCC TACCTGCCAGGCGATGCACGGGGACAATTCCTCGATTCACTTGGCATTTCGCTGCCGGAA GCAGTTCTTTCGCGAGACACCGGCGACAGCTTCTTTGTCGATGTCCCCGCTGAAAGCGTC AAAGACGTAGACGGTGATGTTCTCCTCGTGCTTTCCAACGACGAAAATCTGGATATCACA GCAGAGAATCCACTGTTTGAAACACTCAACGTTGTGCAAAAAGACGCAGTAATTGTGGCA ACAACCGAAGAACGCGGGGGGATTACCTACAACTCAGTGCTGTCTGTTCCTTTTGCGTTG GAACATCTCGCACCACGTATTGCTGAG >RXA00482-upstream GCGATTTCTATGAAATTCTTCACCCATCCACAACTATCTACTATACTTTTAGAAGTAATA ACTATTGAGTTAATATAAACATGAAGAAAGGATTTGCTTT >RXA00482 ATGCGCATTTCAAGCAAACTTGTCACCACAGCACTACTCGCAGCCATTTCACTTTTCGGG ATATCCACGGCACAAGCCCAAGACATTTTTGACGGCGGACGACTTGCAGGTGGCTCGTCG CAGGTATCTAACCTAAGTTCGGTTCCTGAAAACGTAGCGCTGCCCGAAATTGAAAATAGC ATTGACCTAGAACGCTACAAAGGCAAGTGGTATCAAGTCGCAGCAATTCCCCAACCATTC TCTTTACAGTGCTCACATGACGTTACCGCTGATTACGGCGTGATCGACTCGGACACAATC TCTGTAACAAATAAGTGTGGCACTTTCTTTGGGCCTTCAGTTATTGAAGGCAGCGCTAAA GTAGTTTCCAATGCTTCATTAAAGGTTAGCTTCCCAGGTATTCCATTTCAGAGTGAAGAC AATCAAGCAAACTACCGCGTGACCTATATCGAAGATGATTATTCACTAGCAATCGTCGGC AGCCCAAGCCGGTCCTCAGGATTTATACTATCCCGCACGCCACAGCTCAGTAGTGACCAA TGGTCTCACGTTCGGAACATTACAGAGGACAGTGGGTGGTGGCCATGCGCATTCATTACA GTCCCAGCGACAGGTGGCTTAAACACCGCCACTCCGCTCTGCACACTT >RXA00482-downstream TAATTAACGTAGATGGTCATCTA >RXA00523-upstream TGGCGCGGCGGGGGTGAATTTTTCAGACG >RXA00523 GTGTTGCGTAATCAGTTGGCGTCGCCGGATATTATCGGCATTTCTTCTGGCGCGTCGGCG GCGGGCGTAATTTGCATTGTGTTTTTCGGAATGTCGCAGTCTGCAGTGTCGGCGATTTCT TTGTGTGCGTCCTTGGCTGTGGCGTTGTTGATTTATCTGGTGGCGTATCGCGGTGGTTTT TCGGCCACGCGTCTGATTCTTACCGGCATTGGTATTGCTGCGATGCTGAATTCATTAGTG TCGTATTCGCTGTCCAAGGCTGATTCTTGGGATCTGCCGACCGCGACGCGCTGGCTTACC GGCTCGCTCAATGGTGCGACGTGGGATCGTGCGATGCCGCTGATTGTCACCACTGTGGTA CTCATTCCGCTGCTGGTGGCTAATGCGCGCAATGTGGATCTTATGCGTTTGGGCAATGAT TCCGCGGTGGGTTTGGGCGTTGCTACTAATCGCACGCGCGTCATTGCGATTATTGCCGCT GTTGCGCTCATCGCCGTTGCTACCGCTGCATGCGGCCCGATCGCATTCGTGGCGTTTGTG TCTGGCCCCATTGCCGCGCGCATTTTAGGCTCCGGCGGATCGCTCATCATCCCCTCCGCA CTCATCGGCGGGTTGATCGTGCTCATCGCCGACCTAATTGGCCAATACTTCCTCGGCACC CGCTACCCCGTCGGAGTTGTCACCGGCGCATTCGGCGCCCCATTCCTTATCTATTTACTC ATTCGTTCCAACCGCGCGGGAGTAACCCTG >RXA00523-downstream TGACCACGAACCATCAACTATGC >RXA00525-upstream CCATCGTGTTTATTAGTCACAACCCTGAGCTTGCTGATGAATCTGATCGGGTGGTCACCA TGGTTGACGGGCGCATCATTGGGTGTGAGGTGAkACACTC >RXA00525 ATGAGCCTTGCAGAATCAATTCTTTTGGCGCTCACCAGCCTGAGAAGCAACAAGATGCGT GCATTGTTGACGCTGTTAGGAGTCATCATTGGTATCGCATCAGTCATCGGAATTTTGACC ATTCGTAAAGCCCTGCAGGATCAAACTTTGAATAGTTTGGAAAGCTTGGGCGCGAATGAT CTGTCGGCGCAGGTGGAGGAACGCCCCGACGAAGATTCCCCCGAACCCGATATGTTCGCT TTTTCTGGGGCTGCAAACTCTAGTGGCAATCTGATTCCGGAAGAAACAGTTGATACGCTG GGCGATCGTTTCGCAGGCAGCATCACGGGAATCAGCGTTGGCGGAATGGGTACGCAAGGC ACTCTCATCGGCGACAGCGCAGATCTTAAATCCGATCTCCTCGGCGTCAACGAGGATTAT ATGTGGATGAATGGCGTCGAAATGAACTACGGCCGCGCCATCACGCAAGACGATGTTGCC GCTCAGCGCCCCGTTGCGGTCATCGCCCCAGACACCTTTAATACGCTTTTCGACGCAAAC CCCAACCTCGCTCTGGGGTCCGAAGTAGCTTTTGAACTCAACGGTCAAGAGACATTTTTG CGGGTTATCGGTGTGTATAAAGAAGCCGCAGCAGGTGGACTTGTGGGAAGCAATCCAACC >RXA00556 TACAGCCCATATACGGTGGGCAATGACATCACCCACACGAAAGATGGATTGAACACGTTA AGTATCCGTGCAGCTCAGGGCGTAGACCAGGATTGACTTAAGGGTTCAGTGCAAACCTAC TTCGACGCGCTGTACGCCAACAATGACTCGCACCACGTTGCCATGTTGGACTTCCGTAAA CAGATCGAAGAGTTGAACACCATTCTCGGGGCAATGAGTTTGGGTATCTCAGCCATCGGC GGAATTTCCTTGCTTGTCGGTGGCATCGGAGTGATGAACATTATGTTGGTGTCTGTCACC GAGCGAAGCCGGGAAATCGGTGTCCGAAAAGCCCTCGGCGCTCGTCGACGTGACATTCGC CTGCAATTCGTGGTTGAAGCCATGATGATTTGTTTCATCGGTGGCATCCTGGGCGTGCTT TTGGGCGGCATTTTGGGATTGATCATGTCCAGCGCTATTGGCTACATTTCCTTGCCACCA GTGAGTGGAATCGTGATCGCCTTGGTATTTTCCATGGCTATCGGCCTGTTTTTCGGCTAC TACCCCGCCAACAAGGCAGCAAAGGTCGATCCAATTGACGCCTTGCGTTATGAG >RXA00556-downstream TAAAAGCCTCGTTTTTAAGGTAG >RXA00596-upstream GCGCCACCGACGGCCTCTTGAACACCGATGCATACCAACAGGCTGTGCTCGGTGAAAATG CCATCGGAGTGCCAAGCCCTAGCTACCAGGGAGGAAACTA >RXA00596 ATGCTTAACGCCCTGAAATTCATCCCATGGCTGATCGGCCAGATTTTCCTCTGTGGCTTC AGCGTGATCACCGCTGCGGTAAAAAAGGACAGCGGCTTCAACCCCGTTGTTATCCGCTAC GCACTTCGAGTGACCACGGACTTCCAGATCGCAGCCCTGTCAACGTGCATCACCGCGACT GCTTCCACCCTGTCCCTTGGCCTACGCGAACCCCGCAAGCCCGGCGACCCCACCATTTTG CTGATCCAAGCAGTGTTTGGTTCCGATCCAGTAGAAGTTTTTGAATCCATCGCCGATATG GAACAACGCCTCGTCCCTTCGGTCGCTTCAATTGACCACGGCGTCCCAGGCCAAGGGGCT TACAAGGAGATCGGCCCCAGCGATGCTGAGTGGCCAAGTCGCGAGATCGCTGACACCGCC CAAAACACCGTCAGCCAAGACAAGAGGGAGTTT >RXA00596-downstream TAAAACAACATGACTGCTTTTGG >RXA00634-upstream AAGTGTTTTTAATTACCGCAGCTTTGTCTTAGGAGAAGTCATGGTCCAACTGGATCAACG GGTTAGGTTCAAAAGCGCAACCTCAATAATCAGTATTGAA >RXA00634 ATGTGGGAGCGATTCAGCTTCTACGGCATGCAAGCACTCTTGGTGTACTACGTGTATTTT GATGTTGCAGCCGGTGGATTAGGCCTTGATCAAACCCAAGCAACAGGACTGGTCGGCGTT TATGGCGCACTGCTCTACCTCTGCTGTTGGGCAGGCGGTTGGGTCAGTGACAGAGTCCTG GGCGCAGAAAAAACCCTGCTGGGCGGTGCGATCTCAGTAACCATCGGACACCTTGTGCTT GCTGGCCTCGGCGGGAAAATTGGTCTAGCCATTGGCCTTGGATGCATCGCGATCGGTTCA GGATTTGTGAAAACAGCAGCCATGACCGTGCTGGGATGCAGGCATGGTGAACAAGAAGGA GACGCAAAGGCAGATCCCGCATTCCAACTCTTCTACCTAGGCATCAACGTTGGTGGACTG CTCGGACCACTCCTGACCGGTTGGCTCTCCAGCAGGTATTCCTTTGAAATGGGATTCGGC GCAGCCGCAGTCGTTATGATCGGCGGATTGGGAATCTACGCAGCGTTGGGGAAACCAATG CTGCAATCGTTCCCGCTCGAGGTGAAGAAAGCGCTGCTCCGCGCCCAAAACCCTGCAGAA AAACATGTGATTAGCACGGCATTTGCTGCAGTGGCTGTGCTTTGCGGAGTGCTGCTTTAT CTTCTCCTTACAGAAACAGTCAGCGCAGACCAACTAGCTGGAGCTCTGCTTTTAGTAACA ATCGGTGCAGCACTATGGCTCATTATCCAGCCCTTACGACACCCACAAGTCAGCTCCGAA GAGAAACGAAAAGTGCTGGCATTCATCCCGATCTTCGTCTGCTCAAGCGCATTCTGGGCA GTGCAAGCACAAACCTACGGCGTACTAGCTGTGTACTCCCAAGAACGTGTTGACCGCATG GTTGGCGATTTTGAGATCCCAGCAGCCTGGTCACAATCACTCAATCCTTTTTTCATCCTG GCGCTGTCCATCCCGATTTCCCTGTGGTTTATGCGCGGATCACGCGCCCCAAGAGTGAAA ATTGGAATCAGCATTGGAGTGATCATTGCGGGAAGTGGGCTTCTAGTTCTTATTCCATTT GTTGGAATGCCGCTCGCGGCAGTGTGGGTGCTGCCTTTAAGTGTTTTCCTCATCTCACTG GGAGAACTTTTCATCGGACCCGGAGGAATGGCTGCGACTGCGCACCACGCACCACGAATA TTTGCCACACGATTCTCCGCCCTGTATTTCGTCACACTCGCCATCGGCATGTCTATTGCA GGTAATGTGTCCAAATTTTACGACCCCAGCAACCACACCTCCGAGCTCCGATACTTCGCG GTATTTGGCATTTCGATCATCGTCATCGGTGTCGGTTCACTGATGGTGGCCAAGAAGGTT GGA >RXA00634-downstream TAACAGGGTTAATGTTGGGTGAT >RXA00665-upstream ACCAAACACTTCTGTGCGTGACACGCGCCACCTTATACTCCCACAAGCAACACAGAACAC TCGGGATCTCAAAGTTTCGAGAAACACAGAAAGGGGAGCA >RXA00665 ATGAGGAGCTCAACACTTCTCCTGGCTTCAGGACAAGTCACGGCATTAGCCGCTGACTAC ACGCTCAGCCACACCCCCTCAGATGGCATCCTGGTAGTCCTTGGCTTCGCCATGATCGTC ACCTTCATGACCCTGATCATGCTGGGTGGACTCACCCCAATGGTGGCCATGCTGTTGGTC CCCACCATCTTCGGTCTCATCGCCGGCGCAGGACTCGGCCTTGGTGACATGGCGCTTGAC GCCATCAAGGACATGGGGCCTACCGCGGCACTCCTGATGTTCGCGATTATGTTCTTGGGA ATCATGATCGACGTGGGACTCTTCGACCCCCTGATCCGCGTGATCACCCGCGTTCTTCAC GATGACCCCGCAAAGGTCGTCATCGGCACCGCAGTACTTGCAGGTGTTGTCTCCCTCGAC GGCGACGGCTCCACCACC >RXA00702 TTAGGGCTCCCACCTGCGGTGATGCGCAAGGGCGTAGAGGAAACCCTTGATCTTTTAGGC ATGGCGGAGCTGCGATACGTGCCATTGGCGGAACTATCTGGTGGTGAGCAGCAGCGCGTG GCGATTGGCGCGGTGCTGACCACTCGCCCCGCGCTGATTATCTTGGATGAACCAACCAGC GCTTTGGACCCTAATGGTGCCGAGGATGTGCTGGCAACCGTAACCAAGCTGGCTCATGAC TTGGCGATGACCGTAGTGCTTGCTGAACACCGCATCGAGCGCGTACTGCAGTACGTGGAC CGCGTGGCGGATGTGGGCGCTGATGGGCACGTCACTGTTGGGACGCCGGAAGAAATCATG GCTGATTCTGATGTGGCACCACCCATTGTGGAATTAGGACGCTGGGCTGGCTGGGCTCCC CTACCGCTATCGATCCGCGATGCACGCGCACACTCCGCTGACATGCGCAAACGCCTGTAT CAGCGTGGTTTAGTGGTGAACAAATTACACAACCACGCTGTCCAGCCACTTTTGATCGCC GAAGATATCATGGTTGATTTCCCCGAAATCCGTGCCGTTGACGGCGTGAACTTGAATCTC AACTCCGGTGAAATTACCGTGCTCATGGGCCGAAACGGCTGCGGAAAATCATCCCTGCTG TGCGCTTTACAAGGTTCAGGGACTAGAAATCAGGGCTCGGTGCAGGTGCTTGATGAGGCC GCGGGATTTTCGTGGACAGACCCCAAAACTTTAAAGCCCGCCAAGCGGCGCAATCTTGTG TCCATGGTTCCGCAAACACCGACCGATATTTTGTATGAATCAACCGTGCATGCAGAGCTC GCACGCTCTGATAAAGATGCCGCAGCACCCGCCGGCACCACGCGGGAAATCCTGGATTCA CTGGTCCCGAATATCCCGGACCATCTCCACCCACGTGATCTATCAGAAGGCCAAAAGCTC TCCCTCGCGCTGTCCATCCAACTCGCCGCAAAACCCCGCGTGGTATTTTTCGACGAACCC ACCCGCGGCCTAGACTACGACGGCAAGAAATCCCTCGCCCGCTCCTTCCAACAACTCGCA GACGACGGCCACGCCATTTTGGTGGTCACCCACGACGTGGAATTCTCTGCACTGTGCGCC GACCGAGTGTTGTTTATGGCCTCTGGAAAGATCATCTCCGATGGCACAGCCGTAGAAATC CTCCCCGCATCACCGGCTTACGCCCCACAAGTCGCAAAAATCACCGCCGGCATCCAAGAG GAATCACACTGGCTCACAGTCTCGGCCGTGAAAGCTGCGCTAGGGCATGGTGAAATCTCA >RXA00702-downstream TGATCAACGCCATCACACTCAAG >RXA00728-upstream GATTACTTCACAGATGTGAGATCTTAATCAAGGGCCTGGAGCTTCAACGGCCCAACGGAA ACCGATTGAAGCCAAGCCACTACGCCACCCTGGCCGGTGG >RXA00728 GTGGCAGCCGCTATCATCGTGGCACTGCTCGCATGGTTTATCATCAGCGCGCTCAACAAT GAGGCCTACGGTTGGGATACCTACCGCTCGTATCTTTTTGACACCCGCATTGCCACCGCG GCACTTCACACCATTGCGCTGACCTTGCTGTCCATGATCTTGGGTGTGGTTCTCGGCGCA ATCTTGGCCGTCATGCGTATGTCCGGCAACCCTGTCATGCAGGGCGTAGCGTGGCTGTAC CTGTGGATTTTCCGCGGCACCCCAATTTATGTGCAGTTGGTGTTCTGGGGCCTGCTGGGT TCCTTGTACCAGTCGATCAACCTCGGTTTCGCAGAGATCGATCTGCAAAGCTTGCTGTCT AATATGTTCCTGCTCGCGGTGATCGGTCTGGGTCTCAACGAGGCTGCGTACATGGCGGAA ATCGTGCGCTCGGGCATCCAAGCGGTGCCTGAGGGCCAGATGGAGGCGTCGAAAGCTTTG GGTATGAACTGGTCAATGACCATGCGTCGCACCATCTTGCCGCAGGCCATGCGCATCATC ATTCCGCCAACCGGCAATGAACTGATCTCCATGCTCAAGACCACCTCTCTGGTTGTTGCG ATTCCTTATTCTCTCGAGCTGTACGGCCGCAGCATGGATATTGCGTACTCCCTCTTCGAG CCAGTTCCAATGCTTCTGGTTGCTGCGAGCTGGTACTTGGTCATCACGTCTATTCTTATG GTTGGTCAGTACTACCTGGAGAAGCACTTCGAAAAGGGCAGCACCCGCACCCTGACCGCA CGTCAGCTCGCT >RXA00732-upstream TCTTTGGCAAGGTAGTGAACTTCTCTGAGCGTGAGATGGGTCAATTTGGCGCACCCGTCG CTGATCACCGGGAAACACCAACGATGTGCAGCAGGTTCAG >RXA00732 ATGCTGGTGCAGATGACCTCCACTTTGATGATTTGCGCCCCGATGCTGGCCATTGGTGGC ATCATCATGGCGGTGCGTCAGGATCTTGGTTTGTGTTGGCTGATGGTGGTCAGTATTCCG GTGCTGATCATCGTGGTGGCGCTGATCATTGTGCGCATGGTTCCGTTGTTCCAAACCATG CAAAAGCGCATTGACCGCATCAATCAGATTATACGCGAGCAGCTCACCGGTATCCGCGTG ATCCGCGCGTTCGTGCGTGAAGATGTGGAACGCGAACGATTCACCACTGCTAGTAAAGAT GTCGCTGATATCGGCGTGCGCACCGGTAACCTGATGGCGTTGATGTTCCCTGCCGTGATG CTGATCATGAACCTTTCTGCCGTTGCTGTGATTTGGTTTGGTGCTTTCCAGGTGGAATCC GGCGAGACGCAGATCGGTACGCTCTTTGCATTCTTGCAGTACATCATGCAGATCCTCATG GGCGTCATGATGGCAGCGTTCATGTTTGTCATGGTTCCGCGCGCTGCCGTTTCCGCTGAT GGCATCGGTGAGGTTCTGGAAACCACACCGTCTGTGCAGGCGCCAGAAACACCGGCGCAG CCGTCGACAAGCGCTGGCGAAATCGTGTTCAACAACGCGACTTTTGGCTACCCCGGCGCG GATGACGCCGTGTTAAATAATGTGAGCTTCCGCGTTGCGCCTGGTAGCACGACGGCGATC ATCGGCTCGACGGGTTCGGGTAAGACGAGGTTGATCGGGCTGGTTCCTAGGCTTTTCGAC GTCACCGAAGGCGACGTTACCGTCGATGGCACCGATGTTCGT >RXA00734 AGGCAGCTGCGTTATGGCAATGAAGATGCCACGGAAACGCAGCTGTGGCAGGCGCTTGCA ATTGCTCAGGCGGCGGACTTTGTGCGTGAGATGCCAGAGGGTCTTGATTCTGAGATTGCT CAGGGTGGAACCAATGTTTCTGGTGGTCAGCGCCAGCGACTAGCCATTGCCAGGGCGTTG TTGAAGCAACCTGAGATCTATATTTTCGACGATTCTTTCTCCGCCCTCGATGTGAGCACA GACGCGGCTCTTCGCCGAGCGCTGAGCACCAACCTGCCGGATGCAACCAAGTTGATTGTC GCCCAGCGTGTCAGCACGATTCGAGATGCCGATCAGATTGTGGTGCTTGATAACGGCGAG GTTGTCGGTATTGGAACGCACACGAATTTGCTGAACACGTGCGGTACCTAGCGTGAAATT GTTGAATCCCAAGAGACTGCGCAGGCGCAATCA >RXA00734-downstream TGAGTAATACTGCAGGCCCCCGC >RXA00759-upstream TCACCTTGAACACTTAAAACATAACTTCATCCGGCGCTTTATTAGCTTGAAGCGCCCCGC ACCATAATCCATTCCCCAGCAAGCAAGGACACCCACGCTC >RXA00759 ATGCTTCGTTACGTCGGGCGACGTTTGCTCCAAATGATTCGGGTCTTTTTCGGAGCGACC TTACTGATTTACGCCCTCGTGTTCCTCATGCCTGGTGACCCAGTCCAGGCATTGGGAGGT GACCGCGGCCTAACCGAGGCTGCGGCCGAGAAAATCCGTCAAGAATACAATGTTGATAAA GCGTTCATCGTTCAATACCTCGTGTACATCAAGGGCATCTTCGTGTTAGATTTTGGAACA ACCTTCTCTGGTCAGCCAGTTATTGATGTGATGGCCAGGGCCTTCCCCGTCACCATCAAA CTCGCCATCATGGCCCTGCTGTTTGAATGAATCCTCGGCATTATCTTTGGTGTCATCGCA GGTATTCGCCGCGGAGGAATCTTCGACTCCACCGTGCTGGTCCTTTCTCTGATAGTCATC GCAGTCCCCACCTTCGTCATTGGTTTCGTGCTGCAGTTCTTANTCGGCGTGAAATGGGGC TTACTGCCCGTCACCGTAGGTTCCAACACATCAATAACGGCGCTGATCATGCCGGCTGTC GTACTGGGTGCAGTATCGTTCGCCTACGTTCTTCGCCTCACCAGACAATCCGTGAGCGAA AACCTCCGCGCTGATTACGTTCGAACCGCTCGAGCAAAAGGCATGTCCGGATTCAACGTG ATGAACCGCCATGTGCTTCGAAACTCACTGATTCCCGTTGCCACCTTCCTGGGCGCCGAT CTCGGTGCACTGATGGGTGGAGCGATTGTCACCGAAGGTATCTTCGGCATCAACGGTGTC GGTGGAACGCTCTACCAGGCCATTTTGAAAGGTGAACCCACCACGGTTGTCTCCATTGTC ACTGTGCTGGTCATCGTCTACATCATCGCCAACCTTCTCGTGGACTTGATCTACGCCGTT CTCGATCCGAGGATCCGCTATGCC >RXA00759-downstream TAATAATGAATTCCACACAAACC >RXA00760-upstream ACCACGGTTGTCTCCATTGTCACTGTGCTGGTCATCGTCTACATCATCGGCAACCTTCTC GTGGACTTGATCTACGCCGTTCTCGATCCGAGGATCCGCT >RXA00760 ATGCCTAATAATGAATTCCACACAAACCACTCGTTGGGCCAAGATGATCAAACCCCAGAT CAGGCTCATTTCTTCCCACAAGGACGAGGCGAGGCTCTAGTTCGACCAGGTGAAGAGCAC TTCATCGCAGCGACTGATGAAACGGGACTTGGTGCCGTCGATGGTGTTGCTGATGACTCT GCACCAAGCTCCATGTGGGGGGAAGCGTGGCGAGACCTTCGTCGTCGACCACTGTTCTGG GTCTCTGCGGTGTTGATTATTTTGGCGCTTCTCCTGGCCGCAGTTCGGCAGCTGTTTACC TCAACGGATGCGCAGTTCTGTGTGCTGGCAAACTCTCTTGATGGTCCACAGTCTGGACAT CCCTTCGGATTCGACCGTCAAGGTTGCGATATTTTTGCTCGTACCGTCTACGGTGCTCGT GCCTCGGTCGCCGTCGGTGTGTTGACCACGTTAGTGGTCGCCCTCATCGGTAGTGTATTT GGTGCTTTGGCTGGCTTCTTTGGTGGCATCATGGATACCATCCTCTCCCGCATCACCGAC ATGTTCTTCGCCATTCCACTGGTTCTGGCAGCCATCGTTGTGATGCAGATGTTCAAGGAA CACCGCACGATCGTCACCGTGGTTTTGGTGCTTGGGCTTTTCGGCTGGACCAACATTGCG CGTATTACCCGTGGAGCGGTGATGACCGCAAAGAATGAAGAGTATGTCACCTCCGCACGT GCGCTTGGTGCATCAAAAGCCAAGATACTGCTGTCTCACATCATGCCAAACGCCGCAGCA CCCATCATTGTGTATGCAACTGTGGCACTGGGAACATTCATCGTGGCAGAGGCGACGCTC TCCTTCCTGGGCATTGGCCTTCCACCATCAATTGTCTCCTGGGGTGCTGATATCGCGAAG GCACAAACGTCCCTTCGTACCCAACCCATGGTGCTGTTCTACCCCGCAATGGCACTTGCA CTAACCGTTTTGAGCTTCATCATGATGGGCGATGTCGTCCGCGAGGCTCTGGATCCTAAG TCGAGGAAGCGA >RXA00760-downstream TGACCACCAACATCCCACAAACC >RXA00761-upstream TGCTGTTCTACCCCGCAATGGCACTTGCACTAACCGTTTTGAGCTTCATCATGATGGGCG ATGTCGTCCGCGACGCTCTGGATCCTAAGTCGAGGAAGCG >RXA00761 ATGACCACCAACATCCCACAAACCCCCAACCACGAGGGTGAACAGCCACTGCTCGAGCTG AAGGATCTAAAGATTTCCTTCACCTCCTCCACCGGTGTTGTCGACGCTGTCCGTGGCGCA AACCTCACCATTTATCCTGGCCAATCTGTTGCCATCGTGGGTGAATCCGGTTCAGGTAAA TCGACCACGGCAATGTCGATCATCGGTCTGCTTCCAGGCACCGGCAAAGTGACCGAAGGT TCCATCATGTTTGATGGCCAAGACATCACAGGCTTGAGTAACAAGCAGATGGAAAAGTAC CGCGGTTCAGAAATCGGACTGGTCCCCCAGGATCCGATGACCAACTTGAACCCGGTGTGG CGCATCGGCACCCAGGTCAAGGAATCCCTCCGAGCCAACCACGTGGTTCCAGGCTCAGAG ATGGACAAGCGCGTGGCAGAAGTTCTGGCCGAGGCAGGTCTTCCTGATGCTGAGCGTCGC GCAAAGCAGTACCCACATGAGTTCTCTGGCGGTATGCGCCACCGCGCACTGATCGCCATT GGTTTGGCGGCACGCCCGAAGCTCTTGATCGCCGACGAGCCCACGTCTGCG >RXA00774-upstream ATTATCGGCTTATAGTGTTGCCATGGGTACTGCATATAGACAGCAATTGGATGAATTCGC ACACAATCTAATCATTTTGTGTGATCTAACTAAGGAGTGC >RXA00774 ATGGATAAGGCGACTGATGCCCTCCTGCGCACTTCTTTGGCATCGGCAGAAAGCGCTTTA GGCAATGCAGAAAAGCTTGAAGAGCTTCGTACTGGATGCGAGTCTCAAGCCGTCGAACTT TTGGCGCTTGAAACTCCTGTAGCCCGTGATCTTCGCCAGGTTGTCTCCTCCATCTACATC GTCGAGGAAATTACCCGTATGGGTGCTCTGGCAATGCACGTGGCTAATTCCGTGCGCCGC CGTTACCCCGATCCGGTGATCCCGGAGGACATGCGTGGCTATTTCAAGGAGATGGCCCGC CTCGCAGCTGACATGACAGATCATATTCGTCAGATCCTCATTGATCCTGAACCAGATCTT GCCCTAGAGATGGCTAAAAGCGATGACGCGGTGGATGATCTGCATCAGCACATCATGCGT ATTCTCACGCTGCGTCCTTGGCCTCACGACACCAAGAGCGCGGTTGATTTGACGCTGCTT TCCCGCTTCTACGAGCGTTACGCCGATCACACGGTAAACGTGGCCGCCCGTATCATTTAC CTGTCCACCGGGCTGCACCCGGAGGAGTACATGGAAAAGCGCGAGCAACAAAGGGCCGAT GCCGACATGGAGAAGCGCTGGGCCGAGCTGGAGCGGCAGTTCCGCACCAGCGAG >RXA00774-downstream TAAAAAGGTGCTTCTCGACGCTA >RXA00775-upstream TCATGATCGCTGTCGTGAACATTGGCGCACGAATCATCTCCGCCAAGTTCTCTGTCAAGC AATAATAATCTCAGAAAATACAACAGGAGTATCTAAAGCG >RXA00775 ATGTCGAAGCTCAAGCTCAATGATGTCAACATCTACTAGGGTGATTTCCACGCAGTGCAG AACGTGAACCTCGAGGTTCGTGCAGGCTCTGTCACCGCATTCATGGGACCATCCGGCTGT GGCAAGTCCACAGTTCTCCGCTCCATGAATCGTATGCACGAGGTCACCCCAGGTGCATAC GTCAAGGGCGAGATCCTTCTCGACGGCGAGAACATCTACGGCTCCAAGATCGACCCAGTT GCAGTCCGTAACACCATCGGCATGGTGTTCCAGAAGGCTAACCCATTCCCAACCATGTCC ATCGAGGACAACGTGGTTGCAGGTCTGAAGCTTTCCGGGGAGAAGAACAAGAAGAAGCTC AAGGAAGTTGCTGAGAAGTCTCTTCGTGGCGCAAACCTGTGGGAAGAGGTTAAGGATCGT CTGGACAAGCCAGGCGGCGGCCTCTGCGGTGGTCAGCAGGAGCGTCTGTGCATCGCTCGC GCGATCGCGGTTGAGCCAGAAATCCTCCTCATGGACGAGCCTTGCTCCGCGCTTGACCCA ATCTCAACCCTGGCTGTGGAGGACCTTATCCACGAGCTGAAGGAAGAGTTCACCATCGTC ATCGTGACCCACAACATGCAGCAGGCTGCACGTGTGTCCGATCAGACCGCGTTCTACTGC CTGGAGGCGACCGGTAGGCCAGGTCGTCTGGTTGAAATCGGACCTACCAAGAAGATCTTC GAAAACCCAGATCAGAAGGAAACCGAAGATTACATCTCCGGCCGCTTCGGA >RXA00775-downstream TAAATCGAAGAATTAAAGCCACT >RXA00776-upstream CGTACATCTCCGCCGGCCTCGTGCTGTTCGCCCTTACCTTCATCGTCAACGCTGGCGCTC GCGCCATGGTTAACCGCGGAAAGTAGAAGGGGACAAAATC >RXA00776 ATGACTAACAATGTTGTTACTCCGCGCATGGATGAGCCTTTAAAGAAGAGCTCAGCCTTC ACCGACATCTCCTCCAGCCGTAAGACCACCAACACCGCAGCAACCGTCATCATTTATGGT GCGATGCTCATCGCAGCTGTGCCACTGGTTTGGGTGCTGTGGACCGTGATCTCTCGAGGC ATCGCTCCGATCCTCACTGCTGATTGGTGGTCCACCTCCCAGGCTGGCGTCATGCTGATG CTGCCAGGCGGCGGTGCAGCTCACGCCATGATCGGTACCTTCATGCAGGCGGTAGTCACC TCGGTGATTTCCATTCCAATCGGTATCTTCACCGCAATCTACTTGGTGGAATACTCCAAC GGTAACCGTCTCGGACGCTTGACCACCTTCATGGTTGACATCCTCACCGGTGTTCCTTCC ATCGTTGCGGCACTGTTCGTGTACTCCTTGTGGATCGTGCTCTTCGGCTTCGACCGCTCC GGCTTCGCAGTGTCCCTGTCACTGGTGATTTTGATGGTTCCAGTGATCATCCGAAACACC GAAGAAATCCTCCGCGTTGTTCCTCAGGATCTGCGTGAAGCGTCCTACGCACTGGGCGTG CCAAAGTGGAAGACCATCGCAAAGATCGTTCTCCCAACCGCACTGTCCGGTATCGTCACC GGCGTCATGCTCGCAGTCGCTCGTGTCATGGGTGAGTCGGCACCAGTTCTGGTCTTGGTT GGTTCCTCCCAGGCCATCAACTGGAACCCATTCGGCGGTCCGCAGGCTTCCCTTCGACTG ATGATGCTTGATATGTACAAGGCCGGCACCGCACCAGCAACGCTGGACAAGCTGTGGGGC GCAGCCCTCACCGTGGTGCTCATCATCGCTGTCCTGAACATTGGCGCACGAATCATCTCC GCCAAGTTCTCTGTCAAGCAA >RXA00776-downstream TAATAATCTCAGAAAATACAACA >RXA00777-upstream TTAAGTGAATCGGGCGCCCTCTCCCAGCAATTGAGGGTAGGGCGCCCGATTTTACTAACA AGCTTTTTATCAATACGCCAGTTAAGGAAATAAACCACCA >RXA00777 ATGGCCACTAATGAGTCAGTCTCGGAGAAGCAACGCCTGGATGCAACCAGGGTGCAGGCA CATCCTGTAGCAGTTAATGCGAACTCCTCTCAGACCAAGCCTTCAAAGAAGATTGTCGCC GAAGGTGGCGGAAGCGTTAAGCGTCCCGGCGATCGCATCTTCGAAGTCCTATCCACCGCT TCTGCAGCAATCATTACTGCGATAATGATTGCCATTGCGGCGTTCCTTATCTGGCGTGCT GTTCCCGCCTTGATGCGAAATGCTGAAGGTATTGGCGGATTCTTCACTTATTCAGGCGCT TGGAACACCACCGACATTGATGCAATGTACTTCGGTATTCCAAACCTGCTAGCTGCAACA CTTCTCATCTCTGTCATGGCACTGATCATCGCCATGCCGATTGCTCTTGGTATTGCGATC TTCTTGTCCAACTACTCACCAAAGCGCCTGGTTAAGCCACTTGGCTACATGGTGGACATC CTGGCTGCTGTGCCTTCCATCGTCTACGGCCTTTGGGGCTGGCAGGTGCTCGGACCAGCT CTGTCCGGTTTCTACACCTGGATTGAAAGCTGGGGCGGAAGCTTCTTCCTCTTCGCTACT TACCAAAACTCACCTTCTTTTGCTACCGGCCGTAACATGCTCACCGGTGGCATGGTGCTC GCAGTGATGATCCTTCCTGTTATCGAAGCAACCGCACGTGAAGTTTTCATAGAGACTCCA AAGGGCCACATTGAATCTGCTCTTGCACTTGGCGCAACCGGCTGGGAAGTCGTTCGTTTG ACGGTTCTCCCATTCGGAATGTCCGGCTACGTTTCCGGCGCGATGCTCGGCCTCGGCCGC GCACTGGGTGAGACCATGGCGCTATACATGGTTGTTTCTCCATCCTCGGCGTTCCGCTTC TCGCTTTTCGATGGCGGTACCACCTTCGCAACGGCCATCGCCAATGCCGCTCCAGAATTC AACGACAACACCCGCGCAGGCGCGTAGATCTCCGCCGGCCTCGTGCTGTTCGCCCTTACC TTCATCGTCAACGCTGGCGCTCGCGCCATGGTTAACCGCGGAAAG >RXA00777-downstream TAGAAGGGGACAAAATCATGACT >RXA00828 GAGCACCAATTTGTGGCGCGCACTGTGCGTGATGAGCTAGAAATTGGTCCGAAAATCATG AAAGTTGATGCAAGCGAGCGCATCGAGGAGTTGCTTGATCGGTTGCGCCTCCGCCACTTA GAAAATGCTAATCCGTTTACCTTGAGTGGTGGAGAAAAGCGCCGCCTATCTGTGGCGACA GCCTTGGTGGCAGCACCGAAACTTCTCATTTTGGATGAGCCTACGTTTGGCCAAGATCCC GAGACCTTGACAGAGCTGGTGACGATGTTGCGTGAATTAACAGACAACGGAATCAGCATT GTGTCAGTAACCCATGATCGTGATTTCATCGCAGCGCTGGGCGATCACCACATTGAGGTG AGCGCGAAG >RXA00828-downstream TGAACCTGCTGATCAAAATTAAT >RXA00832 ACACTGACAGCAGTGGTGTACGGGTTCTTCCTGTTTCGCCAAATGGGTGCGCAAGCTGGT GAATTTCAAGAGGTCGAGGTCGCAGAAAAGGCAGACGACGCAGCAAAATGGGAGGTCCCA TTTAGAGGCTTAATCTTGATTATCACTGTGCTCCCCATCGTGTTGCTGTCCCATGACATG GCCACGGTGATGGATGAAGTCCTGGCAAGCCTTGGTGCACCCGTAGCAATGGCTGGATTA ATTATTGCCACCATTGTCTTCTTGCCAGAGACCATCACCTCCTTGAAAGCTGCGTGGACA GGAGAGATTCAGCGAGTAAGCAACCTGGCGCATGGAGCCGAAGTATCAACGGTGGGGCTG ACAATCCCAGCTGTTCTAGTGATCGGCGTGATCACAGGTCAAGATGTAGTTTTGGGGGAG ACCCCGATCAACTTGTTGCTGCTGGGAACCACCATTGCGGTGACAGCCATTGCGTTTAGC TCCAAGAAAGTCAGTGCTGTGCATGGCTCGGTGCTGCTCATGCTTTTCGGTGTTTACATG ATGAGCATGTTCGCC >RXA00832-downstream TGATTTAGGTAGCCTGGTGGGAA >RXA00934 CCAAGTTTTTCCATGGCGGCGCTAGCGTTTGCGGAAGGCCCCATCGTTGCTACTTACCAC GCCTCCAGTAGCGGATCGAAGCTGGTCAAGGCTTTCTTACCAGTGCTTTCGCCCATGCTG GAGAAAGTGCGCGCAGGCATCGCCGTGTCTGAAATGGCTCGGCGCTGGCAGGTGGAGCAA GTCGGCGGCGATCCCGTGCTGATCCGCAACGGGGTAGAGACCTCCATGTTCAAAGCCGCG GGCCAAATCGAACCGAATGATCCTGTAGAGATCGTCTTTTTGGGTCGCCTCGATGAGTCC CGCAAAGGCCTCGACATCCTCCTGCGCGCTCTGACCAGGCTGGATCGCCCGTTTACCTGC ACCGTCATTGGCGGCGGCACCCCGCGAGAAGTCGCCGGCATCAACTTTGTGGGCCGCGTC AGCGATGAGGAAAAGGCAGCAATCTTAGGTGGCGCAGACATCTATGTCGCACCCAACACC GGCGGCGAAAGCTTCGGCATCGTGCTAGTTGAAGCGATGGCCGCGGGATGCGCTGTCGTC GCCAGCGACCTAGAAGCGTTCTCCCTGGTCACCGATTCTGAAGCCGCACAGCCAGCGGGC GTGCTATTTAAAACCGGCTCAGACGCCGACCTAGCCAAAAAACTTCAAGCGCTTATCGAC GACCCCTCCTCCCGTTCCACGCTTATCGCCGCGGGGCTAAAGCGCGCAAACGCCTACGAC TGGTCGACAGTATCCACCCAGGTCATGGCAGTCTATGAAACCATTGCGATCGACAAAGTG AGGCTTGGA >RXA00934-downstream TGACCCTTGTTTACCTCCTCATC >RXA00939 GGTGTCCTGCTCGGTGGAGTGACCATGTCGATTGGCATGCTCGTGCACGAGGCCTCCGTC CTGGTGGTCATCGCGATTGCGATGCTCCTGCTGCGCCCGACCCTGAAGGAAGACAAGGAC AAGGCAGACGTCAGTACTGCTGACGGCGCGAAGGAGAGGCTGAGCGCC >RXA00939-downstream TAACGACACAATCGCCACAGCCA >RXA00942-upstream CATTGACCGGCAGCTGGTCTGATTGACTGCACATCGTACATTGGACGGTGGACACGTTTC AGAGTCCGCTGGATTTCATCACATCGGAAGGAAGAGAATT >RXA00942 TTGAGTACCAAAAATTACCACGTCGAGGGTTTGACCTGCGCAAACGGTGTAGCTTCCGTA GAGGATGAAATCGGCATTGTTGCGGGCACCCAGGGTGTGGATATTGATATTGAGACCGGC CGCGTCACGGTGACTGGTGAAGGTTTCACTGACGAGGAAATCATTGAGGCTGTCGCGAAC GCGGGCTACAAAGTTTCTGGGCGG >RXA00942-downstream TAGCACAATTACACATTCATCTC >RXA00950-upstream TCTCCGTACGCCCCACGAAGACACCTCGAAGTTCCCACGCGAAATGTTTCACGTGAAACA TCTGCTGATTTTTGTCTCCAAGTGGAGTTGAATGAGAGTT >RXA00950 ATGAACACTCCGGCAGTTCAGGTTCAAAATCTAAGTTTGAGTTTTGGGTCGTTCACAGCT GTCAACGGCCTGAGCCTCACGGTGGAGCAGGGGAGCATTCACGGCTTCCTCGGCCCCAAC GGTGCAGGAAAGTCAACAACCATCAGGGCACTCATTGGAGTGCTAAAACCCCAAACAGGT TCAGTCGCTATTCTCGGCCAAGATCCTGTTGCTCACCCCGATGTCCTTCGAAGAGTTGGC TACGTTCCAGGAGATGCCACACTGTGGGACAACCTCACTGGGGCGGAAGTTTTCAGGGCG CTCGAATCACTCCGCAAGACTCCATCCAACCGAGCTCTAGAAAACGAGCTCATTGACGCC TTCCAATTGGATCCCTCGAAGAAGATCCGCGAATACTCGACAGGTAACAGAAGGAAAGTC AGTCTCATCGCGGCGCTCAGTCATGAGCCCGAGCTCCTCATCGTTGACGAGCCCACCGCA GGCTTGGATCCCATCATGGAGCAAGTCTTTGTCACCTATGTCCGCAAGGCACGAACCAAC GGCGCGTCCGTGTTACTCAGCAGCCACATTCTCAGTGAGGTGGAGCAGCTGTGTGATTAC GTCACGGTCCTTAAAGAGGGGCGAGCAGTTGCATCTAATGAGGTGAGCTATCTGAGGAAG ATCTCCGCTCACCGCATTACTGCCACGATTCCGGCGGTACCTCAACACCTTGCTGGCAGG GGAGAAGTGGATTTCGATGCTGGCCATCTCAGCATCACCTGCGATGCCTCCGAGGTTCCC GATATTTTGCGCATCATCATCGACGCTGGCGGCCAGGACATCATCAGCACCGCGGCGTCG CTGGAGGAGATCTTCTTGCGTCACTATGGAGAAACGGTGAGTGGTTCAGAAAGCAAGGCA TCACAA >RXA00950-downstream TGATCCGTCTTAATCTACGTCTT >RXA00960 CTGAAAAACGATGTTGATGTCAACGTCGCAGGCTTTGTTGTCCCACTGTGCGCCACCATC CACCTAGCTGGATCGATGATGAAGATCGGCCTCTTCACCTTCGCTGTTGTCTTCATGTAC GACATGGAAGTAGGCGTCGGCCTCTCCATCGGATTCCTCCTCATGCTGGGCATCACCATG ATCGCCGCACCAGGCGTTCCCGGCGGAGCCATCATGGCAGCAACCGGCATGCTGGCCTCC ATGCTCGGATTCAACACCGAACAAGTCGCCCTCATGATCGCCGCTTACATCGCGATTGAC TCCTTCGGCACCGCAGCAAACGTCACCGGCGACGGCGCAATCGCAGTCATCGTGAACAAA TTCGCCAAGGGCCAGCTGCACACCACTTCCCCAGATGAAATCGAAGAAGACGACCGCGTT GCCTTCGACATCACTCCATCGGATGTGGAACATCACAAG >RXA00960-downstream TAGAAACCCGCATTTTCTGTAGT >RXA00980-upstream GTTGATGGACAGGCAGGTTGCTGTTGGATCTGCTGAGTTACTTGATCATGAACCAGACTC GACCAGGATGCTGGAGCTAAATGCCGAAGGAAAGACGGCG >RXA00980 ATGTTTGTCGGAGTGAACGGACACGCCATTGGAATCGTGGCCGTCGCCGACGCCGTTCGT TCAGATTCTGCCTCAGCAATCGAATCGGTGCATAAGGCGGGCATTCAAGTTGTCATGGCG ACTGGCGACGCTCACCGCGTTGCACAAAACGTGGCCTCCAAGCTGGGAGTGGATGAAGTC TACTCAGAGCTACTCCCTGAACAGAAATTAGAACTGGTGCGTGATCTGCAAGCTGGCGGC AAAACGGTCGCGATGGTGGGTGACGGAGTCAACGACACCCCAGCATTGGCAGCTGCTGAT ATCGGAGTAGCGATGGGGGTGGCAGGTTCCCCTGCAGCGATTGAAACCGCTGATATCGCA CTCATGGCGGATCGTCTCCGACGGCTGGCACATGCAGTGACCTTGGCAAAACGCACCGTA AGAACCATGCGCATCAATATTCTGATTGCGTTGGCTACCGTGATGGTGTTACTAGCTGGC GTCCTATTTGGCGGAGTTACCATGTCGGTTGGCATGCTCGTTCACGAAGCAAGCGTGCTG CTTGTTATCAGCATCGCCATGCTGTTGCTGCGTCCAACACTTAAAGAAGATGCTGCGGAA GCAAGTGATATTAAACGCTCGGAAATACAACAGATCGCA >RXA00980-downstream TAACCAATGGCTGGGTACTGATG >RXA01000 ATGTTGGCTGCCCGCGGGGTGGGACCTTATTGGCTGCGTACCGTTTTACGGTTCGTGTTC GCGGTGATTCGTGCGTTCCCCGAAGTGGTTATCGCAATTATTTTGCTAACTGTCACCGGC CTAACTCCTTTTACTGGTGCGCTCGCATTGGGTATCTCCGGTATTGGACAACAGGCAAAG TGGACCTATGAAGCCATTGAGTCCACTCCCACCGGCCCGTCAGAGGCAGTGCGTGCAGCG GGTGGAACTACGCCGGAGGTTCTGCGGTGGGCGTTGTGGCCACAGGTTGCGCCATCCATT GCATCTTTTGCCCTGTACCGCTTTGAGATCAACATCCGTACCTCTGCGGTATTGGGGATC GTTGGTGCAGGTGGTATCGGTAGTATGCTTGCCAATTACACCAACTACAGGCAGTGGGAC ACCGTGGGCATGCTGCTCATCGTCGTGGTTGTCGCAACGATGATCGTCGATCTCATCTCC GGCACCATCCGCCGCCGCATCATGAAGGGGGCTAGTGACCGTGTCGTGGCACCAAGCAAC >RXA01000-downstream TGACGCTCCACCAAGCATCCGCA >RXA01002 CCCACGGAGCACGACAAGCAGATTGCTTTTCACGCGTTGGAGTCCGTGGGCATTTTGGAC AAAGTGTGGACCCGAGCTGGTGCTTTGTCGGGTGGACAGAAACAGCGCGTTGCTATTGCG CGCGCCTTATCGCAAGATCCGTCTGTCATGCTGGCAGATGAGCCTGTGGCAAGCCTTGAT CCGCGAACCGCGCATTCCGTGATGCGCGATCTAGAAAACATCAACAACGTGGAAGGCCTC ACCGTGTTGGTGAACTTGCACTTGATTGATTTGGCTCGTCAATACACCACAAGGCTTGTG GGTTTGCGTGCCGGCAAGCTGGTCTATGACGGTCCTATCTCTGAGGCCACCGATAAAGAC TTTGAAGCTATCTATGGTCGCCCCATCCAGGCTAAAGACCTGCTAGGTGATCGCGCA >RXA01002-downstream TGACCACGCCTTCTTCTACACTT >RXA01003-upstream AGCTGGTCTATGACGGTCCTATCTCTGAGGCCACCGATAAAGACTTTGAAGCTATCTATG GTCGCCCCATCCAGGCTAAAGACCTGCTAGGTGATCGCGC >RXA01003 ATGACCACGCCTTCTTCTACACTTATCCCACAAAAGCCTCGGGCTGGGGTAAAGACCTAT CTCATCATCGGCGCCATCGTTGTCTTCACCGTGGCAACAGCAACCCCAGCGCTAGGTGGC ATTGAGCTTGATTTCGCTTCCATTGCTGCGAATTGGCGCAATGGTGCCAACAAACTCCTG CAAATGCTGCAGCCCAACTTTGCGTTCTTGCCTCGTACGTGGCTTCCCATGTTGGAAACC CTGCAGATGGCGCTTGTTGGAGCTGTCTTGTCTGCTGCCGTATCGGTGCCTTTGACGTTG TGGGCAGCGCAGGCAACCAACACCAGTGCGATTGGTCGTGGCATTGTCCGCACCATCATT AACGTGGTGCGCTCTGTCCCCGACTTGGTGTATGCCACCATCTTGGTCGCCATGGTTGGT GTCGGCGCATTACCTGGCATTTTGACGCTGTTTCTGTTCAACCTGGGCATCGTGGTCAAG CTTGTCTCTGAGGCCATTGATTCCACTGAGCATCCCTATATGGAAGCAGGACGCGCAGCA GGTGGATGACAGTTCCAAATCAACCGAGTGTCCGCGCTTCCTGAAGTCATGCCGCTCTTT GCCAACGAATGGCTCTACACCCTAGAGCTGAATGTACGCATCTCCGCCATCCTTGGCATC GTGGGCGCAGGTGGCATCGGCAGGCTGCTTGATGAACGCCGAGCTTTCTATGCCTACGCG GATGTTTCCGTGATCATTCTGGAAATCCTCATCGTGGTGATTGTCATTGAAGTAATCTCC AACGCACTTCGAAAGAGGCTGGTA >RXA01003-downstream TGAGCACCTTAACCTCTCACCGC >RXA01006-upstream GCCTTACGTGAAGGGCTTTAGCCCCGAAGTGATCGGCCGCCCCAGCTTCTATGAGACCTA CATTGACCATTCCAGCGACCATTCCAGTGAGGAGGACTAA >RXA01006 ATGACTACCTCGCAGATTCTGCGCCGCATCGGCCAAGCCGTCTTGGTCTTGTTGGTCACC TTTACCTTGGCGTTCATCATGCTTTCCGCCCTCCCTGGCGATGCTGTGTCCGCCCGCTAT TCCAGCCCTGATTTGGGTCTGTCACCTGAGCAGATCGCACAGATCCGTGAATCCTATGGT GGCGATGAATCCCTGATCGCTCAGTACTTCTCCACCTTGGGTGGCTTCCTTGTAGGTAAC TTCGGTTACTCCGTACAAACCGGAACTGCCGTGGCAACCCAGCTGGCAGAAGCCCTACCA GGCACCTTGACCTTGGCTATTTTGGCATTCTTGCTCGCAGCCATTTTGGCACTGGTTATT TCCATTCTTGCCACCATGGATCGCTTTGCATGGATCAAGGCCATCTTCCAGGCTCTGCCT CCATTCTTTGTGTCCCTTCCAAGTTTCTGGTTGGGCATCATCTTGATCCAGATCGTGTCC TTCCGCCTTGGTTGGGTCCCCGTTATTGGGACCACCCCGGCACAAGGACTGATCCTGCCG ACCATCACCTTGTCCATCCCAATTACCGCTCCGCTTGCACAGGTGCTCATCCGCTCGATT GAAGAGGTCAAGGCACAACCGTTCATCGCGGCTGTTCGTGCTCGCGGTGCGGGTGAAATG TGGATCTTCTTCCGCAACATCATTCGCAACGCCCTTTTGCCAACCCTGACGATTGCCGGC ATCTTGTTTGGTGAACTAGTCGGTGGGGCCGTGGTCACCGAGGCAGTGTTCGGCCGCGCT GGACTTGGCCAAATGACCGTCAACGCAGTGGCCAAGCGCGATATGCCAGTGATGCTTGCC ATCGTGGTGATCGCAGCT >RXA01012-upstream GACCTCATGGTGGCTGACTGTGCTGCCTGGTTTTGTCATCATCGCCGTGGTTATGTCTGC CAACTACCTAAGCCGCATCATTCAGAAGGAGGCATAGAAA >RXA01012 ATGACTACTCCCTTGTTAGAGATCAACGATCTGGTTGTCTCCTATCAAACTGCTAAAGGT TTGGTGCATGCTGTCAACAATGTCAGCCTGGAGGTGCACCCTGGCCAAATCACCGCGATT GTTGGTGAGTCCGGTTCTGGTAAGTCCACCACCGCTCAGGCCGTGATTGGTTTGCTGGCT GATAATGCTGAAGTGGATTCTGGTCGGATTTCTTTCAACGGCCGTTCCCTTGTTGGCTTG AACGCACGTGAGTGGAAAAACGTTCGCGGTACCAAAATTGGTTTGATTCCGCAGGACCCC AACAACTCTCTGAACCCGGTGAAAAGTATCGGCGCTTCAGTGGGGGAGGGCTTGGCTATC CACAAGCGTGGAACGGCCGCCGAGCGCAAAAAGAAGGTCATTGAGCTTCTAGAGCGCGTG GGTATTGATAACCCAGAGGTCCGCTATGAGCAGTACCCGCATGAGCTGTCTGGTGGCATG AAGCAGCGCGCGTTGATTGCCGCTGCCATTGCACTTGAACCAGAGCTGATCATTGCCGAT GAGCCCACATGTGCGCTGGATGTGACCGTGCAGAAAATTATTCTCGATCTGCTGGAAGAC ATGCAGCGTGAATTGGGGATGGGTATTTTGTTCATTACTCACGATCTAGCCGTGGCAGGC GATCGGGCGGATCGCATCGTCGTCATGCAAAAAGGCGAGGTGCGCGAAAGTGGTTACGCG GCTTCGGTCTTGACCGACCCCCAGCATGAGTATTCCAAGAAGTTGCTTGCCGACGCGCCC TCCCTCACCATCGGCGAGATCCCCACGCGAGTTCCGGCCGTAGATCCGGAGGTAGCGCAG GCCAAAGGCCCGCTTCTGGTAGTGGATAAATTCCGCAAGGAACACCAACGAGGCAAAGAA GGAGCATTTGTTGCCGCAAATGATATTTCCTTCGAAGTACTGCCTGGCACCACGCATGCC ATCGTCGGTGAATCCGGTTCTGGTAAAACCACGCTTGGCCGCGCGATCGCGATGTTTAAT ACGCCGACCTCTGGTTCCATTTCAGTAAGTGGCAAGGACATCACCAACCTGTCCAAGGCC CAGCAGCGGGAACTGCGCCAGCAAATCCAGCTGGTGTACCAAAACCCGTATTCTTCCCTG GATCCTCGCCAAACCATTGGCTCCACCATCGCGGAACCTCTGCGCAATTTCACCAAGGTG AGCAAGCAGGAAGCCGACGAAAAGGTGGCACACTACCTGGAACTGGTGGCGCTTGACCCG GCTCTTGCCACCCGTCGCCCACGTGAGCTCTCTGGTGGTCAGCGCCAGCGCGTCGCCATT GCTCGTGCCATGATTTTGGAACCTGAATTGGTGGTTTTCGACGAAGCCGTATCCGCGTTG GATGTGACTGTGCAGGCACAAATCCTGCGCCTGCTCGACGATCTGCAACGAGAGCTAGGC TTGACTTACGTGTTTATTTCCCACGACCTGGCTGTGGTCCGTGAAATCTCTGACACTGTG TCTGTGATGAGTCGCGGCAACCAGGTGGAACTTGGAAAAACCGGAGAAGTATTTAACAAC CCGCAAAGCGATTTCACTCGCCGACTCATCGACGCGATCCCAGGATCGCGCTATCGTGGT GGCGAACTCAATCTTGGACTA >RXA01012-downstream TAGGAGCAGATCTTAAAAATGTC >RXA01013 TTGGGCAATCCTTGGACGAGGCCTGCTGCTGTTATTTCCATCGTGGTACTCGCCGTTGCG GTGCTGATGGCACTTGTTCCTGGACTGTTTACCTGCCAGGATCCGTTCACTGGCGATGAT GTGGCGCTGCTTGGGCCAAGTGGCACCCACTGGTTTGGTACCGATTCCGTGGGACGCGAT CTCTACAGTCGTGTTGTTTACGGCGCGAGGGAAACCCTGCTCGGTGCACTGATCGCAGTG CTGGTTGGTCTGATCGTGGGAACCCTGATCGGACTGCTCGCAGGTGCACAGCGCGGTTGG GTTGACACTGTATTAATGCGTTTCGTGGATGTGCTGTTGTCCATCCCGGGACTGCTGCTC AGCTTGACTGTCATTATCCTTTTGGGATTCGGCACCATGAACGCAGCGATCGCAGTCGGT ATTACCTCTGTTGCCACCTTCGCGCGTCTGGCGCGTTCCCAGGTGATGACTGTTGCAGGT TCGGATTTCGTGGAAGCTGCATACGGTTCCGGTGGCACCCAGGCGCAGGTGTTGTTCCGC CACATTCTGCCTAACTCTCTGACCCCAGTGTTTGCTCTTGCAGCACTGCAGTTCGGTTCC GCGATTTTGCAGCTGTCCGTGTTGGGCTTCTTGGGCTACGGCGCTCCGGCACCAACAGCA GAGTGGGGTCTGCTGATCTCTGATGCCCGCGACTACATGGCGACCTCATGGTGGCTGACT GTGCTGCGTGGTTTTGTCATCATCGCGGTGGTTATGTCTGCCAACTACCTAAGCCGCATC ATTCAGAAGGAGGCA >RXA01013-downstream TAGAAAATGACTACTCCCTTGTT >RXA01070-upstream CAGCTTCGGTTAATTTGGTCACACTAATGCAATAAATTCCTGTCTACAGCGTTACAGTTA ATGAATTCAATTCAACCGCTAAACGCAAGGAGTGCTACCC >RXA01070 ATGGCTAACGCCACCGCACAGAAGGGCCGTTTCGGCCTTCCCGGCTGGATGACTGGCTTT GGTGCCCAGGTTATCGCCGGCCTCATTCTTGGTCTTATTCTCGGCCTTGTCGCCGGAGGC ATGGACAGCGGCGCTGCAGACGGTGAAGCAAGCTGGCTTACCGGTCTTCTTAGCGGCGTC GGTTGTGCTTATGTTTCTCTACTTAAAGTTATGGTTCCACCACTGGTGTTCGCTGCAGTG GTTACCAGTGTGGCAAAGTTGCGCGAGGTAGCTAACGCTGCTCGCCTGGGTGTTTCCACC TTGGTGTGGTTCGCCATTACTGCATTCTTCTCTGTGCTCGCGGGTATCGCCGTAGCGCTG ATTATGCAGCCTGGTGTTGGATCCACTGTCGACGCATCTAATGCTGCTGATCCTTCTCGC GTGGGCAGCTGGCTGGGCTTTATCCAGTCCGTTATTCCATCAAACATTCTGGGACTTTCC GGTTCTTACAGTGAGAACTCTGGTGTGAACCTGTCCTTCAACGTGCTGCAGATCCTGGTT ATCTCCATTGCGATTGGTGTTGCAGCTCTGAAGGCTGGCAAGTCCGCCGAGCCTTTCTTG AAGTTCACCGAGTCCTTCCTCAAGATCATCCAGATCGTGTTGTGGTGGATTATTCGCCTG GCTCCAATTGGTTCCGCTGCGCTGATCGGTAATGCTGTTGGTACCTACGGTTGGTCTGCA CTTGGATCCCTGGGCAAGTTTGTTCTTGCGATCTACGTTGGTCTGGCAATCGTCATGTTC GTTATCTACCCAGTGGTGCTGAAGCTCAATGGAATTCCTGTTCTTGGATTCTTGAAGCGC GTTTGGCCTGTCAGAAGCCTTGGCTTTGTTACCCGTTCCTCCATGGGCGTTATGCCAGTT ACCCAGCGCGTTACTGAGCAGTCCTTGGGTGTTCCATCTGCGTACGCTTCCTTTGCTATC CCACTGGGTGCGACCAGCAAGATGGACGGCTGCGCTGCTGTCTACCCAGCTGTTGCCGCT ATCTTCGTGGCACAGTTCTACGGCATTGACTTGAGCATCATGGATTACGTACTGATCATG ATCGTCTCTGTCCTGGGCTCTGCTGCAACTGCAGGCACCACTGGCGCAACCGTCATGCTG ACCCTGAGCCTATCCACCTTGGGTGTGCCACTTGCTGGTGTTGGTCTGCTGCTGGCTATC GAGCCAATCATCGACATGGGACGTACCGCAACCAACGTCACCGGTCAGGCACTGGTTCCT GCGATCGTTGCTAAGCGCGAGGGCATTCTGGATCAGGATGTGTGGGATGCTGCTGAAAAG GGTGGCGCTGCTATTGAAATGGCAACCGTCTCTGAGAAAGAAACTGAGCCTGCAGAGGTT CGCTCC >RXA01070-downstream TAAGCTCTCTTGAGTACCTGAGA >RXA01094-upstream GTCAGCTGACCGGGGTAGCGGGCGGTGGGCGGACAAGTCTTGCTAGATTGAAGTGCATTA CTTGTGGCCTGACTGTTAGGTTTACGTTGTTGTGGATGTC >RXA01094 ATGACTTTGGCGACGATTCCCTCACCACCGCAGGGTGTGTGGTACTTGGGTCCCATTCCG ATTAGGGCCTATGCGATGTGCATGATCGCTGGCATTATTGTTGCCATTTGGCTGACGAGA AAGCGCTACGCCGCCCGCGGTGGAAACGCTGAAATCGTCGTTGATGCAGCGATCGTGGCA GTTCCTGCCGGAATCATCGGTGGACGCATTTATCACGTCATTACCGACAACCAAAAGTAC TTCTGGGATACCTGTAACCCCGTCGACGCCTTCAAAATCACGAACGGTGGTCTGGGCATC TGGGGTGCAGTGATCCTCGGTGGCCTGGCAGTGGCCGTATTCTTCCGGTACAAAAAGCTT GCTCTTGCACCTTTCGCAGATGCCGTGGCACCTGCAGTTATCCTGGCGCAGGGAATTGGT GGTCTGGGCAACTGGTTTAACCAGGAGCTCTACGGTGCAGAAACTACCGTTCCATGGGCT TTGGAAATCTACTATCGGGTAGATGAAAATGGAAAATTCGCACCGGTGACAGGAAGATCC ACCGGTGAAGTAATGGCTACTGTTCATCCAACATTCCTCTATGAAGTGTTGTGGAACCTA CTGATCTTCGCTTTGTTGATGTGGGCTGACAAGCGATTCAAGCTGGAACATGGCCGAGTA TTTGCTCTCTACGTAGCTGGTTACACCTTGGGCGGTTTCTGGATTGAACAAATGCGCGTT GATGAAGCCACGCTTATTGGCGGCATCCGAATGAACACGATCGTCTCCGCAGTAGTGTTT GCCGGCGCGATCATCGTGTTGTTCCTGTTGAAGAAGGGTAGGGAAACTCCCGAAGAGGTA GATCCGACTTTCGCAGCGTCTGTTGCAGCAGATGCTGTAGCTTCGCCAGATAGAAAACCC TTGCCGAAAGCAGGGGAGGGCATTGATGGAGAAAGGCCCTCAACGCGA >RXA01094-downstream TAGGTTTCAACCATAGGCCTGAC >RXA01135-upstream CATTTACTAATCTCACAAGACATCGCCTAATGAATACAGACTAGCCTATTCAAATTCAAA GAACACTCGGTATGGCACGTGATTTAAGGATGCTGCAATC >RXA01135 GTGACACATATCCTCTTCGACAGCAGGCGTTTTCTGCAACTGGGCGCTTTTGCGTCCTTG AGCACCGCATTGGCCGGAGCGGCCCGCTACGTGACGTCGACAAGCAATAATGAACCTGCG GATAACACTCCCCTGACCATTGGCTACGTGCCTATTGCGGGCTCGGCGCCGATTGCTATC GCAGATGCGCTAGGGCTGTTTAAGAAACACGGCGTGAATGTCACGTTGAAGAAGTACTCA GGCTGGTCCGACCTGTGGACCGCCTATGCAACAGAGCAGCTTGATGTTGCGCAGATGCTG TCGCCGATGACTGTGGCGATTAAT >RXA01141 GTCAATTCAGCGGCGGATCTTAAAGGCATGGTGCTGGGAATTCCTTTTGAATATTCAGTC CATGCGCTGCTCCTGCGCGATTATCTCGTCTCAAACGCAGTTGATCCCATCGCCGATCTT GAGCTTCGCCTGGTCCGACCTGCCGATATGGTCGCACAATTGACAGTTGAGGGCATCGAT GGATTCATTGGGCCTGGGCCGTTTAATGAACGCGCGATCAGCAATGGCTCCGGCCGGATT TGGGTGCTGACCAAACAAGTGTGGGACAAACATCCATGCTGCGCCGTGGCGATGGCCAAA GAGTGGAAAGCTGAACACCCCACGGCGGCTCAGGGTGTGCTTAATGCGCTGGAGGAAGCC TCCGCAATTTTGAGCAATCCGGCACAATTTGATTGCTCGGCACGCACGCTGTCGCAGGAA AAATACCTCAACCAGCCTGCCACGTTGCTGGATGGACCGTCG >RXA01141-downstream TAATCATCGGCATCACCGGCTTA >RXA01142 ACCCGCACCCACCTCGAACAAGTAGGCCTCACCGACGCCGCCGAACGGCGCCCCGCCCGC CTCTCCGGCGGCATGCAACAGCGAGTCGGCATCGCACGCGCCTTCGCCATCGACCCACCA ATGATGCTTCTCGACGAACCCTTCGGAGCCCTCGACGCCCTCACCCGCCGCGAACTCCAG CTCCAACTACTCAACATTTGGGAAGCCTCCCGCCGCACCGTCGTCATGGTCACCCACGAC GTCGACGAGGCCATCCTGCTCTCCGACCGAGTTCTCGTGATGTCCAAGAGCCCCGAAGCC ACCATCATCACCGATATTCCAGTGAATCTTCCCCGCCCCAGACACGAGCTGAGTGAAGAC GCTTCTGTTGAAGCCGAGACCACAGCCCTGCGTAAGCGGATGCTGCATCTGCTGGAGCAC >RXA01142-downstream TAGTTTCTAACACGTCTTTTAAA >RXA01164-upstream GCCGATCGTGATTGATGAAGACGAGATCCAAGCGTGGACTTCTGATGTCAAACCTGAAGA TTTCACCAAAGGTAAAGATGAATCCGACGGTGAGAAATAA >RXA01164 GTGACAGTGTTTGTTCGGCTCGCCCTTGCTGCTGTGGGCGGGCTTTTTGTCTTTGGTTGC AATGAACCGATCGGCTGGTTTGTCGGGGGAATTGTTGGCACTGCATTATTTTTTATCTCC CTTGCGCCGTGGGATCTGGGAGTTCGCCAAAAGCGGCGGAAGAAGAATGAGCCAGTGCCA TTTTTGCAACAGATGTCCACGGGCCGAACTGTTGTACAGGGCATGCTTTTAGGTTTTGTC GATGGCCTGGTGACATATTTGCAGCTGTTGCCGTGGATCGGTGAGTTTGTTGGCTCACTG CCTTATGTCGCGTTGTCAGTTGTCGAGGCGCTTTATTCCATTGCTCTTGGTGCTTTCGGC GTGCTCATTGCGGGTTGGAGGGACTGGAAGGTTCTGCTGTTTCCGGCGATGTATGTGGCT GTGGAGTATCTAACAAGCTCGTGGCCATTTGATGGATTCGCGTGGGTTCGCCTGGCATGG GGTCAAATTAACGGTCCGTTGGCTAATCTCGGAGCGGTTGGTGGGGTAGGGTTTGTCACT TTTTCCACGGTGCTGGCTGCCGTGGGTGTGGCGATGGTGATTATTTCCAAGAAGCGACTG GCCGGCGCAATCATCACCGCGAGTGTGATTGCTATCGGCGGGGTGTCATCCCTGTACGTT GACCGCAATGGCACGAGCGATGAAAGCATGGAAGTAGCCGCAATTCAGGGCAATGTGCCT GGGATGGGATTGGACTTCAATGCACAGCGCCGCGCGGTGCTGGCGAATCACGCACGGGAA ACCCTGAAGCTGGATGAACAAGTGGATTTGGTGATCTGGCCGGAGAATTCCTCAGACGTC AACCCATTTTCCGATGCACAAGCAAGAGCCATTATCGATGGAGCAGTGGAAGATGTTCAG GCACCTATTTTGGTGGGGACGATCACCGTCGATGAGGTTGGTCCACGCAACACCATGCAG GTATTTGATCCTGTTGAAGGTGCGGCGGAGTACCACAATAAGAAGTTCTTGCAGCCGTTT GGTGAATACATGCGGTTTCGCGAATTCCTGAGAATTTTCTGGCCCTACGTTGATTCCGCT GGAAACTTCCAGCGCGGTGATGGCACCGGCGTAGTGGAGATGAATGCTGCGAACTTAGGG CGCGCTGTGACAGTGGGCGTGATGACGTGTTACGAGGTCATCTTCGACCGTGCTGGCCGC GACGCCATCGCCAATGGGGCTGAATTTTTGACCACGCCCACGAACAACGCCACCTTCGGA TTCACGGACATGACGTATCAGCAATTAGCAATGAGCAGGATGCGTGCCATCGAATTTGAT AGGGCGGTGGTTGTTGCAGCTACATCGGGTGTTTCGGCTATCGTCAACCCTGATGGAAGC ATTTCCCAAAACACCGGAATTTTTGAGGCCGCCACCTTGACGGAATCCATTCCACTCAAG GACACTGTCACCATCGCAGCGCGGGTTGGTTTCTATGTTGAATTACTGTTGGTTATCATT GGTGTATTAGCTGGACTATTCGCCATTCGAATGAATAGCCGTTCAAAGTCTGCGAAAGGT TCCGCTCGGCCCGCA >RXA01168 CGCACCGCAACCCCTGACGTTCACGTACTCATCGTGGACGACAACAGCCCAGACGGCACC GGCGAGCGCGCAGACAAGCTTGCTGCTGACGACGACCACATTTTTGTCCTCCACCGCGAA GGCAAAGGCGGCCTGTGCGCAGAGTACATGGCTGGCTTCCAGTGGGGCCTGGAGCGCGAC TACCAGGTCCTGTGCGAAATGGACGCCGACGGCTCCCACGCACCAGAACAGCTGCACCTG CTGCTCGCTGAGATCACCAATGGCGCTGACCTGGTCATCGGCTCGCGCTACGTGCCAGGC GGCCGCGTAGTCAACTGGCCCAAGAACCGTTGGCTCTTGTCCAAGGGCGGCAACGTCTAC ATCAGCGTCGCGCTCGGCGCCGGCTTGACCGATATGACCGCAGGGTACCGCGCTTTTCGA GGTGAAGTGCTAGAAGCAGTGCCGCTTGATGAGCTCTCCAACGCTGGGTACATTTTCCAA GTTGAGATTGCCTACCGTGGAGTTGAAGCCGGATTCGATGTTCGTGAAGTTCCCATCACT TTCACCGAGCGTGAGATCGGCGAATCCAAGCTGGACGGCAGCTTTGTCAAGGATTCCGTG CTCGAGGTAACCAAGTGGGGCGTCAAGCACCGCGGTGGCCAGGCCAAGGAACTGTCCAAG GAAATGGTCGGGCTGCTGAACTATGAGTGGAAGCACTTCAAAAAGCGGAACACCTGGCTC >RXA01168-downstream TAAACTGCTTGCCGGTTAGTGAA >RXA01185-upstream TCAGCTGGTAGCGTCGCATGTATTATTGGTGCTTTTCACTAATAGCAATGCACTAACGCA CATAGCCGCCGACACGTGAATCGAAAGAAGTTCATCTCCG >RXA01185 ATGACTGATCCTGAAAACTCGCAAGGAACCCCACAGATTTGTCCGACTGATCCGACTACG CAAGCATTAGGAGTTCGGGGCTTAACCAAGTCCTATGGTGATGCAACAGTAGTGAACAAT ATCAATCTGGACATCCCCAAAGGAGCCATTTACGGCATCGTTGGACCTAATGGTGCAGGT AAAACCAGGATGCTGTCCATGGCAACGGGTTTACTGAGGCCGAATAAAGGCAGCGCGTGG ATTTCGGGTTTCAATGTGTGGGAAGAGCCAAACGATGCAAAACGAAGCATGGGATTGTTG GCAGATGGCTTGCCCATCTTTGATCGCTTGACTGGCAAAGAACTGCTCACATATGTCGGG GCATTGCGTGAGTTGGATGAAGGCATTGTTGATCAACGTAGTGAGGAATTGCTGGAGGCG CTCGGGCTTAAAGAAGCAGCGGGCAAGAGAGTCGTCGACTATTGCGCCGGCATGACGAAG AAGATTCTTTTGGCCCAGGCCGTCATTCACAATCCGAAAGTGCTCATCCTTGATGAACCT TTGGAAGCGGTTGATCCGGTGTCTGGTCGTTTGATTCAGCAGATTTTGAAGAAGTTTGGG CAAACGGGTGGAACCGTCGTTTTGAGTTCGCATGTGATGGAATTGGTTGAGGGGTTGTGG GATCACGTTGCCATCATCAACAGGGGAGTGGTGGAGATTGCCGGACATGTGAATGAGGTT CGTCGGGGCAGATCTTACCGGATGTCTTCGTTAATGCGGTTGAAGGCGCTGCTGTTCAAG AGGGGTCACTATCTTGGTTGGGTGCGTCCGAAGGCCATAGCGAAGGCCAAAATCAGAACG AGGATCGGGCTGAGTAAA >RXA01185-downstream TGACTAAAACACTTCTGAAACTA >RXA01188-upstream AAACAGTTAGAAGCAGCTAAACAGTTTTTCCGATAACTGTTGTCATTTTGTGACCGCCTG GCTTTGTAGTTTTCGCTCCGGTGTCCAAGATGAATATGAC >RXA01188 ATGATGAATGGCGTGGTAGAGCCTCAGGAACATCTCGATGCAACGTTGATTGCTGCAGAC TTCCACGGCAACCCCGAAAACTCTGGTGACCGCAAAGAGCGCCTGAATTTTCAAGGTTGG AAGTATGCCCTTAATCGCACGGTCAGGGATGTTTTTCCAGATGGCCTGCTCGATTTGGCG GCCTTGTTGACGTTCTTTTCCATTCTGTCGATCGCCCCTGCAGTGCTGCTGGGCTATTGG GTGATCACGATTTTTCTGGCCAGTGACTCCACCGAAATCCTCAACCTTGTCCGCGATGAG GTAAATCAGTACGTTCCGGAAGATCAATGGCATGTTGTCAACGGCGTGATTGATTCGATC GCAGGCTCGGCAGCTGCAGGTCAGGTCGGTGTCGCGGTCGGTGTGATCACGGCATTGTGG ACATCTTCGGCATATGTGCGCGCTTTTTCCAGATGTGCCAACGCTGTTTATGGCCGAAGC GAAGGCCGCACATTGATCAAACGCTGGGCAATGCTGCTTTTCCTCAACCTTGCTTTGGTG CTTGGAATCATCATCATTTTGGTCTCCTGGGTGCTCAACGAGACCTTGGTGATGGGAATT TTCGCCCGCATCGCGGAACCACTTCATCTCACGAATGTGCTCAGCTTCCTCACGGACCGG TTCATGCCGATCTGGATCTGGGTGCGGTTCCGAGTGATTGTGGGGGTGCTCATCATGTTC GTGGCCACGCTGTATTACTGGGCCCCGAACGCCCGCCCGTGGAAGTTTCGCTGGCTCAGC CTCGGATCATTCTTGGCGATCGTTGGCATCCTGCTCGCAGGCGTGGGCTTGAATTTCTAC TTCACGCTGTTCGCCGCTTTTAGTTCCTACGGCGCGGTGGGTTCGCTGCTCGCGGTTTTT ATTGCGCTGTGGGTGTTCAACATTTGCTTAATCATCGGCCTGAAAATCGACGTGGAGATC AGCCGCGCCAAGCAACTGCAGGCAGGAATGCCGGCGGAGGATTACAGTTTAGTGCCACCA CGCTCTATCGAGAAGGTGGCGAAAATGAAGCAGCGCCAGCAGCGCTTGATGGATCAGGCT GCGGCGATCCGGGAGGAAAGCAAT >RXA01188-downstream TAAAAAATTGCTTATCGACGTCC >RXA01245 GCCTCCTGGGTCACCACGCTGGGGCTGGGCGGGTTCCACCTAGATTTCTGGTGGGAACTG GCCCTGCTGGTGACGATAATGCTGTTGGGCCACTGGCTGGAGATGCGCGCTCTTGGTGCA GCCTCCTCCGCGCTTGAGGCGCTGGCAGCGCTCCTGCCCGATGAGGCCGAGAAGGTCGTG GACGGGACCACCCGCACCGTAGCGATCTCAGAGCTGGGGGTCGACGATGTGGTGCTGGTG GGAGCAGGTGCCGGCGTCCCGGCCGACGGGACCATGATGGACGGAGCGGCCGAATTCGAT GAGGCCATGATCACCGGCGAATCCCGACCCGTCTACCGGGATACCGGTGAGACCGTGGTG GCCGGCACCGTGGGCACCGACAACACCGTCCGTATCCGGGTGGAGGCCACCGGTGGGGAC ACCGCCCTGGCAGGCATCCAGCGCATGGTCGCCGACGCCCAGGCCTCCTCCTCCCGGGCC CAGGCCCTGGCCGATCGAGCCGCAGCCTTACTGTTCTGGTTCGCCCTGATCACGGCCCTG ATCACCGCCGTGGTCTGGACCATCATCGGCAGCCCCGACGATGCCGTGGTCCGCGCGGTG ACCGTGCTGATCATCGCCTGCCCGCACGCCCTGGGCCTGGCCATCCCGCTGGTCATCGCG ATCTCCTCCGAGCGCGCCGCGAAATCCGGGGTGCTCATCAAGGACCGCATGGCACTCGAG CACATGCGCACCATCGACGTCGTCTTGTTCGATAAGACCGGCACCCTGACCGAAGGCGCA CACGCCGTCACCGGCGTGGCTCCGGCCACGGGTATCGCCGAGGGTGAGCTGCTGGCCCTG GCCGCCGCCGCTGAGGCCGATAGTGAGCACCCCGTGGCCCGCGCGATCGTGACTGCCGCG GCCGCACACCCGGAGGCCTCGCAGCGTCAGCTGCGCGCAACCGGTTTCACCGCCGCCTCC GGCCGCGGGATCCGGGCCACCGTGGACGGTGCCGAAATCCTCGTGGGCGGGCCGAACATG CTACGCGAGTTCAATCTGACCACCCCGGGTGAGCTCGCCGACATCACCGGTTCCTGGGCA GAGCGAGGTGCCGGAGTGGTACATGTCGTCCGCGACGGTGAGATCATCGGTGCGGTGGCA GTGGAGGACAAAATCCGCCCCGAATCCCGCGCGGCGGTACGCGCCCTGCAGGCCCGCGGG GTGAAGGTGGCGATGATCACCGGTGACGCCACCCAGGTCGCCCAGGCAGTGGGCAAGGAT CTGGGGATCGATGAGGTCTTCGCCGAGGTTCTGCCGCAGGACAAGGACACCAAGGTCACC CAGCTGCAGGAGCGCGGTCTGAGCGTGGCCATGGTCGGCGACGGTGTCAATGACGCCCCG GCCCTGGCCCGGGCCGAGGTCGGTATTGCGATTGGCGCGGGTACAGATGTGGCGATGGAG TCCGCCGGGGTGGTCCTGGCCAGTGATGATCCCCGGGCGGTGCTGTCGATGATCGAGCTC TCCCATGCCAGCTACCGGAAGATGGTCCAGAAGCTGGTCTGGGCGACCGGGTACAAGATC GTGGCCGTTCCGCTGGCGGCCGGTGTGCTCGGCCCTATCGGTGTGCTGCTTCCGCCGGCG GCGGCCGCCATCTTGATGTCCCTGTCCACGATCATGGTCGCCCTCAACGCCCAGGTGCTA CGCCGGATCGACCTGGACCCGGCTCACCTAGCTCCGACCGACGGGAAGGAGGAGAAGGCT GCTGTGAGCTCTGCAGCCCCCGTCCGC >RXA01245-downstream TGACTTTCAATGCTTCATGGACT >RXA01247-upstream TCCGATGACCACCCCGACTTCCCCCTTGCTGCCGCTGGCCTCCGACGGTTGTGGATGCTG CGCGCGCTCTACACCGTCCGCGAGCGTCTCCGCCTCGGCC >RXA01247 GTGGCCGCGGCAACCGACGCAACACCTGAAGGTCCCACCACCTACCAGGTCACAGGCATG ACCTGCGGACACTGCGGCGACAACGTCACCGAGGCGGTGAGCGCTCTGCCCCAGGTCGAC GACGTCCAGGTCGACCTCATCGCCGGTGGGGTCTCCATCGTCACGGTCACGGGTTCCGTG CCCCTGGAAACCGTCCACCGGGCAATTGAGGAGACCGGCTACACCGTCTTGTCC >RXA01247-downstream TGATCGATTCACCCATGATCTCG >RXA01285 CCACAGACCTCCATCGGCCCAGAAGGCATCCGGGTTTACGATCTCATGGCGCGCGGGCGC GCTCCCTACCAAAGCCTCATACAACAATGGCGCACCTCCGACGAAGAGGCCGTCGCGCAA GCGCTCGCCTCCACGAATCTCACCGAACTTGCAGCTCGCCTCGTCGATGAACTCTCCGGT GGCCAGCGCCAACGAGTGTGGGTGGCCATGTTGCTCGCCCAGCAAACACCGATCATGCTT CTCGACGAGCCCACCACGTTCCTCGACATCGCCCACCAATACGAACTCTTGGAATTGCTG CGCGCATTCAACGAGGCCGGGAAAACTGTGGTCACTGTGCTTCACGATCTCAACCAAGCC GCCCGCTACGCCGACCACCTCATCGTGATGAAAGATGGGCACGTACATGCCACGGGCACA CGGGAGGAAGTCTTAACTGCGGAGATGGTTCAAGGAGTTTTTGGCCTGCCCTGCATCATC TCCCCAGACCCCGTCACAGGAACCCCCACCGTCGTTCCCCTCAGTCGGTCTCGCGCAGGA GCT >RXA01285-downstream TAAGTAGGTACGCGTCCAACGGA >RXA01289-upstream CTCACCTAAGATGTTGTAAGCGTTTTAGTTTCAGCTAGTTTTAAGGAGTTTCGATGTCTG ATACTTTTCTTTCCCCCTCGATCTTTAGGAGTCACGCGAT >RXA01289 ATGACGGCGGTGGCGGTAGAGAAGCAGAAGGAGACGTCGATAAGCAAAAACCTCGGCAGG CGCCGAGCGCTGGGCATTCTCGGAATCGTCGTGGCACTGGGTGCGCTTATTGTTTTAAGT ATTGCTGTGGGTGCGAACCCACTTTCTTTTAGCTCCGTATGGCAGGGTTTTACCGCACAC GACAGCTCTGAGGCGTCGATTATCGTGTGGTCAATGCGTATTCCGCGCACGCTGGTGGGC ATCGTGACTGGCGCTGCTTTTGGTGTGGCGGGTGCTTTAATTCAAGCGCTGACGCGCAAC CCGCTTGCCGATCCCGGAATTTTGGGAGTTAACGCGGGTGCAGGTTTCGCAGTGACCGTA GGTGTCGGATTTTTCGGACTCAGCAGCGTGACGGGCTACATCTGGTTGGCATTCCTGGGC GCTGCCGCCGCTACCCTGCTGGTGTATTTCATTGGTGCGAGCACCAGCGGCAGCGTTAAT CCTGTTGCTCTGGTCCTCGCCGGCGTTGCTCTGGCCGCCGTGCTTGGTGGCGTCACGAGC TTCCTCACACTGATTGATGCTGAGACTTTTGAAAGCATCCGCAATTGGAATCTTGGTTCT GTTGCACGCACCGACCTCAGCGACACCATGACCGTATTGCCATTCCTGGCAGTCGGACTG GCCATCGGGCTCCTGCTGTCGGGAGCACTGAACTCCATTGCGCTTGGCGATGACCTTGCT GCATGCCTGGGCACCAAAGTGATGGGCACCCGCGTGCTCGGCATGATTTCAGTCACCTTG TTGGCCGGCGGCGCGAGCGCCCTTAGTGGTGGTATCGGCTTCGTAGGCCTTATGGTTCCC CACGTTGTGCGCTGGGTAGTTGGCCGCGATCAACGATGGATCATCACCTTCAGCGCCCTG TGCGCCCCTGTTCTTGTAGTCGGCGCAGACATTTTGGGACGCATCATCGCCCGCCGCGGC GAAATTGAAGTAGGCATTGTTACCGCAGTCATCGGCGCACCTGTCCTGATCGGACTAGTT CGACGGAGGAAAGCCAGTGGTCTT >RXA01289-downstream TAATATCAAATCTAGAACTGATG >RXA01290-upstream GGACGCATCATCGCCCGCCCCGGCGAAATTGAAGTAGGCATTGTTACCGCAGTCATCGGC GCACCTGTCCTGATGGCACTAGTTCGACGGAGGAAAGCCA >RXA01290 GTGGTCTTTAATATCAAATCTAGAACTGATGAAACTCGTGTTGCTGCGTCTGAGGCGGTG GAATCCACTAGACCTGTGTCTGAAGCTTCGACAAGCCCTGCGCTTAACCCCGGCTACCAC GCAGTTTCAGTGCAGAGGCGCCGGTTCTCTTTCCGCATCCCAGCCCGCCTCATGGTGGTT AGCCTTATCCTTTTCGCGATCGCGCTATGCAGCGCCAGATGGGCTATCACGATGGGCGAT TACCCACTGTCTTTGGGGCAGGTGATTAATGGACTTGCTGGCACCGGCGAGAAATTCCAG TTGTTGGTGGTGCGGGAATGGCGTGTACCTGTAGCCATTGCTGCTGTTGTCTTCGGCGCG CTGCTTGGCATAGGTGGAGCGATTTTCCAGTCGATTACTCGAAACCCGTTGGGTTCACGT GAGGTGATTGGTTTCGATGCAGGTTCTTACACGGCGGTGGTTCTTGTCATTTTGGTCCTG GGCAACACTCACTACTGGAGCATCGCTTTCGCTGCCATCGTCGGTGGCATTGTTACGGCC TTTGCCGTGTATGTCCTGGCGTGGCGTAAAGGTGTGCAAGGTTTCCGCTTGATCATCGTG GGCATCGGTGTCTCGGCCATGCTCAGTTCGGTTAACGCGTATCTAATGACCCGCGGCGAT GTGGAAGACGCCATGGTTGTGGGCTTCTGGAGTGCCGGTTCCATCAACCGCATTACCTGG CAATCTCTGCTCCCCTCTCTGGTGATCGCTGCTGTCATCATCGTGGCCGCCATTGTGCTG GCAAGGTCACTGCGTTTCATGGAAATGGGCGATGACGTAGCCACCACCCTCGGTGTGAAA ACAAACTCCACCCGCTTGGCACTCATCGTTGTCGGCGTTGCTACCTCCGCGTTGGTTACA GCAGCTGCCGGACCGATCTCCTTCATCGCGTTGGTTGCCCCACAGCTGGCACGTCGCCTC ACTAAAACCCCTGGTGTCAGCCTGGTTGCTGCCGCTGCAATGGGTTCCGCACTGCTCAGC TGCGCTCACCTCCTTTCCCTGATTATCAGCTCCTTCTACCGCACCATCCCGGTTGGCCTG TTGACTGTATCCATCGGTGGTTGCTAGATGATGTGGCTTCTGCTGCGCGAAACCCGCCGC CAATACCGCACCGGCACCATCCGA >RXA01290-downstream TAGTTCTTTTAAGGATCCCTCAT >RXA01297-upstream TCCTGTTGCTGCTGATTATCACTGTTATCCAGGTTCGATACATGGATAAGGAGAACAAGC AGAAATGATCTCGACTGATAGAAACGTTTTGGTCAAAATC >RXA01297 ATGGGCTATGTCGGCATGGTTCTTGCCATCTTGTTCATTGGCCTTCCGCTGGTATTTATT GTGCTGACTAGCTTCAAGCAGCAGTCAGAGATTTACACCCAGCCGGTCACGTGGTTGCCT TCGGAATTTAATTTCGATAACTATGCAAATGTTTTCGAGCGGGTTCCGTTCCTGAAGTAC TTCCGCAACTCGATCATCATCACGGTTATTTTGTGTCTGGTGAAGATTATCTTGGGTGTG ATCTCTGCATATGCGTTGTCGATTTTGCGCTTCCCGGGTCGAAACCTTGTGTTCTTGCTG GTTATCTCCGCGCTGATGGTGCCTTCCGAAGTGACTGTTATTTCCAACTATGCGTTGGTC AGTCAGCTTGGTTGGCGCGATACCTACCAGGGCATCATCGTTCCGCTAGCGGGTATTGCT TTCGGAACGTTCCTCATGCGTAACCACTTCATGTCTATTCCTTCTGAGCTCATTGAAGCT GCGCGAATGGATCACTGTGGACACTTCAGGTTGCTCTGGAAGGTTTTGCTTCCAATCTCT ATGCCTACGTTGGTGGCGTTCTCCATGATCACCGTGGTGAATGAATGGAACCAATACCTG TGGCCTTTCCTGATGGCAGAAACCGATAATTCAGCAACTCTGCCCATTGGTTTGACCATG CTTCAAAACAATGAGGGTGTCTCCAACTGGGGACCTGTCATGGCCGCAACGATCATGACC ATGTTGCCTGTGCTTGTGATGTTCTTGGCACTGCAGGAGTACATGATCAAGGGACTTATG TCCGGCGGCGTCAAGGGC >RXA01297-downstream TAAAAACTTCTCGCTAAAAACTT >RXA01298 TTCGTGTGGAAGAACTTGGGCTACTCCTTTGTTATCTACGTGGCTGCATTGCAGGGGCTA AACAAGGATTTGTCTGAGGCCGCACCGGTGGATGGCGCGAGCGCGTGGACACGTTTTTGG AAGGTTAGTCTTCGGCAGCTTCGCCCAACCACGTTCTTCCTTTCTATTACTGTCACGCTG AACTCGGTTCAGGTCTTCGACATGATTCACACCATGACTCGTGGTGGCCCCTTGGGTAAC GGTACGACCACGTTGGTTTACGAGGTGTACACCGAGACTTTCACGAACTATCGGGGGGGA TATGGTGCAACAATCGCAACGATTTTGTTCCTGTTGCTGCTGATTATGACTGTTATCCAG GTTCGATACATGGATAAGGAGAACAAGCAGAAA >RXA01298-downstream TGATCTCGACTGATAGAAACGTT >RXA01303-upstream AACATGCGGGCGCAGGTCAGAGCTGTTATCTTAGTACTTATCACAGCCATAGGGCGGGCT TGACGGAAAGCCTTTCCGCGTAACGATGAAGAGGGATCAC >RXA01303 GTGACACAACTCAACACCAAAGGCGTTGTTCTGCAAGGGTGGGATCCAGAAGATCCTGAA CATTGGGACTCGAAAATTGCATGGCGAACCCTGTGGATTACGACCTTGTCCATGATTATT GGGTTCTGCGTGTGGTATTTGGTTTCTGCCATCGGTCCGCTACTCAATCGAATTGGATTT GATCTCTCAGCAGGTCAGCTTTATTGGCTCGCATCTATGCCCGGTTTGGCCGGCGGATTA ATCCGATTGATTTACATGTTCCTTCCACCGATTCTTGGAACCCGCAAATTGGTGGGAATT TCCTCCGGTCTATTTTTGATCCCCATGTTTGGGTGGTTCCTGGCTGTCCAAGATTCAAGC AGTCCCTAGTGGTGGCTTCTCACACTCGGTGCACTCACTGGGATTGGTGGTGGGGTGTTC TCTGGATATATGCCGTCCACGGGATACTTCTTCCCCAAGGCAAAATCGGGCACTGCGCTG GGCATTCAGGCAGGTATCGGCAACCTCGGCGTCTCGATAATTCAGTTCATGGGCCGATGG GTCATGGGTTTCGGTCTGCTGGGCATTGGTTTCCTCACCCCGCAGCGCACCATTGAAGGC ACCACGGTGTTTGTGCACAATGCTGCGATTGTGTTGGTCCGGTGGACTATTCTCGCGGCC GTTTTATCGTTCCTGTTTCTTAAAGATGTCCCAGTCACCGCAAATTTCCGGCAACAGATC GATATCTTTGGCAACAAGAACACATGGATTTTGTGCATTATCTACTTGATGACATTCGGT GCCTTCGCCGGTTTCGCCGCGCAGTTCGGTCTGATCATCAACAACAACTTCGGCATCGCT TCCCCGATGGCAGAGACTTATCCAGCTGAGATGCTTCACGCCGGTGCTACGTTCGCGTTT CTTGGACCTTTGATTGGTGCTTTGGTGCGTGCTGCATGGGGTCCACTGTGTGACAGATTC GGTGGAGCTATCTGGACGTTTGTCGGTGGCATCGGAATGACTATCGCCACTGCAGCTGCC GCAATCTTCCTAAGCAGAGCGGAGACACCTGATGATTTCTGGCCATTCCTGTGGTCCATG CTTGCCCTGTTCTTCTTCACCGGTCTGGGCAATGCTGGCACCTTGAAACAAATGCCCATG ATTTTGCCTAAACGCCAAGCAGGTGGCGTGATCGGCTGGACCGGTGCCATTGGTGCCTTC GGCCCCTTCATTGTCGGTGTCTTGCTCTCCTTCACTCCAACTGTCGCGTTCTTCTGGGGC TGCGTGGTGTTCTTCATCATCGCCACGGCTTTGACCTGGATCTAGTACGCCCGCCCGAAC GCTCCATTCCCGGGA >RXA01303-downstream TAAACCGAAAGGCCAATCCATGA >RXA01323-upstream CACGTGGTTTACGCCAGGCATGTTCCCGCGAAGGGTTGACCCATACCCCTAGGGGGTATA CAGTGAGTCATGTAAACATACTCGCAGAAGGAGGGATCCC >RXA01323 ATGGCTCAGACACCCGCCAAAATCCCGGCGGCACTGAATTTCATTGACGTCGACCTCGGC GTTACGGGCATGACCTGCACTTCTTGCTCCGCGGGCGTCGAGCGCAAACTGAACAAGCTC GACGGCGTTGAAGCAACCGTCAACTACGCGACGGAATCCGCACAGGTCAGCTACGACCGC TCAAAGGTCAGCCCTGAACAGCTGATTAAGACTGTTGAGGACACCGGCTACGGTGCTTTC ACGATGGCTTCCGCAGCTGCCGAATCAGAAGAGGACAACGCTCCAGCTGACAGCGGCCAG TCCCGGATCGACGCAGCTCGCGACCACGAAGCAGCCGACCTGAAACACCGCGTGATCGTC TCTGCACTGTTGTCAGTTCCTGTGGTTTTGGTCAGCATGATCCCGGCGCTGCAATTCAAC AACTGGCAGTGGGCCGTACTCACTTTGGTCACCCCGATTTTCTTGTGGGGCGGTTCACCG TTCCACAAGGCAACGTGGGCAAACGTGAAGCGCGGTTCCTTCACGATGAACACCCTGGTT TCACTCGGCACGTCCGCTGCTGACCTGTGGTCCCTGTGGGCTTTGTTCATTGAAAATGCT GGTCACCCTGGCATGAAGATGGAGATGCACCTGCTGCCGTCGGCCTCCACGATGGATGAG ATTTACCTCGAAACCGTGGGGGTCGTTATTACGTTCGTGCTGCTTGGACGCTGGTTTGAG ACAAAAGCTAAGGGCGAATCTTCGGAAGCTCTGCGCAAGCTGCTGGACATGGGCGCCAAA GATGCAGTCGTCTTACGTGACGGCGCCGAAGTCCGGGTTGCTGTGAATCAGCTTAAACTC GGCGACGTTTTCATCACCCGCCCCGGCGAGAAAATGGCCACCGACGGTGAAGTCGACGAA GGTTCCTCCGCAGTCGACGAATCCATGCTCACCGGCGAATCCATCCCGGTTGAAGTCACC AAGGGCTCCAAAGTTACCGGCGCAACGCTGAAGACTTCCGGCCGCCTCATGGTGAAAGTA ACCCGCATCGGGGCCGACACCACCCTGTCGCAAATGGCTAAACTGGTCACGGACGCAGAG TCCAAAAAGGCCCCTGTCCAGCGTCTTGTTGACCAAATCTCGCAGGTTTTGGTTCGCGTT GTCATCGTAATTGCTATTGCGACGCTGATCGGGCACCTGGTGTTCACGGACGCCGGCCTC GCCCCAGCATTCACCGCAGGAGTCGCCGTGCTCATTATCGCGTGCCCTTGTGCCCTCGGC CTGGCAACCCCAACCGGACTTCTGGTCGGAACCGGCCGCGGCGCGCAACTTGGTCTGTTG ATCAAGGGCGCTGAAATCCTCGAATCCACCAAAAAAGTCGACAGGATCGTCCTCGACAAA ACCGGCACCGTCACCACCGGCACCATGTCCGTCACCGACGTCAGCGCCATCAACTACAGC GAAACCGAAATCCTGGAATTCGCTGCAGCCGTCGAGTCCGCCTCGGAACACCCCATCGCC CAGGCAATGGCCAAGGCCGCCGAACACGAGGAAGTCACCGACTTCCAAAAGACGGCAGGT CAGGAAGTCACCGGTGTAGTCCGCGGACAGGAGGTCCGCGTGGGCAGGCCTTCAAGCACG CTTATCGACGGCCTGCTCCACCCCTTGCAACACGCCCAAAAAATCGGCGGAACCCCCGTA GTCGTCACGATTGACGGCGTAGATTCGGGAATAATCACGGTCCGCGACACCGTCAAAGAC ACCTCCGCCGAAGCAATCCGCGGACTCAAGGAACTGGGACTCACCCCAATCCTACTCACC GGAGACAATGAAGGCGCAGCTAAATCCGTAGGCGCTGAAGTCGGCATCGACCAAGTCATC GCCAACGTCCTCCCCCACGAAAAAGTCCAAAACGTAGAAGCCCTCCAAGCACAAGGCAAA AACGTTGCGATGGTCGGGGACGGCGTCAAGGATGCCGGAGCTCTTGCCCAAGCTGAGGTC GGAGTCGCCATGGGAGCCGGCACCGACGTAGGCATCGAAGCCTCCGACATCACCCTCATG AACAACGAGCTCCGATCCGCAGTCGACGCCATCCGACTGTGCCGTAAAACGCTCGGCACC ATCAAGGGAAACCTTTTCTGGGCTTTCGCCTACAATGTTGCACTAATCCCAGTAGCGGCG ATCGGACTCCTCAACCCAATGCTTGCCGGCATTGCGATGGCCTTCAGTTCAGTTTTCGTC GTCTCCAATTCCTTGGGTCTGCGAGGATTCAAAGCAAGGAGCAAC >RXA01323-downstream TAATGTCCAACAGCGAATGCCAC >RXA01338-upstream ATCCTTGCCTTGCCAAGGGAAGCCTGTACATGCTGGTCAGGGACATTTTTATGGGTGATA ATGGGGTTTATGAATAAAAACTTATACCCCAAATCCCTGG >RXA01338 ATGTTATTCATCCGCTCATTTGATGGCATCATCACTGTCGCAGCCCTTGTTGCCATCGCA ATACATCTCATTTTATGGCTGGCTCTAGATCTAGATGGCCTTGCTAAAAACTGGCCTTTA ATAGCCATCGTTATCGTAGGTGGCATTCCGTTGATGTGGGATGTGCTGAAATCAGCCATT AAAACTCGCGGTGGGGCGGATACTTTAGCAGGAGTCTCCATCATTACTTCTGTGTTGTTA GGGGAGTGGTTGGTTGCCGCGATCATCGTGCTCATGCTCTCTGGTGGTGAAGGGCTAGAA GAGGCAGCATCACGGCGAGCCAGTGGCACCTTGGACGCACTTGCCCGGCGCGCACCAAGT ACAGCTCACCGCGTGTTGGGTGCAAGGATTGTTGATGGAACCGAAGAGATGGCGGTGGAA GAGATCACGGTTGGTGATTTAGTGGCGGTGGTCCCGCATGAACTTTGTCCCGTGGATGGT GAAATCGTGGGAGGCCACGGCACGATGGATGAGTCTTATCTCACGGGTGAGCCCTATGTG GTGAGTAAATCTAAAGGTTCGCAAGCAATGTGGGGTGCAGTCAATGGTGATACTCCGCTG ACGATTGTTGCGACAAAGCTTGCCCATGATTCCAGATAGGCCCAAATTGTTGGTGTACTC CATGAAGCAGAAAACAACCGCCCAGAAATGCGCAGGATGGCTGACCGTCTTGGCGCGTGG TATACGGTGATTGCACTTGCCCTCGGTGGTCTTGGCTGGATTGTCTCCGGCGACCCAGTG AGGTTCTTGGCTGTTGTCGTTGTCGCCACCCCATGTGCATTGCTCATTGCAGTGCCAGTG GCGATCATCGGTGCGATTTCTCTTGCGGCTCGTCGGGGCATCATCGTGAAGAACCCTGGA ATGCTGGAAAACGCTTCAGGAGTAAAGACAGTGATGTTCGATAAGACTGGAACGCTCACC TATGGCAGGCCAGTGATTACTGATATCCACACTGCTCCCGGAGTTGAGGAAGATACAGTC CTAGCTTTGGCTGCTTCAGTAGAGCGCTACTCCAGACACCCGTTGGCTGACGCGATTCGT GAGGGCGCAAAAGCCAGGGAACTTCATCTGCCTGATGTAGTGGAAGTATCGGAACGTCCA GGACAGGGACTAACCGGCACGGTGGGCGAGGACCTGGTTCGAATAACCAATAGGCGCAGC ACACTAGAAATTGATGCAGACAGCAAGAACTACATTCCGGTGACAAGTTCCGGCATGGAA TCTGTGGTGCTTGTTGATGATAAATATGCAGGACTCATTCGCCTCGGGGATGAACCTCGT GCATCTGCCAGTGAGTTCATCGCGCACTTGCCCAAGAAGCACAAAGTGGACAAGCTCATG ATTATCTCTGGTGATCGCGCATCTGAGGTTCGTTACCTTGCGGACAAGGTTGGCATTGAT GAGGTACACGCAGAGGGCTCACCGGAAGACAAGCTGAACATTGTTAATCGGCATAATGAG CACGGGGCCACCATGTTCTTAGGTGATGGAATCAACGATGCGCCAGCGATGGCCGTTGCC ACCGTTGGTGTCGCGATGGGAGCAGACTCCGATGTCACGTCCGAAGCAGGAGATGCTGTG ATTTTGGATTCTTCCCTGGAACGTGTCGACGATCTGGTCCACATCAGTGCACGGATGCGT CGAATAGCGTTGCAATCTGGGGGCGGTGGCATGGCGTTGAGTGTCATAGGAATGATCCTC GCGGTATTTGGATTCTTGACGCGAGTGATGGGTGCGATCTTCCAAGAGGTCATTGACGTG CTGGCTATCCTCAATTCGGCTGGGGTCGCACTGCCACGCGGAGCGATTAGTGATTTTGAT ACGCAAGAAAAAGTTTCT >RXA01338-downstream TAGCAGGGTAACCTAAATGTCGT >RXA01395-upstream CTCAAAAGCACTGATAAAAGCAGTCAACCCACCTCGGGTTGGCTGCTTTTTTGCATCCAG ATGCACAAAGCGGTGGCACAAACGAGACAAAGTGAGCACA >RXA01395 ATGGCTGTCATGGCATATCAACCAGCAGACAATCGCTATGACGACATGATCTACCGGAGG GTGGGAAATTCTGGGCTGAAGCTTCCGGCAATTTCGCTTGGGCTGTGGCACAACTTCGGT GATGACAAGCCGGTTTGAACGGAGCGCAGCATTATTCACCGCGCGTTTGATAGGGGAGTC ACTCACTTCGATTTGGCTAATAACTATGGACCTCCAGCAGGTTGCGCAGAGACCAACTTT GGCAGGATTTTGCGTGAGGATCTCAAAAGGGACCGCGATGAGTTGATCATTTCTTCCAAG GCGGGTTGGGATATGTGGCCTGGACCTTATGGTTTTGGTGGTTCCCGAAAGTATCTAGTG AGTTCCCTTGATCAGTCCCTGACTCGCCTCGGCTTGGATTACGTGGATATTTTCTATCAT CACCGCCCGGATCCAGATACTCCTTTGGAAGAAACCATGTACGCATTGCGTGACATTGTT GCGTCTGGAAAGGCTCTTTAGGTGGGTATTTCTTCCTACGGTCCAGAGCTCACAGCGGAG GCGGCTGAGTTCATGGCGGAGGAGGGCTGCCCGCTTCTGATTCATCAGCGAAGCTATTCC ATCATTAATCGTTGGGTGGAGGAACCGGGCGATGACGGTGAGAACTTGTTGCAGTCAGCT GCCAACAATGGTCTTGGCGTCATTGCTTTCTCACCACTTGCGCAGGGCCTGCTCACGGAC AAATATCTCGATGGAATTCCAGAGGGTTCCCGCGCCAGCCAGGGTAAGTCCCTKTSTKAC GGSWTGTTGAACGTGAACAATATTGATWTGGTCCCMARSYTNAWKRSAWTTTCCMARRAM ACCGGGCAGTCCTTTNNCCNAAAGGNCTTTTGTTGGGTTGTTGCCCAACCAAGGAAAGTA CGGCGCCGGATTACCGTGACCAGTGCATTGATTGGTGCTTCGTCAGTTGAGCAGCTGGAC AACAGCCTTGATTCACTCAACAACTTGGAGTTTTCTGACGCCGAGTTGGAGGCGATCGAT GAGATTTCCCACGACGCCGGCATCAACATTTGGGCGAAGGCCACCGATTCCAAAACCCGC GAAAAC >RXA01395-downstream TAACCCATCAACATCAGTTTGAT >RXA01411 TTCATTGCGCAGGTAATGCTTGGAATGGGGGCGGTTACCGCTAACTGCGTTACCTCAGTA ATGATGGCCGAGGTCTTCCAAGAGGTCACGCGCGGTACTTCCGGCGGCATTACCTACAAC GTCACTTACGCAATCTTCGGCGGCTCGGCTCCATTTATCTCCACCGCATTGGTCTCCTGG ACCGGGAGCCCGCTGGCCCCTGCGGTATAGATGATCATCATTGGGCTCTTCGCCTTCACC GCGTCGCGCTTCATTCCTGAAACCTCCCCAGTTTTTGTCAGCGCAACCCCGGCCATTAAG GCACCAAAGGTGCTGGTCAACGCGGGT >RXA01411-downstream TAAACCACGGTTTTCGACGAAAA >RXA01454-upstream GGCCAGGACTTTGGCGTTTCGGATCAGCAGTTCGGCTTGGATTATGGATTCTACGCGTTT GATCTTCCGATGCTTCGCCTCATCGCTTGACTCACTGTCG >RXA01454 ATGATGTTGATCGTTGCTTTCGTGATCGCAGTGGTTGGCCATTACCTCATGGGTGGCATT GGCGCTGGAAACCAGATGACGGGCCAGAAGTCCTTTGTATCCCGTGGTGCGCGCACTCAG CTTGCGGTAACTGCTGGTCTGTGGATGCTTGTTAAGGTCGCTGGCTACTGGCTGGATCGC TATGACCTGCTGACTAAGGAAAACTCAACCTTCACAGGTGCAAGCTACACCGACATCAAT GCACAGCTGCCAGCGAAGATCATCCTG >RXA01455-upstream AGAGTGGGGGAGAAACGCATAATCACGTACATATAAGGATATTGTGTTGTCGACTGGTCT CACACCTCGTCCCCAACCGATCAAGCGACCTCCCAAGGGG >RXA01455 GTGACATGGATCTTCGCGATTATCGCGTTGGTCATTCTCATCGGCGCAATGAGTGTTGGC TTCTATACGGACTGGCTTTGGTTCGGTGAAGTCGATTTCCGAGGCGTTTTCAGCAAGGTT ATTGTCACTCGCATTGTTCTCTTTGTGATCTTTGCGCTAATTGCTGGGTTTGTCACATGG CTTGCTGGTTATTTTGTGACAAAACTTCGACCTGATGAGATGTCGGCGTTTGATACCCAG TCGCCTGTGTATCAGTACCGTGAGATGATCGAAAACAGCCTTCGTGGCGTTATGGTGATC ATTCCAATTTTCGTCGCGTTGCTGGCTGGCCTAATTGGTCAGCGTTCGTGGCGCACCGTT CAAATGTGGCTGAATGGCCAGGACTTTGGCGTTTCGGATCAGCAGTTCGGCTTGGATTAT GGATTCTACGCGTTTGATCTTCCGATGCTTCGCCTCATCGCT >RXA01455-downstream TGACTCACTGTCGATGATGTTGA >RXA01625-upstream GGGAGCGAAGTTCCCTGGGTTAAATTAACCACTTGCAGTATACCCTAGTGGGGTATATTG TCTGCTGTTAGAAGATACCCGACAGAAAGGGGCCAATAAT >RXA01625 ATGGCTATCAAGAACTACAGCGTCGAAGGCATGACTTGTGGACACTGCGTCTCCTCCGTA AAGGAAGAGGTCGGAGAGGTTGCTGGCGTCACCGCTGTGGACGTCACCCTAGAAACCGGT GCCGTGCAGGTTACCGGCGAAGACTTCACCGACGAGGCTGTCAAGGCTGCTGTCGTTGAG GCTGGCTACAAGGTTGTTGCA >RXA01625-downstream TAAACCCCTGAAAAGTTTAAAGC >RXA01756-upstream GCTTCAAACAGGATTTAATCTAAAATCTTAAACCTCGTATTTTCCCTGATAGGCTCAGAT GCGCCTGAAATCGGGCTTGTTGAGGGGAGAGGTGTGTGAC >RXA01756 ATGAAAGAGTTGGAACTGGGCGAGGCGAGGGACGTCGCTGCAACGTTGGAAGCGATGCCG ATCCAGGAGGTTATTGATCAGGTTGAGCGAACTTCTATAACTAAAGGTGCGGTACTGCTG CGTCTGCTGAGTAAAGATCGATGGTTGTTGGTCTTCGATGCTCTTGGTCCGCGACTCCAG GCTGATCTCATTGGTGCTTTTCAGGATGCGGAAGTGCTGGATTATTTCGCTGACCTTGAC CCTGATGACCGCGTTTGACTGCTTGATGAGCTGCCGGCGTGGATCGCTGACGAGTTGCTT CGCAGTCTCGATCCGCAGGAAAAGCAGGTCACGGAGCTGGTCTTGGGTTACGCAAAGGGG TCGGTTGGACGTTGGATGTCGCCCCAGGTTTTATTGCTTTTCGACGACATGTCCGTCGCC GAAGTCTTAGATTTTGTGCGCAATCATGCTGCTGAGGCTGAGACGATTTATGCCTTACCT ATTGTGAACCGTGCTCGCCAAGTGATGGGCGTGGTGTCGTTGCGAAAGCTGTTCATCGCA GATCCCACTCTAAAAGTCTCGGAAATCATGGTGCGTCCTGTTTCGGTGTTGGCGTCCGCG GATATTGAAGAAACGGCCCGCTGGTTCCTACAGTTGGACCTCGTTGCGATGCCCGTTGTG GATGAATCGAACATGCTCTTAGGAGTGCTGACCTTCGATGATGCGCAAGACATCGTGGAG CAAGCCGACTCTGAGGAGTCCGCTCGCAGTGGTGGTTCGGAACCTGTCCAGCAGCCGTAT CTATCCACGCCGATTCGGAAACTGGTGAAGTCCCGCATCGTATGGCTTCTGGTTTTGGCA GTGTCAGCAATTTTGACGGTTCAAGTTCTTGATATTTTCGAAGCCACCTTGGTTGAAGCC GTGGTACTGGCATTGTTCATTCCTTTGCTCACTGGTACTGGCGGAAACACCGGAAACCAA GCTGCAACAACCGTGACCCGTGCGCTCGCATTGGGTGACGTCCGAAAATCAGATGTCTTC CGCGTCTTGGGCAGAGAAATCCGAGTCGGCCTCATGCTCGGGGCATTGTTGGGTGCCGTT GGATTTGTGATCGCATCGCTTGTTTACGGCATGCCCGTAGGCACTGTCATCGGTCTGACA TTGTTGGGGGTGTGCACGATGGCCGCATCAGTTGGCGGAGTAATGCCAATTATTGCCAAG GCGATCGGAGCGGACCCAGCGGTGTTCTCTAATCCTTTTATTTCAACCTTCTGTGATGCA ACAGGTTTGATCATCTACTTTGCAATTGCCAAGTTGGTGCTCGGAATC >RXA01756-downstream TAAAAGATTTTTGCTTTTCGACG >RXA01808 ATGCGCGGGGGTGCACCAGCGCGAACCTCAAAGCCTGGATTCCGGCTTGAAGCCGCGGAA GCTTTGATCGCAGAAGTGCCAGCGCCACGCGACAAAGTCGAGCTGATGGCATTTTCCAAG TCCAGGGAAGGCCGCGTTGTCATTGAACTTGAAGACGCCACAGTAGCCACCCCTGATGAT CGCATCCTGGTAGAAGACCTCACCTGGCGTTTGGCTCCAGGAGAGCGCATCGGTCTTGTC GGCGTCAACGGCTCCGGCAAAACCAGGCTGCTGCGGACCCTTGCGGGCGAGCAGCCACTT CAGGCAGGCAAACGCATCGAAGGCCAAACCGTCAAACTGGGATGGCTCGGCCAGGAACTC GATGACCTAGAGCTCAGCCGCCGACTCATCGACTGCGTTGAAGATGTCGCTTCCTACGTG ATGATGGGGGACAAGCAGGTCTCCGGTTCCCAATTGGGAGAACGGGTCGGATTCTCACCC AAGAGGCAACGCACCCCAGTTGGTGACCTGTCCGGTGGTGAACGCCGCCGACTCCAACTC ACCCGCGTGCTCATGGCCGAACCAAACGTGCTGCTCCTCGACGAGCCCACCAACGACCTG GACATTGACACCCTCCAAGAGCTGGAATCCCTTGTCGACGGATGGCCAGGCACCATGGTG GTTATCTCCCACGACCGTTACCTCATCGAACGCGTCACCGAGTCCACCTGGGCACTCTTC GGCGATGGCAAGCTCACCAAGCTGCCAGGCGGAATTGAAGAGTACCTGCAGCGACGAGCA GCGATGGCCGCGGCCGAAGACAGTGGAGTGCTGAACTTGGGTGCGGCCACGCAGGCTGGA ACCTTTTCTGCTGCAACAGAGCAGGCTGCCACTTCTGTGGAAAGTTCCGGAATTTCTTCC CAAGAACGCCACCGCATCACCAAGGAAATGAACGCCCTGGAGCGCAAAATGGGCAAGCTT GACCAGCAAATGGACAAGCTTAATCAGCAGCTCGCTGATGCAGCGGAGGCCATGGACACC ATAAAGCTCACCGAGCTGGACACCAAGCTCCGCGCAGTGCAGGAAGAACACGGCGAGCTG GAAATGCAGTGGCTGGAACTCGGCGAGGAAATCGAGGGC >RXA01808-downstream TAGTTCATGCCGTCGGCAGGCGA >RXA01822 ATGGCCAGACAAAATAGCAATACCGGCGGGTTGCGTCTGGTGTTGGTTGGTATCGGAAGA GGTGCATTTTTGGGTGCTGCTCGTGATTTCTTCATGGTGCGCGCAGATATTACGGGTGCT TCGACGGTACAGCTGTGGTCTGCCGGTTCGTTGAGCGGGCGCGACTGGAATCATGCCCTG TTGGTGTTGATTTCGTGTGCAGTGATTGTGCGAGCACTGTGCATTATTGTCCGCCGTTTA CGCCTGATGGAAATGGGTGATGATGCAGCTGGGGCACTTGGAATTTCAGTGGAGAGAACA CGGTTGATAGCCATTTTGTTGGCTGTGCTGCTGGTGGGGATCGCCACCGCAGCTGCAGGT CCCATCGCTTTTATTGCACTGGCAGCACCTCAGATTGCCCGGGCTCTGGCCCGGGAGGAT GGAGTGCTGGTGGCTGCGTCGATAAGCATTGGCTCTGGGCTGTTAGTTGCGGCGGATTGC CTAGAGCAACACGTTGATACTGAGCTGCACACGCCCGTTGGCCTGGTGACCAGTTTGCTG GGCGGGGTGTATTTGATGTGGCTTTTGAGCCGAAAGGAGGCA >RXA01822-downstream TAAATGCTGCAAGCGCATGATCT >RXA01890-upstream GCTGAGGTTGAGACCAAGCTGAACACCATCTACACCCGCGACATCGAACCACTTATTTAA TCCGAGCACTTCAGCTACAGCTATTTAAGGAGGCTGTGAC >RXA01890 ATGGCGTCAATCGTCTTTGAAAACGTCACACGCAAATACTCTCCGGGCGCACGCCCGGCC GTCGAGAAGCTTAATTTGGAAATCGCGGACGGCGAGTTGCTAGTTCTCGTTGGACCCTCA GGCTGTGGAAAGTCCACTTCTTTGCGCATGCTGGCTGGTCTTGAGCCTATCGACGAGGGA CGTCTACTCATTGATGGTAAAGACGGCACGGAACTGCGTCCGCAGGATCGTGACATCGCT ATGGTCTTCCAGAGCTACGCGCTGTACCCGAATATGACTGTTCGGGACAACATGGGCTTT GCGCTGAAGAATCAGAAGGTGGCTAAGGCTGAGATCGAAAAGCGTGTTGCTGAAGCCTCA CGCATTCTGCAGCTGGATCCGTATCTTGATCGTAAGCCTGCAGCTTTGTCTGGTGGTCAG CGCCAGCGCGTGGCCATGGGCCGTGCAATTGTGCGTGAGCCATCGGTGTTCTGCATGGAT GAGCCACTGTCCAACCTAGATGCGAAGCTGCGTGTGTCTACGCGTGCGGAGATCTCTGGT TTGCAGCGTCGCATGGGCGTGACCACGGTGTATGTGACTCACGATCAGGTCGAGGCCATG ACCATGGGTGATCGCGTCGCTGTGCTTTTGCTCGGTGTGCTGCAGCAAGTAGACACCCCG CAGAACCTGTACGACTACCCAGCAAATGCGTTCGTCGCCAGCTTCATTGGTTCCCTTCCA >RXA01890-downstream TGAACTTGATTGAGGGCACCATC >RXA01900-upstream AAAGGTGACACGCCTTAGATTCTTGTGGTCTGACCATGAGGTTGGGCCAATCGGTTTCAG CCCGTTTACTCGCGCCGTCCGTTTCAGAGAAGAGGTCACC >RXA01900 ATGACAACCGCAGTAGATCAAAACTCACCGCGCAAGCAGCAACTCAACAAGCGCGTCCTG CTGGGCAGCTTGAGTGGCAGCGTTATGGAATGGTTGGACTTCCTGGTTTACGGAACCGTC GCCGCGCTGGTCTTCAACAAGATGTACTTCCCCAGCGGCAACGAGTTCCTCTCCACAATC CTGGCGTACGCATCCTTCTCCCTGACCTTCTTGTTCCGCGCCATTGGTGGCGTCATCTTC GCCCACATCGGCGACCGCATTGGGCGTAAGAAGACCCTGTTCATCACCTTGATGCTCATG GGTGGCGGCACCGTGGCGATTGGTTTGCTGCCCGACTACAACGCCATCGGCATTTGGGCA GCAATCCTTCTGATGTTCCTCCGCATTTTGCAGGGCATCGGAATTGGCGGCGAATGGGGT GGCGCACTGCTCCTGGCATACGAATACGCTCCAAAGAAGCAGCGTGGGCTCTACGGCGCA GTTCCTCAAATGGGCATTTCCCTGGGCATGCTGCTTGCAGCTGGCGTGATCTCTCTGCTC ACCCTCATGCGGGAAGATCAGTTCCTCACCTGGGGCTGGCGCATCCGATTCGTCGGATCC ATCCTCCTAGTGTTCATCGGCCTGTTCATCCGAAACGGCCTTGATGAAACCCCCGAGTTC AAGCGTATCCGCGATTCCGGCCAGCAGGTAAAGATGCGTCTGAAGGAAGTTCTGACCAAG TACTGGCCAGCCGTTCTGGTCTCCATCGGCGCAAAAGCTGCCGAGACGGGCCCCTTCTAC ATCTTCGGCACCTACATCGTTGCTTACGCAACCAACTTGCTGAACATCCGCGACAACATT GTCCTTCTGGCAGTTGCTTGCGCCGCCCTCGTTGCCACCATCTGGATGCCACTGTTCGGA TCCTTCTCCGAGCGCGTCAACGGTGCAGTGGTGTACAGGATCTGTGCATCCGCAACCATC GTGCTGATTGTCCCTTACTACTTGGTCCTCAACACCGGCGAAATTTGGGCACTGTTTATC ACTACCGTGATTGGCTTCGGCATCCTCTGGGGTAGCGTCAACGCAATCCTCGGAACCGTC ATCGGAGAAAACTTCGCACCTGAGGTCCGCTACACGGGCGCTACCCTGGGTTAGCAAGTC GGAGCAGCACTCTTCGGCGGTACCGCACCCATTATCGCAGCATGGCTGTTCGAAATCTCC GGCGGACAATGGTGGCCAATCGCCGTCTACGTCGCTGCATGTTGCCTTGTCTCTGTGATC GCCTCGTTCTTCATCCAACGCGTCGCGCACCAAGAGAAC >RXA01900-downstream TAAAATCTAAGTAAAACCCCTCC >RXA01939 TCTACAAGCGGCACCGATCTTACGTCCTTGAGCCACAAGGAAATCTTCCAAATGCGACGC AAACTGCAGGTGGTGTTCCAGAACCCCTACGGCTCGCTTGATCCGATGTACTCCATCTAC CGGTGTATTGAGGAACCGCTGACCATCCACAAGGTTGGTGGAGACCGCAAGGCACGCGAA GCTCGCGTCGTTGAACTTCTCGATATGGTGTCCATGCCCAGGTCCACCATGCGCCGCTAC CCCAACCAGCTTTCCGGTGGCCAACGTCAGCGCATCGCCATCGCCCGTGCATTGGCACTG AATCCAGAAGTGATCGTGTTGGATGAAGCGGTTTCCGCTTTGGACGTGTTGGTTCAGAAC CAGATCCTCACCCTGCTTGCAGAACTTCAGCAGGAACTGAAGCTCACCTATTTGTTCATC ACCCACGACTTGGCCGTTGTTCGACAAACCGCCGACGATGTTGTGGTGATGCAAAAGGGA CGAATCGTTGAAAAGGGTCGTACCGACGACATCTTCAACGATCCTCAGCAGCACTACACC CGCGATTTGATCAATGCGGTACCTGGTCTGGGAATCGAGTTGGGTACTGGAGAAAACCTG GTT >RXA01939-downstream TAACCCGCACAGCCTCACTAAAC >RXA01972-upstream ACGCGTTGCTGGATATCACCCTGGCCGTCGATGACAACGCCGAATGCATCGACGCCGGAT GCGCCGTACCTGGGTGTGTCACTGGACAGGAGAGTGCGTA >RXA01972 GTGGCAACCGGTCTACTGTCGGCGATTGGTCTGTTTATCGCCACCAATATCGACGACATC ATCGTGCTCTCGCTGTTTTTTGCCCGCGGGGCGGGGCAAAAAGGGACCACGCTTCGGATT CTGGCTGGTCAGTACCTCGGCTTCATGGGCATCCTCGCGGCCGCAGTCCTGGTCACGGTG GGGGCAGGAGCATTCCTACCTGCTGAGGCGATCCCGTACTTCGGACTAATTCCCCTGGCC CTGGGACTATGGGCGGCCTGGCAGGCCTGGCGAAGCGATGATGACGACGATGATGATGCG GAGATCGCCGGGAAAAAGGTGGGTGTGCTGACCGTCGCCGGTGTGACGTTTGCCAACGGT GGCGACAATATCGGCGTCTACGTCCCGGTCTTCCTCAACGTGGACACTGCCGCCGTCATC ATCTACTGCATCGTTTTCCTCGTCCTGGTGGCAGGCCTGGTCCTGCTGGCAAAGTTCGTG GCCACCCGCCCGCCCATCGCAGAAGTCCTTGAGCGCTGGGAGCACGTGCTGTTCCCGATC GTCCTGATCGGCCTGGGCATCTTCATCCTCGTCAGCGGCGGCGCGTTCGGCCTC >RXA01972-downstream TAATAAGCCCATCCCGAGGGCCC >RXA01986-upstream GCCACGATTAAAGACATTGGTGATGTGAATCACTGGGTACTACATCGTGTTTCGTGACGC TGCACCTCCAAGTAAGGGCACGACAAACTTAGGAGAGAAG >RXA01986 ATGGCTAGTACCTTCATTCAGGCCGACAGCCCTGAAAAAAGTAAGAAGCTGCCCCCACTC ACAGAAGGTCCGTATAGAAAGCGGCTATTCTACGTTGCACTAGTTGCGACGTTTGGTGGG GTGCTCTTCGGATATGACACCGGAGTAATCAACGGTGCACTCAACCGAATGACACGTGAG CTCGGACTAACCGCGTTCACCGAGGGTGTTGTAACTTCTTCCCTGCTGTTTGGTGCAGCA GCTGGTGCGATGTTTTTCGGTGGCATTTCCGACAACTGGGGTCGCCGGAAAACAATCATC TCACTTGCAGTAGCTTTCTTTGTCGGCACCATGATGTGCGTGTTTGCTCCATCTTTTGGA GTAATGGTTGTCGGACGTGTGCTTCTTGGACTCGCAGTTGGTGGCGCTTCCACTGTTGTC CCTGTCTACCTGGCTGAACTTGCTCCTTTTGAAATCCGTGGCTCAGTGGCTGGCCGTAAT GAGTTGATGATTGTTGTTGGTCAGCTCGCAGCTTTTGTCATCAATGCGATTATTGGAAAT GTTTTTGGACACCACGATGGTGTGTGGCGCTAGATGCTGGCAATTGGCGCAATCCCAGCA ATTGCCCTCTTCTTTGGA >RXA01995-upstream CCGACGGAAAGGCATGCGCCTGCGTGTCTCGAGTAGTCTCCTCCCCTTCCTCGTCCCCAA CCTCGACCATTACGGTCGCCGTCTCCTAAAGGAGGCTGGC >RXA01995 ATGGATATCCGCCAAACAATTAACGACACAGCAATGTCGAGATATCAGTGGTTCATTGTA TTTATCGCAGTGCTGCTCAACGCACTGGACGGCTTTGATGTCCTCGCCATGTCTTTTACT GCGAATGCAGTGACCGAAGAATTTGGACTGAGTGGCAGCCAGCTTGGTGTGCTGCTGAGT TCCGCGCTGTTCGGCATGACCGGTGGATCTTTGCTGTTCGGTCCGATCGGTGACCGTTTC GGCCGTAAGAATGCCCTGATGATCGCGCTGCTGTTCAACGTGGTGGGATTGGTATTGTCC GCCACCGCGCAGTCCGCAGGGCAGTTGGGCGTGTGGCGTTTGATCACTGGTATCGGCATC GGCGGAATCCTCGCCTGCATCACAGTGGTGATCAGTGAGTTCTCCAACAACAAAAACCGC GGCATGGCCATGTCCATCTACGCTGCTGGTTACGGCATCGGCGCGTCCTTGGGCGGTTTC GGCGCAGCGCAGCTCATCCCAACATTTGGATGGCGCTCCGTGTTCGCAGCCGGTGCGATC GCAACTGGTATCGCCACCATCGCTACTTTCTTCTTCCTGCCAGAATCCGTTGATTGGCTG AGCACTGGCCGCCCTGCGGGCGCTCGCGACAAGATCAATTACATTGCGCGCCGC >RXA02033-upstream TGATCTGCTGTATCAGGTGGTTGATCCAAGAGTCGGTGCTGTTGGGGTTGCTAGCACTAA GGTTCCAGGGAGCGTGGCTTAAGTGACAACGATCAAAAAC >RXA02033 ATGCCCCTTTCAGGGAAAATCGGCGGCTTCATCGTTGGCGTTGTATTTGTTCTTGCTGCG CTGTCTTTCATTTGGACTCCGTTTGATCCAGTTCAAGCTTTCCCACAGGAGCGCCTTGAG GGAAGTTCTTTGAGGCACCTGTTGGGAACGGATCGTTATGGTCGCGATGTTTTATCCCAG ATCATGGTTGGTTCCCGCGTCACGTTGTTGGTGGGCATGATTGCGGTGGCGATCGCAGCA TTAATCGGCACGCCACTGGGTATTGCTGCGGGAATGCGCCGTGGCATGGTGGAAACCTTT GTCATGCGTGGTGCCGATTTAATGTTGGCGTTCCCAGCACTGTTGTTGGCGATTATTTCC GGCGCCGTTTTCGGCGCCTCCACGTGGTCCGCGATGGTCGCGATCGGCATCGCAGGCATC CCTAGTTTTGCCCGCGTGGCTCGTGCAGGCACATTGCAGGTGACCAGTCAGGATTTCATC GCAGCTGCTCGGCTATCAAAAGTAAGTTCCGCCCGGATCGCGCTTCGCCATATTTTGCCC AACATCACCAGCATGTTGATCGTTCAGGCATCAGTAGCTTTTGCCCTGGCGATCCTGGCG GAAGCCGCATTGAGTTTCCTCGGTTTGGGCACGACTCCCCCGGATCCCAGCTGGGGTCGC ATGTTGCAAACCGCTCAAGCATCCATCGGCGTCACCCCCATGTTGGCGGTGTGGCCCGGT GCTGCGATCGCTTTGACGGTCCTTGGTTTTAATCTTTTCGGTGATGGTTTACGCGATGCC ATCGATCCA >RXA02033-downstream TAGTATTATAT >RXA02034-upstream TCGTGGTGATGTCACCAGAGATCACCGGCATTGATCCCAACGTGGTGTCCGGGGCGTTGG AATTGTCGTTGATTGGTCGGAAAGAATCCGGGGTAGCGCA >RXA02034 GTGAGTAAAACAATCGCTTGGACTGTGCTGCGGTACACCCTGACTTTTGTGATGGCCAGC ATCATCATTTTTGTGCTGATTCGAGTCATCCGCGGTGACCCCGCCGCTGTTGCCCTGGGA ATTACCGCGACACCAGAAGGAATCGCTGCGTTGCAATCACAATTAGGTACTGATCAACGG CTTTTCCAACAGTACTTTTCCTGGATAGGTGGAATGCTCACTGGCGATTTCGGCACCTCG CTGAGCTCTGGCCAAGACCTTTCCCCGATCATTTTTGACCGCTTACAAGTGAGCCTCATT TTGGTGGGATGCTCCATTGTGTTGTCGTTGCTCATTGCCATTGCACTTGGTGTGCTTTGG GCCCGGCGCGGTGGCGTGATCATTTCCGGCATCAGCCAGATTGGCATTGCGATCCCTAGT TTGCTCGCCGGTATTTTGTTGGTCGCTGTCTTCGCGGTTGGTTTGGGGTGGCTGCCCGGC AATGGCTGGATTCCGCCGTCGGAAAACTTTGGAGGTTTCTTAGCCAGGCTGATCCTCCCG GTTCTGGCTCTTACTGCTGTTCAAGCAGCAATTTTGACCCGCTATGTCCGCTCTGCAGTA ATGGATGTAATGGGGCAAGATTTCATGCGCAGCGCGAGGTCGAAAGGTATGAGCTTCAAC CGCGCGTTGATCATCCACGGTCTTCGGAATGCTGCTCTTCCTGTCCTTACCGTCACTGGT TTGCAGCTAACAACCTTGGTTATCGGCGCCGTGGTGATTGAACAAGTCTTTGTCATCCCC GGAATCGGTTCGATGCTGCTGGAGTCCGTGTCCAACCGTGATCTCATCGCTGTGCAATCT ATTGTCATGCTGCTGGTGGCGTTCACGTTGCTGGTTAATTTGGTGGTTGATCTGCTGTAT CAGGTGGTTGATCCAAGAGTCGGTGCTGTTGGGGTTCCTAGCACTAAGGTTCCAGGGAGC GTGGCT >RXA02034-downstream TAAGTGACAACGATCAAAAACAT >RXA02035-upstream GGATTTTCCATTGGCGGAGGTTCATGCGGCGGGTATCCATTGCCTTCCATTTTAGTTTTC CATTTACTTTCCCGCATCACACCGACTAATCTCAGAAGCC >RXA02035 ATGAAGATCACGCGCGGACTCCTGCCATCATTGCTGTTGGCAAGCACAATCGTGGTGTCG TCATGCTCTGCTGGATCGACTGCGTATCAGCAGCCCCCTGCTGTTGATCAATCATCCATT GTCATTGCTACCACGGCTGCTGCGGCGTCACTTGATTTCACCAATGCTGCGGGCGCTGCT ATTCCGCAGGCGATGATGTCCAATATTTACGAGGGGCTTGTGCGCATCGATGCGGAGGGT GAGATTCAGCCGCTGCTTGCCACGTCGTGGGATATTTCACACGATCGCACCCAGTACATT TTCCATTTGCGGGAGGGTGTGCTGTTTTCCAACGGCGATCCCTTCAATGCTGATTCTGCG AAGTTTTCCATTGATCGGGTAAAAACTGACTGGACCAATGGTTTGAAAAGTGGCATGGAT GTGGTGGAGTCCACCGAGGTGATTGACGATCACACGCTGAAAGTTTCGCTGGTCAGGCCG TCCAAGCAATGGTTGTGGAGCATGGGTACCGCGATGGGTGCCATGATGACGGAGGGGGGC GTCGATAAGCTGGCAACTGATCCCGTTGGCACCGGCCCGTACACGGTGACGCACTGGGCG CCGGGGCGCGCAATTGGGTTCGGCGCGCGGGCCGATTATTGGGGGCAGAAGCCGCTTAAC GACGCCGCAACCATCCGCTACTTCAGCGATGCGACGGCCTCGACCAATGCGCTGCAAAGC GGTGACGTGGACGTGATTTCGGCGATGCAAGCGCCCGAACAGCTGGCTACGCTCCAGCAA TACACCGTGGAAGTGGGCACAACCAATGGTGAGATGTTGGTGTCGATGAATAATCAGCGT GCACCTTTTGATGATGTGCGTGTGCGCCAGGCGGTGATGTTTGCGATTGATCGCCAAGCC GTCATTGATACCGCGTTGGAAGGTTACGGCACCGACACTGGTGGCGTGCCTGTTCCGCCG ACTGATCCGTGGTACGAGAAATCCACGATGTACCCCTACGATCCGGACCGCGCACGGGCA TTGTTAGAGGACGCCGGCGCCGAGGGAACGCGGATCACCATGTCCATTCCTTCGTTGCCG TACGCTCAGGCAGCCTCTGAAATCCTGTACTCGCAACTGCGAGATGTTGGTTTTGATCCT GTGATTGAATCAACCGAGTTCCCAGCCGTCTGGTTGGCACAGGTCATGGGGCAAAAAGAC TACGACATGTCACTAATCGCGCATGTGGAACCCCGCGACATCCCCACGCTGTTTAGCCCC AACTACTATTTGGGCTTTGACGACACCGAAACCCAAGCCCTCCTCGCAGAGGCAGACAGT TCAGCAAACGAAGTGGAATTGATGCAACAAGCTGTCGATCGAATCATGGAACAAGCCGTC GCCGACAACCTCATGAACGTGGCCAACATCGTGGTGATCTCACCAGAGATCACCGGCATT GATCCGAACGTGGTGTCCGGGGCGTTGGAATTGTCGTTGATTGGTCGGAAAGAATCCGGG GTAGCGCAG >RXA02035-downstream TGAGTAAAACAATCGCTTGGACT >RXA02062-upstream TTGTCTAAACATCGTTTTGGGGTCCGAATGATAGCCCCTTTTAATGCCCCCATTTCGGTA TCGCTGCGCAACTGTTTTTAGATGGCTAATCTTTGAAATT >RXA02062 ATGAGAGTCGGAATGATGACAAGAGAGTATCCACCAGAGGTTTACGGCGGCGCTGGCGTG CACGTCAGCGAATTGACCCGATTCATGCGTGAGATCGCTGAAGTTGATGTTCACTGCATG GGTGCACCTCGCGATATGGAGGGAGTTTTCGTCCACGGCGTCGATCCTGCCTTGGAAAGC GCGAACCGTGCGATTAAGACACTGTCCACCGGTTTACGCATGGCAGAAGCTGCAAACAAC GTGGATGTCGTGCACTCACACACTTGGTATGCAGGTCTTGGCGGCCACCTTGCAGCTCGT CTCCACGGCATTCCTCACGTGGCTACCGCGCACTCTTTGGAGCCAGATCGCCCATGGAAG CGTGAGCAGCTTGGCGGTGGATACGACGTGTCCTCCTGGTCTGAAAAAAATGCCATGGAA TACGCTGACGCGGTCATCGCTGTGTCGGCTCGCATGAAAGATTCCATCCTCGCTGCGTAC CCTCGCATCGAGCCGGACAACGTGCGTGTTGTCCTCAACGGCATCGACACTGAGTTGTGG CACCCTCGCCCGACTTTCGATGACGCGGAAGATTCCGTACTCCGCTCCCTAGGCGTTGAC CCACAGCGGCCCATCGTCGCATTTGTCGGCCGCATCACCCGCCAAAAAGGCGTCGAGCAC CTCATCAAGGCAGCAGCGCTTTTCGACGAGTCCGTGCAGCTTGTGCTCTGTGCCGGCGCG CCAGACACCCCCGAAATCGCAGCTCGCACCACCGCCCTGGTGGAAGAACTCCAGGCAAAG CGCGAAGGCATTTTGTGGGTTCAGGACATGCTGGGCAAGGACAAAATCCAAGAGATTCTC ACCGCTGCTGACACCTTCGTGTGCCCATCCATTTACGAGCCACTGGGCATCGTGAACTTG GAAGCAATGGCCTGCAACACCGCAGTTGTCGCATCCGACGTTGGAGGCATCCCTGAGGTT GTTGTCGAGGGCACCACCGGCGCCCTCGTTCACTACGACGAAAATGATGTCGAAACCTTC GAGCGCGATATCGCCGAAGCGGTGAATAAAATGGTCGCTGATCGAGAGACCGCAGCCAAA TTTGGTCTCGCAGGGCGCGAACGTGCTATGAATGATTTCTGCTGGGCAACGATTGCTCAG CAGACCATTGATGTGTACAAATCCTTGATG >RXA02062-downstream TAAAACCGAAAGCCGGGGAACCT >RXA02068 ATTTTTGTCCCCATGTTGCGTATCGCTGCCATTGAACCGAAAGACATTACTTTGGTTACC GGTTCTGTATCACTTCGAACCTTTCGCGTGCGCACCGGTGAATTGCAGGTCATGGGCGAT ATTGTGGGTGCAAAAGTACATACCGATGATCCAGAGCTGCAACAATTCCACGGTCGCGCG GTAGAAATCGCCGATGTGGAGCTGGAGTTATCGCGCACTCGCGATTGGATCATCACGCGC GTGGCGGTGCTGGGTGAGCGCGCTAAATTTGGCCGGCGCCCAGTGCTGCACACAGTGCCG TGGAGTCATATCGACGGCATCACCGCAGGTGGTGTCGGCGAGTCCAATCACACCGCCGAA CTCATCGCAGGGTTTGAGGATATGAGGCCTGCGGAGGTGGCAAAGCAGCTTTATCAGCTG CCTACGGCTCAGCGTACCGAAGTGACGGAAGAGCTTGACGACGAAAAGCTGGCGGATATC CTGCAGGAATTGTCCGAGGACCGCCAAGCCGAGTTGATTGAAGAATTAGACATCGAACGT GGCGCGGACATTCTGGAGGAAATGGATCCAGATGATGCTGCAGACTTGTTGGGTGAGCTG CCTGATGACAAAGCTGATGTGTTGTTGGATCTGATGGACCCTGAGGAATCTGCGCCGGTG GGTCGTTTGATGGATTTCTCCGCGGACACCGTTGGTGCGGTGATGACTCCTGAGCGATTA ATTATGGATCCTTCCACCACAGTCGCTGAAGCGTTGGCGATGGCCAGAAACCCCGACCTT GCTACTTCTTTGGCATCGTTGATCTTTGTGGTGCGGCCACCGACGGCCACGCCTACTGGA AAATACCTCGGCTGCGTGCATCTGCAGAAACTGCTTCGGGAGCCTCCATCAAGTTTGATT GGTGGCATCGTCGACCCCGATCTGCCACCGCTCTACGCTGATGATTCTCAAGAAACCGCA GCTCGATTCTTTGCCACCTACAACTTGGTGTGCGGCCCGGTCTTGGATGAAAACCGCCAT CTGCTTGGTGCCGTAGCTGTCGATGACTTGCTCGACCACATGCTGCCAGAAGACTGGCGC GACGCCGGAATCCGACCAGGAAAGGAGCACACCCATGGC >RXA02068-downstream TGATTTCAACCGCTCTGAATTAG >RXA02079-upstream CGGGGAGCCGTGCGGACGCTGCGGAACATTAATCATCGGGGAGAGTTTCATGAACCGCGG CTCCCACTACTGCCCAAACTGCCAGAAGCGGCGCTAGCTG >RXA02079 ATGAGCGAAGCTTTTGATGCAACCAAAGTGCGCAAAGCTGTGCTCACGGTGGCGCTGCTT AACTTCGCTTATTTCTTTGTAGAATTCTTTATTGCATTAAGCGCAGGCTCCGTTTCTCTA CTGGCTGACAGTGTCGATTTTCTTGAAGACACCTCGATGAACCTGCTCATTTTCATTGCC CTAGGATGGCCGTTGGCGAGGCGCGCAGTGATGGGCAAACTTATGGCGATTGTGATTCTT GCACCTGCTGCTTTTGGTGCGTGGGCAGCGATTCAACGGTTTTCCGCACCGCAAGCGCGC GAAGTGTTTCCGATCATCGTCGCTTCTCTGGGGGCGGTCGTGATCAACGGCGCGAGTGCC ATCATTATTTCTCGAGTGCGACAACATGGTGGCTCGCTTGGCCAAGCTGCCTTCCTATCC GCCCGAAATGACGTCCTGATCAAGATTGCCATCATCATGATGGCCTTAATTACCGCATGG ACGACGTCTGGATGGCCAGATTTGATGCTAGGTTGTTTCATCATTCTGCTCGCACTGCAC GGCGCTCAGGAGGTGTGGGAAGTCAGTGAGGAAGAACGCCTCGCCTCCAAAGCCCTTGCT GGGGAAGCCATCGAT >RXA02079-downstream TAGGGGAGCAGTATGAGCTTTTC >RXA02096-upstream CGCTTCGACGACCTCACCCACAGCGATATCCGCAGGAATGTCATCGCGGTTTTTGATGAG CCGTTCTTGTAGTGCTCCTCCATACCGCGAGAACATCTCG >RXA02096 ATGGGTTTGGATGTCAGTGATGAGCAGATCGAACACGCAGCCAGGCTTGCCCAGGCTCAT GATTTTATCGATCGCCTTCCAAACAAATACGAGGAAGTCATTGGCGAACGCGGCCTGACG CTTTCTGGTGGTCAACGCCAACGCATCGCCCTCGCACGGGCTTTCCTGGCGCATCCCAAA GTGTTGGTGCTTGATGATGCCACCTCTGGCATTGATGCCTCCACTGAGGACCGCATTTTC CAGGCCTTGCGGGAAGAACTGCACGATGTCACCATTTTGATCATCGCGCACCGCCACTCC ACTTTGGAGCTCGGCGATCGGGTTGGTCTGGTCGAAGATGGACGGGTAACAGCACTGGGA CCGTTGAGTGAGATGCGTGATCACGCTCGTTTCTCGCATCTGATGGCTCTTGATTTCCAG GATTCTCAGGATCCGGAATTCACCCTCGACAACGGTTCACTACCCAGCCAAGAGCAATTG TGGCCGGAGGTCTCCACAGAAAAGCAGTACAAGATTCTTGCGCCTGCCCCTGGTCGAGGC CGTGGCATGTCCATGCCAGCAACCCCTGAGCTGCTCGCCCAGATTGAGGCGCTGGCAGCA GCAACGGAAGAAACACGAGTTGATGCCGGGAGGCTACGCACCAGTACCTCCGGTTTCAAA TTGCTCAGTTTATTCAACCAGGTCCGTTGGCTCGTCGTCGCGGTCATCGCGTTGTTGCTG GTGGGCGTAGCCGCCGATCTAGCATTTCCAACACTGATGCGCGCAGCCATCGACAACGGT GTGCAAGCACAAAGCACCTCCACGTTGTGGTGGATCGCCATCGCAGGCAGCGTAGTAGTC CTTCTGTCCTGGGCCGCCGCCGCGATCAACACGATTATCACGGCACGCACCGGTGAACGG CTGCTTTACGGCTTGCGTCTGCGCTCATTTGTGCATCTATTGCGCCTGTCCATGAGCTAT TTCGAACGCACCATGTCCGGCCGCATCATGACGCGCATGACCACCCACATCGACAACCTC TCGTCCTTGCTCCAATCAGGTCTGGCGCAAACAGTTGTCTCTGTGGGCACGCTCATCGGT GTGCTCACCATGCTCGCCATCACCGACGCACAACTAGCACTCGTTGCGCTGTCCGTGGTG CCGATCATCATCCTGCTCACTCTCATTTTCCGACGCATCAGCTCCAGGCTGTACACCGCT TCACGCGAGCAAGCCAGCCAGGTCAACGCGGTATTCCACGAGTCCATCGCCGGTTTACGC ACCGCGCAGATGCACCGCATGGAAGACCAAGTCTTTGACAATTATGCGGGCGAAGCA >RXA02119-upstream TTCGGTCCGCTCTGGCAAAAATGGCTGGCTGCCACCTCGGCGCAGCAGCTTAAGGGCTGG GCTTAAATTGCTTGTCGACGCCTAGTGCCACAATGGAGAC >RXA02119 ATGACCGAAACACTTGTGGTGAATGGCCTAGCAGGCGGCTATGGGCACCGCACATTATTT AACGATGTGAATCTCACCGTAGCTGCCGGCGATGTCGTGGGCGTTGTCGGCGTCAATGGC GCTGGTAAATCCACATTTCTAAAAATTCTGCCGGGCGTGGAAAAGCCACTGGCTGGAACT ATCGCGCTTTCGCCAGCCGATGCTTTTGTGGGCTACTTGCCACAGGAACACACCCGCACG TCTGGAGAGACGATCGCAGTTTACATTGCTCGTCGAACCGGCTGCCAAGCTCCAACAACT GCCATGGATGACACCGCCGAAGCGTTTGGTGCGGATCCAGACAACGCTGCCTTGGCCGAT GCATACGCCGAGGCGCTGGATCGGTGGATGGCCAGTGGCGCAGCCGATTTGGATGAACGC ATCCCCATCGTGCTCGCTGATTTGGGCTTTGAGCTTCCCACCTCGACGCTGATGGAAGGA CTTTCAGGCGGGCAGGCAGCCCGCGTCGCGCTGCCGGCGTTACTGTTGTCACGTTTTGAC ATTGTGCTTCTCGACGAGCCCACCAACGATTTGGATCTCGACGGTCTTGAGCAACTGGAG AATTTTGTTCACGGGCTTCGCGGGGGAGTCGTACTGGTCAGCCATGATCGTGAGTTTCTT TCCAGGTGTGTGACCACTGTGCTGGAACTCGATCTGCACCAAAATTCCCACCATGTTTAT GGCGGTGGATATGATTCCTACCTTGAGGAACGCGCAGTGCTACGCCAGCACGCCCGTGAC CAATATGAGGAATTTGCGGAAAAGAAGAAGGACCTTGTGGCACGTGCTCGAACGCAGCGT GAATGGTCTAGTCACGGTGTCCGCAATGCTATTAAACGTGCACGTGACAACGACAAACTT CGGAACAAAGCCGCTGCGGAATCCAGTGAAAAGCAGGCTCAAAAAGTCCGCCAGATGGAA AGCCGCATCGCTCGGTTAGAAGAAGTTGAAGAGCCACGTAAAGAATGGAAACTGCAGTTC AGCGTCGGTAAGGCGTCGCGGTCAAGTTCTGTTGTTTCCACGTTGAATGATGCAAGCTTC ACCCAAGGCGATTTCACGTTGGGACCAGTATCCATCCAAGTAAATGCTGGCGATCGCATT GGCATCACAGGACCCAACGGTGCTGGTAAATCCACATTGCTGCGCGGACTATTGGGAAAC CAAGAACCCACCAGCGGTACTGCCACGATGGGCACGAGCGTGGCGATCGGAGAAATCGAT CAGGCACGAGCGTTACTTGATCCACAGTTGCCACTGATTTCTGCGTTTGAAAAGCATGTT GCAGACTTACCGATCAGTGAGGTGCGCACACTGCTCGCGAAATTTGGGCTGAATGATAAT CATGTGGAAGGGGACGTCGAAAAGCTATCTCCTGGCGAGCGCACGCGCGCCGGACTTGCG GTGCTACAGGTGCGGGGCGTCAACGTGCTTGTTCTTGATGAGCCCACCAACCACCTTGAC CTGGAGGCCATCGAGCAATTGGAGCAAGCGTTGGCCTCGTATGATGGTGTGTTGCTGCTG GTCACGCACGATCGTCGCATGTTGGACGCTGTGCAGACCAATCGTCGTTGGCATGTCGAG GCTGGCGAAGTTAGGGAGCTA >RXA02119-downstream TAACCGTTTCCGTATTGATGCCA >RXA02220-upstream GGGCTTTCGCCGCGGAATGGTCCCTCGTCCAGGTCTTTAATTGATGTCTTGACGTGATCT GGGCGGGCACGCGGCCAATCATGTGAAAGGTCTGTTTTAG >RXA02220 GTGTCGTCCCCTCTCCCCGCTGCCGTGACATCAAAACCCGCCCACGCGCTTTCCTCTGAT GAGGTGTTAGAAAATCTCGGGGTCCAGGACACCGGATTGACCTCCGCGGAGGCAACACAG CGTTTGGAAGCAAACGGGCCAAACGAGGTTCCTCAAACTCCACCTGAAACAGTCTGGCAA CGGCTATTCCGCCAGGTGAACGATCCAATGATCTACGTTCTCATTGCCGCCGCGGTACTC ACGGCGTTTCTTGGGCATTGGACAGACACCATCGTGATCGGCGCCGTTGTCATCATCAAC ATGATGGTTGGGTTCATCCAAGAGGGCAAAGCTGCGGATGCGTTGGCATCGATCCGCAAC ATGCTCTCCCCGGAATCCGCGGCGTTGCGCGATGGGGTCTTCCACAAAATTGATGCGGCA GAGCTGGTGGTCGGTGACGTTGTGAAACTATCCGCCGGCGATAAAGTGCCCGCTGACCTG CGCATGCTCGCCGCCACCAATCTGCACATTGAGGAATCCGCGCTCACCGGCGAGGCGGAA GCAGTGGTCAAAGGTACTGATCCAGTTGAGGCGGACGCCGGAATCGGCGACCGCACATCC ATGGCGTTTTCAGGAACGCTGGTGCTCACAGGCAGCGGCACCGGCGTGGTCACCGCCACC GGTGCAGGCACAGAAATCGGGCACATCACCACCATGCTTGCCGACGTCGACTCCGTGGAT ACCCCATTGACTCGGTCGATGAAAAAGTTCTCATCGGCGTTAGCAATCGTGTGTGTATTC CTAGCGATCCTCATGCTGGTGGTTGCCGGTCTAGTCCACCACACACCTTTGGAAGAGCTC ATTCTTTCCGCCATCGGCTTTGCGGTGGCTGCCATTCCGGAGGGTCTACCTGCGGTTATC GCCATCACGCTGGCATTGGGTGTGCAAAAGATGGCAGCTCGAAATGCGATTACGCGCCGG TTGAATTCCGTGGAAACACTTGGCTCTGTCACCACCATCTGCACGGATAAAACCGGCACA CTCACCCGCAATGAGATGACAGTCGGCGCAATCGCCACCGGTACGAGTCTTTATGACGTC AGTGGAGCAGGCTACGAAGCTCTCGGGGAAATCCGCTTAAAAGACGGCGAGCAAGTATCC AAGCAGGATTTCCCAGATCTCTACGGGATGGCGTTGGTGGCAGCGAACGTCAACGACGCC GAAATTTACGAAGAAGACGGCATGTGGAGGCTTTCCGGCGAACCCACGGAGGGCGGTATT CGTGCCTTTGCAATGAAAACCAACGCTGAAATCTTGACCCGAAGAGCCGAAGTCCCCTTC GATTCCGCATAGAAATACATGGCGACGCTTCACACCATCGATGGAGCAAACACCATGCTG GTCAAGGGCGCTGCCGATCGTTTATTGGATAGAAGTGCACAGCAGCGCAACGGTGAACCA CTTGACCGGCCGTATTGGGAACAGCTGATCGAGGACCTCGCGTCCCAAGGGCTCCGCGTG CTGGCTGCGGCATATAAAGAGCTTCCCCACAGCACGTCAACAATTACTCCAGAAGATGTT GACCAGGGCGAACTCACCTTCCTCGGGCTCTACGGCATCATGGATCCGCCACGCGAAGAA GTCATCGAAGCCATGAAAGTGGTGCAATCGGCAGGCGTTCGCGTCCGCATGATCACCGGC GATCACTCCTCCACGGCCCGCGCAATCGCCCGCGAAGTGGGAATCCGCGGCCAGAACGTG CTCACCGGTGCGGAAATTACTGCGGCTACTGATGAGGAGCTGCAGGGACTCGTCGATAAT GCTGATCTTTTTGTGCGCACCAGCCCCGAGCACAAGCTGCGCGTCGTGCGCGCACTGCAA GCTAACGGCGAAGTCGCGTCCATGACGGGCGACGGGGTCAACGATGGGCCAGCGCTAAAA CAAGCCGACGTCGGCGTCGCCATGGGCATTAAGGGCACCGAAGCCACCAAAGACGCGGCC GACATCGTGCTTGCCGACGACAATTTCGCCACAATCGCCGGCGCCGTAGAAATGGGTCGC ACCATCTACGACAACCTGCGCAAAGCCGTCGTCTTCATGCTCCCCACCAACGGCGCCCAA GGCCTCGTCATTTTCATCGCGATGCTGCTCGGCTGGGAACTGCCCATCACCGCACTTCAA GTGCTGTGGATCAACCTCATCACCGCGATCACACTGTCCCTGGCGCTGTCCTTCGAGCCG GCCGAGCCCGGCATCATGAACAGAAAAGCCAGAAACCCCAAGAGGGGGCTTATCGACGCC CCCTCCGTGCTTCGCATGGTCTATGTCTCCCTGCTGCTCGGCGGAGCAACGTTCTGGGCT TTCCTTGGCGCGCGCGACGCAGGAATCGACATCGACACCGCCCGCACCATCGCGGTGACC ACCCTTGCAGTCAGCCAAGTGTTCTACCTTTTAAGCTCCCGATACTTCGAAGTATCCGCG CTGCGAAAAGAACTGTTCACCACCAACGCGATTTCCTGGCTGTGCATCGCACTCATGCTG ATCCTGCAAGTGGCCTTTGTCTACGTGCCGTTCATGCAAAGCACCTTCGACACCGCCGCA CTGACGCTTAGAGATTGGGTCATGCCACTGGTGTTTGGTGTTGTTGTCTTTGCGGTCGTT GAAACCGAGAAATTGATCAGGCGCCTTAAAGGGTCT >RXA02220-downstream TAAGGTTTCAGCCCCTCAAGATA >RXA02222-upstream CATGCGCTGAACATCGTCTGTCTACAGCGTTTGGAGAACGGGAAAAAGATGAGGCAGTAC AAGATTGCAAAAACCTTGAAAAAGTGTATGGCAGCGATGG >RXA02222 TTGGGTCGACCTCCCCCAGGAGACGTTCATACTCTCCTAGACGATATCGGAGCAGAGGAA TCTGAAGCAGATAAAGTTCCAATTGAATGGCAAAACGCCCTGACTAAGGCAGACAGGTAT GCAAACCGGCAACACATGTCTCAGGCACGACTCTATCGCCAATTAACCAGTGATGTTGGA GAGGGCTTCACTGAAGAAGCTGCCCAATACGCAATCGAAAATGTGAACGCAGACTGGAAC GCTAACGCCCTAGTAAAAGCAAGAAATTACCAGGAGCGCCAAGCAATGTCAGTAGACGGC ATTTACAGGCAACTTACTAGTGAACACGGTGAAGGGTTTACCCCAGAGCAGGCACAATAC GCGATCGACAACCTA >RXA02222-downstream TAAGGCATAAAGATCCTAGTATT >RXA02312-upstream TTAGCGCCCATTAACGCTTCACATCCTTATATTCCCAAGGAGCACGACCATTTCTGATTC AGCAGTCCAGGAGAATCACGAACCGCACCTCAAGCGCGGT >RXA02312 TTGAGCAATAGACACCTTCAGCTCATCGCCATCGGCGGAGCGATCGGTACGGGTCTGTTC ATGGGGTCCGGCAAGACGATCTCCGTTGCGGGGCCATCAGTAATTTTGGTGTACGCCATT ATTGGTTTCATGCTTTTCTTCGTCATGCGTGCCATGGGAGAGCTGCTGCTCGCCAATTTG AATTACAAATCTTTGCGCGATGCGGTCTCTGATATTTTGGGTCCTGGCGCAGGTTTTGTC ACCGGCTGGACATATTGGTTCTGCTGGATTGCCACAGGCATGGCGGACATCGTGGCGATC ACTGGATACACCCAATACTGGTGGCCTGAGATCCCATTGTGGCTTCCAGGTGTGCTCACC ATTGCGTTGCTGTTTGCCCTGAACTTGGCTGCGGTACGACTGTTGGGTGAGATGGAGTTT TGGTTCGCCATCATCAAAATCGTGGCTATCGTGTCCTTGATCGTCGTGGGACTTTTCATG GTGGTCACAGCCTTTGAATCACCTAATGGCACCACCGCGCAGTTCAACAACCTCATTGAG CATGGCGGATTTTTCCCCAACGGCATCACCGGTTTCTTGGCTGGTTTCCAGATCGCTATC TTTGCGTTCGTCGGGATTGAACTTGCCGGCACTGCAGCTGCAGAGACTGAGAATCCCAGC AAGACGCTTCCTCGGGCAATCAACTCCATTCCCATCCGCATCGTGGTGTTCTATGTTTTG GCGTTGGCTGTCATCATGATGGTCACCCCATGGGATCAGGTCCGTGCTGACAACAGCCCA TTGGTGGAGATGTTCGCGCTGGGAGGAATCCCAGCGGGGGCAGGCATCATTAACTTTGTG GTCATCACTTCTGCAGCGTCGTCTGCCAACAGTGGTATTTTCTCCACCTCGCGCATGTTG TATGGATTGTCTTTGGAAGGCGCAGCTCCGAAACGGTGGAGCCGGTTGTCCAAGAACTTG GTGCCAGCCAGGGGATTGACTTTTTCTGTGATTTGCCTCATTCCAGCGGTGGGTTTGCTG TACGCTGGCGGCACTGTCATCGAGGCATTCACACTGATCACCACGGTTTCTTCGGTGTTG TTCATGGTGGTGTGGTCCTACATTTTGGTGGCTTATATCGTCTACCGCCGCAACAGCCCG GAATTACACAAAAAGTCGATTTTCAAAATGCCTGGCGGCGTGGTCATGGCAGTTGTGGTG TTGGTGTTCTTCGCAGCGATGTTGGTGGTGCTGTCCCTGGAGCCGGATACCCGTGCAGCG CTCATCGCGACGCCAGTGTGGTTCATCATTTTGGGTATCGGTTGGTTGTCCATCGGTGGA GCTAAGGGCGCTAAGCATCGCAGCCAAATAACCTCCCAC >RXA02312-downstream TAAAGCTCCTGGGTTAGACTCGA >RXA02313-upstream CAGGATGTAACCGAAAAGATCTCAACACTTAAATAAAGTTCTCGATAAAGCCATGTTGGG TTAACTGCGATGTAGGCATGATGTGGAGATAATAAGGCCC >RXA02313 ATGCGGGTAGCAATTGTTGCAGAGTCGTTGCTTCCAAATGTCAACGGAGTCACGAACTCG GTGCTCCGGGTGTTGGAGCATTTGAAAGGCAAGGGACACGACGCGCTCGTCATCGCGCCG GGTGCCCGGGATTTTGAAGAAGAAATCGGCCACTACCTGGGCTTTGAAATTGTGCGCGTC CCCACCGTTCGGGTCCCACTGATTGATTCACTGCCCATCGGTGTTCCTCTGCCCTCAGTT ACCTCTGTGCTGCGCGAGTACAACCCAGACATCATTCACCTGGCATGCCCATTTGTGCTC GGTGGAGCGGCAGCATTCGCAGCAAGGCAGCTGCGCATCCCAGCAATTGCTATCTATCAA ACTGATGTGGCAGGGTTCTCCCAGCGCTACCACCTGGCACCGTTGGCCACTGCAAGCTGG GAATGGATCAAGACGGTCCACAACATGTGCCAGCGGACCCTTGCTGCCTCATCGATGAGC ATTGACGAGCTGCGTGACCACGGAATTAATGATATTTTCCACTGGGCTCGGGGCGTGGAC TCCAAGCGTTTCCACCCTGGAAAGCGTTCCGTAGCGCTAGGTAAGTCTTGGGATCCAAGT GGAGCAAAGAAGATCGTTGGTTTCGTTGGGCGCCTTGCATCCGAAAAGGGCGTGGAGCGC CTTGCTGGATTATCCGGACGCTCAGACATCCAATTGGTCATCGTCGGTGATGGCCCAGAG GCCAAGTACCTGCAGGAAATGATGCGGGATGCGATCTTCACAGGAGCTCTCGGCGGCGAG GAACTAGCCACCACCTACGCATCACTCGATCTGTTTGTGCACCCAGGTGAGTTTGAAAGC TTCTGCCAGGCGATCCAGGAAGCCCAAGCATCAGGTGTGCCCACCATTGGCCCACGCGCA GGTGGTCCCATTGATTTGATCAACGAAGGCGTCAAGGGCCTGCTTCTTGATGTTGTAGAT TTCAAGGAAACCCTCCCCGCTGCAGCCGAATGGATTTTGGACGATTCCCGCCACTCCGAA ATGTGCGCAGCTGCTTGGGAAGGTGTGAAAGACAAGACCTGGGAAGCTTTGTGCACCCAG CTTCTCCAGCACTACGCGGATGTAATCGCATTGTCACAGCGCATCCCACTGACATTCTTT GGCCCTAGCGCTGAAGTAGCAAAGCTTCCACTGTGGGTTGCTCGCGCGCTGGGTGTTCGC ACCCGCATCAGCATCGAGGCT >RXA02313-downstream TAACTCTGCAGAATTAATCCATG >RXA02344-upstream AAAGACCCGAGCCGAAGCCCTGGCCTGCGCATACTTCCTTGTCAACGCTCGCTGGGATTA GGTCTTTTCTGAGCGCTAGCATTTCTCCACTCAAAGGAGC >RXA02344 ATGCTTAACCGCATGAAAAGTGCGCGGCCAAAATCAGTCGCTCCAAAATCCGGACAAGCT TTACTCACTCTCGGTGCCCTAGGTGTTGTGTTCGGCGACATCGGCACCAGCCCCCTGTAC TCACTTCACACTGCATTCAGCATGCAGCACAACAAAGTCGAAGTCACTCAGGAAAATGTG TACGGCATCATCTCCATGGTGTTGTGGACCATCACTTTGATCGTCACCGTCAAATACGTC ATGCTGGTCACCCGAGCTGACAACCAAGGACAAGGTGGCATCCTGGCGCTCGTTGCTTTG CTGAAAAACCGTGGGCACTGGGGAAAATTCGTGGCAGTAGCCGGCATGTTGGGCGCCGCA TTGTTTTATGGCGATGTGGTGATCAGCCCGGCGATCTCTGTTCTCAGCGCAACAGAAGGC TTGACGGTTATCTCCCCAAGCTTTGAGCGCTTCATTCTGCCCGTATCTCTCGCAGTTCTG ATCGCTATTTTTGCAATCCAACCGCTCGGTACAGAAAAAGTCGGCAAAGCCTTCGGCGCC ATCATGTTGCTGTGGTTTGTCACCCTTGCAGGATTGGGAATTCCGCAAATCATCGGGCAC CCAGAAATCTTGCAGAGCTTGTCTGCACATTGGGCCCTGCGCTTGATTGTGGCTGAGCCT TTCCAAGCATTTGTGCTG >RXA02348 CCAATCAGAGTGGGGTGGTTTTGCGTCGTCATGCCTGCTTTAATCTTGACGTATTTGGGG CAGGGCGCCTTGGTGATCAACCAGCCTGAAGCGGTGCGCAACCCCATGTTTTATCTCGCG CCGGAAGGTCTGCGGATTCCGTTGGTTATTTTGGCGACCATCGCTACGGTGATCGCATCG CAGGCCGTGATTTCTGGTGCGTATTCATTGACCAAGCAGGCCGTGAATTTGAAACTGCTG CCACGCATGGTGATCCGGCATACCTCCCGCAAAGAGGAAGGCCAGATCTATATGCCACTG GTTAATGGATTGCTGTTTGTATCCGTGATGGTTGTGGTGCTGGTATTCCGATCCTCTGAA AGCCTCGCCAGCGCGTACGGACTTGCAGTGACCGGAACCTTGGTGCTGGTCAGCGTCCTG TATCTGATCTATGTTCACACCACATGGTGGAAAACAGCGCTGTTCATTGTGCTCATCGGT ATTCCAGAAGTACTTCTATTCGCCTCGAACACCACGAAAATTCACGACGGTGGCTGGCTT CCACTACTTATTGCGGCCGTGCTCATCGTGGTGATGCGGACCTGGGAGTGGGGAAGTGAC CGCGTCAATCAGGAACGCGCAGAGCTGGAACTTCCCATGGATAAGTTCTTGGAGAAACTC GATCAGCCACACAATATTGGTCTGCGTAAAGTTGCCGAAGTGGCAGTATTTCCACATGGC ACCAGCGATACTGTCCCGTTGTCATTGGTTCGCTGCGTGAAAGACCTCAAGCTTTTATAC CGAGAGATCGTGATCGTTCGAATCGTCCAAGAACACGTTCCGCACGTGCCAGCAGAGGAA CGCGCGGAAATGGAAGTGCTCCATCACGCCCCGATCAGAGTCGTGCGAGTTGATCTGCAC CTTGGTTATTTTGATGAGCAGAACGTGCCTGAGCATCTCCATGCCATTGACCCAACATGG GATAACGCCACCTACTTCCTGTCTGCCCTGACTCTTGGGAGCAGGTTGCCTGGAAAGATT GCTGGCTGGCGTGATCGTTTGTATCTTTCGATGGAACGTAATCAGGCATCTCGAACTGAG TCTTTCAAATTGCAACCAAGCAAAACCATCACGGTTGGAACAGAGCTGCACCTT >RXA02348-downstream TAATCAGGCAGTTGCTGGCCAAC >RXA02353 ATGGCACTGCTGATCCTCGCCGGTCTGCAAATGATCCCGAAGGAAACCTACGAAGCAGCC CGCGTCGATGGCGCAACCGCGTGGCAGCAATTCACCAAGATCACCCTCCCGGTGGTGCGC GCAGCTTTGATGGTGGCAGTACTCTTCCGCACCCTCGATGCGCTACGCATGTATGACCTC CCCGTCATCATGATCTCCAGCTCCTCCAACTCCCCCACCGCTGTTATCTCCCAGCTGGTT GTGGAAGACATGCGCCAAAACAACTTCAACTCCGCTTCCGCCCTTTCCACACTGATCTTC CTGCTGATCTTCTTCGTGGCGTTCATCATGATCCGATTCCTCGGCGCAGATGTTTCGGGC CAACGCGGAATAAAGAAAAAGAAACTGGGCGGAACGAAGGATGAGAAACCCACCGCTAAG GATGCTGTTGTAAAGGCCGATTCTGCTGTGAAGGAAGCCGCTAAGCCA >RXA02353-downstream TGACTAAACGAACAAAAGGACTC >RXA02354-upstream GAATAAAGAAAAAGAAACTGGGCGGAACCAAGGATGAGAAACCCACCGCTAAGGATGCTG TTGTAAAGGCCGATTCTGCTGTGAAGGAAGCCGCTAAGCC >RXA02354 ATGACTAAACGAACAAAAGGACTCATCCTCAACTACGCCGGAGTGGTGTTCATCCTCTTC TGGGGACTAGCTCCCTTCTAGTGGATGGTTATCACCGCACTGCGCGATTCCAAGCACACC TTTGACACCACCCCATGGCCAACGCACGTCACCTTGGATAACTTCCGGGACGCACTGGCC ACCGACAAAGGCAACAACTTCCTCGCAGCCATTGGCAACTCACTGGTCATCAGCGTCACC ACAACAGCGATCGCTGTTCTCGTGGGAGTGTTCACCGCCTACGCTCTAGCCCGACTGGAA TTCCCGGGCAAAGGCATTGTCACCGGCATCATCTTGGCAGCCTCCATGTTCCCCGGCATC GCCCTGGTCACTCCGCTGTTCCAGCTCTTCGGTGACCTCAACTGGATCGGCACCTACCAA GCGCTGATTATCCCGAACATTTCCTTGGCGCTACCTCTGACGATCTACACGCTCGTATCC TTCTTCAGGCAACTGCCCTGGGAACTCGAAGAATCAGCACGTGTCGACGGCGCCACACGT GGCCAAGCGTTCCGCATGATGCTGCTTCCTCTAGCAGCGCCCGCACTATTTACCACCGCG ATCCTCGCATTCATTGCAACGTGGAACGAATTCATGCTGGGCCGCCAACTATCCAACACC TCCACAGAGCCAGTGACCGTTGCGATCGCAAGGTTCACCGGACCAAGCTCCTTCGAATAC CCCTACGCCTCTGTCATGGCAGCGGGAGCTTTGGTGACCATCCCACTGATCATCATGGTT CTCATCTTC >RXA02394-upstream TGTTGATGAATCAGAAGAACCTCGAGATTTGGACGAGCTAGAGGCCCAAAGCGCTATAGA TTCTGCAAGTTCAGCGGAAGGTAGGAACTAAT >RXA02394 ATGTTGTCGCCAGCAGCTGTAGCAGCTTTAATTCTTGTCATCGGCATTGTGGTGCTCATC ATCGCATCAGTGCCCGTTGCCATTGCCATCGGTTTGCCATCACTTTTTGCCGCGATGGCC GTGCTTGGCCCAGAAAACGCCGCGCAGGCCGTCGCGCAGCGCATGTTTACCGGCACAAAC TCCTTTACACTCCTTGCCATTCCGTTCTTCGTGTTGGCGGGTTTGCTGATGAACTCGGGT GGTATTGCCACGCGGCTTATCGACGCCGCGAAGGTGCTTGTCGGCCGCATGCCTGCCTCC ATCGCCAATACGAATATCGCAGCAAATGGTCTCTTCGGAGCAGTTTCAGGGGCAGCGGTA GCATCAGCTTCTGCCGTGGGAACCGTCATGACACCAAAAATGAAGGAAGAGGGCTACTCG CGCGCTTACGCAGCGGCCGTCAACGTGGCTTCAGCACCTGCGGGCATGCTGATCCCGCCA TCAAACACTTTTATTGTGTATTCCTTGGTGTCCTCGACATCAATTGCAGCACTATTTATG GCCGGTGTTGGACCCGGTCTGCTCTGGATTCTGGCCTGTGTCATCGTGGGAACTTGGTTA GCGCGAAAGGAAAACTACAAGCGCGAGCAGATTCATCCAACATTCAAGCAGTCGCTCGTT GTGCTGTGGAGGGCGCTGCCTTCACTGCTCATGATCGTCATTGTTGTTGGAGGTATCTTG CTGGGCTGGTTCACTCCAACTGAATCCGCTGCTATTGCTGTAGTGTACTGCCTGGTCTTG GGCTTTATTTACCGCACAATCAAGGTGGGAGATGTGGCAGATATTTTGCTCAAGGCAACT CGCACCACATCAATTGTCATGTTGCTCATTGCAGTTTCTGCAGCACTGTCGTGGGTGATG GCCTTTGCCAAGATCCCTCAGATGATCTCTGATGCGCTTCTTTCGGTATCCGATTCCAAG GTTGTCATGTTGTTGATCATGATGTTCATCCTGTTACTCATGGGTAGCGTAATGGACCCA ACACCAGCAATTTTGATCTTCGTCCGGATCTTCGTTCCAGTGGTTACCGAACTTGGTGTG GACCCAGTCCACTTCGGTGCGATGGTGGTAATGAACCTGTCCGTGGGCGTGATTACCCCA CCAGTAGGCAACGTGTTGTTCGTTGGTTCGCAAGTGGCAGGGCTGCGTGTGGAAACTGTG ATCAGACGACTGTGGGCGTATCTCATTGCCATTATTGTTGCGCTGTTCGTGGTTGTTTTC GTACCGCAGATCTCTATCTGGCTGCCGACAACAATGGGATTGATGGGAGGC >RXA02394-downstream TAAACCTCCAGCCATCAGCTAAG >RXA02402-upstream CACTACTGCGTTAAGGTATGAAAGTTCGCACACCAGCGATTTAATTCTGTGCCCACCACT AGCACGAGCATTTCAGTTTTAACTTTCTTGGAGTTTTCTA >RXA02402 GTGTCCAAAACAGAAGAAGGCCGTTCAGCGGCGATAATTATTTACGCGTTTCCAACTTTG ATTGTGCTGGGCGCGATCATTGCGTTTATCTTCCCGGAACCATTCATTCCGCTGACAAAC TACATTAATATCTTCCTCACGATCATCATGTTCACCATGGGTTTGACCTTGACGGTGCCC GATTTTCAGATGGTGCTTAAACGTCCACTGCCTATCTTGATCGGTGTAGTAGCGCAGTTT GTCATCATGGCATTCCTGGCGATCGTGGTTGCGAAAATGTTCAACCTCAACCCAGCACTC GCCGTTGGCCTTCTCATGCTGGGATCGGTTCCGGGTGGCACCTCCTCCAATGTGATTGCG TTTCTGGCCCGAGGAGATGTCGCGCTATCGGTCACCATGACCTCTGTGTCCACGATTGTT TCCCCAATGATGACGCCTTTCCTCATGCTCATGCTGGCAGGTACTGAAACCGCCGTCGAT GGTGGAGGCATGGCGTGGACTTTGGTACAAACAGTGCTGCTGCCTGTGATCATCGGCCTA GTTCTGCGTGTCTTCTTGAACAAGTGGATCGACAAGATTTTGCCGATCCTTGCTTATGTC TCCATCCTCGGTATCGGTGGCGTGGTGTTCGGCGCAGTCGCAGCCAACGCGGAACGACTC GTGTCTGTCGGACTCATCGTGTTCGTTGCAGTTATCGTGCACAACGTACTTGGATACGTT GTGGGATACCTCACCGGCCGTGTA >RXA02422-upstream CTTAAACGTCACCTTATTTATGCATTATGTTGGTTTCAGACTCGAACAATTCAATTAGAA AACACTAATCGGACATTTAGGTCACATAACATTTCCGCTC >RXA02422 GTGTCCACATTAATTTCTGAACCCGAGGTGGATAAGCTACGTAAACGTGCCAAGAGATCA AGGCGGACAGAATGGTGGCTTGCCGCCGCACTTCTTGCCCCAAACTTGCTTCTCTTGGCC ATCTTTACGTATCGGCCACTGTTAGATAACTTCCGGTTGTCCTTTTTCAACTGGAACATT TCCTCGCCCACATCAAGCTTCATTGGGTTTGATAACTACGTTGAGTTCTTCACTCGTAGT GACACTCTCCAAGTTGTTTTAAACACCGTCATCTTCACGGCATGTGCTGTGATCGGATCG ATGGTGCTCGGTTTGCTCGTGGCGATGTTGTTGGATCAGAAGCTTTTCGGCCGTAACTTT GTGCGTTCCATGGTGTTTGCCCCGTTTGTGATTTCCGGTGCTGCCATTGGTGGTGCTTTC CAGTTCGTTTTTGAC >RXA02438-upstream CAGGTTGGAACCCTGACTGGTTCATGTTCTTCCTCGGCGGCACCCTACTTCTGGCTGTTT TGCTCAATCACCGATTCGAGCGTTTCAACAAGGAGCGATC >RXA02438 ATGACAGACCTCATTCAACTCCGCGAAGTATCCAAAAAATACGGTGGTTTCCAGGCCCTC AACGACATCAATTTGAACGTCCGCGCAGGCGAAGTCACCTGTGTTCTGGGTGACAACGGC GCCGGAAAATCCACCCTCATCAAGATTCTCTCCGGCCTGCATCCCGGCACCTCCGGCGAA GTAATCGTGGCCGGCGATGTAGTGAATTTTGGATCCCCCCGCGACGCCCTCGACGCCGGA ATCGCCACCGTCTACCAAGACCTAGCAGTGGTCGGGCAGATGAGTGTGTGGCGCAACTTC TTCCTCGGCCAGGAACTCACCGGCCGATTTGGCGTTCTGAAACAAGAAGAAATGCGCCGC ATCACCGACGAACAACTCCGCGAAATGGGCATCGAACTCCGCGATGTCGACGTCCCTGTG GCCTCCCTTTCAGGTGGTCAACGCCAAGTTGTCGCCATCGCCCGGGCCATCTACTTCGGC GCGCGCGTCCTCATTTTGGACGAGGCCACCGCAGCGGTGGGCGTGAAACAATCTGGCATG GTGCTGCGCTTTATTGCCGGAGCACGCGACCGGGGGATCGGCGTCATTTTCATGACGCAC AACCCCCACCACGCCTACCTTGTCGGTGATCACTTCATCCTGCTCAACTTAGGCAAGCAG GTCATGGACAAATGGCGCGCAGAAGTCGAGGTGGAAGAAGTCACCCTCGGCATGTCCGGC GGCGGCGAGCTCGACTCACTCAGCCACGAATTGAAGCGT >RXA02438-downstream TAACCTAGTTCTTCTTTTCGCTC >RXA02439-upstream GCACCACTGTTGGTGGCGGACGACCCGTGTACACAGGACCAGCCATTGTGGATGCCACCA ACGTTGATGTCATTGCTGAAGCCGTTGGGGAGGGTCTGCG >RXA02439 ATGACAAAAATCAAGAGTGGGGAGGCGTCGACAAGCATTGTTGAGCGCGCCTTAAAGCGC CCCGAACTGACCAGCGTGCTTGGCGGCGTGCTTGTTTTTACGCTGTTTATGGTGGTCGCG GCGGCATTTAGGTCATGGGATTCGATGGCGACCGTGCTGTATGCGAGTTCCACGATCGGC ATCATGGCGGTTGCCGTGGGCGTGCTGATGATCGCTGATGAATTCGACCTGTCGACCGGC GTTGCCGTGACAACTGCAGCGCTGGCGGCCTCGATGTTTAGCTATAACCTGTGGCTGAAC ACCTGGGTGGGCGCGCTGATTGCATTGGTGATTTCGCTGGCCATCGGCTTTTTCAACGGC TTTTTGGTAGTGAAAACCAAGATTGGATCCTTCCTGATCACCCTTGCCACTTTCCTTATG CTGCAGGGTATTAATCTGGCGGTCACCAAGCTGATTTCCGGCACCGTGGCCACGCCAACC ATCGCGGATATGGAAGGTTTTCCTTCAGGGCGTGCGGTGTTTGCCAGCTCGATTCCCATC TTTGGTGTGAATATTCGCATCACTGTTTTTTGGTGGCTGCTGTTTGTTATCGTCGGCACT TTTGTGTTGTTTAAGACGCGCATCGGCAACTGGATTTTTGCGGTCGGTGGCGATGAAGAG GCAGCTCGCGGAGTCGGGGTTCCCGTGCGTGGCGTGAAAATCGGCCTGTTCATGTTCGTT GGTTTTGCCGCCTGGTTTGTGGGCATGCACAACCTGTTCCTCTTTGATTCGATTCAGGCT GGTCAAGGCGTGGGTAATGAGTTCCTCTACATCATCGCTGCGGTGATCGGAGGCATCTCC ATGACTGGTGGGCGCGGAACAGTGGTGGGCACAATGATTGGTGCACTCATCTTTGGAATG ACCAACCAAGGCATTGTTTATGCAGGTTGGAACCCTGACTGGTTCATGTTCTTCCTCGGC GGCACCCTACTTCTGGCTGTTTTGCTCAATCACCGATTCGAGGGTTTCAACAAGGAGCGA TCA >RXA02439-downstream TGACAGACCTCATTCAACTCCGC >RXA02441-upstream CCGGCGACCAGGGCGCGGGAGATGAATGAAACGTCAAAGGCACTATGAGGGCGTCAGTA AAAAACTTCATTTGAAAATGATAACCGTTATCATTAAGGA >RXA02441 ATGGCAGAACTGAGCGTCCGGAATCTCACATGCACATACGGCAATCACATCGCGCTCAAC AACATCACGGCACGCTTCCCAACCGGAAAAATAACTGCCCTCATCGGCAGCAACGGCTCC GGAAAATCCACACTGTTGGAAACTTTGGCGGGCATGCTGGCACCCCGCAGCGGAAGCATT AACAACGTTGTGCCAGAAATCGCGTTCGTCCCCCAACGCAGGCACGTCTCGGATAATTTG CCCATCAGGATCAGACAAACAGTCAGCATGGGGCGATGGTCAGCCAAGAAAAACTGGCAA CGACTCACTGCCGCAGATTGCAACATCGTGGACAGCTGGCTCGACCGGCTCGAAATCTCC GGCCTCGCCGACCGCCCCCTCGGCGAAGTATCAGGCGGGCAGCGCCAACGCGCCCTCATA GCGCAAGGTTTAGCGCAACAGGCGCCGTTATTGCTTCTCGACGAACCCCTCGCCGCCGTG GACTCCCACGCGGCAAGTCTTATCGAAGATGTCATTAACCAACAACGGAACCAAGGAACC ACAATTATTCTTGCGACTCACGATCTTGATCAAGCACATCAAGCAGATCAGATTATCGCC TTGGAAAAAGGAATCATAAAGCCACAGCGCAAAGCCACTGAATCAATAAAGAAGCGT >RXA02441-downstream TAATAAAGTTTGACTTGTGCCTC >RXA02442-upstream GCGGTGATGTTGTTGAGCGCGATGTGATTGCGGTATGTGCATGTGAGATTCCGGACGCTG AGTTCTGCCATTCCTTAATGATAACGGTTATCATTTTCAA >RXA02442 ATGAAGTTTTTTACTGACGCCCTCATAGTGCCTTTTGACGTTTCATTCATCTCCCGCGCC CTGGTCGCCGGATGCCTGGCCGCAATTTTATGCTCACTCATTGGAACGTGGGTTATTTTG CGCAGGCTAACCTTTTTCGGCGACGCTATGTCGCACGGCTTGCTCCCCGGAGTAGCCACG GCATCACTATTGGGCGGAAATCTCATGTTCGGCGCAGCAATCAGCGGATTAATCATGTCA GCCGGAGTGGTGTGGACCAGGAGAAAATCCAGCCTCTCGCAAGACGTCAGCATTGGCCTG CAATTTATTACCATGCTTTCCCTCGGCGTGGTTATTGTGTCCCACTCCGATTCCCACGCC GTAGACCTCACCAGTTTCCTTTTTGGAGACATTCTTGGCGTGCGACCCTCGGATATATTC ATCATCGCCATTGCAACAGTGTTGGGTGGATTGACTATTTTTGTCTTCCACCGACAGTTC ACTGCACTCGCTTTCGACGAGCGTAAAGCTCACACCTTAGGACTCAATCCCCGCTTTGCA CACCTAGTCATGCTGGCACTGATCGCATTAGCTACGGTGGTGTGGTTTGAGGTGGTGGGA ACGCTTTTAGTGTTTGGACTTGTCATTGGTCCGCCCGCCACGGCTGGACTTTTAGTGCAA GACAAAGCAAGTATTTGACTGATCATGATCGTCGCGTCGCTTCTTGGATGCGCGGAAATT TACCTCGGGCTTTTAATCAGCTGGCACGCAAGCACTGCCGCGGGAGCCACTATCACTTTG TTAAGTGCTGCGATATTTTTTGCCACCTTATTGACAAAGAGTGGCATTAGTAGGTTAAAC TTCACCGCG >RXA02442-downstream TGATACTGAAAGACATTTTCAAT >RXA02447 TGGGTGTGGCTGGCGGAAATCTTCCCAGTCCGAATGAAGGGTATCGGCACCGGTATTTCG GTATTCTGCGGTTGGGGCATCAATGGGGTCCTAGCGTTGTTCTTCCCAGCACTGGTCTCC GGCGTGGGTATCACCTTCTCCTTCCTTATCTTGGCAGTCGTCGGAGTCATTGCCCTGGCG TTCGTCACCAAGTTTGTTCCTGAAACGGGTGGCCGCTCACTTGAAGAACTCGATCACGCA GCATTCAGCGGCCAGATCTTCAAGAAGGCT >RXA02447-downstream TAAACCCCCTCCGATGTCTTTGG >RXA02451-upstream GATCAACTTAAGCCTCTAGCTATTTTCAACTGTGTTTCAGTTGCGGGATCGTTGGGTGCC TAATTGGAGTTGTGCTTTTAGGTGGAGGATCATAGAGGTT >RXA02451 ATGAACACCGACACAACTCAAGACGGTGTGAGTCCTGAACCTTCCGACCCCCACCTAGGG TCTGAAGTGGCGGAAACTCACCGCGAAAAGAAATTCTTCGGCCAGCCTTGGGGGCTGGCA AATCTCTTCGGCGTGGAGATGTGGGAGCGATTCAGCTTCTACGGCATGCAGTCCATCCTT GCTTTCTATCTGTACTACTCCGTCACCGATGGCGGACTTGGTATGAATCAGACAGCTGCA CTGTCCATTGTGGGCGCCTACGGCGGCTTCGTCTACATGACCTCCCTCGTGGCTTCGTTC ATTGCAGACCGAGTATTGGGCTCTGAACGTACACTCTTGTACTCCGCGATCATCGTCATG CTGGGCCACATTGCCCTGGCCTTGATTCCGGGATATACGGGACTGTCCATCGGCTTGGTC CTCATCGGCCTTGGCTCAGGTGGCGTGAAGACGGCAGCGGAGGTTGTGCTGGGCCAGCTG TACTCACGCACGGACACGCGTCGAGACGCAGGCTTCTCCATCTTCTACATGGGCGTCAAC CTCGGTGGCCTCTTTGGCCCGCTGATCACCAACGCTCTGTGGGGATGGGGAGGATTCCAC TGGGGCTTCGGTATCGCCGCAGTCGGCATGGCTTTGGGTCTCATCCAATACGTGGCGATG CGTAAAACCACGATCGGTGCGGCAGGCCATACTGTTCCTAACCCACTGCCTAAGAATGAA TATGCGCGCTGGATTATCGGTGCAGTCGTGGTTGTCGCAGCAGTTGTCGCTGTCATCGCA ACGGGCATCATCAAGCTGGAATGGCTGTCCAACATCACCGCAGCGATCGCACTGATTGCG GCTATTGCTCTGCTTGCTCAGATGTACGTTTCCCCACTGACCACCGCAGCGGAAAAGTCC CGCTTGTTGGGATTCATCCGGATGTTCATCGGTGGCGTGCTTTTCTTCGCGATCTTCCAA ACCCAGTTCACGGTCCTCGCGGTTTACTCCGACACCCGCCTGGACCGTAACTTCTTCGGC ATTGATCTTCCTCCAGGATTGATCAACTCCTTCAACCCAATCTTCATCATCATCTTCTCC GGAATCTTTGCCACCTTGTGGACAAAACTCGGAGCAAAGCAGTGGTCTACTGCAGTGAAG TTCGGTGTCGCCAACATTGTCATTGGTTGCGCGCTGTTCTTCTTCCTGCCGTTCGCCGGC GGTGCAGAGAACTCTACCCCAATGGCACTGATCATTTGGGTCTACTTCCTCTTCACCATC GCTGAGCTTCTGCTCTCCCCTGTCGGCAACTCACTTGCAACCAAGGTCGCACCCGAGGCA TTCCAGTCCCGCATGTTCGCCGTGTGGCTGATGGCTGTCTCCATGGGTACGTCCCTGTCC GGCACCCTGGGTGGTTACTACGATCCAACCGATGCAGGATCTGAAAAGGTCTTCTTCATT ACCGTTGGCGTTGCAGCCATCGTTCTTGGTGCAATCGTCATAGCAGCCAAGGGCTGGGTG CTGAAGAAGTTCATCGACGTCCGA >RXA02451-downstream TAGGCCTCACAAAGCCTCAAAAC >RXA02491-upstream TTTCGTATGCTGACATGGTGTCGCTTCAACTGCGTTGCTTTAGTGCCCTTTAGTATATAG AGACGTCCCGCTGCTTTCTTCGGCGATCTAGAATGTGGGC >RXA02491 ATGGGCGTAGCTATGATTTCCATGCACACCTCTCCATTGCAGCAGCCCGGAACTGGTGAT TCAGGCGGGATGAACGTCTACATTCTTTCGACCGCGACTGAGCTAGGGAAACAGGGTATC GAGGTCGATATTTACACTCGTGCCACGAGGCCTTCTCAGGGTGAGATGGTGAGAGTAGCT GAGAATTTGCGGGTGATTAATATCGCTGCGGGGCCGTATGAGGGGGTTTCCAAAGAGGAG GTTCCTACTCAGTTGGCGGCGTTTACCGGCGGAATGTTGTCGTTTACGCGCCGGGAGAAG GTTACTTATGATCTGATCCATTCTCACTATTGGCTGTCTGGTCAGGTGGGGTGGTTGCTG CGCGATTTGTGGCGGATTCCCCTTATTCATACGGCACACACTTTGGCGGCGGTGAAGAAT TCTTATCGGGATGATTCGGACACTCCGGAGTCGGAGGCGCGTCGCATTTGTGAGCAGCAG CTGGTGGATAACGCTGACGTGTTGGCGGTGAACACTCAGGAGGAGATGCAGGATTTGATG CATCACTACGATGCGGATCCGGATGGGATTTGTGTGGTGTCACCGGGTGCGGACGTGGAA CTTTATAGCCCTGGAAATGATCGCGCGACGGAACGTTCCCGTCGTGAGCTGGGCATTCCG CTGCACACAAAGGTAGTGGCTTTTGTGGGTCGGTTGCAGCCGTTTAAGGGCCCGCAGGTG CTGATCAAGGCGGTTGCGGCGTTGTTTGATCGCGATCCGGACCGAAATGTGCGCGTCATT ATTTGTGGCGGCGCTTCTGGTCGGAATGCGACACCGGATACCTATAGGCATATGGCAGAG GAACTGGGCGTCGAAAAGCGAATTCGCTTTTTGGACCCGCGCCCGCGGAGCGAGCTAGTG GCCGTGTATCGGGCGGCGGACATCGTGGCCGTGCCAAGTTTTAATGAGTCCTTCGGAGTC GTCGCCATGGAGGCGCAAGCCAGCGGCACACCGGTCATTGCGGCCCGGGTTGGCGGCCTG CCCATCGCAGTCGCGGAAGGGGAGACGGGATTGCTTGTCGACGGCCACTCCCCGCATGCC TGGGCCGACGCGTTAGCCACACTCTTGGAGGATGACGAAACGCGCATCAGAATGGGTGAA GACGCCGTCGAACACGCCAGAACATTCTCCTGGGCGGGCACCGCCGCACAGCTATCGTCG CTGTACAACGACGGTATTGCCAACGAAAATGTCGACGGTGAAACGCATCACGGC >RXA02491-downstream TAAGTAAACGCGCGTCGTGGAAC >RXA02507-upstream ATTACCCACAATTTCAATCGGTTTATACAACCAGCCTCTAACTGGCAACAGGACTGCAGA CAGAAACTGTTGCTGGAACCTTCGATGAACAGGATCGACA >RXA02507 ATGAGCGAACAACTTCAGGGTGTAACTCACTCCGAATCAACTCCGGGCAAGACGCCCAAG CGAGCAGCACTATCCAGCTGGATCGGCTCAGCTCTCGAATACTACGACTTCGCTGTTTAC GGAACCGCTGCAGCGCTGGTTCTTAACCACCTCTTCTTCCCAGCTGATACTTCACCAGGC ATCGCAATTTTGGCTGCGATGGGTACCGTGGGTGTTGCTTATGTGGTTCGCCGTCTTGGT GCGCTGATCATGGGTCCATTAGGTGACCGTTACGGACGTAAATTTGTCCTCATGCTGTGC GTCTTCCTGATTGGAGCATCCACTTTCGCAGTTGGCTGCTTGCCAACATTTGATCAGGTC GGTTACTTGGCTCCGGCACTGTTGGTGCTGTGCCGTGTGATCCAGGGACTGTCTGCATCC GGTGAGCAGTCCAGTGCGATTTCCGTTTCTTTGGAGCACGCCGATGAGCGTCACCGCGCA TTTACTGCTAGGTGGAGTCTTCACGGAACCCAGTTCGGTACCTTGCTGGCAACCGGAGTA TTTATCGCATTCACCTTGTTCCTGAGTGAAGATGGTCTAATGTCATGGGGTTGGCGCGTT CCGTTCTGGCTGTCCGCTGCTGTTGTTTTGGTTGGTTTCCTCATCCGTCGTGGAGTGGAA GAGCGACCAGCATTCCGTGAAAACAAGGAAGCAGTTGCAGGCGCAGCATCTCCACTGGCG ATGACCTTGCGTTACGACAAGGCGGCGGTTGCTCGCGTTGCTATTGCTGCGATGATCAAC TCCGTGAACATTGTGTTTACTGTGTGGGCACTGTCGTTCGCCACCAACATTGTTGGCCTG GATCGTTCAACTGTTTTGCTGGTTCCAGTTGTTGCGAACTTGGTTGCACTGATTGCGATT CCTTTGTCCGGCATGCTGGCTGACCGCATTGGTCGCCGACCAGTGTTCATCATGGGTGCC ATTGGTGGTGGCCTGGCCATGAACGGTTACCTGGGAGCTATCTACTCCGGCAATTGGACC ATGATCTTCTTCATGGGCGTGTTGATGTCTGGTCTGCTGTACTCCATGGGTAATGCCGTG TGGCCAGCGTTCTACGCAGAAATGTTCCCAACCTCTGTGCGTGTCACCGGCTTGGCTCTT GGAACTCAGATTGGTTTCGCAGTCTCTGGTGGTTTCGTCCCAGTTATCGCATCCGCGCTT GCTGGTGATCAGGGTGACCAGTGGATGAAGGTGTCCATCTTCGTTGGTGTTGTTTGTGTG ATTTCTGCACTGGTTGCCATGACCGCTAAGGAAACCAAGGCTCTGACTCTGGATGAGATC GATGCTCTGCACACTGCTGGTGGTGAGGCCGCAGACCTGGCAGCCGCAAGCAAAGCCTCC GAGGCCCAACTCGCGGCTCAG >RXA02507-downstream TAAAACCAAAAGGAATCTTTGAC >RXA02515-upstream GTGGCTAAGCACAGTTAGTTGGCGAAGCTGGGCGGCAGAAAAACCGGCCGAGCTAATACT TCAGTTTAAAATTGGCTTCAACCCTGAAAGATTGTGACAG >RXA02515 ATGAGCAGTCTTGAAATGGGTAACCTGCACGCACAGGTCCTGCCGTCCGATGAGTCCGCT GAGCCTAAGGAAATCCTCAAGGGCGTCAACCTCACCATCAACTCTGGTGAGATCCACGCC ATCATGGGCCCTAACGGTTGGGGCAAGTCCACTCTTGGTTACACCCTTGGTGGACACCCA CGCTACGACGTAACCGCAGGCGAGGTCCTCCTCGACGGCGAGAACATCCTGGAGATGGAA GTTGATGAGCGTGCAGGCGCTGGTCTCTTCCTGGCCATGGAGTATCCAACTGAAATCCCT GGCGTTTCCGTTGCTAACTTCCTGCGTTCCGCAGCGACCGCAATCCGCGGCGAGGCTCCT AAGCTTCGCGAGTGGGTTAAGGAAGTCGGCACCGCTCAGGAAGCTCTGGCAATTGACCCT GAGTTCTCCAACGGCTCAGTCAACGAAGGTTTCTCCGGTGGCGAGAAGAAGCGCCACGAG GTTCTGCAGCTTGATCTGCTGAAGCCAAAGTTCGCGATCATGGATGAGACCGACTCCGGC CTTGACGTGGATGCACTGCGCATTGTTTCCGAGGGCATCAACTCCTACAAGCAGGAGACC GAAGGTGGCATCTTGATGATCACCCACTAGAAGCGCATCCTCAACTACGTTAAGCCTGAC TTCATTCACGTTTTCGCGAATGGCCAGATTGTGACCACCGGTGGCGCTGAGCTTGCTGAC AAGCTCGAGGCTGACGGCTACGACCAGTTCATCAAG >RXA02515-downstream TAACATGTCCGATTTCCTCAATG >RXA02562-upstream CGGGTGCGCTGAGGGTGAGGTTGGGGCGACGAGGCGTGCATGGACTTTAGGTTAGGTTAT TGAGCAGATTTATTTGGGCTTTTGTCTAGGGTGGGGAGCT >RXA02562 ATGTTCTTGACAAAGGTTTCGCTGCTTGATCATCCGGAGTCATTGCCGGGGTATTTATCG AGCCTGGCGATCGTGGAATATCTGCATGAACAGCCGTTGGAGTTTCGTGCACCGATTACT GTGATTACTGGTGAAAATGGGGTGGGTAAATCCACGTTGGTTGAGGCTTTGGCGGTGGGG ATGCGCCTTAATCCGTCTGGTGGCTCTAGGCATGCAAACTTTGGCAGGGAAGGCGATATT GTGTCGTCGCTTCATCAGTCGTTGAAGTTGGTGCGGAGAGAAAACCCTCGGGATGCGTTC TTTTTTCGGGGTGAGACGATGTATAACGTGGCTTCCTATTATGAGGAGTTAATGGGGGAA AAGAACATGCATGATCTTCACAAGATGAGCCATGGCGAATCGGTATTTGCGGTGATTGAT CGGCGTTTTAACAATCAAGGATTTTTTGTTTTGGACGAGCCTGAGGCAGGCCTTTCCATG CTGAGGCAGTTGGAGTTGTTGGGAAAGTTGGGCAACCTTGCTCGAGGTGGTGCGCAGATC ATCATGGCTACGCACTCTCCAATATTGTTGGCTATTCCGGGGGCAGAGATCCTTGAAATT ACATCTTCGGGTGTTGCAAAGGTGAATTTTGAGGATGCGGAGGCTGTTCGTGCGGCTCGG GAATTTGTGGCAGATCCGCGAGGTACGGCGGCGTTTCTGACTGCGGAGGAGGATCACCAA >RXA02562-downstream TGATGCCGTATATCACCGATATT >RXA02595-upstream GTGGGTAAAGGGGACTCCGAGGAAGTCCACGTCGTCTTCTTTCGCGGCGCTGAGGATGGT TTCGCGGATTTGTGCGGGGGAGTGGGTGGGAGAGAAAACG >RXA02595 GTGATCGTTGTGGCCATGGCTTCCATTATGGCTTGTTTAAAAGCAGCTAGACTGAATAAC CCTATGAAGATCCTTTTGTTGTGCTGGCGTGATACCACTCATCCTCAAGGTGGCGGAAGT GAACGCTATCTGGAGCGGGTGGGTGAGTTTTTGGCGGATCAGGGCCATGAGGTGGTGTTT CGTACTGCTGGGCACACGGATGCGCCACGGCGTTCTTTCCGCGATGGTGTGAGGTATTCC AGGAGCGGTGGGAAGTTTAGTGTGTATCCCAAGGCGTGGGTGGCCATGATGTTGGGTCGT GTGGGGATTGGCACGTTTTCCAAGGTTGATGTGGTGGTGGATACGCAGAATGGCATTCCG TTTTTTGGAAAGTTTTTCTCCGGTAAGCCGACTGTGTTGCTCACGCATCATTGCCATAAG GAGCAGTGGCCGGTGGTGGGTCGGGTGCTGGCGAAGGTTGGTTGGCTGATTGAGAGCCAG ATCGCGCCGCGCGCTTACAAAACTGCGCCGTATGTGACTGTTTCAGAGCCGAGCGCTGAG GAGCTCATTGCGTTGGGTGTGGATCAGCAGCGGATTCATATCGTGCGCAATGGCGTGGAT CCCGTGCCGCTGGACACGGCGAAGCTGGATCGCGATGGCCAGCATGCGGTG >RXA02597-upstream ATACCCAGTTTGCAAGAATTACAAACGGGGGCAGCCTCAATGACTTGAAAGACTTTATAG AGTAGAAAGTGAGTCACGACACTTTTTAAAGGAGGATGCT >RXA02597 TTGCCCGAAGAAGACTTAACGAGCTTGGCCAATGATTGGCTCCAAGCTTTTGAAAAGGCC ACTGCTAGTTCCAGCCCTGATGAAGCTGCCACTGCAGTCGTGCAACTTTTTGAGGATGAA GGATAGTGGCGAGACCTTCTTGCATTGACGTGGAACCTCACCACCGCTGAAGGTGGAGAT GAAATGGCCGAGATGATTCGCAATAGGTGGCCATCAAGCATCTTCCGAAACGTTGAGCTA AAGGGCGAAGCAGGTGATGAAGGAGATGGTGTCAGTCGCGTACATTTCTCCTGCGAATCC GCAGACTTGAAGTGCACGGGCATTGTCCGCCTTCGTAATGGCAAGGCGTGGACGCTACTC ACCTGAGCTCGTGAGCTGCTGGAGCAGCCAGAGCCCAAGGGGCGCAACCGTGAGATGGGC GTCGTCCATGGACAAAATGAGGACACCCGAAATTGGACTGACCGCAAGAATGATCGACAA GCAGCGTTGGGTGTCACCGAGGAGCCATACACCCTCATGATCGGTGGTGGACAGGGTGGC ATTGCCTTGGGCGCACGACTCAAGCGACTTGGTGTACCCGCTCTAATGATTGATAAAGCA TCTCGCCCGGGCGACCAGTGGCGTAGCCGTTACCATTCTCTGTGCCTGCACGATGCAGTT TGGTACGACCACGTGCCTTACATTCCATTCGCAGATCATTGGCCAGTATTTACTCCAAAG GACAAGATGGGTGACTGGCTCGAGCACTATGTCGGCATGATGGATTTGGACTATTGGACC AACACCGAGTGCCTGCGCGCCTCATACAATGAGGACACCAAGCAGTGGGATGTGACGGTG AATCGTGATGGCGGGGAGTCCACGCTCCACCCGACCCAACTAGTCATGGGTACTGGAATG TCGGGCAGCCCGAACAAACCAACTTTGCCTGGGCAGGATAAGTTCCAGGGTGAAATTGGG CACTCTTCAGAGCACCCCGGCGGCGATGTCGATGGCGATAAGAACGTTGTAGTTCTGGGC GCTAACAAGTCAGCGCACGACATCTGCGCGGATCTTTATTCCAATGGTGCAAAGCCCGTG ATGATTCAGCGCTCGTCTACACACATCGTGCGTTCTGATTGGCTGATGCGCGAAGTCTTC GGGCCTCTCTATTCTGAGGATGCCGTTGAAGCCGGAATTGATACGGATACTGGCGATCTC CTGTTTGCGTCGTGGCCATATAAGGTGCTGCCAGGTGTGCAGAAGCAGGCTTTGGACAAG ATCCGTGAGGACGACAAGGAGTTCTACGACAAGCTTGAAAATCCTGGATTCTTGCTTGAT TTCGGCGATGACGATTCGGGGCTTTTCTTAAAGTACCTTCGCCGTGGCTCTGGCTACTAC ATCGATGTCGGCGCCTCTGAACTGGTGGCTGATGGAAAGATTCCGGTGCGCTCCAATGTC AGCATTGAAGACGTCAAGGAAAACTCTGTGGTGCTCACAGATGGTACTGAGCTCCCAGCT GACGTGATTGTTCTAGCGACCGGCTATGGAAACATGAACAACTGGGTTGCTCAGCTGGTT GATCAGGAAACCGCTGACAAGGTCGGCCCATGCTGGGGTCTGGGCTCTGAAACCACCAAG GATCCAGGCCCATGGGAAGGCGAGTTGCGCAATATGTGGAAGCCCACAAACGTGGATTCG CTGTGGTTCCATGGTGGCAACCTTCACCAGTCACGCCATTACTCACGGTATTTGTCCATG CAGTTGAAGGCGCGCTACGAAGGTATGAACACTCCGGTGTACAGCAAG >RXA02597-downstream TAGATACAAAGAAAAGGGCATCT >RXA02605-upstream TGCGATCCTGTCATCTACATGTGGGAGAGTTTCCTTACCCAGGAATTGCCTGCATACCTT GAGCAGAACTTCGGCGTTGCGCGAAACAACAACTCCATTG >RXA02605 GTGGCCTGTCCATGGGCGGGAACTGCGGGGCTGAACCTCGCAGCAAAGCACCCAGATCAG TTCCGCCAGGCTATGTCTTGGTCCGGCTACTTGAACACCACTGCGCCAGGCATGCAAAGC CTGCTGGGTGTGGCCATGCTGGACACCGGTGGATTCAACGTCAACGCAATGTATGGCTCA ATCATTAACCCACGTCGTTTTGAAAACGACCCATTCTGGAACATGGGCGGCTTGGCTAAC ACCGACGTCTACATCTCTGCAGCTTCCGGCCTGTGGAGCCCTCAGGATGATGGAGTTCGC GTAGACCACCGCCTCACTGGTTCTGTGCTTGAATTCGTGGCAATGACATCCACCAGGATT TGGGAAGCAAAGGCAAGGCTTCAGGGTCTGAACCCAACTGCGGATTACCCAATGTATGGC ATTCACGGCTGGGCTCAGTTCAACTCCCAGCTGGAGAGAACTCAGGGTCGTGTTCTAGAC GTCATGAACGCCTGG >RXA02605-downstream TAGAGCCACACCAAAGGCCACAC >RXA02614-upstream TCATTGTATACGCCACCCTCGGTCTGCTGTCTGAAGCGCTGATCAGAGCTTGGGAACGTC ACACCTTCCGCTACCGAAACGCATAAGAAAGTTGCTCGCC >RXA02614 ATGACTGCCACATTGTCACTCAAACCCGCAGCCAGTGTCCGTGGATTGCGCAAATCATAG GGAACTAAAGAAGTCCTCCAAGGAATCGACCTCACCATCAACTGCGGCGAAGTAAGCGCG CTGATCGGACGCTCAGGTTCAGGAAAATCCACCATCCTGCGCGTGTTGGCGGGCCTATCT AAAGAGCATTCCGGCTCTGTAGAAATTTCCGGAAACCCGGCCGTTGCCTTGCAAGAGCCT CGGCTGTTGCCGTGGAAAACGGTGCTCGATAATGTGACCTTTGGCCTCAACCGCACTGAT ATTTCCTGGTCAGAAGCACAAGAACGCGCCTCGGCACTGCTTGCAGAAGTCAAACTTCGC GACTCCGACGCCGCCTGGCCCCTCAGGCTCTCCGGCGGCCAAGCCCAGCGCGTCTCCCTT GCGCGAGCGCTCATCTCCGAGCCAGAGCTTTTGGTTCTCGACGAACCCTTCGGCGCCCTC GATGCTCTGACAAGACTGACAGGGCAAGACCTGCTGCTGAAAACCGTGAACACCCGAAAC TTGGGAGTTCTGCTGGTCACCCATGATGTTTCCGAGGCCATCGGCCTGGCCGACCACGTC CTTCTTCTTGAGGACGGCGCCATCACACACAGTTTGACTGTAGATATCCCCGGCGATCGC CGCACCCACCCCTCCTTTGCGTGCTACACCGCTCAACTCCTTGAGTGGCTCGAAATCACC ACACCTGCC >RXA02614-downstream TAGAAAGAAATCATGAAATTTAA >RXA02616-upstream AGTGTTACTTCCGGTAGATAACAAGATGGTCTCAATTAAACTTCGATAGCGTGATATAAG CTTCGAAAAGTTTTGTGGGAAGAATCGGAAGCAGGCGAAA >RXA02616 TTGCAGAAGGACACTCGAGGTGGCAAGCACCGCAAGCAGACTACCTCCCCAGTAACTAAG GGTGGTGTCGCTTTTGTTGCAGTAGCTACCGGTGCCGTGTCAACTGCAGGCGCAGGCGGA GCAGTTGCTGCACAGGCTTCCAATCAGCCCGTTGAGGTCAACTTCGAGCTTACTGCAAAC GACACAACTGACCTCGTGGCTGGAAGCTCCGCCCCTCAGATCCTGTCCATCGCTGAGTTC AAGCCAGTTGTGAACTTGGGCGATCAGATCGTTAAGACCATTCAGTACAACGCTGACCGC ATTCAGGCTGACCTGGACGCTCGTGGCCCTTCAGTGGTTGGCCCTGCTGAAGGTTCTTAC ACCTCCGGCTTCGGTGCTCGTTGGGGCACCAACCACAACGGTGTGGATATCGCTAACGCA ATCGGCACTCCAATCCTCGCTGCCATGGACGGCACTCTTATCGATGCAGGTCCTGCTTCC GGTTTCGGTAACTGGGTTCGCCTCCAGCACGAAGATGGCACCATCACCGTGTACGGCCAC ATGGAAACCGTTGAGGTGACCGTTGGTCAGACTGTTAAGGCTGGCGAGCGCATCGCAGGC ATGGGTAGCCGAGGATTCTCCACCGGCTCCCACCTCCACTTCGAGGTTTACCCTGCAGGC GGTGGCGCTGTTGATCCAGCTCCTTGGCTTGCAGAGCGCGGCATTACTCTT >RXA02616-downstream TAATTAACTTTTGGGCGACCCTT >RXA02627 GATGTCACTGTGGAAAGCCAACCAGAACGCGTCGTTGCCCTGGGTTGGGGAGATGCTGAG GCTGCGCTGGAATTCGGTGTGCAGCCTGTGGGTGCATCAGATTGGCTCGCATTCGGTGGT GAAGGCGTGGGACCGTGGATTGAGGATTGTGCCTACGATGAAGCGCCAGAAATAATCGGA ACCATGGAACCGGAGTATGAAAAGATTGCAGCGCTTGAACCGGATCTGATTTTGGACGTG CGCAGCTCTGGCGACCAGGAACGCTATGACAAGTTGTCTTCAATCGCACTGACCATCGGC GTTCCAGAAGGTGGCGATAGCTACCTCACCCCACGCGCTGAGCAGGTAACCATGATCGCC ACTGCTCTGGGGCAGGCTGAACGTGGTGAAGAAGTGAACGCTGAATACGAGCAGCTCACT GCTGATATTCGTGCAGCTCAGCCGGGCTGGCCTGAGAAGACCGCGGCTGGTGTATCTGCA ACGGCAACCAGCTGGGGTGCATACATCAAGGGCTCCAACCGTGTAGATACTTTGCTGGAC CTGGGCTTCCAGGAAAACCCTGAGCTGGCTAAACAGCAACCTGGCGATACGGGTTTCTCC ATCAAATTCAGTGAAGAGACTTTCGGCGTTGTGGATTCCGACCTGGTTGTCGGCTTTGCC ATCGGTATGACTCCTGAGGAAATGGCAGAGCAGGTTCCATGGCAGATGTTGACCGCCACT CGTGACGGCCGTTCCTTTGTGATGCCCCGTGAGATTTCCAATGCGTTTTCTTTGGGTTCC CCGCAGTCCACTCGGTTCGCGTTAGACGCCTTGGTGCCACTTCTGGAGGAGCATGCAGGG GAG >RXA02627-downstream TAGTGGTCCGGTGGTGCGGGCAG >RXA02628 ATGCTTGAAGGTTTTAGAGATTTCGTCCTTCGGGGAAATGTCATTGAACTCGCAGTTGCC GTGGTCATCGGTACTGCCTTCACCGCTATCGTGACAGCATTCTCCGAGAGCATCATCAAC CCATTGATCGCTTCCATGGGCAGCACAGAGGTTGAAGGCCTCGGCTTCGACATCCGCGCC GGCAATGCCGGAACATTCGTGGATTTTGGTGGTGTCATCACCGCAGCGATCAACTTCCTC ATCATCGCAGCAATTGTCTACTTCGTTCTCGTTGCTCCAATGAACAAGCTCAGCGAAAGG CTCGCAAAGCGCAAGGGTGTTGAAGAAGACGAGACCCCAGCTTCCATCGAAGCAGAACTC CTCACCGAGATCCGCGATCTCGTGGAGGAGCAAAAGCGCCTTCAG >RXA02628-downstream TAGTTAAAAGGCCCTAAAAGCAC >RXA02650-upstream GAATTTTTGCTGCAACTGTGTAAAAACCAGCGGTGAATTAAAGATCACCTTTCACCCTTA ATTGAGCCTGGGTGGAAGTTTCTACCGCTCATGGGGAAAG >RXA02650 ATGGTCAACGTGACCTCAAAGGATGCAGGGGCAAACGTGACCCCCATGAGTAAGAAAGAA AAGAGGACAACCGTTAAACAGGTGGTTGCCTTGATGGCCGCCATCGTTGTGGTGATTGCG TCCCTAGACCAAATAGTCAAGGAGATTATGCTTAGTTGGTTGGAACCTGGCGTTCCCGTT CCCATCATTGGGGATTGGTTCCGCTTCTACCTCCTGTTTAAGCGCGGAGCCGCATTTTGG ATGGGTGGGGAAAACAGCACCTGGATCTTTACAACCATCCAGTTGAGCTTGGTCATCGGT ATCGCAATTTATGCCCCACGCATCAAACAGAAGTGGATCGCGGCAGGACTTGCCCTTGTT GCCGGTGGAGCCTTGGGAAACGTGTTGGACCGGTTGTTCAGAGATCCTTCCTTCTTCTTC GGACATGTTGTTGATTACATCTCCGTAGGAAACTTTGCAGTATTTAATATCGCCGATGCC TCGATTTCTTGCGGCGTCGTGGTGTTCCTGATCGGAATGTTCCTTGAGGACCGTGAAAAC GCCCAGCATGCCAAAGCAACTGACGAGAAGGATGAGGCC >RXA02650-downstream TGATGAACAACCGACAAAGCAGA >RXA02660-upstream CATTTTTCAGCACACTTTTTAAGATCTCATCGAAAGCGCGATACCCACTATGTCCAATCT TTTGAGACTTGTCGGCCGACGGCTCATCGCTTTACCGATC >RXA02660 ATGATTATTGGCGTCACCCTGCTGGTTTTCATCGTCATGTCATTCTCTCCTGCCGACCCG GCACGAGTTGCCCTAGGCGAATCAGCCTCCCCCGAAGCACTTGAAGCCTACCGTGAAGCC AACGGCCTCAACGATCCAATGATGGTTCGCTATTTCGACTTCATCCTCGGCATGCTCAAA GGCGACTTGGGAACCTCTAGCGGTGGCGTAGCTGTTACCGACATTGTTGCCCGCGCTTTC CCCATCACCCTGCAGCTAACATTCTGGGGACTCATGATCGCTGTTGTAGTGGCGTTGATC CTCGGTGTCATGGCCGCTCTATACCGAGACCGCTGGCCTGACCAGTTGATTCGCGTGGTC TGCATTGCGGCTCTTGGTACTCCTTCATTCTGGTTGGCTATCTTGCTGATCGAGTGGTTG GGTACTATCCCTGGAGCCTGGGGTTTCTTCCGAGCACTTGTCACCCGGTGGGTGCCATTC AGCGAAGATCCCGCCACCTACTTCAACAACATCGCACTTCAGCGATTGCGTTGGCAGTCC CCGTTGCAGGTTCTTTGGCCCGCGTTGTTCGTACCTCCATGGTGGAAGAACTGGACAAGG ACTAGGTCCGCACAGCAATCGGTGCAGGATCCCCAAAAC >RXA02660-downstream TGAAGTTGTTGCCCGCAATGTTC >RXA02661-upstream TGGACAAGGACTACGTCCGCACAGCAATCGGTGCAGGATCCCCAAAACTGAAGTTGTTGC CCGCAATGTTCTGCGCAATGCGCTGATCACCCCAATCACC >RXA02661 GTGATTGGTCTTCGCGTTGGTTCGCTCATGGGTGGTGCGGTGATCATTGAGATCATCTTC AACATCCAAGCAATGGGACAGCTCATCCTAGACGGTGTGACCCGAAATGACGTCTACCTC GTCCAAGGTGTCACCCTCACCGTTGCCATCGCCTTCATCATCGTCAATATCGCCGTGGAC GTGCTCTACGTCCTGGTCAATCCACGTATTAGGAGCATC >RXA02661-downstream TAGATGCGCCGTAAACTAACCAC >RXA02663-upstream GTGCAAATATCTGTCCAGTTCGTGAGACTACGTCAATGCTTCCAAGGTCATTGGCGCATC AACCGCTCACATCTTGATCAAGCACGTTGCGCGAAACTGC >RXA02663 ATGGCTCCGATTCTGGTGTTCGCCACCGTCCTGGTCGCCGATGCGATTGTCTTCGAAGCA TCCCTGTCCTTCATCAACGCTGGTGTGAAACCACCATCACCTTCATGGGGCAACATCCTT GCCGATGGTAAAGCCCTGCTGGTTAGCGGCGGATGGTGGGCAACCTTCTTCCGAGGTTTG ATGATCCTGCTGACCGTTCTCTGCTTGAACATGCTTTCTGAAGGCCTCACCGACACCCTG GCCAGCCCTAAGCCAAAGCCTGTTTCAGCTTCTGCAAAGAAGGCACTGAAGAAGGAAGAA TCCGGTGAAAAGGAAGGCTCCGGAATCGTGCTTGGGCACACCACACGTGAAGAAGCCAAC GCCTCACTGCTCGCATCACTTGCTGCGCTATCCACCAGCGAAAACAATTCCAATAACCGG CTTATATTTGATGGCAACCCCACTCCTCTGTTGGAAGTTCGCGATCTAAAGATCTCCTTG GCCAATGCTCACGGAGATATCAATATTGTCGACGGCGTGAACTTCACCGTCGCCCCAGGC CAAACCATGGGTCTTGTCGGTGAATCCGGCTGTGGTAAATCGATTACCGCAATGTCGATC ATGGGTCTGCTGCCTCCAACAGCAAAGATCGAAGGCGAGATCCTTTTCGACGGAAAGAAC CTCCTTGATCTGAAACCAGACGAGCTCAATGCACTGCGTGGACATGAAATCGGCATGATC TACCAAGATGCACTCTCCTCACTCAACGCATCCATGGTGATCAGCGCCCAAATGAAGCAG CTGACCCGCCGCGGTGGAAAGCGCAGTGCCGAAGAACTCGTGGAACTTGTAGGCCTTGAT CCAAAGGGGACCCTGCAGTCGTACCCGCATGAGCTTTCAGGTGGCCAGCGCCAGCGAGTT CTCATCGCAATGGCACTGACGAGAAACCGACGCCTCCTCATCGCCGACGAGCCAACCACC GCGCTAGACGTCACTGTTCAGCAGCAGGTTGTGGATCTGCTTAATGAACTGCGTGAAAAG CTCGGATTCGCCATGATCTTTGTATGCCACGACTTGGCTCTTGTCGCCCGCCTGGTGCAC AAGCTCACCGTCATGTACGCAGGTCAGGTTGTTGAGCAAGGAACCACCCGCGAAATCCTT ATCGATCCTCGACACGAATACACCCGCGGTTTGCTCGGATCCGTGCTCTCCATCGAAGCT GGTGTGGACCGCCTCTACCAGGTCCCAGGCACTGTTCCATCACCAAAGGAATTCGTGGCA GGCGACCGCTTTGCACCACGATCAGAATTCCCAGAACTTGGCCTTGACCAAAAGCCAGTA CTTCGCCCCATCACGGGCACAGAGCATGCATACGCAGCAACCGATGAACTTCTTGCCGCA AAGGGAGAACAACGA >RXA02663-downstream TGACCTCGACAATCGACACCAGG >RXA02664-upstream ATCCACAAAGAGCCGTACGGGAAAGCTGTTTCGCCCAGACCAGGTCCACGCCAACAAAAA CATCAACTTCAAGGCCTACCGCGATGAAGTAATCGGCATC >RXA02664 GTGGGTGAATCTGGTTGCGGAAAATCTACCCTTGCCCGCGTTATGGTTGGCCTGCAACCG GTCACCTCCGGCGAAGTGCTGTTGAAAGGCAAGCCCATGAAGCCTCGTGGTGCGCAGCGC AAAGAACTCGGCAGCTCAGTATCCGTCGTGTTCCAGGATCCTGCGAGCTCGTTAAAGCCA CGAATGACCGTGCGCGAACAGCTCCTGGATCCACTTCGAGTACACAAAGTTGGCGATGAA GCATCCCGCAACCAGTGGGTTTCAGAGCTGATCTCCATGGTTGGCCTCCCGCAATCCGCG TTGGAAGTACTCCCCCGACAGGTTTCCGGTGGCCAACGCCAACGCGTGGCCATTGCTCGA GCACTTGCGCTGAAACCTGACATCATCGTTGCCGACGAACCAACCTCCGCGCTGGATGTA TGCGTTGGTGCGCAGGTCCTCAACCTTCTGCTGGATCTGAAAACTGAACTCGGCCTGGGA TTGGTATTCATCTCCCACGAGATCAACACTGTTCGCTACGTTTCTGATCGCATCGCAGTC ATGCTGGCTGGAGAAATCATTGAGGAAAACACCACCTCAGAGATCTTCAACAATGCGCAG CAGGACTACACCCGCACTCTGCTCGAAGCGACACCATCGCTGCTGAACAAAACTCGTTTG >RXA02664-downstream TAGTCTCCAACCCTTTATTCCCT >RXA02684-upstream GCAGGTTCGTCCACAGCCGCCGGTGATTGCAGGGGATGGGGGGAGGCGTCGAAAAGCAAT ATCTTTTAAGGCCCGTGGCTGCCTGGGCACGATCGCGGGC >RXA02684 GTGCTTGGTGTGGGCTTGGTGCTTGTGTTTGTGGTGACGCTGTGGGGGGATTCGAAGCTG AATCGCGTGGATGCCACGCCTGCGACGCAGGTGGCGAACACTGCCGGAACGAACTGGCTG CTGGTAGGTTCGGATTCGCGGCAGGGTTTAAGTGATGAGGATATTGAGCGGCTAGGTACC GGCGGCGATATCGGTGTGGGCCGTACGGACACGATCATGGTGTTGCATATGGCGCGTACT GGCGAGCCGACGCTGTTGTGGATTCCGCGTGATTCTTATGTCAATGTCCCTGGCTGGGGC ATGGATAAGGCAAACGCCGCATTTACCGTGGGTGGCCCGGAACTGCTGACGCAAACCGTG GAGGAGGCAACTGGCCTGCGAATTGATCACTATGCAGAAATCGGCATGGGTGGTTTGGCG AACATGGTTGATGCCGTGGGCGGGGTGGAAATGTGTCCTGCTGAGCCGATGTATGATCCG CTGGCGAACCTGGATATTCAGGCTGGTTGCCAGGAATTTGATGGGGCAGCCGCGCTGGGT TATGTGCGCACTGGTGCCACAGCCCTGGGTGATCTGGACCGGGTGGTGCGTCAGCGGGAA TTCTTGTCCGCTCTGCTGAGTACAGCTACGTCCCCGGGCACGTTGCTGAATCCGTTCCGC ACCTTCCCGATGATCTCCAACGCGGTGGGAACATTCACCGTCGGCGAGGGCGATCACGTG TGGCACCTGGCCGGATTGGCGCTGGCGATGCGGGGAGGAATCGTGACGGAGACCGTGCCG ATTGCCTCATTCGCAGATTACGATGTGGGAAATGTTGCGATTTGGGACGAAGCTGGAGCC GAAGCACTATTTAGCTCCATGCGC >RXA02684-downstream TAAAACCCCAGGTAATCGTTCAC >RXA02728-upstream ATCCCATACGTTGCCTTCCGATCGGCATTTTCACAGCGCTGGTCGGCGGCCCAACATTCT TCATAATGTTGGGCCGAATGATGAAAAGGGCGTGCACTAA >RXA02728 ATGGCCATTGTTTCCCTCGACAACGTCACCGTATCCATTGAAGGAAAAAAGCTTCTCGAC GCCGTCTCCCTCAAGGCCTACCCGGGGGAAGTGTTGGGACTCATCGGCCCAAACGGTGCC GGAAAATCCACTCTGCTGAGTGTCCTTTCAGGCGATCGGCTTCCCGATTCAGGCGAAGTC AACGTCGGTGGCTTAGATCCCGCAACAGCAGCGGCATCCGATATGGCCAGGGTGCGAGCA GTCATGCTTCAAGATGTCAGCGTGGCATTTTCCTTCCTCGTGTGGGACGTCGTAGAAATG GGCAGGCGGCCGTGGCAGAAGGCGTCAACCCCCGAAGAGGATCATGAAATCATCGAAGCA GCGCTTGCCGCCACCTCGGTATCGCACCTTGCCGAACGTGAAATCACCACACTGTCAGGC GGCGAGCGGGCACGCGTTGCCTTGTCCCGTGTCCTTGCTCAGCAAACCCCCATTGTGCTG TTGGACGAACCAACAGCCGCGATGGATATCAGCCACCAAGAACAAACTCTGGGCACAGCG CGAGCACTGGCAGCCGCCGGGGCAGCAGTGATTGTGGTCCTTCATGATCTCAATGCGGCC GCTGCATATTGCGACAGCATTGTGTGTCTCAGTGATGGTCGAGTGATTGCCTCCGGTTCT GTTGATCAGGTGTATTCCACGGAAACGCTGTCCCGTGTTTACGGTTGGCCTATCAGGGTC GATCATAGTGGAAAATATGTTCGAGTGGAGCCGGACCGTTCTGAGGCGAATTTACCCTCC GTACTACAGGTGAAAAATACGGTTTCACCAGCT >RXA02728-downstream TAGATACATGACTAACTAAGGTT >RXA02750-upstream GTTCCATGGACGATGTATTTCTAGCAGTTACAGCTGAACGGAAACGATCATGATTACAGT TCTGACACGCAGACACTTGCGCTGCTTTTTCCGCGACCGC >RXA02750 ATGGCAGTGCTGTTTTCCATCATGGGTGCGCTCATCCTTTTGGTCCTGTACGTGCTGTTT TTAGGAAAACTGCAAATTGACGGTCTCATGGTGGATCTACCTGACTGAGCCCGAGACGAT GTTGAAGGATTCGTCTTCAATTGGGTGTTTTCCGGAATTCTCATCACGTCCGCAATCACT GTTCCGCAAGCAGCACTTGGAGTGCTGGTTGAAGATCGCACCCGCGGAGGCATCAAAGAT TTCCTCGTGGCACCCGTATCCAGAACGACGCTGACGGTGTCCTATATCTTCGCAGCAGTC ATTGTCGCCATGACGATTTTGATCTTTGAAATCGTGGTGGGAAGTATTGGTTTAGCTATT TTGGGGCACTTCAGCATGAGCATTGCTCGCGTGCTCGAATTGGTAGTCGCCTTGCTTCTG CTCACCCTGGTGTTTTCCGCAATTGCAGCATTTCTGATCACCTTGGTGAAATCTCAAGGC GGAATGTCTGCGCTTTCAAGCCTGGTAGGCACCCTGGCGGGCTTTTTATCTGCTGCTTAT ATTCCACCCATCGCATTGCCTGAAGCAGTGACAAACGTGTTGAACTTCCTCCCGTTTACC CCAGCTGGAATGTTGATCAGACAAATTGTGGTTGCCCCAGCATTGGACGCGATTTCACTT CCACCCGAAGCCTTCGATATCTTCCAATTCGGATACGGACTCAAACTGGAAATGTTTGGG GAACCCGTTTCTACATGGGTGGCAGTAGGAATTGTTGCCTCATGGGGAGTGGTGTTTGGA CTCATTGCCGCGTTCAAAATGAAAAGCGTGGTGCGA >RXA02750-downstream TAAATCCTGCTAAAGAATGCTTC >RXA02761-upstream CAGGTTGTTCTCATTGAGGTGGTTTCTCCGAGAATGCAGCTTTGATCGCCAACGTGGCGC CAGAAGTGATCGCAGTTGTCGGGCATTCATCGCACTGTGG >RXA02761 ATGATGGATGGTATCAACCGCCGTACCACCCTCATTACCGGTTATTCTCTCACCACCATT AGCCACGTATTGATCGGTATCGCATCCGTAGCATTCCCAGTCGGCGATCCTCTTCGCCCC TACGTTATCTTGACTCTGGTTGTGGTCTTCGTGGGATCCATGCAGACCTTCCTCAACGGT AGCTACCTGGGTTATGCTCTC >RXA02761-downstream TGAGCTGTTCCCGCTGGCAATGC >RXA02762-upstream TTCCCAGTCGGCGATCCTCTTCGCCCCTACGTTATCTTGACTCTGGTTGTGGTCTTCGTG GGATCCATGCAGACCTTCCTCAACGGTAGCTACCTGGGTT >RXA02762 ATGCTCTCTGAGCTCTTCGCGCTGGCAATGCGGGGTTTCGCAATCGGTATCTCAGTGTTC TTCCTCTGGATCGCAAACGCGTTCCTGGGATTGTTCTTCCCAACCATCATGGAAGCAGTA GGACTAACCGGAACCTTCTTCATGTTCGCCGGAATCGGTGTGGTTGCCTTGATCTTCATC TACACCCAGGTTCCTGAAACTCGTGGACGTACCTTGGAGGAGATTGATGAGGATGTTACT TCCGGTGTCATTTTCAACAAGGAGATCCGAAAAGGAAAGGTGCAC >RXA02762-downstream TAAAAACCCAGACACTGCATAGA >RXA02769 ACAGTAGTTCCGGTGTACCTCGCTGAACTCGCACCACTAGAAATCCGCGGCTCCCTGACC GGCGGAAACGAGCTTGCTATCGTCACCGGCCAGCTGCTTGCCTTCGTGATCAACGCGCTT ATCGCCGTCACCCTACACGGAGTTATTGATGGAATCTGGCGCATCATGTTCGCCGTCTGT GCCCTCCCTGCCGTCGCCCTCTTCCTCGGCATGCTGCGGATGCCGGAATCACCACGCTGG CTGGTCAACCAGGGGCGTTACGACGACGCCCGCCGCGTCATGGAGACCGTCCGTACCCCT GAGCGTGCGAAAGCCGAAATGGATGAAATCATCGCGGTGCACTCTGAAAACAATGCGGCA GTTCCTGGTGTTAAGCAGTGTTCGGGCCAGGGTTCAGGCCAGGTTTCTAGCAAGCACACC CACATGTCCATCGGCGAAGTCCTCAGCAACAAATGGCTGGTTCGTCTGCTCATCGCCGGC ATCGGTGTTGCAGTTGCCCAGCAGCTCACCGGCATCAACGCCATCATGTACTACGGAACC CGCGTCCTCGAGGAATCCGGCATGAGCGCAGAAATGGCTGTGGTTGCCAACATTGCTTTC GGTGCCGTTGCCGTCATCGGTGGACTGATCGCACTGCGCAACATGGACCGCCTGGATCGC GGCACCACCTTCATCATCGGCGTGTCACTGACCACCACCTTCCACCTTTTG >RXA02795 ATCGACGTCTCCCTCCCCGAACGCACCGCTTCGGCCTACCCACACGAACTTTCAGGCGGG CAACGCCAACGCGCACTAATCGCAATGGCGCTGGCCAATGATCCTGACCTGTTGATCTGC GATGAACCCACCACGGCTTTGGATGTGGTTGTGCAAAAACAAATCGTCGATCTGCTGCTG GGTCTCACCAAAGAACGTGGCACCGCTTTATTGTTCATCACCCACGATCTTGGACTCATC GCGCGCACCTGCGAACGCTTATTGGTGATGAAATCCGGCGAAACCGTAGAACGCGGCGAC AGCGAGGCAATTCTTCGCTCCCCCGCCCATTCGTATACCCAACAGCTCCTTGATGCTTCA ATCCTTGACCAGCCAGAAATCGCCTCAGATTCTGGCGCGCCGGTAGTGATTGATGTGGAG GAGGCGTCGAAAAGCTTTAAAGAAACCACCGCCCTCCACAAGGTTTCATTGGCGGTGCGC AAAGGTGACCTGCTTGGAATAGTCGGCGGATCAGGTTCCGGCAAAACGACTCTGCTGAAG CTCATCGCCGGTTTGGATAAGCCCACAACCGGTACCGTTGCGGTAACCGGTGGTGTGCAG ATGGTGTTTCAGGATCCCCAATCAAGCCTCAACCCACGGATGAAAATCAAAGACATTGTC GCCGAACCACTGCTTGGTTGGAACGCGGCGGAGAAAACCACACGGGTTGCGGAAGTCATC ACCCAAGTGGGACTGAGCCCCGATGTCTTAGATCGCTACCCCCACGAATTCTCCGGAGGA CAGCGCCAACGAATCTCCATCGCGAGAGCCCTGGCCATCAAACCAGCGATCGTGCTTGCC GACGAACCTGTCTCCGCCCTCGATGTGTCCGTACGTAAACAAGTACTGGATCTTCTCCAA CAACTCGTCGAAGAATACGGCATCACCTTGGTGTTCGTCTCCCACGATCTGGCAGTGGTG AGACACCTGTGCACAACGGTGTGGGTGATGGAACAGGGACGAGTCCTTGAGCAAGGGCCC ATCGATTCGGTTTATGATCACCCAGAGAGCGAATACACCAAGGAGCTGCTTGATGCCGTT CCGCGGTTGAGCCTT >RXA02795-downstream TAAACCAGCGCAGATGACAACGC >RXA02808 TTTTACTTCGGCATCCTCCGAGTCCTTGCAGAAAGTGCTTCGCACTTCGGCATCGAGCCT GTGGAAATGGCCCGCGCATCCATCACTGGGCAGCCCGTTCACATGCAAAGGCGGCTGGTC CCAGCGATCGTCCTGCTGGTTTCCCTCGCCAACGTCAACCTTGGCGACCAGGACAAGAAG GTTCTGTGGCGCGCCTGCATCGTGTCCATCGCGATGCTCGCCGTAGCCCTCTTCATCGGC GTCGTGCCACTCAGCGCA >RXA02808-downstream TAAAATAGCTTTTCGACGCCAAA >RXA02863-upstream AGGGACTGCCCATTGCGGTGCGCGATGATCCCGAAACCAGCTCACTTCGCGTGATCCCGC ATCCAAATCCCTTTTGATTGAAAGTTTGACTTAAAAACCC >RXA02863 ATGAAAAAATCACTCATCGCCATTGTTGCCAGTGCGCTCGTGTTAAGCGGCTGCACCTCT GATTCTTCTGACTCTTCCGGCACTTCCGGAACTGTGGAAACCACTTCGATTACAACCAGC GTTGCCGCAGCTGACGGCGCATTCCCACGCACCGTCACACTCGACGATTCCTCCATCACC TTAGAATCCAAACCAGAGCGCATCGCCGTACTCACCCCAGAGGCAGCATCCTTGGTTCTC CCCATCACAGGCGCCGACCGCGTCGTGATGACCGCCGAAATGGACACCGCTGACGAAGAA ACCGCAGCTCTGGCCTCCCAAGTGGAATACCAAGTCAAAAACGGTGGCAGCCTCGACCCC GAACAAGTTGTCGCCGGCGACCCAGATTTGGTGATCGTCAGTGCGCGTTTCGATACCGAA CAAGGCACCATCGACATTTTGGAAGGCCTCAACGTCCCCGTAGTTAACTTCGATTCAGAC GCTTGGGGAGACATCGACGCCATCACCAAACACCTAGAAATTGTGGGTGAACTCGTCGGC GAAGAAGACAAAGCCGCAGAAGCAATCGCAGAAATCGATGCAAACCGCATCGACATCGAC AAGCCTGCCACCTCCCCCACTGTGCTCACTTTGATGCAACGCGGACCACGCCAAATGGTC ATGCCAGAATCTGCCATGCTCAACGGCCTGATCCGCGAAGCCGGCGGCACTCCAGTGGTA GATTCTCTCGGCGCGGTAGGCACCATCACTGCAGACCCAGAACAAGTTGTTGCGATGGCA CCTGAGATCATCATCATTCAGGACTTCCAAGGTAAAGGCCGAGAGAACTTCGCTAATTTC CTCTCCAACCCAGCGCTAGCCAACGTTCCCGCCATTGAAAACGACAAGATTTTCTACGCC GACACTGTCACCACTGGAGTTACTGCAGGTACCGATATCACCACTGGTCTGCAGCAAGTG GCAGAAATGCTGAGC >RXA02863-downstream TAGTTTTGAGATGTTGAAACTAG >RXA02864-upstream CTTGCAAACAGGCGTGGTGGTGGCGTTCATTGGCTCACCAATTTTCCTTTATTTACTGCT CAGCATGCGCAAGCGACGCGGATTGGGGCTGTAAAAACTC >RXA02864 ATGCCTCAATTAGTTGAAATTGGTGATCTCAACGTTGAATTCCCCTCTCGCCATGCAGTG AAAAACGTGTCTTTTTCTGCACCTGCTGGAAAAGTCACCGCACTGATTGGCCCAAATGGT GCTGGTAAAAGTACTGCCCTTTCGGCGATTGCAGGATTGGTTGAATCCACCGGCGAGGTA ATGGTTGGTGGGAGTGGGGTTGCGTCGAAAAGCGCTAAAGCCCGAGCCCGCCTGCTCTCA CTCGTGCCGCAAAACACCGAGTTGCGCATTGGTTTTAGTGCACGCGACGTTGTCGCGATG GGCCGCTACCCGCATCGTGGCCGCTTCGCCGTGGAGACCGACGCAGATCGACGCGCCACC GATGACGCCCTGCGCGCCATCAACGCGCTCGACATCGCCGAGCAGCCCGTCAACGAATTA TCGGGCGGCCAGCAGCAGCTCATCCACATCGGCCGAGCGCTCGCCCAAGACACCGCCGTC GTGCTTCTCGACGAGCCCGTCTCCGCCCTTGATCTACGGCACCAAGTTGAAGTCCTTCAA CTCCTGCGCGCCCGAGCTAATTCCGGCACCACCGTGATCGTCGTCCTTCACGATCTCAAC CACGTTGCCCGTTGGTGCGACCATGCAGTGTTGATGGCCGACGGCGAAGTTGTCTCCCAA GGTGACATCCGCGAGGTGCTCGAACCTGCGACACTGTCCACCGTGTACGGACTGCCCATT GCGGTGCGCGATGATCCCGAAACCAGCTCACTTCGCGTGATCCCGCATCCAAATCCCTTT >RXA02864-downstream TGATTGAAAGTTTGACTTAAAAA >RXN00001-upstream TGTCATAGGCAGCACTCTAGATGGCGCACAGTGACTCACTTCACTGTTTCTCACACTACG GATCGTTGGGCACGTACCTGCCGATGGAGGAGATTCTGCA >RXN00001 ATGGCAACCGTAACGTTCAAAGATGCTTCCCTAAGCTAGCCGGGAGCAAAGGAACCCACC GTCAAGAAATTCAACCTGGAAATCGCCGATGGCGAGTTCCTCGTCCTGGTCGGCCCTTCC GGCTGTGGTAAATCCACCACGCTGCGCATGCTGGCCGGTTTGGAAAACGTTACTGACGGT GCCATTTTCATCGGAGACAAGGACGTTACCCACGTTGCACCGCGTGACCGTGACATCGCC ATGGTTTTCCAGAACTATGCTCTCTACCCCCACATGACCGTGGGCGAGAACATGGGCTTC GCACTGAAGATCGCCGGCAAGTCCCAAGACGAGATCAATAAGCGCGTCGACGAAGCCGCC GCCACTTTGGGCCTGACCGAATTCTTGGAGCGCAAGCCGAAGGCCCTGTCCGGTGGTCAG CGTCAGCGTGTGGCCATGGGCCGCGCCATTGTTCGCAACCCGCAGGTCTTTCTCATGGAT GAGCCGCTGTGTAACCTCGATGCCAAGCTGCGTGTTCAGACCCGTACGCAGATTGCAGCC CTGCAGCGCAAGCTTGGGGTTACCACCGTTTACGTCACCCACGACCAGACGGAGGCCTTG ACCATGGGTGACCGCATCGCGGTGCTGAAGGATGGCTACCTGCAGCAGGTTGGCGCGCCC CGAGAGCTTTATGACCGCCCCGCGAACGTCTTCGTCGCGGGCTTCATCGGCTCCCCAGCC ATGAAGTTGGGCAGCTTCTCGGTCAAGGATGGTGACGCTACCTCTGGTGACGGTCGCATC AAGCTTTCCCCGGAAACGCTCGCCGCCATGACGCCGGAGGATAATGGCGGCATCACCATT GGTTTCCGCCCGGAGGCACTGGAGATCATTCCGGAAGGCGAGTCCACCGATGTTTCCATC CCAATCAAGCTCGACTTCGTGGAGGAACTCGGTTCCGATTCCTTCCTCTACGGCAAGCTG GTAGGCGAGGGCGACCTTGGATCCTCCAGCGAGGATGTCCCCGAGTCCGGCCAAATCGTC GTCCGCGCTGCTCCGAACGCCGCGCCTGCTCCGGGCAGTGTTTTCCACGCACGCATCGTG GAGGGCGGCCAGCACAACTTCTCGGCGTCGACTGGCAAGCGCCTCCCT >RXN00001-downstream TAAGCGCGCGTACCGGCTACCCC >RXN00099-upstream CTCTGGTGAAGAGGATGTTGACTCGGGAGATTCTTCCACTGATTCACTGATTAAGTGGTA CCGCGCAAATAGGTAGTCGCTTGCTTATAGGGTCAGGGGC >RXN00099 GTGAAGAATCCTCGCCTCATAGCACTGGCCGCTATCATCCTGACCTCGTTCAATCTGCGA ACAGCTATTACTGCTTTAGCTCCGCTGGTTTCTGAGATTCGGGATGATTTAGGGGTTAGT GCTTCTCTTATTGGTGTGTTGGGCATGATCCCGACTGCTATGTTCGCGGATGCTGCGTTT GCGCTTCCGTCGTTGAAGAGGAAGTTCACTACTTCCCAACTGTTGATGTTTGCCATGCTG TTGACTGGTGCCGGTCAGATTATTCGTGTCGCTGGACCTGCTTCGCTGTTGATGGTGGGT ACTGTGTTCGCGATGTTTGCGATCGGAGTTACCAATGTGTTGCTTCCGATTGCTGTTAGG GAGTATTTTCCGCGTCACGTGGGTGGAATGTCGACAACTTATCTGGTGTCGTTCCAGATT GTTGAGGCACTTGCTCCGACGCTTGCCGTGCCGATTTCTCAGTGGGCTACACATGTGGGG TTGACCGGTTGGAGGGTGTGGGTCGGTTCGTGGGCGCTGCTGGGGTTGGTTGGGGCGATT TGGTGGATTCCGCTGTTGAGTTTGCAGGGTGCCAGGGTTGTTGGGGCGCCGTCGAAGGTT TCTCTTCCTGTGTGGAAGTCTTCGGTTGGTGTGGGGCTCGGGTTGATGTTTGGGTTTACT TCGTTTGCGACGTATATCCTCATGGGTTTTATGCCGCAGATGGTAGGTGATCCTCAGCTC GGTGCGGTGTTGTTAGGCTGGTGGTCAATTTTGGGATTGCCGCTGAACATTCTGGGACCG TGGTTGGTGACGCGTTTCACTAACTGCTTCCCGATGGTTGTTATCGCCAGTGTCATGTTT CTCATCGGTAATGGTGGGTTTTGTTTGGCTCCGGATGTTGCGCCGTGGTTGTGGGCGACG TTGTCTGGTCTTGGTCCCCTTGCGTTCCCGATGGCGTTGACGCTCATTAATATTCGTGCT GAAACTAGTGCTGGTGCTTCTGCGTTGAGTTCCTTCGGGCAGGGTTTGGGTTATACGATT GCGTGTTTCGGTCCCTTGTTGACTGGTTTCATTGTCGATGCGACAGGCAGCTTCCGAACA ATCTTTGTGCTTTTTGCGGTTGCAACACTCTTCGTTATTAGAGGCGGTTACTTTGCGACA AGGCAGGTTTACGTCGAAAAGCTTTTAAATCGC >RXN00099-downstream TAGGATGGCGCTATGCCGCAAAG >RXN00193 AAAGCTTTCTNCCAACGCGAAGGTTTCATCTCAGCGTTCGGTTTCACCGTCGTCGTGGTC ATCGTCTCCGTGATCACAGTCAACATGTTCGCCTTCCTCTTGGCGTGGTTGCTGACCCGC AAACTCCGCGGTACCAACTTTTTCCGCACAGTCTTCTTTATGCCGAACCTTATCGGCGGC ATTGTGCTGGGTTATACCTGGCAGACCATGATCAACGCCGTGCTTTCGCACTATGCCACG ACTATTAGCGCGGACTGGAAATTCGGCTACGCCGGCCTCATCATGCTACTTAACTGGCAG CTCATCGGCTACATGATGATCATTTACATCGCCGGCCTGCAAAACGTCCCACCAGAGCTC ATTGAGGCTGCCGAACTCGACGGCGTCAACAAGTGGGAGATGCTGCGGCACGTCACTATT CCGATGGTCATGCCATCCATCACCATCTGCCTCTTTTTGACTTTGTCGAACTCCTTTAAG CTCTTCGAGCAGAACCTGGCGCTGACCAACGGCGCTCCTGGGGGGCAAACTGAGATGGTG GCGCTGAACATCATCAACACGCTGTTTAACCGTATGAATGTCGAGGGCGTCGGT >RXN00378-upstream ACCGTGAGCCTTATACTGTGAGGACATTAAAAGTGACACGTCTTTTTCTATCTTTTACAA CGCAAGAAGGTTTATCGTGAGCACACCGGATTCTTGCTCG >RXN00378 GTGGACAAGGCCGTAAACACTGCTATCTCTGACGCCAAAACAGCGGCGCTCAAGGCAGGT GTTGGATTGAACCGAGCCACCGCCTCAGAAGAAGAGGAAGATTTAAGCTCAAGCATTAAG GTTTCTTTGGCCTTTGAGCTCGAGGGGTTAAGCAATGCACCATCGTTGATGGTGGTGGAA AAAGCCGTAGAGAAGATCCCCGGTGTATCCGCGGATCTGATTTACCCTTCACAAACTGCA TGGATTACAGCAACTGATCGGGTACATCCCGAAACCCTCATTGAGGTGTTTGAGCAGTTC GGCATCAAAGCACACCTTTCTAATTCATCGCTGCTGCGCAGGCATCAACAGCTCAGCGCG GAAGTAAATAGGGAAGCACGCCTTGATCGTTACCGCTCCCGAATGGATGCCAAGCGAATC TCGCCTCGTGTGCGAAGGCATAACCGACAAGAAATGGTACATGCGGTACGCGCTCGTGAA AGTGGTTGGATTAAACGCAGGAATCACACCACCTCGCAGCATGAAGACCCAATGTCGGGC GATGTGCTGTTCACCGCCCGCGCACTGATTACACCTAAGCGTTTGTGGGTGTCGTTGCCG TTTGCGCTCATCGTATTGGCGTTATCGTTGAATCCTTCGTGGCAGTTTGATTATTGGCAG TGGTTGTCCGCTGTGTTGGCTATTCCTGTGGTGGTGTGGGGTGCCTGGCCGTTTCACCGC GCTGCAGCAGGCGGTATTCGTCGAGGAATTTCCGCTCTTGATGCGACCAGCTCAATCGCT ATTGCTGCTGCATACGCGTGGTCTATCGCCATGCTGTTGTTTGAAACCCCAGGAGGTAAA TCCTGGCGGTCATATCCGTCCTGGTTCGCTTTTGACCACGGCACGTTGACCCAAAACGAG ATTTATTTTGATGTGGCCTGCGGAATCACCGTGTTGCTTCTTGCCGGACGGCTGCTGACA AGGCGTCGAAGCCAATCCAGTTTGTTAGCGGAACTTGGTCGCCTCCAAATCGATCCACAG CGCATTGTCACTGTGGTGCGTAAACACCGATTGAAGCGCGTAGTCCAGGAACTGAACATT CCAGTGCAGGAAGTCCGTGTCAATGACGATGTGAAAGTTCCACCTAATACCACGATCCCT GTGGATGGCACTGTCATCGGTGGCGGTTCGCGGATCGCAGCTAGCATCATCATGGGACAA GACCAGCGTGATGTAAAAGTAAATGACAAAGTTTTCGCCGGCAGCCTCAACCTCGAATCC GAAATCAAGGTTCGTGTTATTCGCACTGGTCACCGCACCCGCATCGCCGCGGTACATAGG TGGGTTAAAGAAGCGACGTTGAAGGAAAACCGCCACAATAGGGCAGCGATCCGTTCGGCC GGTAACCTTGTGCCCATCACGTTCACCCTTGCTGTGGTGGACTTGTGTCTGTGGGCACTG ATCTCTGGAAACATCAACGCTGCATTTAGCACTACCTTGGCTGTCCTTGGGTGCGTGGCT GCGGTGGCCTTAGCGTTGTCTGCTCCACTTGCCACGAGGAATTCCATGGAAGCTGCAGCA CGACACGGTATTTTGGTCCGCTCTGGTGAAATTTTGCGAGTTCTCGATGATGTGGATACT GCCGTATTTAATCGTGTGGGCACACTAACCGATGGCGAAATGACAGTGGAAACCGTCACA GCAGACAAAGGCGAGGACCCAGAACTAGTGCTGCGTGTCGCCGGGGCGTTGGCCATGGAA TCCCACCACGCGATTTCCAAAGCACTGGTGAAAGCATCCCGTGAAGCTCGTGATACCGGC GCCGGTGGTGAAGATGTCCCACACTGGATTGAAGTAGGCAACGTGGAAATCACCGAAGCC GGCTCATTCCAAGCAACCATCGAGCTGCCACTGATCAAACCATCTGGCGAAAAAATCATG CGCACCACAGAAGCACTCCTGTGGCGACCACGATCCATGACAGAAGTCCGTGAGCACTTA AGCCCCCGACTAGTGGCAGCAGCAACCTCAGGTGGCGCACCACTGATCGTGCGATGGAAA GGCAAAGACCGCGGAGTTATCACTCTAAGTGACCACGTGAGATCAGATTCCTCCGATGCG ATTATTGCGATTGAAGAACAAGGCATCGAGACCATGATGCTTTCACGTGATACTTACCCG GTGGCACGTCGATACGCAGACAGCTTAGGCATCACCCACGTCTTGGCCGGCATCGCGCCG GGCAAGAAAGCCCAGGTCGTCCGTGCAGTCCACACCCGCGGATCCACTGTCGCGATGATC GGCGATGAATCAGTAATGGACTGTTTGAAAGTCGCTGACGTGGGTGTACTGATGGGCGTC GATCGTCCCTCAGATCTGCGTGATGATTCCGATGACCCGGCAGCTGACGTTGTGGTCATG CGCGAAGAGGTCATGAGCGTGCCGACGCTGTTTAAACTGGCTCGACGCTACGCCAAGTTG GTCAATGGCAATATTGCTCTGGCCTGGATCTATAACGGTGTTGCCATGGTGCTTGCAGTG TCTGGCTTGCTGCATCCAATGGCTGCGACCGTGGCTATGCTGGCGTCTTCGCTGCTTATT GAATGGCGCTGGGGCAGGGCGGGCAAGTAC >RXN00378-downstream TAACCAGCAATTCCCAAGCCCAA >RXN00412-upstream GTTTTGACGAACACCACGTCGCGTACGGTTCCTCGGGGCGTTAAACTATTTGTCTTCCAG GTTTTGTCCCCCGACTTTTGTACGAATCGAGGACACCGTC >RXN00412 GTGTCACACACCGCGTCCACACCGACGCCAGAGGAATACTCCGCGCAGCAACCCAGCACC CAGGGCACTCGCGTTGAGTTCCGCGGCATAACCAAAGTCTTTAGCAACAATAAATCTGCT AAAACCACCGCGCTTGATAATGTCACTCTCACCGTAGAACCCGGTGAGGTAATCGGCATC ATCGGTTACTCTGGCGCCGGCAAGTCCACTCTTGTCCGCCTCATCAATGGCCTTGACTCC CCCACGAGCGGTTCGTTGCTGCTCAACGGCACGGACATCGTCGGAATGCCCGAGTCTAAG CTGCGTAAACTGCGCAGTAATATCGGCATGATTTTCCAGCAGTTCAACCTGTTCCAGTCG CGTACTGCGGCTGGAAATGTGGAGTACCCGCTGGAAGTTGCCAAGATGGACAAGGCAGCT CGTAAAGCTCGCGTGCAAGAAATGCTCGAGTTCGTCGGCCTGGGCGACAAAGGCAAAAAC TACCCCGAGCAGCTGTCGGGCGGCCAGAAGCAGCGCGTCGGCATTGCCCGTGCACTGGCC ACCAATCCAACGCTTTTGCTTGCCGACGAAGCCACCTCCGCTTTGGACCCAGAAACCACC CATGAAGTTCTGGAGCTGCTGCGCAAGGTAAACCGCGAACTGGGCATCACCATCGTTGTG ATCACCCACGAAATGGAAGTTGTGCGTTCCATCGCAGACAAGGTTGCTGTGATGGAATCC GGCAAAGTTGTGGAATACGGCAGCGTCTACGAGGTGTTCTCCAATCCACAAACACAGGTT GCTCAAAAGTTCGTGGCCACCGCGCTGCGTAACACCCCAGACCAAGTGGAATCGGAAGAT CTGCTTAGCCATGAGGGACGTCTGTTCACCATTGATCTGACTGAAACGTCCGGCTTCTTT GCAGCAACCGCTCGTGCTGCCGAACAAGGTGCTTTTGTCAACATCGTTCACGGTGGCGTG ACCACCTTGCAACGCCAATCATTTGGCAAAATGACTGTTCGACTCACCGGCAACACCGCT GCGATTGAAGAGTTCTATCAAACCTTGACCAAGACCACGACCATCAAGGAGATCACCCGA >RXN00412-downstream TGAACGAGATGATCCTCGCAGCT >RXN00431-upstream TGGATCGTCCTCGCCTTCACATTCGTCCGCCTTGGCCTTGCTCTCCTCGCGATGAAGCAA TGGCGATTCCGCGTCAGCTACTGGGTATAAGGAGCACCAC >RXN00431 ATGGTATCCATCGATACATACAACGCCTGCGTCGACTTCCCCATCTTCGACGCCAAATCC CGCTCCATGAAGAAAGCCTTCCTCGGCGCAGCCGGCGGAGCAATCGGGCGCAATCAAGAC AACGTCGTAGTCGTCGAAGCGCTGAAGAACCTCAACCTGCACTTGCGCGAAGGTGACCGG GTCGGACTCGTCGGCCACAACGGCGCCGGCAAATCCACCCTCCTGCGACTCCTCTCCGGC ATCTACGAACCCACCCGCGGAAGCGCTGACATCCGTGGACGCGTCGCCCCCGTCTTCGAC CTCGGCGTCGGCATGGATCCAGAAATCTCCGGCTACGAAAATATCATCATCCGCGGCCTC TTCCTCGGTGAAACCCGCAAACAGATGAAAGGCAAAATGGAAGAAATCGCCGACTTCACC GAACTCGGCGAATACCTCTCCATGCCTCTCCGAACCTACTCCACCGGCATGCGCATCCGC GTAGCCCTCGGCGTGGTCACCTCCATCGAGCCCGAAATTCTGCTTCTTGATGAAGGCATC GGCGCCGTCGACGCCGCCTTCATGGGCAAAGCCCGCGACCGCCTCCAAGCCCTCGTCGAA CGATCCGGCATCCTCGTCTTCGCCTCCCACTCCAACGACTTCCTCGCCCAACTCTGCAAC ACCGCACTCTGGGTCGACCACGGACAAATCCGCGAAGCGGGACTAGTTCCAGACGTGGTG GAAGCCTACGAAGGCAAGGGCGCCGGCGACCACGTCCGCAGACTCCTCACCCGCATGGAA GAAGAAAAG >RXN00431-downstream TAGCTCCTGCGTTTCGGGTTTGC >RXN00444-upstream TACCCAATGGCATTGACCACCACCGGTGAAGACAACGAGGTAGCGAAGGCTTTCGCAGAG TTCCTCAGCAGCGATCGTGCCAAGGAGATCCTTGCCAGCT >RXN00444 ATGGTTTTGGCACAAACTAAAAAGGCTCGTCGAAGCGAGAATCATATCCTCCCAGGGTGG TTGCTCATCCCAGCCACCCTGGCCATGCTGCTGATCATTGGACCTATTTTTGCTTTGCTG TTGCAGATCCCCTGGGATCGGTCTTGGGAGTTGCTTACCGCGCCGGAATCTTTAGGAACC GCACGGTTATCTATCGGAACTGCTCTGTTTTCTACCGCGCTATGCGCAATTGTGGGTTTC CCGCTAGCGTTGGCGCTGCATTTATATGAGCGTTCGCACCCCAGGGTGACATCAGTTTTG ACGGTGCTGGTTTATGCGCCTTTGGTGTTGTCGCCGGTGGTGTCTGGTTTGGCGCTGACT TTTCTGTGGGGCAGGCGTGGTTTTTTAGGTTCTTGGCTTGATCAGGTTGGATTGCCGATT GCATTTACCACCACGGCTGTGGTGTTTGCCCAGGTGTTTGTAGCGTTGCCATTTTTCATT TCCACTGTGACTACTGCACTGCGTGGCATTCCAAAACAGTTTGAGGAAATCGCAGCTACT GAAGGCGCAACCCGCTGGGAGATGATGCACAAGATGATCATTCCGCTGGCGATGCCTGGA ATTTTCACCGGTATGATTTTGGGATTCGCCAGGGCCTTGGGCGAGTATGGTGCGACACTG ACTTTTGCTGGAAATATTGCAGGTGTTACCCGCACCATTCCGTTGCATATTGAGCTTGGT TTGAGTTCCAATGACATGGATAAAGCCTTGGGAGCGGTGATTATGCTTTTGGCTGTCTAT GTCCTCATCATTGGAGCCATCGGAGCGTTACGATTGTTTTCCAAGGTGAGAAAGGTT >RXN00444-downstream TAATTGATGTCTCGTTCGCCGGA >RXN00466-upstream TTTAAAAGCGCACTAAGAGCTCGTCAATTCTTTAAAACAAGCTGAGAATGTGAATAATAG GATAGGTTAACCTGATTCGATTAGAAAACGGAGATTTGTC >RXN00466 GTGCAATCCCGCCTGTCCAAAATCCTGCGCAGTAGCGTCGTAGGCGTTGCTGTCCTAGCC CTGTTAGCTGGGTGTTCTAACAATGCAGATGACACCGACGCTGATTCAACATCCACGGGA AACTCCGCTTTTCCTGTTTCGATTGAACACGAGTTCGGAACCACCACAATCGATGATGTA CCCGAAAGAGTTGTCAGGCTTGGCGTTACCGACGCCGATATTGTCCTGGCATTGGGGACC GTCCCAGTAGGCAACACCGGATACAAATTCTTCGAAAACGGATTGGGACCGTGGACTGAT GAGTTAGTGGAAGGCAAAGAATTAACACTGCTTGACTCTGATTCCACACCAGATCTTGAA CAAGTAGCAGCCCTGGAGCCAGACCTGATTATTGGAGTCTCTGGGGGGTTTGACGACGTT GTATACGAGCAACTATCTGATATCGCACCGGTGGTCGCCCGTCCAGCGGGAACAGCTGCA TACGCAGTAGCTCGCGAGGAAGCTACCAACCTTGTTGCCCGTGCGATGGGGCAATCAGAA AAAGGACAAGAGCTCAATGAGGAAACAGATGCTCTGATCCAAGCTGCGCGTGATGAAAAT CCTTCTTTTGACGGTAAAACAGGAACCGTCATCTTGCCATACCAGGGTAAATACGGTGCC TACCTGCCAGGCGATGCACGGGGACAATTCCTCGATTCACTTGGCATTTCGCTGCCGGAA GCAGTTCTTTCGCGAGACACCGGCGACAGCTTCTTTGTCGATGTCCCCGCTGAAAGCGTC AAAGACGTAGACGGTGATGTTCTCCTCGTGCTTTCCAACGACGAAAATCTGGATATCACA GCAGAGAATCCACTGTTTGAAACACTGAACGTTGTGCAAAAAGACGCAGTAATTGTGGCA ACAACGGAAGAACGCGGGGCGATTACCTACAACTCAGTGCTGTCTGTTCCTTTTGCGTTG GAACATCTCGCACCACGTATTGCTGAGGCTTTGAAG >RXN00466-downstream TAAAACTCAACTACTCGAGCACA >RXN00523-upstream TGGTGACTCGTCCGAGTGAAATTGCCGTGGGCATCATCATGCCGATCATTGGTGCGCCAC TGTTTATTTGGATTATTCGTCGTCAGAAAGTCAAAGAGCT >RXN00523 ATGAGCCTTAGCCATCAACTCAAGCGCCAGCGCGCATCGCGCAACTCCGGCAGGTGGCTG ATTGTTGCGGCATTGGGCGTCGTCACGCTTGGTATTTTTGCTTTTTCTTTGATGTGGGGC GAGGTGTTTTATGGCCCTGCTGAGGTGCTGAAAGTGTTGTCTGGACAGCAGGTTCCCGGC GCGAGTTATTCCGTTGGCGTGTTGCGTTTGCCGCGCGCGGTGATGGGTTTGACTGCGGGT TTGGCGTTTGGCGCGGCGGGCGTGATTTTTCAGACGGTGTTGCGTAATGAGTTGGCGTCG CCGGATATTATCGGCATTTCTTCTGGCGCGTCGGCGGCGGGCGTAATTTGCATTGTGTTT TTCGGGATGTCGCAGTCTGCAGTGTCGGCGATTTCTTTGTGTGCGTGCTTGGCTGTGGCG TTGTTGATTTATCTGGTGGCGTATCGCGGTGGTTTTTCGGCCACGCGTCTGATTCTTACC GGCATTGGTATTGCTGCGATGCTGAATTCATTAGTGTCGTATTCGCTGTCCAAGGCTGAT TCTTGGGATCTGCCGACCGCGACGCGCTGGCTTACCGGCTCGCTCAATGGTGCGACGTGG GATCGTGCGATGCCGCTGATTGTCACCACTGTGGTACTCATTCCGCTGCTGGTGGCTAAT GCGCGCAATGTGGATCTTATGCGTTTGGGCAATGATTCCGCGGTGGGTTTGGGCGTTGCT ACTAATCGCACGCGCGTCATTGCGATTATTGCCGCTGTTGCGCTCATCGCCGTTGCTACC GCTGCATGCGGCCCGATCGCATTCGTGGCGTTTGTGTCTGGCCCCATTGCCGCGGGCATT TTAGGCTCCGGCGGATCGCTCATCATCCCCTCCGCACTCATCGGCGGGTTGATCGTGCTC ATCGCCGACCTAATTGGCCAATACTTCCTCGGCACCCGCTACCCCGTCGGAGTTGTCACC GGCGCATTCGGCGCCCCATTCCTTATCTATTTACTCATTCGTTCCAACCGCGCGGGAGTA ACCCTG >RXN00523-downstream TGACCACCAACGATCAACTATCC >RXN00525-upstream CCATCGTGTTTATTACTCACAACCCTGAGCTTGCTGATGAATCTGATGGGGTGGTCACCA TGGTTGACGGGCGCATCATTGGGTCTGAGGTGAAACACTC >RXN00525 ATGAGCCTTGCAGAATCAATTCTTTTGGCGCTCACCAGCCTGAGAAGCAACAAGATGCGT GCATTGTTGACGCTGTTAGGAGTCATCATTGGTATCGCATCAGTCATCGGAATTTTGACG ATTGGTAAAGCCCTGCAGGATCAAACTTTGAATAGTTTGGAAAGGTTGGGCGCGAATGAT CTGTCGGCGCAGGTGGAGGAACGCCCGGACGAAGATTCCCCGGAACCCGATATGTTCGCT TTTTCTGGGGCTGCAAACTCTAGTGGCAATCTGATTCCGGAAGAAACAGTTGATACGCTG CGCGATCGTTTCGCAGGCAGCATGACGGGAATCAGCGTTGGCGGAATGGGTACGCAAGGC ACTCTCATCGGCGACACCGCAGATCTTAAATGCGATGTCCTCGGCGTCAACGAGGATTAT ATGTGGATGAATGGCGTCGAAATGAACTACGGCCGCGCCATCACGCAAGACGATGTTGCC GGTGAGCGCCCCGTTGCGGTCATCGCCCCAGACACCTTTAATACGCTTTTCGACGCAAAC CGCAACCTCGCTCTGGGGTCCGAAGTAGCTTTTGAACTCAACGGTCAAGAGACATTTTTG CGGGTTATCGGTGTGTATAAAGAAGCCGCAGCAGGTGGACTTGTGGGAAGCAATCCAACC GTCCACACCTACACCCCATATACGGTGGCCAATGACATGACCCACACGGAAGATGGATTG AACACGTTAAGTATCCGTGCAGCTCAGGGCGTAGACCAGGATTCACTTAAGGGTTCACTG CAAACCTACTTGGACGCGCTGTACGCCAACAATGACTGGCACCACGTTGCCATGTTGGAC TTCCGTAAACAGATCGAAGAGTTCAACACCATTCTCGGCGCAATGAGTTTGGGTATCTCA GCCATCGGCGGAATTTCCTTGCTTGTCGGTGGCATCGGAGTGATGAACATTATGTTGGTG TCTGTCACCGAGCGAACCCGCGAAATCGGTGTCCGAAAAGCCCTCGGCGCTCGTCGACGT GACATTCGCCTGCAATTCGTCGTTGAAGCCATGATCATTTGTTTCATCGGTGGCATCCTC GGCGTGCTTTTGGGCGGCATTTTGGGATTGATCATGTCCAGCGCTATTGGCTACATTTCC TTGCCACCACTGAGTGGAATCGTGATCGCCTTGGTATTTTCCATGGCTATCGGCCTGTTT TTCGGCTACTACCCCGCCAACAAGGCAGCAAAGCTCGATCCAATTGACGCCTTGCGTTAT GAG >RXN00525-downstream TAAAAGCCTCGTTTTTAAGGTAG >RXN00702-upstream TGGGGACGATGCCAGGATTCTTGACGCCCGGCTTGCCGAAGAACAAAGTGAGGGTCAAGC GTCGAAAAGCAATAAATAGCCCAGAAAGGGCCGAAGTTTA >RXN00702 ATGAGTGGTCCTTTTAGCGCGCGCACTGGGTGGTGGACGGAGCCCGTGCTGGAACTGGAA AGCGTCGGTGCCTCGTATTATGACGATGAGCGCACGCTGGCGGCGCCGCAGATCAGCGAC GTGAATCTGACGCTTTTTGAAGGCGAAATCCTGCTGGTTGTGGGGCGCACCGGCTCCGGC AAATCGACGCTGCTGAACGCGATGTCCGGCGCGATGCCGCATGCGACCGGCGGCCGACTT GATGGGGGCGTGCGCGTGGTCGGCCGGGATACGCGTGATTTCCCACCACGCATGCTTTCC GACGTGGTCGGCGTCGTTGGGCAAGATCCGGCGGCAAGTTTTATCACCAACACGGTTGAA GAAGAACTTGCCTACAGCATGGAGCAATTAGGGGTCCCACCTGCGGTCATGCGCAAGCGC GTAGAGGAAACCCTTGATCTTTTAGGCATCGCGGAGCTGCGATACGTGCCATTGGCGGAA CTATCTGGTGGTGAGCAGCAGCGCGTGGCGATTGGCGCGGTGCTGACCACTCGCCCCGCG CTGATTATCTTGGATGAACCAACCAGCGCTTTGGACCCTAATGGTGCCGAGGATGTGCTG GCAACCGTAACCAAGCTGGCTCATGACTTGGCGATGACCGTAGTGCTTGCTGAACACCGC ATCGAGCGCGTACTGCAGTACGTGGACCGCGTGGCGCATGTGGGCGCTGATGGGCACGTC ACTGTTGGGACGCCGGAAGAAATCATGGCTGATTCTGATGTGGCACCACCCATTGTGGAA TTAGGACGCTGGGCTGGCTGGGCTCCCCTACCGCTATCGATCCGCGATGCACGCGCACAC TCCGGTGACATGCGCAAACGCCTGTATCAGGGTGGTTTAGTGGTGAACAAATTACACAAC CACGCTGTCCAGCCAGTTTTGATCGCCGAAGATATCATGGTTGATTTCCGCGAAATCCGT GCCGTTGACGGCGTGAACTTGAATCTCAACTCGGGTGAAATTACCGTGCTCATGGGCCGA AACGGCTGCGGAAAATCATCCCTGCTGTGGGCTTTACAAGGTTCAGGGACTAGAAATCAG GGCTCGGTGCAGGTGCTTGATGAGGCCGCGGGATTTTCGTGGACAGAGCCCAAAACTTTA AAGCCCGGCAAGCGGCGCAATCTTGTGTCCATGGTTCGGCAAACACCGACCGATATTTTG TATGAATCAACCGTGCATGCAGAGCTGGCACGCTCTGATAAAGATGCCGCAGCACCCGCC GGCACCACGCGGGAAATCCTGGATTCACTGGTCCCGAATATCCCGGACCATCTCCACCCA CGTGATCTATCAGAAGGCCAAAAGCTCTCCCTCGCGCTGTCCATCGAACTCGCCGCAAAA CCCCGCGTGGTATTTTTCGACGAACCCACCGGCGGCCTAGACTACGACGGCAAGAAATCC CTCGCCGGCTCCTTCGAACAACTCGCAGACGACGGCGACGCCATTTTGGTGGTCACCCAC GACGTGGAATTCTCTGCACTGTGCGCCGACCGAGTGTTGTTTATGGCCTCTGGAAAGATC ATCTCCGATGGCACAGCCGTAGAAATCCTCGCCGCATCACCGGCTTACGCCCCACAAGTC GCAAAAATCACCGCCGGCATCCAAGAGGAATCACACTGGCTCACAGTCTCGGCCGTGAAA GGTGCGGTAGGGCATGGTGAAATCTCA >RXN00702-downstream TGATCAACGCCATCACACTCAAG >RXN00726 AACGCGGGTCGCTTGTATGTGGATGGCGATCTCATTGGCTACCGAGAGCGCGATGGCGTG CTGTACGAAATCTCTGAGAAGGACGCCGCGAAGCAGCGCTCCGATATCGGCATGGTGTTC CAGAACTTCAACCTCTTCCCCCACCGCAGGGTGATCGAGAACATCATCGAAGCTCCCATC CACGTGAAGAAGCAGCCCGAAAGCAAGGCCCGCGCACGTGCCATGGAGCTGCTTGAGCAG GTCGGCCTCGCCCACAAGGCGGACGCCTACCCCGTCCAACTGTGGGGTGGTCAGCAGCAG GGCGTTGCAATTGCCCGCGCCGTCGCCATGGAGCCAAAGCTCATGCTTTTCGACGAACCC ACCAGCGCTTTGGACCCTGAACTCGTCGGTGAAGTCCTGCGAGTGATGAAACAGCTCGCC GACGACGGCATGACCATGCTTGTTGTCACCCACGAAATGGGCTTCGCCCACGAAGTCGCC GACCAGGTCGTGTTCATGGCCGATGGAGTTGTCGTTGAAGCCGGAACCGCCGAAGAAGTT CTGGACAATCCAAAGGAACAGCGCACCAAAGACTTCCTGTCTTCTCTGCTC >RXN00726-downstream TAACCTTTTCGGGTCTTAAAAAA >RXN00732 AATCACCTCCTCCTACTCCCCACGGTAAAGGCAGACATCATTGACAATGGTGTGGTCACA GGTGACATCGGCTATATTTGGCACACCGGTGGAATCATGCTGGCCCTGACATTAGTCCAG GTTGCCTGCGCTATCGCCGGTGTTTATTTCGGTTCCAAACTATCCATGAGAGTGGGCCGC GATCTGCGTTCGGCGATCTTTGGCAAGGTAGTGAACTTCTCTGAGCGTGAGATGGGTCAG TTTGGCGCACCGTCGCTGATCACCCGAAACACCAACGATGTGCAGCAGGTTCAGATGCTG GTGCAGATGACCTCCACTTTGATGATTTCCGCCCCGATGCTGGCCATTGGTGGCATCATC ATGGCGGTGCGTCAGGATCTTGGTTTGTCTTGGCTGATGGTGGTCAGTATTCCGGTGCTC ATCATCGTGGTGGCGCTGATCATTGTGCGCATGGTTCCGTTGTTCCAAACCATGCAAAAG CGCATTGACCGCATCAATCAGATTATACGCGAGCAGCTCACCGGTATCCGCGTGATCCGC GCGTTCGTGCGTGAAGATGTGGAACGCGAACGATTCAGCACTGCTAGTAAAGATGTCGCT GATATCGGCGTGCGCACGGGTAAGCTGATGGCGTTGATGTTCCCTGCCGTGATGCTGATC ATGAACCTTTCTGCCGTTGCTGTGATTTGGTTTGGTGCTTTCCAGGTGGAATCCGGCGAG ACGCAGATCGGTACGCTCTTTGCATTCTTGCAGTACATCATGCAGATCCTCATGGGCGTG ATGATGGCAGCGTTCATGTTTGTGATGGTTCCGCGCGCTGCCGTTTCGGCTGATCGCATC GGTGAGGTTCTGGAAACCACACCGTCTGTGCAGGCGCCAGAAACACGGGCGCAGCCGTCG ACAAGCGCTGGCGAAATCGTGTTCAACAACGCGACTTTTGCCTACCCCGGCGCGGATGAC CCCGTGTTAAATAATGTGAGCTTCCGCGTTGCGCCTGGTAGCACGACGGCGATCATCGGC TCGACGGGTTCGGGTAAGACGACGTTGATCGGGCTGGTTCCTAGGCTTTTCGACGTCACC GAAGGCGACGTTACCGTCGATGGCACCGATGTTCGTGAATTTGAGCCGCTGAAGCTGTGG GATCGGATCGGTCTTGTTCCGCAGAAGTCGTTCCTGTTTTCTGGAACGATCGCCAGCAAC CTGCGTTATGGCAATGAAGATGCCACGGAAACGCAGCTGTGGCAGGCGCTTGCAATTGCT CAGGCGGCGGACTTTGTGCGTGAGATGCCAGAGGGTCTTGATTCTGAGATTGCTCAGGGT GGAACCAATGTTTCTGGTGGTCAGCGCCAGCGACTAGCCATTGCCAGGGCGTTGTTGAAG CAACCTGAGATCTATATTTTCGACGATTCTTTCTCCGCCCTCGATGTGAGCACAGACGCC GCTCTTCGCCGAGCGCTGAGCACCAACCTGCCGGATGCAACCAAGTTGATTGTCGCCCAG CGTGTCAGCACGATTCGAGATGCCGATCAGATTGTGGTGCTTGATAACGGCGAGGTTGTC GGTATTGGAACGCACACGAATTTGCTGAAGACGTGCGGTACCTACCGTGAAATTGTTGAA TCCCAAGAGACTGCGCAGGCGCAATCA >RXN00732-downstream TGAGTAATACTGCAGGCCCCCGC >RXN00759-upstream TCACCTTGAACACTTAAAAGATAACTTCATCCGGCGCTTTATTAGCTTGAAGCGCCCCGC ACCATAATCCATTCCCCAGCAAGCAAGGACACCCACGCTC >RXN00759 ATGCTTCGTTACGTCGGGCGACGTTTGCTCGAAATGATTCCGGTGTTTTTCGGAGCGACC TTACTGATTTACGCCCTCGTGTTCGTCATGGCTGGTGACCCAGTGCAGGCATTGGGAGGT GACCGCGGCCTAACCGAGGCTGCGGCCGAGAAAATCCGTCAAGAATACAATCTTGATAAA CCCTTCATCGTTCAATACCTCCTGTACATCAAGGGCATCTTCGTCTTAGATTTTGGAACA ACGTTCTCTGGTCAGCCAGTTATTGATGTGATGGCCAGGGCCTTCCCCGTCACCATCAAA CTCGCCATCATGGCCCTGCTGTTTGAATCAATCCTCGGCATTATCTTTGGTGTCATCGCA GGTATTCGCCGCGGAGGAATCTTCGACTCCACCGTGCTGGTCCTTTCTCTGATAGTCATC GCAGTCCCCACCTTCGTCATTGGTTTCGTGCTGCAGTTCTTAGTCGGCGTGAAATGGGGC TTACTGCCCGTCACCGTAGGTTCCAACACATCAATAACGGCGCTGATCATGCCGGCTGTC GTACTGGGTGCAGTATCGTTCGCCTACGTTCTTCGCCTCACCAGACAATCCGTGAGCGAA AACGTCCGCGCTGATTACGTTGGAACCGCTCGAGCAAAAGGGATGTCCGGATTGAACGTG ATGAACCGCCATGTGCTTCGAAACTCACTGATTCCCGTTGCCACCTTCCTGGGCGCCGAT CTCGGTGCACTGATGGGTGGAGCGATTGTCACCGAAGGTATCTTCGGCATGAACGGTGTC GGTGGAACGCTCTACCAGGCCATTTTGAAAGGTGAACCCACCACGGTTGTCTCCATTGTC ACTGTGCTGGTCATCGTCTACATCATCGCCAACCTTCTCGTGGACTTGATCTACGCCGTT CTCGATCCGAGGATCCGCTATGCC >RXN00759-downstream TAATAATGAATTCCACACAAACC >RXN00808-upstream CGCGATGTCGCACCGGCACGTTAGAGTATTGAGCATGAGTCGATTGCTTAGAGCATTGAA ATGGCTGTGGGGCACATCGTGGCCGCTGTATGCTGCGACG >RXN00808 GTGCTCGGCACGAATGTGTTTGGTGCGCTCGCAGTAATGCTGTTTGTGCGCTTCCTCATT CCGCAGCCAGATGCTTCAAATTTCAACGCTGAGATCTCGTATCTGCCAGCTGTTGGTTTC GCATACCTGGCGTTCGCCATTGTCGCGGGCATGCTGGTGACATTTTTGATGTTCCGCCCG GTGCTTGATTGGCAGCGAAGCCCTGAAGATCATGACCGAAATATGGTGCGCAACTTGGTT ATGCGCATCCCCATCTACCAGGCAATTCTGTGCGCAGTGGTGTGGTTAATCGGCATTGCA ATTGCAACGTTGATTTCGGCCAGTGTGTCTACCAGTTTGGCGCTGGTCGTGGCGTTTTCC ACGTTGATGGCTGCCGCAATCGTCGTGCTGCTCACCTACCTTGAGGCTGAGCGTTTGGTG CGTCCGGTTGCTGCGTCTGCCCTGGCGCGTCGATTTGAGGATTCCACGCTGGAACCACCT GTGAGCCAGCGCTTGCGTATGACGTGGTTGCTGACGTTGGGCATTCCAGTGATGGGAATT CTGCTGGTTATTTGGGGCTACTCGCAGGGCATTTTCGGGTCTGATGCCTGCGGAATTATG CCTGCCATCGCAGCGCTCGCGTTTGCATCGTTGGTCACGGGTTACCTGGGCAACCGGCTT GTGGTGTCCTCTGTGGTGGATCCGATTCGGGAACTTCAGGAGGCCATCAACAGGGTTCGT CGTGGTGAAAACGATGTGGAGGTTGATATTTATGATGGCTCTGAGATCGGTGTGCTTCAG GGTGGCTTCAATGAGATGATGCGTGGCCTGCGTGAACGTCAGCGCGTCCGTGACCTTTTC GGTCGCTACGTGGGCGCTGAAGTGGCCAAGCGTGCGCTGGAGGAACGCCCCACTCTGGGT GGCGAGGACCGTAAGGTTGCCGTGTTGTTTGTCGATGTCATCGGCTCCACTACCTTTGCC GTCAACCACACTCCTGAAGAGGTTGTGGAGGCGCTCAATGAGTTCTTCGAGCACGTCGTG GAGGTTGTGCACCGCAACAAGGGTGTTATCAACAAGTTCCAGGGTGACGCGGCGTTGGCG ATTTTCGGCGCTCCCCTGCCCCTGTCTGATGCCACCGGTCATGCGCTTGCGGCTGCCCGT GAGCTCCGCGCAGAGCTGAAAGATCTCCAGCTCAAGGCCGGAATTGGTGTGGCTGCTGGC GATGTCGTTGCTGGTCATATCGGCGGTCACGCGAGGTTTGAGTACACTGTGATCGGCGAC GCGGTGAACCAGGCTGCGCGCCTGACGGAGATCGCGAAAACGACCCCAGGCCGCACCGTC ACCAACGCTTCCACGCTGCGTGAGGCCAACGAGGCGGAGCAGGCTCGCTGGACGCTCATG AAGTCCGTGGAGCTGCGCGGACGTAGCCAGATGACGCAGATTGCGCGGCCTATTCGGCCG ACGTTGGCGGATAGGTCC >RXN00808-downstream TAATACGCTTTTCGACGCAAAAA >RXN00828-upstream CGGTGATCACCGGGCCGAATGGCGCTGGAAAATCCACACTTGCGCTGACCATGGGTGGAT TGCTTCCGCGAAAAGTGGGCAGCTGGAACTGTCTGACACG >RXN00828 GTGCGCGGCGGCGTTAACACGCCCCCGCACAAGTGGCGTTCAGCTGATGTAGCTGCACGT ATTGGCACTGTCTTTCAGGATCCAGAGCACCAATTTGTGGCGCGCACTGTGCGTGATGAG GTAGAAATTGGGCCGAAAATCATGAAAGTCGATGCAAGCGAGCGGATCGAGGAGCTGCTT GATCGTTTGCGCCTCCGCCACTTGGAAAACGCCAATCCGTTTACCTTGAGTGGTGGAGAA AACCGCCGCCTATCTGTGGCGACAGCCTTGGTGGCAGCACCGAAACTTCTCATTTTGGAT GAGCCTACGTTTGGCCAAGATCCCGAGACCTTCACAGAGCTGGTGACGATGTTGCGTGAA TTAACAGACAACGGAATCAGCATTGTGTCGGTAACCCATGATCCTGATTTCATCGCAGCG GTGGGCGATCACCACATTGAGGTGAGCGCGAAG >RXN00828-downstream TGAACCTGCTGATCAAAATTAAT >RXN00832-upstream GAGATTGTGCTAGGTTCTGATGAGGCTTCGGGACGACCCGAAGAAATCTATGACAGCCTG GGAACGGCCCAGAGTTCTTAAGAAAGTTTGACTAGAGAAC >RXN00832 ATGCCGTTTTCTTGGCTAAAACCAATTGATTATGCCCGCATCTTTGTCGGCTGGGCATCG ATTTTTATCATCCCCCTCATCACACTGCCATCAATTATTGAGTTGGCGCTGATCGTGGCA GTCATCCTATTCTGCGCATTTGGCGTGGTGAAGATGGCGGAGCGTTTGGCTCATATTTTG GGTGATCCTTTTGGATCGTTGATCCTTACCTTGTCGATCGTGATCATTGAAGTGATTTTG ATCTGTGCGGTGATGCTGGGGCCTGCTGATTCAACCACTGCTGGTCGGGATTCCGTGATG GCAGTGTCCATGATCATCATGGGTTTGGTCGTGGGATTGTGCCTACTCATTGGTGGTTTA AGGCATGGAAGCATGCCACACAATGGGGTGGGAACTCCGACCTACTTGGTGCTGATCGCA ACTTTTTCCGTAATCGCCTTTGCGGTTCCAGCTTTCAGGGGAGAATACTCCACTGGGCAG GCACTTGTTATTTCAACACTGACAGCAGTGGTGTACGGGTTCTTCCTGTTTCGCCAAATG GGTGCCCAAGCTGGTGAATTTCAAGAGGTCGAGGTCGCAGAAAAGGCAGACGACGCAGCA AAATGGGAGGTCCCATTTAGAGGCTTAATCTTGATTATCACTGTGCTCCGCATCGTGTTG CTGTCCCATGACATGGCCACGGTGATGGATGAAGTCCTGGCAAGCCTTGGTGCACCCGTA GCAATGGCTGGATTAATTATTGCCACCATTGTCTTCTTGCCAGAGACCATCACCTCCTTG AAAGCTGCGTGGACAGGAGAGATTCAGCGAGTAAGCAACCTCGCGCATGGAGCCCAAGTA TCAACGGTGGGGCTGACAATCCCAGCTGTTCTAGTGATCGGCGTGATCACAGGTCAAGAT GTAGTTTTGGGGGAGACCCCGATCAACTTGTTGCTGCTGGGAACCACCATTGCGGTGACA GCCATTGCGTTTAGCTCCAAGAAAGTCAGTGCTGTGCATGGCTCGGTGCTGCTCATGCTT TTCGGTGTTTACATGATGAGCATGTTCGCC >RXN00832-downstream TGATTTAGGTAGCCTGGTGGGAA >RXN00934-upstream CCAACCCCTGTGGTTTGGTGATTTGGATCCGGAGCGTCTCAAGCGCTCTAGGGAGCAGAC AAATGTTCACAAACCGGTGGCATTACAGGAGGACAATTAG >RXN00934 GTGCGAATTGGAATGGTCTGCCCGTACTCCTTCGATGAGCCGGGCGGTGTTCAAGCGCAT ATCCTTGACTTAGCGCGAACCTTCATTGCCCAAGGCCATGAGGTTCAGGTGCTTGGTCCG TGTAGTGCGGATACGCAGGTGCCCGATTTCGTGGTGCGCGGTGGTGGCAGCATCCCGATT CCGTACAATGGCTCGGTTGCCCGCTTGAGCTTTGGGCCGAAAATGTTCAAGGCCGTGCGC ACGTTCCTCCGCGAAGGCAACTTCGATGTGCTGCATATCCATGAACCGAATTCACCAAGT TTTTCCATGGCGGCGCTACGCTTTGCGGAAGGCCCCATCGTTGCTACTTACCACGCCTCC AGTAGCGGATCGAAGCTGCTCAAGGCTTTCTTACCAGTGCTTTCGCCCATGCTGGAGAAA GTGCGCGCAGGCATCGCCGTGTCTGAAATGGCTCGGCGCTGGCAGGTGGAGCAAGTCGGC GGCGATCCGGTGGTGATCCCCAACGGGGTAGAGACCTCGATGTTCAAAGCCGCGCGCCAA ATCGAACCGAATGATCCTGTAGAGATCGTCTTTTTGGGTCGCGTCGATGAGTGCCGCAAA GGCCTCGACATCGTGCTGCGCGCTCTGACCAGGCTGGATCGCCCGTTTACCTGCACGGTC ATTGGCGGCGGCACCCCGCGAGAAGTCGCCGGCATCAACTTTGTGGGCCGCGTCAGCGAT GAGGAAAAGGCAGCAATCTTAGGTGGCGCAGACATCTATGTCGCACCCAACACCGGCGGC GAAAGCTTCGGCATCGTGCTAGTTGAAGCGATGGCGGGGGGATGCGCTGTCGTCGCCAGC GACCTAGAAGCGTTCTCCCTGGTCACCGATTCTGAAGCCGCACAGCCAGCGGGCGTGCTA TTTAAAACCGGCTCAGACGCCGACCTAGCCAAAAAACTTCAAGCGCTTATCGACGACCCC TCCTCCCGTTCCACGCTTATCGCCGCGGGGCTAAAGCGCGCAAACGCCTACGACTGGTGG ACAGTATCGACCCAGGTCATGGCAGTCTATGAAACCATTGCGATCGACAAAGTGAGGCTT GGA >RXN00934-downstream TGACCCTTGTTTACCTCCTCATC >RXN00939-upstream GAATTCCACCCTGGACAAAGATCATCCCACCGTGTCGAAGACGCCCAGG >RXN00939 ATGACAAGGCAAAAAACCCAGCCGTTCCTGGAGAAATTCTCGAAGTACTACACCCCCGGC GTCATGATCGCCGCCGTGGCCGTCGGCCTGATCACGCTGAACGTTGAACTGGCCCTGACC CTGCTGGTCATCGGGTGCCCGGGTGCCCTGGTCATCTCGATCCCGGTCTCGATCGTCGCC GGTATCGGCCGCTCCGCCAAGGACGGCGTCCTGATCAAGGGCGGGGAATACGTGGAGACC TCCGCGAAGGTCGACACCGTAGTCGTCGACAAGACCGGCACCCTGACCAACGGCCGCCCC GAGCTGACCAACGTCGACGTCCTTGACCCCGCCTACTCGGACGATGAGGTGCTCACCCTG GCCGCCCGCGCGGAAACCGCCTCCGAGCACCCCCTGGCCGAGGCCATCATCCGCGGCGCG GAGAACAGGGGCTTGACCGTGGCGATGGTAGAAAAGGCCGAACCGGTCGCCGGCCGCGGC ATCCGGGCTGACGTGGACGGTGCCACCGTGGCCGTGGGCTCAGCCGACCTGCTCGATCAC ACCCCGGATAACACCCGCATTCTCGAGCTCAACGAACAGGGCAGGACCGCCATGTACGTC GGCATCAACGGCAAGGCCGTGGGCATCGTCGCTGTGGCCGACACCATCCGAGATGATGCC CCGGCCGCGATCAGGTCCCTGCACAATAAGGGAATCCGCGTGGTCATGGCCACCGGTGAT GCCGAACGCGTCGCCCGCAACGTCGCCGCCGAGCTCGGTGTCGATGAGGTGAGGGCAGAA CTGATGCCTGAGGACAAGCTCGAGATCGTCAAGGAGCTGCAGGCGCAGGGCCGGGTCGTG GCCATGGTTGGCGACGGTGTCAATGACACCCCGGCACTGGCCACCGCGGACATCGGTGTG GCGATGGGTGCGGCCGGTTCGCCTGCCGCCATCGAGACCGCCGATATCGCCCTGATGGCC GACAAGCTGCCGCGGCTGCCCTACGCCCTGGGTCTGGCCCAGCGCACGGTGCGCACCATG CGGGTCAACATCGGCATCGCCCTGCTCACTGTCACGATCCTGCTGGCCGGTGTCCTGCTC GGTGGAGTGACCATGTCGATTGGCATGCTCGTCCACGAGGCCTCCGTCCTGCTGGTCATC GCGATTGCGATGCTCCTGCTGCGCCCCACCCTGAAGGAAGACAAGGACAAGGCAGACGTC AGTACTGCTGACGCCGCGAAGGAGACGCTGAGCGCC >RXN00939-downstream TAACGACACAATCGCCACAGCCA >RXN00960 ATGGCTCGGCATTGTTGCAGCAATCGCTACGCGTCCACCGTCTTCTCCGGTCTGATCGCC TACGGAGCATCCCAAGCGCTCTACCCATGGCTGCTGAAAGACCACCAAAGCGTCACCGAA ATCGACCTTGATGCAGGTGCCCTGCAGCCCTACTTCAACATCGAGATGCCACCACCATTT GAAGTGATGACCGCACTGCTGCTGGCATTCTGCCTCGGCCTGGGCATGGCTGTAATTAAA TCAGACACCCTGTTCAAGGTAACCCGCGAACTCGAGCGCGTAGTCATGAAGACCATCACC GCCTTTGTCATCCCACTGCTGCCACTCTTCATCTTCGGCATCTTCCTCGGCATGGGCATG AACGGTGGCCTCCTGGAGATCATGTCCGCCTTTGGCAAGGTACTGATTCTCGCCGTCGTG GGAACCCTGCTCTTCCTAGCCATCCAGTTCATTATCGCTGGTGCAGTATCCAAGAAGAAC CCATGGAAACTGTTCAAAAACATGCTCCCTGCATACTTCACTGCACTGGGCACTTCCTCT TCAGCGGCAACCATCCCAGTGACCTACCAGCAGACCCTGAAAAACGATGTTGATGTCAAC GTCGCAGGCTTTGTTGTCCCACTGTGCGCCACCATCCACCTAGCTGGATCGATGATGAAG ATCGGCCTCTTCACCTTCGCTGTTGTCTTCATGTACGACATGGAAGTAGGCGTCGGCCTC TCCATCGGATTCCTCCTCATGCTGGGCATCACCATGATCGCCGCACCAGGCGTTCCCGGC GGAGCCATCATGGCAGCAACCGGCATGCTGGCCTCCATGCTCGGATTCAACACCGAACAA GTCGCCCTCATGATCGCCGCTTACATCGCGATTGACTCCTTCGGCACCGCAGCAAACGTC ACCGGCGACGGCGCAATCGCAGTCATCGTGAACAAATTCGCCAAGGGCCAGCTGCACACC ACTTCGCCAGATGAAATCGAAGAAGACGACCGCGTTGCCTTCGACATCACTCCATCGGAT GTGGAACATCACAAG >RXN00960-downstream TAGAAACCCGCATTTTCTGTAGT >RXN00980-upstream AGAGAGAAAGGGAGAAATCATGAAAACGTGGAAGACCTGGGGGGTCGTCGGAGCTTGAGG CCTCTTGATTATTTTGTCGTGGTTGAGTTCATCGAGCCCG >RXN00980 ATGCTGGCAGATGCATTCATGATCGCGGCTGCAATTGTTGGAGGTTGGCCGATCGCGCAG TCTGCATATCAAGCACTTCGCATTCGAATGGTGTCGATTGACTTACTGGTCGTTGTGGCT GCCGTTGGTGCCATGTTCATCAACAACTATTGGGAGTCTGGGGCGGTGACGTTCCTCTTT GCCCTTGGCAAGGCACTGGAACGCGCGACAATGAACCGCACACGAAAAGCACTATCGGAT CTGGTGGATGCAGCTCCAGAAACTGCAAGAAGGCTCAACGCGGATGACTCAACAGAGGTA GTTGAGCTGTGGGAGCTTGAGCCCGGTGACATCGTCTTGGTACGCAATGGCGAACAAATT CCCGTCGATGGAAACGTGATTGCGGGTGTCGGTGGAATTGATGAATCCAACATCACGGGT GAATCAATGCCGGCTGAAAAGGGTCAAGGCTCTGATGTGTATGCAGGAACCTGGCTGCGA TCTGGTGTTTTGAGAGTCGAGGCAACAGGAATTGGTTCAGACTCAACTTTGGCAAAAATC ATTCACCGCGTTGAAGACGCCCAGGATGACAAAGCCGGCACACAAACATTCTTAGAGAAA TTCTCTAAGTGGTACACCCCGGGCGTCATGATCGGCGGCGCAGTGGTGGGACTTATCACC TGGGACGTAGAACTAGCACTGACGCTCTTAGTGATCGGCTGCCCCGGCGCGTTGGTTATC TCCATCCCGGTGTCCATCGTCGCAGGCATCGGCCGTGGTGCACGCGATGGCGTGCTGATC AAGGGTGGAGAATACCTAGAAACCGCGGCGAAAGTCGACGTCGTTGTCGTGGACAAAACT GGAACGCTGACGACCGGCCGCCCAGAACTCACAGACGTAGAAGTCATCGAGCCCGCCTAC AGCCAGGGCGAGGTGCTGGAGCTCGCCGCGCGCGCCGAGACGGCTTGAGAACATCCGCTT GCCGAGGCCATCATGCGTGGTGCCCAGGATCGGGGGCTGTCCACAAGATTGGTGGAAGCA GCTGAAAACATCACCGGCCGAGGCATTATCGCAAATGTTGATGGACAGGCAGTTGCTGTT GGATCTGCTGAGTTACTTGATCATGAACCAGACTCGACCAGGATCCTGGAGCTAAATGCC GAAGGAAAGACCGCGATGTTTGTCGGAGTGAACGGACACGCCATTGGAATCGTGGCCGTC GCCGACGCCGTTCGTTCAGATTCTGCCTCAGCAATCGAATCGCTGCATAAGGCGGGCATT CAAGTTGTCATGGCGACTGGCGACGCTCACCGCGTTGCACAAAACGTGGCCTCCAAGCTG GGAGTGGATGAAGTCTACTCAGAGCTACTCCCTGAACAGAAATTAGAACTGGTGCGTGAT CTGCAAGCTGCCGGCAAAAGGGTCGCGATGGTGGGTGACGGAGTCAACGACACCCCAGCA TTGGCAGCTGCTGATATCGGAGTAGCGATGGGCGTGGCAGGTTCCCCTGCAGCCATTGAA ACCGCTGATATCGCACTCATGGCGGATCGTCTCCCACGGCTGGCACATGCAGTGACCTTG GCAAAACGCACCGTAAGAACCATGCGCATCAATATTCTGATTGCGTTGGCTACCGTGATG GTGTTACTAGCTGGCGTCCTATTTGGCGGAGTTACCATGTCGGTTGGCATGCTCGTTCAC GAAGGAAGCGTGCTGCTTGTTATCAGCATCGCCATGCTGTTGCTGCGTCCAACACTTAAA GAAGATGCTGCGCAAGCAAGTGATATTAAACGCTCGGAAATACAACAGATCGCA >RXN00980-downstream TAACCAATGGCTGGGTACTGATG >RXN01000-upstream CTTTCTATGCCTACGCGGATGTTTCCGTGATCATTCTGGAAATGCTCATCGTGGTGATTG TCATTGAAGTAATCTCCAACGCACTTCGAAAGAGGCTGGT >RXN01000 ATGAGCACCTTAACCTCTCACCGCACAGTACCGGCCCCCAGCTCTCCCCCGGCGCGCCCC AACAAACTGGCGCGCAATATCGTTGCAATTGTCGCTGCGCTGATTGTCCTTATAGCTACC GGCACGCTCAAGATCGAGTGGAATGAGCTTCCGCAGATGCCCGCGCAGGTGTGGCATTAC TTAGAGCTGATGTTTAGCGATCCCGATTGGTCGAAGTTTGGCCGCGCCGTCCAGGAAATG TGGCGTTCCATCGCCATGGCGTGGTTGGGTGCCATTTTATGCGTGGTGGTCTCTGTCCCT CTGGGAATGTTGGCTGCCCGCGGGGTGGGACCTTATTGGCTGCGTACCGTTTTACGGTTC GTGTTCGGGGTGATTCGTGCGTTCCCCGAAGTGGTTATCGCAATTATTTTGCTAACTGTC ACCGGCCTAACTCCTTTTACTGGTGCGCTCGCATTGGGTATCTCCGGTATTGGACAACAG GCAAAGTGGACCTATGAAGCCATTGAGTCCACTCCCACCGGCCCGTCAGAGGCAGTGCGT GCAGCGGGTGGAACTACGCCGGAGGTTCTGCGGTGGGCGTTGTGGCCACAGGTTGCGCCA TCCATTGCATCTTTTGCCCTGTACCGCTTTGAGATCAACATGCGTACCTCTGCGGTATTG GGCATCGTTGGTGCAGGTGGTATCGGTAGTATGGTTGCCAATTACACCAACTACAGGCAG TGGGACACCGTGGGCATGCTGCTCATCGTCGTGGTTGTCGCAACGATGATCGTCGATCTC ATCTCCGGCACCATCCGCCGGCGCATCATGAAGGGGGCTAGTGACGGTGTCGTGGCACCA AGCAAC >RXN01000-downstream TGACGCTCGACCAAGCATCCGCA >RXN01002-upstream GACTGCTGATACCGCACAGGATGAAATGACTCGTTACGGCGAGATGCTGAAGAAGTTCTC GAACTAATTTCCCTGTTTCCAATACTCAAGGTGTGCGCAT >RXN01002 ATGAATTCTGATGCTTCGGCTACCACCAACTCCTGGGCTATCAACTTCGACGATGTGTCG GTGACGTATCCCAATGGGACGAAAGCCCTCGATGATGTTTCCCTCACCATCAATCCCGGT GAGATGGTTGCCATCGTGGGTCTGTCAGGATCGGGTAAATCCACGCTGATTCGCACGATC AACGGTCTTGTCGGGGCTACGGAAGGCAGCGTGACGGTGGGGCCGCATCAGATCAACACC TTGAAGGGGAAAGCACTGCGTGATGCCCGTGGGCAGATCGGCATGATTTTCCAGGGGTTC AAGCTGTCGGAACGCAGGAGTGTGTTCCAGAATGTTTTGGTGGGCCGCTTGGGGCACACA GGGTGGTGGCGTAACCTCGTCGGGTTTCCCACGGAGCACGAGAAGCAGATTGCTTTTCAC GGGTTGGAGTCCGTGGGCATTTTGCACAAAGTGTGGACGCGAGCTGGTGCTTTGTCGGGT GGACAGAAACAGCGCGTTGCTATTGCGCGCGCCTTATGGCAAGATCCGTCTGTCATGCTG GCAGATGAGCCTGTGGCAAGCCTTGATCCGCCAACCGCGCATTCCGTGATGCGCGATCTA GAAAACATCAACAACGTGGAAGGCCTCACCGTGTTGGTGAACTTGCACTTGATTGATTTG GCTCGTCAATACACCACAAGGCTTGTGGGTTTGCGTGCCGGCAAGCTGGTCTATGACGGT CCTATCTCTGAGGGCACCGATAAAGACTTTGAAGCTATCTATGGTCGCCCCATCCAGGCT AAAGACCTGCTAGGTGATCGCGCA >RXN01002-downstream TGACCACGCCTTCTTCTACACTT >RXN01141-upstream AAAGAACACTCGGTATGGCACCTGATTTAAGGATGCTGCAATCGTGACACATATCCTCTT CGACAGCAGGCGTTTTCTGCAACTGGGCGCTTTTGCGTCC >RXN01141 TTGAGCACCGCATTGGCCGGAGCGGCCCGCTACGTGACGTCGACAAGCAATAATGAACCT GCGGATAACACTCCCCTGACCATTGGCTACGTGCCTATTGCGGGCTCGGCGCCGATTGCT ATCGCAGATGCGCTAGGGCTGTTTAAGAAACACGGCGTGAATGTCACGTTGAAGAAGTAC TCAGGGTGGTCCGACCTGTGGACCGCCTATGCAACAGAGCAGCTTGATGTTGCGCACATG CTGTCGGCGATGACTGTGGCGATTAATGCTGGAGTGACCAACGCGTCGCGCCCGACGGAG CTGTCGTTTACCCAGAACACCAATGGGCAAGCAATTACCTTGGCGTCAAAGCACTATGGT TCCGTCAATTCAGCGGCGGATCTTAAAGGCATGGTGCTGGGAATTCCTTTTGAATATTCA GTGCATGCGCTGCTCCTGCGCGATTATCTCGTCTCAAACGCAGTTGATCCCATCGGCGAT CTTGAGCTTCGCCTGCTCCGACCTGCCGATATGGTCGCACAATTGAGAGTTGAGGGCATC GATGGATTCATTGGGCCTGGGCCGTTTAATGAACGCGCCATCAGCAATGGCTCCGGCCGG ATTTGGCTGCTGACCAAACAACTGTGGGACAAACATCCATGCTGCGCCGTGGCGATGGCC AAAGAGTGGAAAGCTGAACACCCCACGGCGGCTCAGGGTGTGCTTAATGCGGTGGAGGAA GCCTCCGCAATTTTGAGCAATCCGGCACAATTTGATTCCTCGGCACGCACGCTGTCGCAG GAAAAATACCTCAACCAGCCTGCCACGTTGCTGGATGGACCGTCG >RXN01141-downstream TAATCATCGGCATCACCGGCTTA >RXN01142-upstream CTCCCCATCCACCGGCACAGTCAGCGCAGGCAACGAAGAAATTAAAGGACCAGGACCTGA CCGAGGCATGGTTTTCCAAGACCACGCCCTCCTGCCCTGA >RXN01142 TTGACCGCACGCGGCAACATCGACTTCGGGCTCCGCTCCGCGCGCCCCTCCTTGAGCAAA ACCGAACGCGCCGACATCACCCGCACCCACCTCGAACAAGTAGGCCTCACCGACGCCGCC GAACGGCGCCCCGCCCGCCTCTGCGGCGGCATGCAACAGCGAGTCGGCATCGCACGCGCC TTCGCCATCGACCCAGCAATCATGCTTCTCGACGAAGCCTTCGGCGCCCTCGAGGGCCTC AGCCGCCGCGAACTCCAGCTCCAAGTACTCAACATTTGGGAAGCCTCCCGCCGGACCGTC GTCATGGTCACCCACGACGTCGACGAGGCCATCCTGCTCTCCGACCGAGTTGTCGTGATG TGCAAGAGCGCCGAAGCCACCATCATCACCGATATTCCAGTGAATCTTCCCCGCCCCAGA CACGAGCTGAGTGAAGACGCTTCTGTTGAAGCCGAGACCACAGCGCTGCGTAAGCGGATG CTGCATCTGCTGGAGCAC >RXN01142-downstream TAGTTTCTAACACGTCTTTTAAA >RXN01164-upstream GCCGATCGTGATTGATGAAGACGAGATCCAAGCCTGGACTTCTGATCTCAAACCTGAAGA TTTCACCAAAGGTAAAGATGAATCCGACGGTGAGAAATAA >RXN01164 GTGACACTGTTTGTTCGGCTCGCCCTTGCTGCTGTGGGCGGGCTTTTTGTGTTTGCTTCC AATGAACCGATCGGCTGGTTTGTCGCGGGAATTGTTGGCACTGCATTATTTTTTATCTCC CTTGCGCCGTGGGATGTGGGAGTTCGCCAAAAGCGGCGGAAGAAGAATGAGCCAGTCCCA TTTTTGCAACAGATGTCCACGGGCCCAACTGTTGTACAGGGCATGCTTTTAGGTTTTGTC CATGGCCTGGTGACATATTTGCAGCTGTTGCCGTGGATCGGTGAGTTTGTTGGCTCACTG CCTTATGTCGCGTTGTCAGTTGTCGAGGCGCTTTATTCCATTGCTCTTGGTGCTTTCGGC GTGCTCATTGCGCGTTGGAGGGACTGGAAGGTTCTCCTGTTTCGGGCGATGTATGTGGCT GTGGAGTATCTAAGAAGCTCGTGGCCATTTGATGGATTCGCGTGGGTTGGCCTGGCATGG GGTCAAATTAACGGTCCGTTGGCTAATGTCGCAGCGCTTGGTGGGGTAGCGTTTGTGACT TTTTCCACGGTGCTGGCTGCCGTGGGTGTGGCCATGGTGATTATTTCCAAGAAGCGACTG GCCGGCGCAATCATCACCGCGAGTGTGATTGCTATCGGGGCGGTGTCATCCCTGTACGTT GACCGCAATGGCACGAGCGATGAAAGCATCGAAGTAGCCGCAATTCAGGGCAATGTGGCT CGGATGGGATTGGACTTCAATGCACAGCGCCGCGCGGTGCTGGCGAATCACGCACGGGAA ACCCTCAAGCTGGATGAACAAGTGGATTTGGTGATCTGGCCGGAGAATTCCTCAGACGTC AACCCATTTTCCGATGCACAAGCAAGAGCCATTATCGATGGAGCAGTGGAACATGTTCAG GCAGCTATTTTGGTGGGCACGATCACCGTCGATGAGGTTGGTCCACGCAACACCATGCAG GTATTTGATCCTGTTGAAGGTGCCGCGGAGTACCACAATAAGAAGTTCTTGCAGCCGTTT GGTGAATACATGCCGTTTCGCGAATTCCTGAGAATTTTCTCGCCCTACGTTGATTCCGCT GGAAACTTCCAGCCCGGTGATGGCACCGGCGTAGTGGAGATGAATGCTGCGAACTTAGGC CGCGCTGTGACAGTGGGCGTGATGACGTGTTACGAGGTCATCTTCGACCGTGCTGGCCGC GACGCCATCGCCAATGGGGCTGAATTTTTGACCACGCCCACCAACAACGCCACCTTCGGA TTCACGGACATGACGTATCAGCAATTAGCAATGAGCAGGATGCGTGCCATCGAATTTGAT AGGGCGGTGGTTGTTGCAGCTACATCGGGTGTTTCGGCTATCGTCAACCGTGATGGAAGC ATTTCCCAAAAGACCCGAATTTTTGAGGCCGCCACCTTGACGGAATCCATTCCACTCAAG GACACTGTCACCATCGCAGCGCGGGTTGGTTTCTATGTTGAATTACTGTTGGTTATCATT GGTGTATTAGCTGGACTATTCGCCATTCGAATGAATAGCCGTTCAAAGTCTGCGAAAGGT TCCGCTCGGGCCGCACAAGTTCGGGTTAAGAAGGTGCCTGCGAAAAAGGGAGCAACTAAT CGTCGAAAAGTAAAA >RXN01164-downstream TAAAAACGTCCCGAAGGGACGAG >RXN01168-upstream CCGCACAAGTTCGGGTTAAGAAGGTGCCTGCGAAAAAGGCAGCAACTAATCGTCGAAAAG TAAAATAAAAACGTCCCGAAGGGACGAGGAGGACAACACC >RXN01168 ATGAGCAGTGAGGCAGTAGATGCTACGACGCTGGTGATTATTCCAACGTACAACGAGCTG GAAAACCTTCCACTCATCGTGGATCGCGTGCGCACCGCAACCCCTGACGTTCACGTACTC ATCGTGGACGACAACAGCCCAGACGGCACCGGGGAGCGCGCAGACAAGCTTGCTGCTGAC GACGACCACATTTTTGTCCTCCACCGCGAAGGCAAAGGCGGCCTGTGCGCAGAGTACATG GCTGGCTTCCAGTGGGGCCTGGAGCGCGACTACCAGGTCCTGTGCGAAATGGACGCCGAC GGCTCCCACGCACCAGAACAGCTGCACCTGCTGCTCGCTGAGATCACCAATGGCGCTGAC GTGGTCATCGGCTCGCGCTACGTGCCAGGCGGCCGCGTAGTCAACTGGCCCAAGAACCGT TGGCTCTTGTCCAAGGGCGGCAACGTCTACATGAGCGTCGCGCTCGGCGCCGGCTTGACC GATATGACCGCAGGGTACCGCGCTTTTGGACGTGAAGTGCTAGAAGCACTGCCGGTTGAT GAGCTCTCCAACGCTGGGTACATTTTCCAAGTTGAGATTGCCTACCGTGCAGTTGAAGCC GGATTCGATGTTCGTGAAGTTCCCATCACTTTCACCGAGCGTGAGATCGGCGAATCCAAG CTGGACGGCAGCTTTGTCAAGGATTCCCTGGTCGAGGTAACCAAGTGGGGCCTCAAGCAC CGCGGTGGCCAGGCCAAGGAACTGTCCAAGGAAATGGTGGGGCTGCTGAACTATGAGTGG AAGCACTTCAAAAAGCGCAACACCTGGCTC >RXN01168-downstream TAAACTGCTTGCCGGTTAGTGAA >RXN01285 CTCAACGTCACCATCCCCGACAACAGCTTCACCGCCATCATCGGCCCCAACGGCTGCGGC AAATGCACGCTGCTCCGCGGTTTCTCCCGCGTGCTCAATCCGCAGCACGGCAAAGTGCTT CTCGACGGTCGGCAACTCGATTGATTCAAGCCTAAAGAGATCGCCCGAGAACTAGGCCTG CTGCCACAGACCTCCATCGCCCCAGAAGGCATGCGGGTTTACGATGTCATCGCGCGCGGG CGCGCTGGCTACCAAAGCCTCATACAACAATGGCGCACCTCCGACGAAGACGCCGTCGCG CAAGCGCTCGCCTCCACGAATCTGACCGAACTTGCAGCTCGCCTCGTCGATGAACTCTCC GGTGGCCAGCGCCAACGAGTGTGGGTGGCCATGTTGCTCGCCCAGCAAACACCGATCATG CTTCTCGACGAGCCCAGCACCTTCCTCGACATGGGCCACCAATACGAACTCTTGGAATTG CTGCGCGCATTCAACGAGGCCGGGAAAACTGTGGTCAGTGTGCTTCACGATCTCAACCAA GCCGCCCGCTACGCCGACCACCTCATCGTGATGAAAGATGGGCACGTACATGCCACGGGC ACACCGGAGGAAGTCTTAACTGCCGAGATGGTTCAAGGAGTTTTTGGCCTGCCCTGCATC ATCTCCCCAGACCCCGTCACAGGAACCCCGACCGTCGTTCCCCTCAGTCGGTCTCGCGCA GGAGCT >RXN01285-downstream TAAGTAGGTACCCCTCCAACGGA >RXN01298-upstream CTTAAACGTCACCTTATTTATGCATTATGTTGGTTTCAGACTCGAACAATTCAATTAGAA AACACTAATCGGACATTTAGGTCACATAACATTTCCGCTC >RXN01298 GTGTCCACATTAATTTCTGAACCCGAGGTGGATAAGCTACGTAAACGTGCCAAGAGATCA AGGCGGACAGAATGGTGGCTTGCCGCCGCACTTCTTGCCCCAAACTTGCTTCTCTTGGCC ATCTTTACGTATCGGCCACTGTTAGATAACTTCCGGTTGTCCTTTTTCAACTGGAACATT TCCTCGCCCACATCAACCTTCATTGGGTTTGATAACTACGTTGAGTTCTTCACTCGTAGT GACACTCTCCAAGTTGTTTTAAACACCGTCATCTTCACGGCATGTGCTGTGATCGGATCG ATGGTGCTCGGTTTGCTCCTGGCCATGTTGTTGGATCAGAAGCTTTTCGGCCGTAACTTT GTGCGTTCGATGGTGTTTGCCCCGTTTGTGATTTCCGGTGCTGCCATTGGTGTTGCTTTC GAGTTGGTTTTTGACCCTAATTTTGGTTTGGTTCAGGACTTGCTGGGACGCATCGGCGTT GATTCGCCACAGTTCTACCAAAACCCTAACTGGGCATTGTTCATGGTGACGTTCACTTTC GTGTGGAAGAACTTGGGCTACTCCTTTGTTATCTACCTGGCTGCATTGCAGGGGCTAAAC AAGGATTTGTCTGAGGCCGCACCGGTGGATGGCGCGAGCGCGTGGACACGTTTTTGGAAG GTTACTCTTCCGCAGCTTCGCCCAACCACGTTCTTCCTTTGTATTACTGTCACGCTGAAC TGGGTTCAGGTCTTCGACATCATTCACACCATGACTCGTGGTGGCCCCTTGGGTAACGGT ACGACCACCTTGGTTTACCAGGTGTACACCGAGACTTTCACCAACTATGGCGCGGGATAT GGTGCAACAATCGCAACGATTTTGTTCCTGTTGCTGCTGATTATCACTGTTATCCAGGTT CGATACATGGATAAGGAGAACAAGCAGAAA >RXN01298-downstream TGATCTCGACTGATAGAAACGTT >RXN01323-upstream CACGTGGTTTACGCCAGGCATGTTCCCGCGAAGGGTTGACCCATACCCCTAGGGGGTATA CAGTGAGTCATGTAAACATACTCGCAGAAGGAGCGATCCC >RXN01323 ATGGCTCAGACACCCGCCAAAATCCCGGCGGCACTGAATTTCATTGACGTCGACCTCGGC GTTACCGGCATGACCTGCACTTCTTGCTCCGCCCGCGTCGAGCGCAAACTGAACAAGCTC GACGGCGTTGAAGCAACCGTCAACTACGCGACGGAATCCGCACAGGTCAGCTACGACGCG TCAAAGGTCAGCCCTGAACAGCTGATTAAGACTGTTGAGGACACCGGCTACGGTGCTTTC ACGATGGCTTCCGCAGCTGCCGAATCAGAAGAGGACAACGCTCCAGGTGACAGGGGCGAG TGCCGCATCGACGCAGCTCGCGAGCACGAAGCAGGCGACGTGAAACACCGCGTGATCGTC TCTGCACTGTTGTCAGTTCCTGTGGTTTTGGTCAGCATGATCCCGGGGCTGCAATTCAAC AACTGGCAGTGGGCCGTACTCAGTTTGGTCACCCCGATTTTCTTGTGGGGCGGTTCACCG TTCCACAAGGCAACGTGGGCAAACCTGAAGCGCGGTTCCTTCACCATGAAGAGCCTGGTT TCACTCGGCACGTCCGCTGCTGACCTGTGGTCCGTGTGGGCTTTGTTCATTGAAAATGCT GGTCACCGTGGCATGAAGATGGAGATGCACCTGCTGCCGTCGGCCTGCACGATGGATGAG ATTTACCTGGAAACCGTCGCGGTCGTTATTACGTTCCTGCTGCTTGGACGCTGGTTTGAG ACAAAAGCTAAGGGCCAATGTTCGGAAGCTCTGCGCAAGCTGCTGGACATGGGCGCCAAA GATGCAGTCGTGTTACGTGACGGCGCCGAAGTCCGCGTTCCTGTGAATCAGCTTAAACTC GGCGACGTTTTCATCACCCGCCCCGGCGAGAAAATCGCCACCGACGGTGAAGTCGACGAA GGTTCCTCCGCAGTCGACGAATCCATGCTCACCGGCGAATCCATCCCCGTTGAAGTCACC AAGGGGTCCAAAGTTACCGGCGCAACGCTGAACAGTTCCGGCCGCCTCATGGTGAAAGTA ACCCGCATCGGCGCCGACACCACCCTGTCGCAAATGGCTAAACTGGTCACGGACGCACAG TCCAAAAAGGCCCCTGTCCAGCGTCTTGTTGACCAAATCTCGCAGGTTTTCGTTCCCGTT GTCATCGTAATTGCTATTGCGACGCTGATCGCGCACGTCGTCTTCACCGACGCCGGCCTC GCCCCAGCATTCACGGCAGCAGTCGCCGTCCTCATTATCGCCTGCCCTTGTGCCCTCGGC CTGGCAACCCCAACCGCACTTCTGGTCGGAACGGGCCGCGGCGCGCAACTTGGTCTGTTG ATCAAGGGCCCTGAAATCCTCGAATCCACCAAAAAAGTCGACACCATCGTCCTCGACAAA ACCGGCACCGTCACCACCGGCACCATGTCCGTCACCGACGTCACCGCCATCAACTACAGC GAAACCGAAATCCTCGAATTCGCTGCAGCCGTCGAGTCCGCCTCCGAACACCCCATCGCC CAGGCAATCGCCAAGGCCGCCGAACACGAGCAAGTCACCGACTTCCAAAACACCGCAGGT CAGGAAGTCACCGGTGTAGTCCGCGGACACGAGGTCCGCGTGGGCAGGCCTTCAAGCACG GTTATCGACGCCCTCCTCCACCCCTTCCAACACGCCCAAAAAATCGGCGGAACCCCCGTA GTCGTCACGATTGACGGCGTAGATTCCGGAATAATCACGGTCCGCGACACCGTCAAAGAC ACCTCCGCCGAAGCAATCCGCGGACTCAAGGAACTGGGACTCACCCCAATCCTACTCACC GGAGACAATGAAGGCGCAGCTAAATCCGTAGCCGCTGAAGTCGGCATCGACCAAGTCATC GCCAACGTCCTCCCCCACGAAAAAGTCCAAAACGTAGAAGCCCTCCAAGCACAAGGCAAA AACGTTGCGATGGTCGGCGACGGCGTCAACGATGCCGCAGCTCTTGCCCAAGCTGACCTC GGACTCGCCATGGGAGCCGGCACCGACGTAGCCATCGAAGCCTCCGACATCACCCTCATG AACAACGACCTCCGATCCGCAGTCGACGCCATCCGACTGTCCCGTAAAACCCTCGGCACC ATCAAGGGAAACCTTTTCTGGGCTTTCGCCTACAATGTTGCACTAATCCCAGTAGCGGCG ATCGGACTCCTCAACCCAATGCTTGCCGGCATTGCGATGGCCTTCAGTTCAGTTTTCGTC GTCTCCAATTCCTTGCGTCTGCGAGGATTCAAAGCAAGGAGCAAC >RXN01323-downstream TAATGTCCAACAGCGAATGCCAC >RXN01338 AAAACTTATACCCCAAATGCCTGGATGTTATTCATCCGCTCATTTGATGGCATCATCACT GTCGCAGCCCTTGTTGCCATCGCAATACATCTCATTTTATGGCTGGCTCTAGATCTAGAT GGCGTTGCTAAAAACTGGCCTTTAATAGCCATCGTTATCGTAGGTGGCATTGCGTTGATG TGGGATGTGCTGAAATCAGCCATTAAAACTCGCGGTGGCGCGGATACTTTAGCAGCAGTC TCCATCATTACTTCTGTGTTGTTAGGGGAGTGGTTGGTTGCCGCGATCATCGTGCTCATG CTCTCTGGTGGTGAAGCGCTAGAAGAGGCAGCATCACGGCGAGCGAGTGGCACCTTGGAC GCACTTGCCCGGCGCGCACCAAGTACAGCTCACCGCCTGTTGGGTGGAACCATTCTTGAT GGAACCGAAGAGATCGCCGTGGAAGAGATCACGGTTGGTGATTTAGTGGCGGTGCTCCCG CATGAACTTTGTCCCGTGGATGGTGAAATCGTGGCAGGCCACGGCACCATGGATGAGTCT TATCTCACGGGTGAGCCCTATGTGGTGAGTAAATCTAAAGGTTCGCAAGCAATGTCGGGT GCAGTCAATGGTGATACTCCGCTGACGATTGTTGCCACAAAGCTTGCCCATGATTCCAGA TACGCCCAAATTGTTGGTGTACTCCATGAAGCAGAAAACAACCGCCCAGAAATGCGCAGG ATGGCTGACCGTCTTGGCGCGTGGTATACGGTGATTGCACTTGCCCTCGGTGGTCTTGGC TGGATTGTCTCCGGCGACCCAGTGAGGTTCTTGGCTGTTGTCGTTGTCGCCACCCCATGT CCATTGCTCATTGCAGTGCCAGTGGCGATCATCGGTGCGATTTCTCTTGCGGCTCGTCGG GGCATCATCGTGAAGAACCCTGGAATGCTGGAAAACGCTTCAGGAGTAAAGACAGTGATG TTCGATAAGACTGGAACGCTCACCTATGGCAGGCCAGTGATTACTGATATCCACACTGCT CCCGGAGTTGAGGAAGATACAGTCCTAGCTTTGGCTGCTTCAGTAGAGCGCTACTCCAGA CACCCGTTGGCTGACGCGATTCGTGAGGGCGCAAAAGCCAGGGAACTTCATCTGCCTGAT GTAGTGGAAGTATCGGAACGTCCAGGACAGGGACTAACCGGCACGGTGGGCGAGCACCTG GTTCGAATAACCAATAGGCGCAGCACACTAGAAATTGATCCAGACAGCAAGAACTACATT CCGGTGACAAGTTCCGGCATGGAATCTGTGGTGCTTGTTGATGATAAATATGCAGCACTC ATTCGCGTCCGGGATGAACCTCGTGCATCTGCGAGTGAGTTCATCGCGCACTTGCCCAAG AAGCACAAAGTGGACAAGCTCATGATTATCTCTGGTGATCGCGCATCTGAGGTTCGTTAC CTTGCGGACAAGGTTGGCATTGATGAGGTACACGCAGAGGCCTCACCGGAAGACAAGCTG AACATTGTTAATCGGCATAATGAGCACGGCGCCACCATGTTCTTAGGTGATGGAATCAAC GATGCGCCAGCGATGGCCGTTGCCACCGTTGGTGTCGCGATGGGAGCAGACTCCGATGTC ACGTCCGAAGCAGCAGATGCTGTGATTTTGGATTCTTCCCTGGAACGTCTCGACGATCTG CTCCACATCAGTGCACGGATGCGTCGAATAGCGTTGCAATCTGCGGGCGGTGGCATGGCG TTGAGTGTCATAGGAATGATCCTCGCGGTATTTGGATTCTTGACGCCACTGATGGGTGCG ATCTTCCAAGAGGTCATTGACGTGCTGGCTATCCTCAATTCCGCTCGGGTCGCACTGCCA CGCGGAGCGATTAGTGATTTTGATACGCAAGAAAAAGTTTCT >RXN01338-downstream TAGCAGGGTAACCTAAATGTCGT >RXN01411-upstream CTTATCGACGTCCCCATCCCCCTCGCCAATGCTTCGGCGAGGGGTTCTATTTATTGTGTG TGCTAGCCTTTTCGCAATCGTTCAGCCCGCCCCGACGTCA >RXN01411 ATGTTGGGAGTGGGCTGGCGCATTCCATTCCTGATGGCCGTGCCACTAGGGCTTATCGGC TGGTGGATGGGCACCGGTGCCCAGGAAAATGTACGCCCCGCATCCGAACGCCCCGAAGCT CCTATTAAGCAGGCATTGCGTACTGAGTGGAAGATGATGTTGCGGGTAGGTGGCTTTATC TCTTGCACCGGTCTGAGCTTCTACATTTTCACCACGTACATGACCACTTTCCTGCGCAGC ACCGTCGGACTGGAGGGCACGTTAGTGCTGGCTGGAAACATCATCGCTCTGAGCATGGCA GCAATTGTGGCCCCATTTGTTGGCCGCGCAATTGATAAATTCCCCCGCCGGAACATCATG GGTTTCGCTACCTTAAGCACAGTAATTATGGCGATCCCGGCCTACATCATTGCAGGTCAA GGTACTTTGACTGCTTCTTTGATTGCGCAGGTAATGCTTGGAATCGGCGCGGTTACCGCT AACTGCGTTACCTCAGTAATGATGGCCGAGGTCTTCGAAGAGGTCACCCGCGGTACTTCC GCCGGCATTACCTACAACGTCACTTACGCAATCTTCGGCGGCTCGGCTCCATTTATCTCC ACCGCATTGGTCTCCTGGACCGGCAGCCCGCTGGCCCCTGCGGTATACATGATCATCATT GGGCTCTTCGCCTTCACCGCGTCCCGCTTCATTCCTGAAACCTCCCCAGTTTTTGTCACC GCAACCCCGGCCATTAAGGCACCAAAGGTGCTGGTCAACCCGGGT >RXN01411-downstream TAAACCACGCTTTTCGACGAAAA >RXN01808 CAGAGCCTCGCGTGTAAAGAACTCGCATGGATGCGGGGCGGTGCACCAGCGCGAACCTCA AAGCCTGGATTCCGCCTTGAAGCCGCGGAAGCTTTGATCGCAGAAGTGCCAGCGCCACGC GACAAAGTCGAGCTCATGGCATTTTCCAAGTCCAGGCAAGGCCGCGTTGTCATTGAACTT GAAGACGCGACAGTAGCCAGCCCTGATGATCGCATCCTGGTAGAAGAGCTGACCTGGCGT TTGGCTCCAGGAGAGGGCATCGGTCTTGTCGGCGTCAACGGGTCCGGCAAAACCACCCTG CTGCGCACCCTTGCCGGCGAGCAGCCACTTCAGGCAGGCAAACGCATCGAAGGCCAAACC GTCAAACTGGGATGGCTCCGCCAGGAACTCGATGACCTAGACGTCAGCCGCCGACTCATC GACTGCGTTGAAGATGTCGCTTCCTACGTGATGATGGGCGACAAGCAGGTCTCCGCTTCC CAATTGGCAGAACGCCTCGGATTCTCACCCAAGAGGCAACGCACCCCAGTTGGTGACCTG TCCGGTGGTGAACGCCGCCGACTCCAACTCACCCGCGTGCTCATGGCCGAACCAAACGTG CTGCTCCTCGACGAGCCCACCAACGACCTGGACATTGACACCCTCCAAGAGCTGGAATCC CTTGTCGACGGATGGCCAGGCACCATGGTGGTTATCTCCCACGACCGTTACCTCATCGAA CGCGTCACCGACTCCACCTGGGCACTCTTCGGCGATGGCAAGCTCACCAACCTGCCAGGC GGAATTGAAGAGTACCTGCAGCGACGAGCAGCGATGGCCGCGGCCGAAGACAGTGGAGTG CTGAACTTGGGTGCGGCCACGCAGGCTGGAACCTTTTCTGCTGCAACAGAGCAGGCTGCC ACTTCTGTGGAAAGTTCCGGAATTTCTTCCCAAGAACGCCACCGCATCACCAAGGAAATG AACGCCCTGGACCGCAAAATGGGCAAGCTTGACCAGCAAATGGACAAGCTTAATCAGCAG CTCGCTGATGCAGCGGAGGCCATGGACACCATAAAGCTCACCGAGCTGGACACCAAGCTC GGCGCAGTGCAGGAAGAACACGGCGAGCTGGAAATGCAGTGGCTGGAACTCGGCGAGGAA ATCGAGGGC >RXN01808-downstream TAGTTCATGCCGTCGGCAGGCGA >RXN01939-upstream TGCTGTTCTACCCCGCAATGGCACTTGCACTAACCGTTTTGAGCTTCATCATGATGGGCG ATGTCGTCCGCGACGCTCTGGATCCTAAGTCGAGGAAGCG >RXN01939 ATGACCACCAACATCCCACAAACCCCCAACCACGAGGGTGAACAGCCACTGCTCGAGCTG AAGGATCTAAAGATTTCCTTCACCTGCTCCACCGGTGTTGTCGACGCTGTCCGTGGCGCA AACCTCACGATTTATCCTGGCCAATCTGTTGCCATCGTGGGTGAATCCGGTTCAGGTAAA TCGACCAGGGCAATGTCGATCATCGGTCTGCTTCCAGGCACCGGCAAAGTGACCGAAGGT TCCATCATGTTTGATGGCCAAGACATCACAGGCTTGAGTAACAAGCAGATGGAAAAGTAC CGCGGTTGAGAAATCGGACTGGTGCGCCAGGATCCGATGACCAACTTGAACCCGGTGTGG CGCATGGGCACCCAGGTCAAGGAATCCCTCCGAGCCAACCACGTGGTTCCAGGCTCAGAG ATGGACAAGCGCGTGGCAGAAGTTCTGGCCGAGGCAGGTCTTCCTGATGCTGAGCGTCGC GCAAAGCAGTACCCACATGAGTTCTCTGGCGGTATGCGCCAGCGCGCACTGATCGCCATT GGTTTGGGGGCACGCCCGAAGCTCTTGATCGCCGACGAGCCCACCTCTGCGCTGGATGTC ACCGTGCAGCGCCAAATCCTTGATCACCTTGAAACACTGACCAAGGATCTCGGCACCGCA GTGCTATTTATTACCCACGACTTGGGGCTTGCCGCTGAGCGCGCGGAGCACCTCGTGGTG ATGCACCGCGGACGCATCGTGGAGTCCGGGCCATCATTGAAGATTCTGCGCAATCCACAG CACCCATATACCCAACGCTTGGTTAAGGCTGCGCCGTCTCTGGCTTCTGCACGTATTCAA AGTGCGCAGGAACAAGGCATTGAATCTGCAGAACTGCTCTCTGCAACGGCCGTTGCTGAG GGCACTATTCCAGAGATGGAAGAAAAAGTTATCGAGGTGAAAAACCTCACCCGCGAATTT GATATCCGCGGTGCCCGTGGCGATAAGAAGAAGCTGAAGGCCGTTGATGATGTGTCCTTC TTCGTACGTAAAGGCACCACCACCGCACTTGTGGGTGAATCCCGTTCGGGTAAATCCACC GTGGCCAACATGGTGCTCkACCTTCTCGAGCCAACCAGCGGAGAGGTGCTCTACAACGGC ACCGATCTTACGTCCTTGAGCCACAAGGAAATCTTCCAAATGCGACGCAAACTGCAGGTG GTGTTCCAGAACCCCTACGGCTCGCTTGATCCGATGTACTCCATCTACCGGTGTATTGAG GAACCGCTGACCATCCACAAGGTTGGTGGAGACCGCAAGGCACGCGAAGCTCGCGTCGCT GAACTTGTCGATATGGTGTCCATGCCCAGGTCCACCATGCGCCGCTACCCCAACGAGCTT TCCGGTGGCCAACGTCAGCGCATCGCCATCGCCCGTGCATTGGCACTGAATCCAGAAGTG ATCGTGTTGGATGAAGCGGTTTCCGCTTTGGACGTGTTGGTTCAGAACCAGATCCTCACC CTGCTTGCAGAACTTCAGCAGGAACTGAAGCTCACCTATTTGTTCATCACCCACGACTTG GCCGTTGTTCGACAAACCGCCGACGATGTTGTGGTGATGCAAAAGGGACGAATCGTTGAA AAGGGTCGTACCGACGACATCTTCAACGATCCTCAGCAGCACTACACCCGCGATTTGATC AATGCGGTACCTGGTCTGGGAATCGAGTTGGGTACTGGAGAAAACCTGGTT >RXN01939-downstream TAACCCGCACAGCCTCACTAAAC >RXN01995-upstream CCGACGCAAAGGCATGCGCCTGCGTGTCTCGAGTAGTCTCCTCCCCTTCCTCGTCCCCAA CCTCGACCATTACGGTCGCGCTCTCCTAAAGGAGCCTGGC >RXN01995 ATGGATATCCGCCAAACAATTAAGGACACAGGAATGTCGAGATATCAGTGGTTCATTGTA TTTATCGCAGTGCTGCTCAACGCACTGGAGGGCTTTGATGTCCTCGCCATGTCTTTTAGT GCGAATGCAGTGACCGAAGAATTTGGACTGAGTGGCAGCCAGCTTGGTGTGCTGCTGAGT TCCGCGCTGTTCGGCATGACCGCTGGATCTTTGCTGTTCGGTCCGATCGGTGACCGTTTC GGCCGTAAGAATGCCCTGATGATCGCGCTGCTGTTCAACGTGGTGGGATTGGTATTGTCC GCCACCGCGCAGTCCGCAGGCCAGTTGGGCGTGTGGCGTTTGATCACTGGTATCGGCATC GGCGGAATCCTCGCCTGCATCACAGTGGTGATCAGTGAGTTCTCCAACAACAAAAACCGC GGCATGGCCATGTCCATCTACGCTGCTGGTTACGGCATCGGCGCGTCCTTGGGCGGTTTC GGCGCAGCGCAGCTCATCCCAACATTTGGATGGCGCTCCGTGTTCGCAGCCGGTGCGATC GCAACTGGTATCGCCACCATCGCTACTTTCTTCTTCCTGCCAGAATCCGTTGATTGGCTG AGCACTCGCCGCCCTGCGGGCGCTCGCGACAAGATGAATTACATTGCGCGCCGCCTGGGC AAAGTCGGTACCTTTGAGCTTCCAGGCGAACAAAGCTTGTCGACGAAAAAAGCCGGTCTC CAATCGTATGCAGTGCTCGTTAACAAAGAGAACCGTGGAACCAGCATCAAGCTGTGGGTT GCGTTCGGCATCGTGATGTTCGGCTTCTACTTCGCCAACACTTGGACCCCGAAGCTGCTC GTGGAAACCGGAATGTCAGAACAGCAGGGCATCATCGGTGGTTTGATGTTGTCCATGGGT GGAGCATTCGGCTCCCTGCTCTACGGTTTGGTCACCACCAAGTTCAGCTCCCGAAACACA CTGATGAGCTTCATGGTGCTGTCCGGGCTGACGCTGATCCTGTTCATTTGCTCCACCTCT GTTCCATCCATCGCGTTTGCCAGCGGCGTTGTCGTGGGCATGCTGATCAATGGTTGTGTG GCTGGTGTGTACACCCTGTCCCCACAGCTGTACTCGGCTGAAGTACGCACCACTGGTGTG GGCGCTGCGATTGGTATGGGTGGTGTGGGTGCGATTTCCGCGCCACTGCTGGTGGGTGGC CTGCTGGATTCTGGCTGGTCCCCAACGCAGCTGTATGTTGGTGTGGCAGTGATTGTTATT GCCGGTGCAACCGCATTGATTGGGATGCGCACTCAGGCGGTAGCCGTCGAAAAGCAGCCT GAAGCCCTAGGGACCAAA >RXN01995-downstream TAGGGCCGCGATTCCTAGCATGC >RXN02062-upstream TTGTCTAAACATCGTTTTGGGGTGCGAATGATAGCCCCTTTTAATGCCCCCATTTCGGTA TCGCTGCGCAACTGTTTTTAGATGGCTAATCTTTGAAATT >RXN02062 ATGAGAGTCGGAATGATGACAAGAGAGTATCCACCAGAGGTTTACGGCGGCGCTGGCGTG CACGTCACCGAATTGACCCGATTCATGCGTGAGATCGCTGAAGTTGATGTTCACTGCATG GGTGCAGCTCGCGATATGGAGGGAGTTTTCGTCCACGGCGTCGATGCTGCCTTGGAAAGC GCGAACCCTGCGATTAAGACACTGTCCACCGGTTTACGCATGGCAGAAGCTGGAAACAAC GTGGATGTCGTGCACTCACACACTTGGTATGCAGGTCTTGGCGGCCACCTTGCAGCTCGT CTCCACGGCATTCCTCACGTGGCTACCGCGCACTCTTTGGAGCCAGATCGCCCATGGAAG CGTGAGCAGCTTGGCGGTGGATACGACGTGTCCTCCTGGTCTGAAAAAAATGCCATGGAA TACGCTGACGCGGTCATCGCTGTGTCGGCTCGCATGAAAGATTCCATCCTCGCTGCGTAC GCTCGCATCGAGCCGGACAACGTGCGTGTTGTGCTCAACGGCATCGACACTGAGTTGTGG CAGCCTCGCCCGACTTTCGATGACGCGGAAGATTCCGTACTCCGCTCCCTAGGCGTTGAC CCACAGCGGCCCATCGTCGCATTTGTCGGCCGCATCACCCGCCAAAAAGGCGTCGAGCAC GTCATCAAGGCAGCAGCGCTTTTCGACGAGTCCGTGCAGCTTGTGCTCTGTGCCGGCGCG CCAGACACCCCCGAAATCGCAGCTCGCACCACCGCCCTGGTGGAAGAACTCCAGGCAAAG CGCGAAGGCATTTTCTGGGTTCAGGACATGCTGGGCAAGGACAAAATCCAAGAGATTCTC ACCGCTGCTGACACCTTCGTGTGCCCATCCATTTACGAGCCACTGGGCATCGTGAACTTG GAAGCAATGGCCTGCAACACCGCAGTTGTCGCATCCGACGTTGGAGGCATCCCTGAGGTT GTTGTCGACGGCACCACCGGCGCCCTCGTTCACTACGACGAAAATGATGTCGAAACCTTC GAGCGCGATATCGCCGAAGCGGTGAATAAAATGGTCGCTGATCGAGAGACCGCAGCCAAA TTTGGTCTCGCAGGGCGCGAACGTGCTATCAATGATTTCTCCTGGGCAACGATTGCTCAG CAGACCATTGATGTGTACAAATCCTTGATG >RXN02062-downstream TAAAACCGAAAGCCGGGGAACCT >RXN02096-upstream CGCTTCGACGACCTCACCCACAGCGATATCCGCAGGAATGTCATCGCGGTTTTTGATGAG CCGTTCTTGTACTCCTCCTCCATACCGGGAGAACATCTCG >RXN02096 ATGGGTTTGGATGTCAGTGATGAGGAGATCGAACACGCAGCCAGGCTTGCCCAGGCTCAT GATTTTATCGATCGCCTTCCAAACAAATACGAGGAAGTCATTGGCGAACGCGGCCTGACG CTTTCTGGTGGTCAACGCCAACGCATCGCCCTCGCACGGGCTTTCCTGGCGCATCCCAAA GTGTTGGTGCTTGATGATGCCACCTCTGCCATTGATGCCTCCACTGAGGACCGCATTTTC CAGGCCTTGCGCGAAGAACTGCACGATGTCACCATTTTGATCATCGCGCACCGCCACTCC ACTTTGGAGCTCGGCGATCGGGTTGGTCTGGTCGAAGATGGACGGGTAACAGCACTGGGA CCGTTGAGTGAGATGCGTGATCACGCTCGTTTCTCGCATCTGATGGCTCTTGATTTCCAG GATTCTCACGATCCGGAATTCACCCTCGACAACGGTTCACTACCCAGCCAAGAGCAATTG TGGCCGGAGGTCTCCACAGAAAAGCAGTACAAGATTCTTGCGCCTGCCCCTGGTCGAGGC CGTGGCATGTCCATGCCAGCAACCCCTGAGCTGCTCGCCCAGATTGAGGCGCTGCCAGCA GCAACGGAAGAAACACGAGTTGATGCCGGGAGGCTACGCACCAGTACCTCCGGTTTCAAA TTGCTCAGTTTATTCAAGCAGGTCCGTTGGCTCGTCGTCGCGGTCATCGCGTTGTTGCTG GTGGGCGTAGCCGCCGATCTAGCATTTCCAACACTGATGCGCGCAGCCATCGACAACGGT GTGCAAGCACAAAGCACCTCCACGTTGTGGTGGATCGCCATCGCAGGCAGCGTAGTAGTC CTTCTGTCCTGGGCCGCCGCCGCGATCAACACGATTATCACGGCACGCACCGGTGAACGG GTGCTTTACGGCTTGCGTCTGCGCTCATTTGTGCATCTATTGCGCCTGTCCATGAGCTAT TTCGAACGCACCATGTCCGGCCGCATCATGACGCGCATGACCACCGACATCGACAACCTC TCGTCCTTCCTCCAATCAGGTCTGGCGCAAACAGTTGTCTCTGTGGGCACGCTCATCGGT GTGGTCACCATGCTCGGCATCACCGACGCACAACTAGCACTCGTTGCGCTGTCCGTGGTG CCGATCATCATCGTGCTCACTCTCATTTTGGGACGCATCAGCTCCAGGCTGTACACCGCT TCACGGGAGCAAGCCAGCCAGGTCAACGCGGTATTCCACGAGTCCATCGCCGGTTTACGC ACCGCGCAGATGCACCGCATGGAAGACCAAGTCTTTGACAATTATGCGGGCGAAGCAGAG GAATTCCGACGCCTGCGTGTGAAATCCGAGACGGCCATCGCCATCTACTTCCCCGGCCTT GGGGCGCTCTCTGAAATCGCCCAGGCACTCGTCCTCGGTTTCGGCGCACTGGAAGTAACG CGGGGGGACATCTCCACCGGGGTACTCGTGGCATTCGTGCTGTACATGGGCCTGATGTTC GGCCCGATCCAACAACTAAGGCAAATCTTCGACTGCTACCAACAAGCCGGCGTCGGCTTC CGTCGCATCACCGAACTGCTGGCAACGGAGCCCAGCGTCCAGATCTGGGCACCAACAGGC ACGCTAGGCAGGCTGCCACGCAGCCTTTATTGCTTGACGACGTCACCTTCGGCTATTCAG ACGATCCGATCC >RXN02096-downstream TAGACAACGTCACCGTCCAGATC >RXN02348-upstream AAAGACCCGAGCCGAAGCCCTGGCCTGCGCATACTTCCTTGTCAACGCTCGCTGGGATTA GGTCTTTTCTGAGCGCTAGCATTTCTCCACTCAAAGGAGC >RXN02348 ATGCTTAACCGCATGAAAAGTGCGCGGCCAAAATCAGTCGCTCCAAAATCCGGACAAGCT TTACTCACTCTCGGTGCCCTAGGTGTTGTGTTCGGCGACATCGGCACCAGCCCCCTGTAC TCACTTCACACTGCATTCAGCATGCAGCACAACAAAGTCGAAGTCACTCAGGAAAATGTG TACGGCATCATCTCGATGGTGTTGTGGACCATCACTTTGATCGTCACCGTCAAATACGTC ATGCTGGTCACCCGAGCTGACAACCAAGGACAAGGTGGCATCCTGGCGCTCGTTGCTTTG CTGAAAAACCGTGGGCACTGGGGAAAATTCGTGGCAGTAGCCGGCATGTTGGGCGCCGCA TTGTTTTATGGCGATGTGGTGATCACCCCGGCGATCTCTGTTCTCAGCGCAACAGAAGGC TTGACGGTTATCTCCCCAAGCTTTGAGCGCTTCATTCTGCCCGTATCTCTGGCAGTTCTG ATCGCTATTTTTGCAATCCAACCGCTCGGTACAGAAAAAGTCGGCAAAGCCTTCGGCCCC ATCATGTTGCTGTGGTTTGTCACCCTTGCAGGATTGGGAATTCCGCAAATCATCGGGCAC CCAGAAATCTTGCAGAGCTTGTCTCCACATTGGGCCCTGCGCTTGATTGTGGCTGAGCCT TTCCAAGCATTTGTGCTGCTTGGTGCCGTTGTCCTGACAGTAACGGGTGCGGAAGCGCTC TACGCTGATATGGGCCATTTTGGGGCGAGGCCAATCAGAGTGGCGTGGTTTTGCGTCGTC ATGCCTGCTTTAATCTTGACGTATTTGGGGCAGGGCGCCTTGGTGATCAACCAGCCTGAA GCGGTGCGCAACCCCATGTTTTATCTCGCGCCGGAAGGTCTGCGGATTCCGTTGGTTATT TTGGCGACCATCGCTACGGTGATCGCATCGCAGGCCGTGATTTCTGGTGCGTATTCATTG AGCAAGCAGGCCGTGAATTTGAAACTGCTGCCACGCATGGTGATCCGGCATACCTCCCGC AAAGAGGAAGGCCAGATCTATATGCCACTGGTTAATGGATTGCTGTTTGTATGCGTGATG GTTGTGGTGCTGGTATTCCGATGCTCTGAAAGGCTCGGCAGCGCGTACGGACTTGCAGTG ACCGGAACCTTGGTGCTGGTCAGCGTCCTGTATCTGATCTATGTTCACACCACATGGTGG AAAACAGCGCTGTTCATTGTGCTCATCGGTATTCCAGAAGTACTTCTATTCGCCTCGAAC ACCACGAAAATTCACGACGGTGGCTGGCTTGCACTACTTATTGCGGCCGTGCTGATCGTG GTGATGCGGACCTGGGAGTGGGGAAGTGACCGCGTCAATCAGGAACGCGCAGAGCTGGAA CTTCCCATGGATAAGTTCTTGGAGAAACTCGATCAGCCACACAATATTGGTCTGCGTAAA GTTGCCGAAGTGGCAGTATTTCCACATGGGACGAGCGATACTGTCCCGTTGTCATTGGTT CGCTGCGTGAAAGACCTCAAGCTTTTATACCGAGAGATCGTGATCGTTCGAATCGTCCAA GAACACGTTCCGCACGTGCCACCAGAGGAACGCGCGGAAATGGAAGTGCTCCATCACGCC CCGATCAGAGTCGTGCGAGTTGATCTGCACCTTGGTTATTTTGATGAGCAGAACCTGCCT GAGCATCTCCATGCCATTGACCCAACATGGGATAACGCCACCTACTTCCTGTCTGCCCTG ACTCTTCGGAGCAGGTTGCCTGGAAAGATTGCTGGCTGGCGTGATCGTTTGTATCTTTCG ATGGAACGTAATCAGGCATCTCGAACTGAGTCTTTCAAATTGCAACCAAGCAAAACCATC ACGGTTGGAACAGAGCTGCACCTT >RXN02348-downstream TAATCAGGCAGTTGCTGGCCAAC >RXN02354-upstream GAATAAAGAAAAAGAAACTGGGCGGAACCAAGGATGAGAAACCCACCGCTAAGGATGGTG TTGTAAAGGCCGATTCTGCTGTGAAGGAAGCCGCTAAGCC >RXN02354 ATGACTAAACGAACAAAAGGACTCATCCTCAACTACGCCGGAGTGGTGTTGATCCTCTTC TGGGGACTAGCTCCCTTCTACTGGATGGTTATCAGCGCACTGCGCGATTCCAAGCACACC TTTGACAGCACGCCATGGCCAACGCACGTCACCTTGGATAACTTCCGGGACGCACTGGCC ACCGACAAAGGCAACAACTTCCTCGCAGGCATTGGCAACTCACTGGTCATCAGCGTCACC ACAAGAGCGATCGGTGTTCTCGTGGGAGTGTTCACCGCCTACGCTCTAGCCGGACTGGAA TTCCCGGGCAAAGGCATTGTCACCGGCATGATCTTGGCAGCCTCCATGTTCCCCGGCATC GCCCTGGTCACTCCGCTGTTCCAGCTCTTCGGTGACCTCAACTGGATCGGCACCTACCAA GCGCTGATTATCGCGAACATTTCGTTCGGGCTACCTCTGACGATCTACACGCTCGTATGC TTCTTCAGGCAAGTGCCCTGGGAACTCGAAGAATGAGCACGTGTCGACGGCGCGACACGT GGCCAAGCCTTCCGCATGATCCTGCTTCCTCTAGCAGCGCCCGCACTATTTACCACCGCG ATCCTCGGATTCATTGGAACGTGGAACGAATTCATGCTGGCCGGCCAACTATCCAACACC TCCACAGAGCCAGTGACCGTTGCGATGGCAAGGTTCACCGGACCAAGCTCCTTCGAATAC CCCTACGCCTCTGTCATGGCAGCGGGAGCTTTGGTGACCATCCCACTGATCATCATGGTT CTCATCTTGCAACGCCGCATCGTCTCCGGACTCACCGCAGGTGGCGTGAAAGCC >RXN02354-downstream TAGACTAGATACTCATGAGTGCT >RXN02356-upstream TTGGGAGTAGCCATGCGTTCTGCTCCTGACCTTGAACAGCGGTCCCAATTTAGACCCGCT AAACCCACAATGTGTACTGGTGCTGGTAATTTAGTAGAAC >RXN02356 ATGGCAACGGTCACATTCGACAAGGTCACAATCCGGTACCCCGGCGCGGAGCGGGCAACA GTTCATGAGCTTGATTTAGATATCGCTGATGGCGAGTTTTTGGTGCTCGTCGGCCCTTCG GGTTGTGGTAAATCCACTACGCTGCGTGCTTTGGCGGGGCTTGAGGGCGTGGAGTCGGGT GTGATCAAAATTGATGGCAAGGATGTCACTGGTCAGGAGCCGGCGGATCGCGATATCGCG ATGGTGTTCCAGAATTATGCTCTGTACCCTCACATGACGGTGGCGAAGAATATGGGTTTT GCGCTGAAGTTGGCTAAGCTGCCGCAGGCGCAGATCGATGCGAAGGTCAATGAGGCTGCG GAAATTCTTGGGTTGACGGAGTTTTTGGATCGCAAGCCTAAGGATTTATCGGGTGGTCAG CGTCAGCGTGTGGCGATGGGTCGCGCGTTGGTGCGTGATCCGAAGGTGTTCCTCATGGAT GACCCGCTGTCCAACCTGGATGCGAAATTGCGCGTGCAAACCCGCGCGGAGGTCGCTGCT TTGCAGCGTCGCCTGGGCACCACCACGGTGTATGTCACCCACGATCAGGTTGAGGCAATG ACGATGGGCGATCGGGTTGCGGTGCTCAAGGACGGGTTGCTGCAGCAGGTCGCACCGCCC AGGGAGCTTTACGACGCCCCGGTCAACGAATTCGTTGCGGGCTTCATCGGCTCGCCGTCC ATGAACCTCTTCCCTGCCAACGGGCACAAGATGGGTGTGCGCCCGGAGAAGATGCTGGTC AATGAGACCCCTGAGGGTTTCACAAGGATTGATGCTGTGGTGGATATCGTCGAGGAGCTT GGCTCCGAATCGTATGTTTATGCCACTTGGGAGGGCCACCGCCTGGTGGCCCGTTGGGTG GAAGGCCCCGTGCCAGCCCCTGGCACGCCTGTGACTTTTTCCTATGATGCGGCGCAGGCG GATCATTTCGATCTGGAGTCGGGCGAGCGTATCGCT >RXN02356-downstream TAGTTTCGGACGTGGGGAGGCGT >RXN02391-upstream CAAAGTGGCGATCCTGAATTTGCCATCGAATCTGCCGTGAGAAGAGTTGCAGAGCTGGCG AGGCGGTAACGCTGAACGGCGGCGGGTAAGATATTTGAGC >RXN02391 ATGACACAATCAGATTTACCCGATGATGTTCAGGAATTGGTCACTAAGATCTTTGGACTG GCACGTGATGGGGGAGCAGAATCCGCAGCAACCCTCGGTGCATATGTCGACAACGGCGTT GACGTTAACCTGTCCAACCAAGATGGCAACACTTTGCTCATGCTCGCAGCATATGCAGGA CATGCTGATGTCGTGCAGGCGTTGATTGAGCGTGGCGCCGATGTGGATCGCGTGAACAAC CGCAATCAGACGCCGCTGGCGGGCGCGATCTTTAAGAAGGAAGAAGCCGTCATTGAGGCA CTGCTTGCTGGTGGTGCTGACCCATACGCTGGAACTCCAACTGCTGTTGATACCGCCAAG ATGTTTGGCCGCGAGGATCTCGTAGCTCGCTTCGAGTCA >RXN02391-downstream TAGGCCGGTGGAGTGGACCGCTT >RXN02442-upstream GCCGTGATGTTGTTGAGCGCGATGTGATTGCCGTATGTGCATGTGAGATTCCGGACGCTG AGTTCTGCCATTCCTTAATGATAACGGTTATCATTTTCAA >RXN02442 ATGAAGTTTTTTACTGACGCCCTCATAGTGCCTTTTGACGTTTCATTCATCTCCCGCGCC CTGGTCGCCGGATGCCTGGCCGCAATTTTATGCTCACTCATTGGAACGTGGGTTATTTTG GGCAGGCTAACCTTTTTCGGCGACGCTATGTCGCACGGCTTGGTCGCCGGAGTAGCCACG GCATCACTATTGGGCGGAAATCTCATGTTGGGCGCAGGAATGAGCGCATTAATCATGTCA GCCGGAGTGGTGTGGACCAGCAGAAAATCCAGCCTGTCCGAAGACGTCAGCATTGGGCTG CAATTTATTACCATGCTTTCCCTCGGCGTGGTTATTGTGTCCCACTCCGATTCCCACGCC GTAGACCTCACCAGTTTCCTTTTTGGAGACATTCTTGGCGTGCGACCCTCGGATATATTC ATCATCGCCATTGCAACAGTGTTGGGTGGATTGAGTATTTTTCTCTTCCACCGACAGTTC ACTGCACTCGCTTTCGACGAGCGTAAAGCTCACACCTTAGGACTCAATCCCCGCTTTGCA CACCTACTCATGCTGGCACTGATCGCATTAGCTACGGTGGTGTCGTTTCAGGTGGTGGGA ACGCTTTTAGTGTTTGGACTTCTGATTGGTCCGCCCGCCACGGCTGCACTTTTAGTGCAA GACAAAGCAAGTATTTCACTGATCATGATGGTCGGGTCGCTTCTTGGATGCGCGGAAATT TACCTCGGGCTTTTAATCAGCTGGCACGCAAGCACTGCCGCGGGAGCCACTATCACTTTG TTAAGTGCTGCGATATTTTTTGCCACCTTATTGACAAAGAGTGCGATTAGTAGGTTAAAC TTCACCGCG >RXN02442-downstream TGATACTGAAAGACATTTTCAAT >RXN02447 ACAGTAGTTCCGGTGTACCTCGCTGAACTGGCACCACTAGAAATCCGCGGCTCCCTGACC GGCCGAAACGAGCTTGCTATCGTCACCGGCCAGCTGCTTGCCTTCGTGATCAACGCGCTT ATCGCCGTCACCCTACACGGAGTTATTGATGGAATCTGGCGCATCATGTTCGCCGTCTGT GCCCTCCCTGCCGTCGCCCTCTTCCTCGGCATGCTGCGGATGCCGGAATCACCACGCTGG CTGGTCAACCAGGGGCGTTACGACGACGCCCGCCGCGTCATGGAGACCGTCCGTACCCCT GAGCGTGCGAAAGCCGAAATGGATGAAATCATCGCGGTGCACTCTGAAAACAATGCGGCA CTTCCTGGTGTTAAGCAGTCTTCGGGCCAGGCTTCAGGCCAGGTTTCTAGCAAGCACACC CACATGTCCATCGGCGAAGTCCTCAGCAACAAATGGCTGGTTCGTCTGCTCATCGCCGGC ATCGGTGTTGCAGTTGCCCAGCAGCTCACCGGCATCAACGCCATCATGTACTACGGAACC CGCGTCCTCGAGGAATCCGGCATGAGCGCAGAAATGGCTGTGGTTGCCAACATTGCTTTC GGTGCCGTTGCCGTCATCGGTGGACTGATCGCACTGCGCAACATGGAGCGCCTGGATGGC GGCACCACCTTCATCATCGGCCTGTCACTGACCACCACCTTCCACCTTTTGATCGCAGCT GCCGGCACTCTCCTTCCAGAAGGTAACTCCATTCGACCATTCGCCATCATGATCCTTGTT GTTGGGTTCGTGCTCTCCATGCAGACTTTCCTCAACGTTGCAGTGTGGGTGTGGCTGGCG GAAATCTTCCGAGTCCGAATGAAGGGTATCGGCACCGGTATTTCGGTATTCTGCGGTTGG GGCATCAATGGCGTCCTAGCGTTGTTCTTCCCAGCACTGGTCTCCGGCGTGGGTATCACC TTCTCCTTCGTTATGTTCGCAGTGGTCGGAGTCATTGCCCTGGCGTTCGTCAGCAAGTTT GTTCCTGAAACCCGTGGCCGCTCACTTGAAGAACTCGATCACGCAGCATTCAGCGGCCAG ATCTTCAAGAAGGCT >RXN02447-downstream TAAACCCCCTCCGATCTCTTTGG >RXN02455-upstream AAGCCTTCGTTATGGGAGGTCTCCCAGACACAATCGAATACGGGCCGGATATCCATCTCG GCTCATCACCCCGCTTTTTATCAAGAAAGATGAGGACCTC >RXN02455 TTGAAGCGTCTTACTCGCATCGCATCCATCAGCATGGCCTCCATGCTCGCCGCCGCAAGT CTCGTCGCGTGCTCCGGCTCCACCGACGAGGAAGGCGATGTTTACTTCCTGAACTTCAAG CCTGAACAGGACGTGGCATACCAGGAAATCGCAAAGGCCTACACTGAAGAGACCGGCGTT AAGGTCAAGGTCGTTACTGCCGCCTCCGGCTCCTATGAGCAGACCCTCAAGGCCGAGATT GGCAAGGACGAAGCCCCGACTCTCTTCCAGGTCAATGGCCGAGCCGGCTTCATCACTTGG GAGGACTACATGGCAGATATGTCGGACACCGAGGTAGCTAAGCAGCTGACCGACGACATT CCGCCGGTGACCACCGAGGATGGCGAGGTACGTGGCGTTCCGTTCGCCGTCGAGGGCTTC GGCATCATGTACAAGGACGAGATCTTCGACAAGTAGATCGCCACGTCCGGCGGAAAGATC AAGTCCACGGATGAGATGACGAGCTACCAGAAGCTCAAGGAAGTCGCCGAGGATATGCAG GCAAAGAAGGACGAGCTGGGTATCGAAGGCGCCTTCGCCTCCACCTCGCTGACATCGAGT GAGGACTGGCGTTGGCAGACCCACCTGGCCAACGCTCCGATCTGGCAGGAGTACCAGGAC AAGGGAGTCGAGGACACCAACGAGATCGAGTTCTCCTACAAGAAGGAGTACAAGAACCTT TTCGATCTCTACCTTGAGAACTCCACCGTAGAAAAGTCTCTTGCGCCGTCTAAGACGGTG TGTGATTCCATGGCTGAGTTCGCACAGGGCAAGGCCGCTATGGTTGAGAACGGTAACTGG GGATGGTCCCAGATTTCCGAGACTTCTGGCAACGTGGTGAAGGAAGACAAGATCAAGTTC CTGCCCATGTACATGGGTCTGCCAGATGAAGAAAAGCACGGCATCAACGTCGGTACCGAG AACTATTTGGGCGTGAAGTCTGAGGCCTCCGAGGTCGACCAGCAGGGCACCAAGGACTTC GTGGATTGGCTGTTTACCTCTGAAGCTGGCAAGGAGGACGTGGTGAAGGACCTTGGCTTC ATCGCACCGTTCGAAAGCTACACCGCTGAGAACACCCCGAATGACGCCCTTTCTGAGCAA GTCGCGGAAGCTATCGCTAACAAGGATCTGACCACCTACCGGTGGAACTTCCAGTACTTC CCGTCCCAGCAGTTCAAGGATGACTTCGGCCAGGATCTGTCGCAGTACGCCTCCGGAAAG CTGAAGTGG >RXN02515-upstream GTGGCTAAGCACAGTTACTTGGCCAAGCTGGGCGGCAGAAAAACCGGCCCAGCTAATACT TCAGTTTAAAATTCGCTTCAACCCTGAAAGATTGTGACAG >RXN02515 ATGAGCACTCTTGAAATCCGTAACCTGCACGCACAGGTCCTGCCGTCCGATGAGTCCGCT GAGCCTAAGGAAATCCTCAAGGGCGTCAACCTCACCATGAACTCTGGTGAGATCCAGGCC ATCATGGGCCCTAACGGTTCCGGCAAGTCCACTCTTGCTTACACCCTTGGTGGACAGCCA CGCTACGAGGTAACCGCAGGCGAGGTCCTCCTCGACGGCGAGAACATCCTGGAGATGGAA GTTGATGAGCGTGCACGCGCTGGTCTCTTCCTGGCCATGCAGTATGCAACTGAAATGCCT GGCGTTTCCGTTGCTAACTTCCTGCGTTCCGCAGCGACCGCAATCCGCGGCGAGGCTCCT AAGCTTCGCGAGTGGGTTAAGGAAGTGCGCACCGCTCAGGAAGCTCTGGCAATTGACCCT GAGTTCTCCAACCGCTCAGTCAACGAAGGTTTCTCCGGTGGCGAGAAGAAGCGCCACGAG GTTCTGCAGCTTGATCTGCTGAAGCCAAAGTTCGCGATCATGGATGAGACCGACTCCGGC CTTGACGTGGATGCACTGCGCATTGTTTCCGAGGGCATCAACTCCTACAAGCAGGAGACC GAAGGTGGCATCTTGATGATCACCCACTACAAGCGCATCCTCAACTACGTTAAGCCTGAC TTCATTCACGTTTTCGCGAATGGCCAGATTGTGACCACCGGTGGCGCTGAGCTTGCTGAC AAGCTCGAGGCTGACGGCTACGACCAGTTCATCAAG >RXN02515-downstream TAACATGTCCGATTTCCTCAATG >RXN02549-upstream GCAGTCGCAGTAGTTGGGGTTTCAATGATCTCAGGGCAGGACACTGTTCCCACTGGTAAC GCCGTAACTGCAGACGATGCCCTGCTCGGTGGCCCTGAGT >RXN02549 ATGGTTCACGCGAAGCAGACTAAGAAGCCACTTCCCCGTTTTCTTCACTCGGCGCATTTC TATGTGTGGATTGTGCTGGGTTTTGTGGTGTTTGCGCAACCTTATGGTCAGGTTGCTGCC GATACTAAACTAGATTTGCTGCTCAACCGCGGAGGATTTTTAACCGGTGCGCTTCATGCG TGGACTGACACGTTCAGCTTGGGTCAGTTGGAAAACCAAGCTTATGGCTATCTGTTTCCC GAAGGGTTTTTCTTCCTCATAACTGATTTCCTCCCTGACTGGATTGCGCAGCGACTGTGG TGGTGGCTTGTTCTTGGCCTGGGATTTTCTGGATTCTACGCACTGGTAGCCCGGCTGGGG ATTGGCAATCCTGCATTCAGGGTGATCGCCGCGCTGCTGTTTGCTCTGTCCCCGCGCACG CTCACCACCCTCACTGCAATCTCCTCCGAAACTTGGCCTATCATGCTCGCGCCATGGGTA TGTCTGCCTCTGCTTTCGCGAAATGTGGATGCACGGGCCATCGCGTTGTCCTTACTTCCC GCGGCATGCATGGGTGCAGTTAATGCCACCGCCAGGATGGCAGCACTCATCCCGGCAGCG CTGATCTTGCTGTATAGAGGGCTCTTCTTAAGGCTGCTTCTGTGGGGAATGGGCGTTCTC GCTGTTAATTCATGGTGGATCGGACCTTTGTTGGTGCTTGGCAAATACGCCCCGCCCTTC ACCGAATTCATCGAAAGTTCCTCCGTCACCACTTCCTGGCTCAACCCAGTAGAAATACTC CGCGGAACCACCAGTTGGACACGCTTCGTAGACACTGAACGACAAGCCGGATATCTCCTG GTCAACGATGCTCTCTTTGTCACCCTCAGCGTTCTCGTCGCAGCCCTCGGCTTGATCGGC CTCACCTTGATGAAACACCGTGGACTGTGGGCATTCATGCTGGCCATCGGACTCCTCATC CTCGGCAGCGCCCACCTAACGGCTGTTCAAGAATTCCTCGACGGCCCAGGCGCAGCACTT CGAAACATGCACAAATTTGATCTATTAGTCCGCATGCGGTTGATGGTGGGCGTTGCCGCA TTGGGGTGGCATATCAGTCTGCCCTTGCTTGGGACGACTGCATTGACCAGCGGACAAGGC AAACACCACACCATCCCGCTGCCTCTCCAAAAAGGCCAAGCCGCAGGACTCCTCGTGGTG ATCATCGCTGTCGGTGCTCTTGCTCCGGCATGGTCGGCACGGCTGCTACCTCAGGGAACG TGGGATGAAGTGCCTGACTACTGGTACGAAGGCACAGAATTCGTCAACCAAAACGCGACA GGCACCCGGACGTTGATTTGGCCTAGGTGGGCGTTTGCCCGCCAGGACTGGGGATGGAGT CGGGATGAAGCAGCTCAACCACTTCTTGATGTTCCGTGGGCTGTGCGCGATGCCATTCCT TTGGTTCGGCCGGAGGCGATTCGCGGATTAGATGGTCTCGACGACCTAGGCACTGTAGGC AGCGGTCTAAACGACGAGGCTTTAAAACGTCTAGGCATCGGCGCAGTACTGGTGAGGCAT GATCTGGAAGCCGAGCCAGATATTGAGGTGGATCTGCCTGGGGAAAAGCACACTTTTGGC TGCCAAGGCCAAGTAGACGTCTACCTCACCGACCCCGACCGCAATATGTGGATCACTTGC GGCAGATCCAAGCAGCTGCCCACCGTCGCTGGCGGCGGCGAAATGCTCTCGCTGCTAGAC ACCATCAACGGCTATTCCCCGAGGACTTTGGTGAGTGAGAATGCGCAGATCGTCACCGAT ACCCCTCAGCTAGTCGGCACAAATTAGGGCGATGGCACCAGTTCCGCAGCATTGGCCAGC CTTGATGAGACTGAGGTGAAAAACCGGATCGTGGATTATCCTTCCGCGGGGCCAATGACG CAGGTGGTGCAGGAAGGTTCCATCACGGCGTCTTGGTCTGGTTCCGATGCGACTTCTTTC GGGGGCGCGGATCCTGATCGTTCCCTTAATTCACTTCTTGATCATCGTTACAACACGGCC TGGTACCCGACACGTGGCGATACGTCTCCGTGGCTCGAAGTCTCCGGTACCGGCACCACA TTATGGATCTCCCCCCGCAGCACCGTCACCGCCACCATCACCTCCGGCGATTCCGTGATG GTCCGCGAGTTGGAAAAAGGCCGCACCAGCACAGTTACGTTGGCGGAGCCTGAAGCTCGC ATTGAATTCGATGGTTTCGTAGGAATTTCCGAGCTGTCCCTAGAGGGTCTCAGCCGCACC ATCACTGTGCCGGAGACCTCTCCTGAGGTGCAGCAATTCGTTTTCCAACGCCTCACAGTG CCCACCTCGTTCCTCGACCGCACTTTCACAGTCCCCCGCCACATGTCCGTCACCGTGGAG GCCCAATCCTGCGTCACATTGGAACTCGACGGCGATCGCATCGACTGTGGCCCCTCGAAC TCACCCCCGGAACCCACACCCTGCGCACCCAATCGGAATGGGTCACCCTCACCGAATCCG CTCCGCTCGCCGCTGTTCAGCCAGCAACAAACATCGAGGCAGCACCCACCGACCGCGTGC TCGTCACCACGCGCGCTTTCAATTCAGGTACCAGCGCGCTTATCGACGCCACCCCCCTTT CGCCAATCCAACTCGACGCCTCCTCCCAAGGTTTCATCATCCCCGCGAACGCCTCCGGCG AGT >RXN02549-downstream TGAGCTTCGCTTTCGACGGCGAA >RXN02570-upstream CCATTGTTATGCTCATTGTGTTTGTGGTGGTCAAGTCGCTACCCAAGCGCACCACTAGGG CATTGGTTCCGCAGCGGGTTCCGGAGGACGTCGCTTAAAC >RXN02570 ATGAATCCTTTGACATGGATCATTGGCGCATTCAGCATGTGGATCGTGGTGCTGGGCGTT AATAAGCTTGGTTTAAGCATCGCAGTGATCATCATCGCGCAGGTCGTGGCCATGATTCGG GTGCGCAATGTATCTGTGTTGGCTTCAACAGCATTGTTATCGGTTCCTGCATTGGCCTCG ATGGCGCTGATTCACATGCCGTATTCTTCCGACGGCTGGTTGATTGCTCTTACCTTGACG GCTCGTTTTAGTGCGTTGATGTCTATTTTCCTCCTTGCAGCAACAGCGATTACTATTCCT GAGCTGGTGAAATCCCTATATCGTTGGCCCAAGCTGGCGTATATCGTGGGTTCTGCATTG CAGATGATTCCGCAGGGTAAACAGACCTTGGCGTTGGTTCGTGATGCCAATGCTTTGCGC GGGCGCAGCGTTAAACGTCCCGTGCGCGCGGTGAAATATGTGGGTTTGCCCCTGATTACA CATTTACTTAGTGCAGGTGCCGCGCGAGCGATTCCCTTGGAGGTCGCAGGCCTGGACAGG CCGGGGCCGCGTACGGTGTTGGTTGAGGTGGTGGAGGGGCGCGTCGAAAAGCATTGTCGC TGGTTGTTGCCGCTTTTGGCAGTCGGGATGGCGTGGTGGCTC >RXN02570-downstream TAACTCAAATCGTCGGACCGTCC >RXN02595-upstream GTGGGTAAAGGGGACTCCGAGGAAGTCCACGTCGTCTTCTTTCGCGGCGCTGAGGATGGT TTCGCGGATTTGTGCGGGGGAGTGGGTGGCAGAGAAAACG >RXN02595 GTGATCGTTGTGGCCATGGCTTCCATTATGGCTTGTTTAAAAGCAGCTAGACTGAATAAC CCTATGAAGATCCTTTTGTTGTGCTCGCGTGATACCACTCATCCTCAAGGTGGCGGAAGT GAACGCTATCTCGAGCGGGTGGGTGAGTTTTTGGCGGATCAGGGCCATGAGGTGGTGTTT CGTACTGCTGGGCACACGGATGCGCCACGGCGTTCTTTCCGCGATGGTGTGAGGTATTCC AGGAGCGGTGGGAAGTTTAGTGTGTATCCCAAGGCGTGGGTGGCCATGATGTTGGGTCGT GTGGGGATTGGCACGTTTTCCAAGGTTGATGTGGTGGTGGATACGCAGAATGGCATTCCG TTTTTTGGAAAGTTTTTCTCCGGTAAGCCGACTGTGTTGCTCACGCATCATTGCCATAAG GAGCAGTGGCCGGTGGTGGGTCGGGTGCTGGCGAAGGTTGGTTGGCTGATTGAGAGCCAG ATCGCGCCGCGCGCTTACAAAACTGCGCCGTATGTGACTGTTTCAGAGCCGAGCGCTGAG GAGCTCATTGCGTTGGGTGTGGATCAGCAGCGGATTCATATCGTGCGCAATGGCGTGGAT CCCGTGCCGCTGCACACGCCGAAGCTGGATCGCGATGGCCAGCATGCGGTGACGTTGTCG CGCCTGGTTCCGCACAAGCAGATTGAGCATGCGATGGATGTCGTCGCGGCGCTCGACGGC GTGGTGCTGGATGTAGTCGAAAGCGGTTGGTGGCAGAAGGAACTGGTCGATTATGCCCGC ACGCTGGGTGTGAGCGATCGCGTGGTTTTCCACCGCCAGGTCGCCGAGGATCACAAGCAC GCCCTGTTGGAGCGCGCCACGATTCATCTCATGCCTTCGCGCAAGGAAGGCTGGGGCCTG GCGGTCACGGAGGCGGCGCAGCACGGCGTTCCGACGATCGGTTACCGAAGCTCAGGCGGC CTGCGCCATTCCGTCGTCGACGGCGAAACCGGCCTGCTTGTCGACTCCAAGGCCGAGCTT ATTTCAGCCACCAAAACCCTGCTTATCGACGCCTCCCTCCGCTCCAAGCTCGGCGCCAGC GCGAAGCAGCGCGCCGAAAACTACAAGTGGGACACCGCGGGAGCGCAGTTCGAGGAACTA CTTCTTGGTCTTGCGTCGAAAAAG >RXN02595-downstream TAGTCCCAGCGGCAACGCCATCC >RXN02614-upstream TCATTGTATACGCCACCCTCGGTCTGCTGTCTGAAGCGCTGATCAGAGCTTGGGAACGTC ACACCTTCCGCTACCGAAACGCATAAGAAAGTTGCTCGCC >RXN02614 ATGACTGCCACATTGTCACTCAAACCCGCAGCCACTGTCCGTGGATTGCGCAAATCATAC GGAACTAAAGAAGTCCTCCAAGGAATCGACCTCACCATCAACTGCGGCGAAGTAACCGCG CTGATCGGACGGTCAGGTTCAGGAAAATCCACCATCCTGCGCGTGTTGGCGGGCCTATCT AAAGAGCATTCCGGCTCTGTAGAAATTTCCGGAAACCCGGCCGTTGCCTTCCAAGAGCCT CGCCTGTTGCCGTGGAAAACGGTGCTCGATAATGTGACCTTTGGCCTCAACCGCACTGAT ATTTCGTGGTCAGAAGCACAAGAACGCGCCTCGGCACTGCTTGCAGAAGTCAAACTTCCC GACTCCGACGCCGCCTGGCCCCTCACGCTCTCCGGCGGCCAAGCCCAGCGCGTCTCCCTT GCGCGAGGGCTCATCTCCGAGCCAGAGCTTTTGCTTCTCGACGAACCCTTCGGCGCCCTC GATGCTCTGACAAGACTGACAGCCCAAGACCTGCTGCTCAAAACCGTGAACACCCGAAAC TTGGGAGTTCTGCTGGTCACCCATGATGTTTCCGAGGCCATCGCCCTGGCCGACCACGTC CTTCTTCTTGACGACGGCGCCATCACACACAGTTTGACTGTAGATATCCCCGGCGATCGC CGCACCCACCCCTCCTTTGCCTCCTACACCGCTCAACTCCTTGAGTGGCTCGAAATCACC ACACCTGCG >RXN02614-downstream TAGAAAGAAATCATGAAATTTAA >RXN02795-upstream GCGGTGTGGCCCGGTGCTGCGATCGCTTTGACGGTCCTTGGTTTTAATCTTTTCGGTGAT GGTTTACGCGATGCCATCGATCCAAAGCGGGAGGTCGGCC >RXN02795 GTGCTTAAAGTTTCTGATTTAACGGTTGGCAACAATTTTGTCCACAACGTCTCCTTGGAG GTCAACCCGGGCGAACGCGTCGGCATCATCGGCGAGTCCGGCTCAGGCAAATCACTCACC GCGCTATCCATCATGGGTTTAACTGACCTGCCGACCACCGGCCAGATCACCTTCAACGGC AAACCCTCCGCTACATTCCGTGGCACCCGCATCGCCATGGTTTTCCAAGAACCAATGAGC GCACTCAACCCGCTCATGCGCATCGGCCGCCAAATCGAAGAAATGATGACCCTGCACGGG GCAAGCAAAAAAGACGCGCGGGCGCGCTTAAAAAGCTTGCTTATCGACGTCTCCCTCCCC GAACGCACCGCTTCGGCCTACCCACACGAACTTTCAGGCGGGCAACGCCAACGCGCACTA ATCGCAATGGCGCTGGCCAATGATCCTGACCTGTTGATCTGCGATGAACCCACCACGGCT TTGGATGTGGTTGTGCAAAAACAAATCGTCGATCTGCTGCTGCGTCTCACCAAAGAACGT GGCACCGCTTTATTGTTCATCACCCACGATCTTGGACTCATCGCGCGCACCTGCGAACGC TTATTGGTGATGAAATCCGGCGAAACCGTAGAACGCGGCGACACCGAGGCAATTCTTCGC TCCCCCGCCCATTCGTATACCCAACAGCTCCTTGATGCTTCAATCCTTGACCAGCCAGAA ATCGCCTCAGATTCTGGCGCGCCGGTAGTGATTGATGTGGAGGAGGCGTCGAAAAGCTTT AAAGAAACCACCGCCCTCCACAAGGTTTCATTGGCGGTGCGCAAAGGTGACCTGCTTGGA ATAGTCGGCGGATCAGGTTCCGGCAAAACGACTCTGCTGAAGCTGATCGCCGGTTTGGAT AAGCCCACAAGCGGTACCGTTGCGGTAACCGGTGGTGTGCAGATGGTGTTTCAGGATCCC CAATCAAGCCTCAACCCACGGATGAAAATCAAAGACATTGTCGCCGAACCACTGCTTGGT TGGAAGGCGGCGGAGAAAACCACACGGGTTGCGGAAGTCATCACCCAAGTGGGACTGAGC CCCGATGTCTTAGATCGCTACCCCCACGAATTCTCCGGAGGACAGCGCCAACGAATCTCC ATCGCCAGAGCCCTCGCCATCAAACCAGCGATCCTGCTTGCCGACGAACCTGTCTCCGCC CTCGATGTGTCCGTACGTAAACAAGTACTGGATGTTCTCCAACAACTCGTCGAAGAATAC GGCATCACCTTGGTGTTCGTCTCCCACGATCTGGCAGTGGTGAGACACCTGTGCACAACC GTGTGGGTGATGGAACAGGGACGAGTCCTTGAGCAAGGGCCCATCGATTCGGTTTATGAT CACCCACAGACCGAATACACCAAGGAGGTGGTTGATGCCGTTCCGCGGTTGAGGCTT >RXN02795-downstream TAAACCAGCGCAGATGACAACGC >RXN02925-upstream AAACCGTCCACCGGGCAATTGAGGAGACCGGCTACACCGTCTTGTCCTGATCGATTCACC CATCATCTCGACCCCGACCGGGTTGAGCGGAAGGAACCTC >RXN02925 ATGAGCACTCCCCAGCACCACGGTGATCACCCCGCTCCGGAAACAGACCACACCCACCAC CCGAATCATGCCGGTCAGGAGCACCATGCGGATGCCGCCACCCACGGCCAGGCCATGCCG CACGATCATCCGCATTCCACTGTCGATGAAGAACATCAGGTCCACAGTCACGGTGAACAC GCCGGCCACAGCGCCGCGATGTTCCGGGACCGCTTCTGGTGGTCGCTGATCCTGTCGGTT CCGGTGGTGTTCTTCAGCCCGATGTTCGCCGACCTGCTGGGATATAATATTCCGGAGATT CCGGGAGCCTACTGGATTCCTCCGGTCCTGGGCACGATCATCTTCCTCTACGGCGGCACC CCCTTCGTCAAGGGCGCAATGACCGAGCTGAAATCCCGCCAACCGGGCATGATGCTGCTG ATCGCCATGGCGATCACCGTGGCGTTTATCGCCTCCTGGGTCACCACCCTGGGGCTGGGC GGGTTCCACCTAGATTTCTGGTGGGAACTGGCCCTGCTGGTGACCATCATGCTGTTGGGC CACTGGCTGGAGATGCGCGCTCTTGGTGCAGCCTCCTCCGCGCTTGACGCGCTGGCAGCG CTCCTGCCCGATGAGGCCGAGAAGGTCGTCGACGGGACCACCCGCACCGTAGCGATCTCA GAGCTGGCCGTCGACGATGTCGTGCTGGTCCGAGCAGGTGCCCGGGTCCCGGCCGACGGG ACCATCATCGACGGAGCGGCCGAATTCGATGAGGCCATGATCACCGGCGAATCCCGACCC GTCTACCGGGATACCGGTGAGACCGTGGTGGCCGGCACCGTGGCCACCGACAACACCGTC CGTATCCGGGTGGAGGCCACCGGTGGGGACACCGCCCTGGCAGGCATCCAGCGCATGGTC GCCGACGCCCAGGCCTCCTCCTCCCGGGCCCAGGCCCTGGCCGATCGAGCCGCAGCCTTA CTGTTCTGGTTCGCCCTGATCACGGCCCTGATCACCGCCGTGGTCTGGACCATCATCGGC AGCCCCGACGATGCCGTGGTCCGCGCGGTGACCGTGCTGATCATGGCCTGCCCGCACGCC CTGGGCCTGGCCATCCCGCTGGTCATCGCGATCTCCTCCGAGCGCGCGGCGAAATCCGGG GTGCTCATCAAGGACCGCATGGCACTCGAGCACATGCGCACCATGGACGTCGTCTTGTTG GATAAGACCGGCACCCTGACCGAAGGCGCACACGCCGTCACCGGCGTGGCTCCGGCCACG GGTATGGCCGAGGGTGAGCTGCTGGCCCTGGCCGCCGCCGCTGAGGCCGATAGTGAGCAC CCCGTGGGCCGCGCGATCGTGACTGCCGCGGCCGCACACCCGGAGGCCTCGCAGCGTCAG CTGCGCGCAACCGGTTTCACCGCCGCGTCCGGCCGCGGGATGCGGGCCACCGTCGAGGGT GCCGAAATCCTCGTGGGCGGGCCGAACATGCTACGCGAGTTCAATCTGACCACCCCGGGT GAGCTCGCCGACATCACCGGTTCCTGGGCACAGCGAGGTGCCGGAGTGCTACATGTCGTC CGCGACGGTGAGATCATGGGTGCGGTGGCAGTGGAGGACAAAATCCGCGGCGAATCCCGC GCGGCGGTACGGGCCCTGCAGGCCCGCGGGGTGAAGGTGGCGATGATCACCGGTGACGCC ACCCAGGTCGCCCAGGCAGTGGGCAAGGATCTGGGGATCGATGAGGTCTTCGCGGAGGTT CTGCCGCAGGACAAGGACACCAAGGTCACCCAGCTGCAGGAGCGCGGTCTGAGCGTGGCC ATGGTCGGCGACGGTGTCAATGACGCCCCGGCCCTGGCCCGGGCCGAGGTCGGTATTGCG ATTGGCGCGGGTACAGATGTGGCGATGGAGTCCGCCGGGGTGGTCCTGGCCAGTGATGAT CCCCGGGCCGTGCTGTCGATGATCGAGCTCTCCCATGCCAGCTACCGCAAGATGGTCCAG AACCTGGTCTGGGCGACCGGGTACAACATCGTGGCCGTTCCGCTGGCCGCCGGTGTGCTC GCCCCTATCGGTGTGCTGCTTCCCCCGGCGGCGGCCGCCATCTTGATGTCCCTGTCCACG ATCATCGTCGCCCTCAACGCCCAGCTGCTACGCCGGATCGACCTGGACCCGGCTCACCTA GCTCCGACCGACGGGAAGGAGGAGAAGGCTGCTGTGAGCTCTGCAGCCCCCGTCCGC >RXN02925-downstream TGACTTTCAATGCTTCATGGACT >RXN02933-upstream TGATCTGCTGTATGAGGTGGTTGATGCAAGAGTCGGTGCTGTTGGGGTTGCTAGCACTAA GGTTCCAGGGAGCGTGGCTTAAGTGACAACGATCAAAAAC >RXN02933 ATGCCCCTTTCAGGGAAAATCGGCGGCTTCATCGTTGCCGTTGTATTTGTTCTTGCTGCG GTGTCTTTCATTTGGACTCCGTTTGATCCAGTTCAAGCTTTCCCACAGGAGCGCCTTGAG GGAAGTTCTTTGAGGCACCTGTTGGGAACGGATGGTTATGGTCGCGATGTTTTATCCCAG ATCATGGTTGGTTCCCGCGTCACGTTGTTGGTGGGCATCATTGCGGTGGCGATGGCAGCA TTAATCGGCACGCCACTGGGTATTGCTGCGGGAATGCGCCGTGGCATGGTGGAAACCTTT GTCATGCGTGGTGGCGATTTAATGTTGGCGTTCCCAGCACTGTTGTTGGCGATTATTTCC GGCGCCGTTTTCGGGGCCTCCAGGTGGTCCGCGATGGTCGCGATCGGCATCGCAGGCATC CCTAGTTTTGCGCGCGTGGCTCGTGCAGGCACATTGCAGGTGACCAGTCAGGATTTCATC GCAGCTGCTCGGCTATGAAAAGTAAGTTCGGCCCGGATCGCGCTTCGCCATATTTTGCCC AACATCACCAGCATGTTGATCGTTCAGGCATCAGTAGCTTTTGCCCTGGCGATCCTGGCG GAAGCCGCATTGAGTTTCCTGGGTTTGGGCACCACTCCCCCGGATCCCAGCTGGGGTCGC ATGTTGCAAACCGCTCAAGCATCCATCGGCGTCACCCCCATGTTGGCGGTGTGGCCCGGT GCTGCGATCGCTTTGACGGTCCTTGGTTTTAATCTTTTCGGTGATGGTTTACGCGATGCC ATCGATCCAAAGCGGGAGGTCGGCCGTGCT >RXN02933-downstream TAAAGTTTCTGATTTAACGGTTG >RXN02945-upstream TTCCGGTGCGATCCTTGCCGGCCTGCTCAGCTGGTACCTGGTCCGCGCGTTGGCGAGGAC TGGTGGACTTGATCGTTTCGCCGCTGGCGGCGAGGTATAA >RXN02945 ATGACCACCGCACTTGGAACGCGCGTTGTTGCGCGCAACTTTGGCTACCGCCATGCTTCC CGGGAAAACCCCGCGCTCAAAGACATCAACTTCGAGATCGCACCTGGTGAACGCATCCTG CTCACCGGCGCTTCCGGCGCCGGAAAATCCACGCTACTCGCCGCGCTCGCTGGCGTTTTA GGCGCTTCTGATGAGGGCGTTTCTACGGGCGAATTGCTTGTCGACGCCCCCTCCATCGGT TTGCTTCTCCAAGATCCACATTCCCAAGTCATCGCCTCCCGCATCGGCGATGATGTGGCG TTTGGCTGCGAAAACCTCCAAATTCCGCGCGAGGAAATCTGGCCACGGGTGGAACGAGCA CTTGAATTGGTGGGCTTGCATCTACCACTGAGCCACCCCACGAAATATCTTTCCGGTGGC CAAAAACAACGCCTCGCTCTTGCCGGTGTGATCGCCATGGGTGCTCGTCTGATTCTGCTT GATGAACCCACCGCAAACCTTGATCCTCAAGGCCAAAAAAATGTGGTCGCAGCACTGGAT CGCGTTGTTCAGGAAACTGGAGCAACACTCATCGTGGTGGAACACCGCCATGAGCTGTGG GTCAACATCATTGACCGGATCATCAGTATTACTGACGGCGAAGATGTCCAACCTGCAGAG TTGATCAAGGTGGGCCAGTTGCCTGGGGCGCAGCCGTCGACAAGCAAACCGATCTTGTGG GCGAATGATTTGCTGTGCACCTGGGGCGGCCTGCGTAGTTTTGAGGTGCCGGAAGGCGCC TCGACGGTGATCACCGGGCCGAATGGCGCTGGAAAATCCACACTTGCGCTGACCATGGGT GGATTGCTTCCGCGAAAAGTGGGCAGCTGGAACTCTCTGACACGGTGCGCGGCGGCCTTA ACACGCCCCCGCACAAGTGGCGTTCAGCTGATC >RXN02945-downstream TAGCTGCACGTATTGGCACTGTC >RXN02975-upstream TCGTCGGTGCAGTCCTCGGATTGCTTAAGTTGTAGGTGGCTGGGGGCGTCGAAAAGCAGC TTTATTGACCTGGCAACTTCAATTGATAGACTGTTAGGTT >RXN02975 GTGATTGTCACCAATGATTTAGAGGTGCGCGTTGGCGCACGTACCCTTCTCGATGCCCCA GGTCAGCTCCTTCGGGTGCAGCCAGGCGACCGTATTGGTCTGGTTGGTAGAAATGGTGCG GGCAAAACCACCACCATGCGAATCCTCTCGGGCGAAACCAAGCCCTACGGAGCATCCGTA ACCACATCTCGTGAAATCGGTTACCTGCCCCAGGACTCCCGCGAAGGCAACATCGAACAA ACCGCCCGC >RXN02994 ATCAAGATGACGGGAGTGCAAAAATACTTCGGCGACTTTCATGCCCTTACGGATATTGAT CTTGAAATTCCCAGAGGACAAGTTGTCGTCGTACTTGGACCATCCGGATCCGGCAAGTCA ACCCTTTGCCGCACGATCAACCGTCTCGAAACCATCGAGGAAGGCACCATCGAAATCGAT GGAAAGGTTCTCCCAGAAGAAGGTAAAGGCTTAGCCAATCTCCGCGCCGATGTCGGAATG GTATTCCAGTCCTTCAACCTCTTCCCCCACCTCACCATCAAAGACAACGTCACTCTTGCA CCCATCAAAGTGCGAAAGATGAAAAAGTCTGAAGCCGAAAAGCTTGCGATGAGCCTGTTG GAACGCGTCGGCATCGCAAACCAAGCTGATAAATATCCGGCGCAACTGTCCGGCGGTCAG CAACAGCGTGTGGCCATCGCGCGCGCACTTGCGATGAACCCAAAGATCATGCTTTTCGAC GAGCCCACCTCCGCCCTTGACCCTGAAATGGTCAACGAAGTGTTGGACGTCATGGCAAGC CTTGCCAAGGAAGGCATGACGATGGTGTGTGTTACCCACGAGATGGGATTCGCACGCAAA GCAGCCGATCGTGTGTTGTTCATGGCGGATGGGCTCATTGTGGAAGATACGGAACCAGAT TCCTTCTTCACCAACCCTAAGTCTGATCGTGCAAAAGACTTCCTCGGCAAGATCCTTGCC GAG >RXN02994-downstream TAGTTTTTGGCTGCGCCTCTATC >RXN03020-upstream CGCCGCAGCAGGACTCATCGGTGCCGCCATTTCACTCGGCCCCATCCTTCGCGTCGAACC ACGCTCCGCACTCATGAACGCATAAGAAAAGGAACCTCAC >RXN03020 ATGACTCTCCACGTTTCAAATCTCAATCTGACCGTCGCCGACGGATCCACCTCACGCACC GTGCTCAACAACATACACTTTTGGATGTCCAACCAGGCGAAGTCGTCGGTATCACCGGCC CATCCGGGTCCGGAAAATCCACCCTACTCGCCGTCCTCGGCTGCCTCCAAAGCGCCCGAT TCCGGCACCGCGACGCTCGGCGACATCGACCTGGTCAACCCGCAAAACCGAGCTGCTTTA CGACGCAACCACCTAGGAATTGTCTTCCAACAGCCAAACCTGCTCCCCTCGTTGACTGTC CTCGACGAAGTGCTGCTCATTGCCCGGCTCGGCAGGATCCTCCCGGCCAGCCGCAGCGCA CGCACCCAACACAAAGACAAAGCCCTTTCACTTCTGAACTCCATCGGACTCGGCGACTTA GCAAAACGCAAGGTCAGCGAACTATCCGGTGGACAACAAGCCCGCGTTAACTTGGCCCGC GCGCTGATGAACTCCCCCAAGCTCCTGCTTGTCGATGAACCCACCGCCGCCCTCGATCAA CATTCCGCGAGCGAAGTCACCGAACTAATCGTCTCGATGGCCCAGCAATACAACGCCCCC ACA >RXN03080-upstream CTTGCAAACAGGCGTGGTGGTGGCGTTCATTGGCTCACCAATTTTCCTTTATTTACTGCT CAGCATGCGCAAGCGACGCGGATTGGGGCTGTAAAAACTC >RXN03080 ATGCCTCAATTAGTTGAAATTCGTGATCTCAACGTTGAATTCCCCTCTCGCCATGCAGTG AAAAACGTGTCTTTTTCTGCACCTGCTGGAAAAGTCACCGCACTGATTGGCCCAAATGGT GCTGGTAAAAGTACTGCCCTTTCGGCGATTGCAGGATTGGTTGAATCCACCGGCGAGGTA ATGGTTGGTGGGAGTGGGGTTGCGTCGAAAAGCGCTAAAGCCCGAGGCCGCCTGCTGTCA CTCGTGCCGCAAAACACCGAGTTGCGCATTGGTTTTAGTGGACGCGACGTTGTCGCGATG GGCCGCTACCCGCATCGTGGCCGCTTCGGCGTGGAGACCGACGCAGATCGACGCGGCACC GATGACGCCCTGCGCGCCATCAACGCGCTCGACATCGCCGAGCAGCCCGTCAACGAATTA TCGGGCGGCCAGCAGCAGCTCATCCACATCGGCCGAGCGCTCGCCCAAGACACCGCGGTC GTGCTTCTCGACGAGCCCGTCTCCGCGCTTGATCTACGGCACCAAGTTGAAGTCCTTCAA CTCCTGCGCGCCCGAGCTAATTCGGGCACCACCGTGATCGTCGTCCTTCACGATCTCAAC CACGTTGCCCGTTGGTGCGACCATGCAGTGTTGATGGCCGACGGCGAAGTTGTCTCCCAA GGTGACATCCGCGAGGTGCTCGAACCTGCCACACTGTCCACCGTGTAGGGACTGCCCATT GCGGTGCGCGATGATCCCGAAACCAGCTCACTTCGCGTGATCCCGCATCCAAATCGCTTT >RXN03080-downstream TGATTGAAACTTTGACTTAAAAA >RXN03081-upstream ACGGACTGCCCATTGCGGTGCGCGATCATCCCGAAACCAGCTCACTTCGCGTGATCCCGC ATCCAAATCCCTTTTGATTGAAAGTTTGACTTAAAAACCC >RXN03081 ATGAAAAAATCACTCATCGCCATTGTTGGCAGTGCGCTCGTGTTAAGCGGCTGGACCTCT GATTCTTCTGACTCTTCCGGCACTTCCGGAACTGTGGAAACCACTTCGATTACAACCAGC GTTGCCGCAGCTGACGGCGCATTCCCACGCACCGTCACACTCGACGATTCCTCCATCACC TTAGAATCCAAACCAGAGCGCATCGCCGTACTCACCCCAGAGGCAGCATCCTTGGTTCTC CCCATCACAGGCGCCGACGGCGTCGTGATGACCGCCGAAATGGACACCGCTGACGAAGAA ACCGCAGCTCTGGCCTCCCAAGTGGAATACCAAGTCAAAAACGGTGGCAGGCTCGACGCC GAACAAGTTGTCGCCGGCGACCCAGATTTGGTGATCGTCAGTGCGCGTTTCGATACCGAA CAAGGCACCATCGACATTTTGGAAGGCCTCAACGTCCCG >RXN03081-downstream TAGTTAACTTCGATTCAGACGCT >RXN03108-upstream CAACCAGCCTGCCACGTTGCTGGATGGACCGTCGTAATCATCGGCATCACCGGCTTAATC CTTGACCACCTCATCGGTGAGTTGCAGAAAGTAGTTCGCT >RXN03108 ATGACTAAACCAAACGCTTCCGTCGAGCTGAATACGATCACCAAGTCCTACGGCTCCACC ACTATCATTGGCGATACGAGCATCACCATCAACGACGGTGAATTCGTCTCCCTCCTCGAC CCTTCCGGCTGCGGAAAATCAACAATTCTCAAAATGATCGCCGGACTGGCCTCCCCATCC ACCGGCACAGTCAGCGCAGGCAACGAAGAAATTAAAGGACCAGGACCTGACCGAGGCATG GTTTTCCAAGACCACGCCCTCCTGCCC >RXN03108-downstream TGATTGACCGCACGCGGCAACAT >RXN03116-upstream AGGGGAATGGCTTAATATCGTAGGTCCCAACGGCTGCGGAAAGAGTACGTTGCTGCACGC TTTTGCTCAGGTACTGTCACTGGAATCGGGAAGGCTGAAA >RXN03116 ATGGGGGAGGGGGACGTCGAAAAGGATTTTGCTTTTGGTCTTAAAGCTGCGAAGCAGCGT CGCTTTTTCGCGCGTACCGTGGCGCTCATGCCACAGAATCCTACTATTCCTGCAGGTCTG AGCGTTTTTGATTATGTGCTGCTGGGGCGTCATCCGCACAGTTACGCGCCGGGGCGTGCT GATGATGAGATCGTGAAGCGGTGCCTCGCTGATCTGAAATTGGAGCATTTCAGCGACCGC GGCTTAGACGAATTGTCCGGCGGCGAGCGTCAACGCGTCAGCCTTGCCCGCGCGCTCGCC CAAGAACCGCGCATCGTGCTTCTCGACGAGCCGACCTCCGCGCTTGACATCGGCCATGCG CAGGAAACGCTTGAGCTTATCGACGCCATCCGGCACCGACTCGGCCTCACCGTGATCGCG GCGATGCATGACCTCACCCTGACTGCGCAATACGGCGATCGGGTGCTCATGATGAATGGT GGCCGCAAAGTTTTCGAGGGCACTGCAGCCGAAGTGCTCACCGCGGAGCGGATTTCGGAG ATTTATGATGCCACTGTGATTGTTGAGGTTATTGATGGGCGTCCCGTGGTGATTCCGCAA CGGTCGCAC >RXN03116-downstream TGACCTGTTGTGGCAGACGAGAC >RXN03129-upstream GCTGAGGTTGAGACCAAGCTGAACACCATCTACACCCGCGACATCGAACCACTTATTTAA TCCGAGCACTTCAGCTACACCTATTTAAGGAGGCTGTGAC >RXN03129 ATGGCGTCAATCGTCTTTGAAAACGTCACACGCAAATACTCTCCGGGCGCACGCCCGGCC GTCGACAAGCTTAATTTGGAAATCGCCGACGGCGAGTTCCTAGTTCTCGTTGGACCCTCA GGCTGTGGAAAGTCCACTTCTTTGCGCATGCTGGCTGGTCTTGAGCCTATCGACGAGGGA CGTCTACTCATTGATGGTAAAGACGCCACGGAACTGCGTCCGCAGGATCGTGACATCGCT ATGGTCTTCCAGAGCTACGCGCTGTACCCGAATATGACTGTTCGGGACAACATGGGCTTT GCGCTGAAGAATCAGAAGGTGGCTAAGGCTGAGATCGAAAAGCGTGTTGCTGAAGCCTCA CGCATTCTGCAGCTGGATCCGTATCTTGATCGTAAGCCTGCAGCTTTGTCTGGTGGTCAG CGCCAGCGCGTGGCCATGGGCCGTGCAATTGTGCGTGAGCCATCGGTGTTCTGCATGGAT GAGCCACTGTCCAACCTAGATGCGAAGCTGCGTGTGTCTACGCGTGCGGAGATCTCTGGT TTGCAGCGTCGCATGGGCGTGACCACGGTGTATGTGACTCACGATCAGGTCGAGGCCATG ACCATGGGTGATCGCGTCGGTGTGCTTTTGCTCGGTGTGCTGCAGCAAGTAGACACCCCG CAGAACCTGTACGACTACCCAGCAAATGCGTTCGTCGCCAGCTTGATTGGTTCCCCTTCC ATGAACTTGATTGAGGGCACCATCCGTGGCGATAAGGTCACTTTGGGTACTGGAATTCAG ATTTCAGTTCCTGATGAGGTGGCAGCAGAGGTTCGCAACAACCCGGATCGGTTTGAGGGT CGTCCAGTCATTGTTGGTGCTGGTGCGGAGCACATGTATTTGACCACGGCGAATGAGAGT GGTGCTGTATTGGGCGAAGTCAGGGACATTGATGAGCTCGGCGCGGATTCAATGGTCTAC GTATTGGCGTGTGGTGTGAAGAACGCGAATACTGATCTTTTGGGTGAGGGGATTCCAGAG GATATGCGCGTGACCGTTGTCGGTGCTGAAGAGACCGATAAGGCCCGGCTGGGTATTCGT GTTGAGCGCCATCACGGTCTGAAGGCCGGCGATAAGGTGCACGTTGTTGCTGCACCGAAG GATGTTCACCTCTTCGACGGTCTTGATGGCCGTCGAATGGGTGCATCGGTTGTAGCTCCA GCCCATACAGTCCAGTCTGGTCAC >RXN03129-downstream TAGATTATTTACCAGTGCAACTC >RXN03164-upstream CTTTTTTGCATCCAGATGCACAAAGCCGTGGCAGAAACGAGACAAACTGAGCACAATGGC TGTCATGGCATATCAACCAGCAGACAATCGCTATGACGAC >RXN03164 ATGATCTACCGCAGGGTGGGAAATTCTGGGCTGAAGCTTCCGGCAATTTCGCTTGGGGTG TGGCACAACTTCGGTGATGACAAGCCGCTTTCAACGCAGCGCAGCATTATTCACCGCGCG TTTGATAGGGGAGTCACTCACTTCGATTTGGCTAATAACTATGGACCTCCAGCAGGTTCC GCAGAGACCAACTTTGGCAGGATTTTGCGTGAGGATCTCAAAAGCCACCGCGATGAGTTG ATCATTTCTTCCAAGGGGGGTTGGGATATGTGGGCTGGACCTTATGGTTTTGGTGGTTCG CGAAAGTATCTAGTGAGTTCCGTTGATCAGTCCCTGACTCGCCTCGGCTTGGATTACGTG GATATTTTCTATCATCACCGCCCGGATCCAGATACTCCTTTGGAAGAAACCATGTACGCA TTGCGTGACATTGTTGCGTCTGGAAAGGCTCTTTACGTGGGTATTTCTTCCTACGGTCCA GAGCTCACAGCGGAGGCGGCTGAGTTGATGGCGGAGGAGGGCTGCCCGCTTCTGATTCAT CAGCCAAGCTATTCCATCATTAATCGTTGGGTGGAGGAACCGGGCGATGACGGTGAGAAC TTGTTGCAGTCAGCTGCCAACAATGGTCTTGGCGTCATTGCTTTCTCACCACTTGCGCAG GGCCTGCTCACGGACAAATATCTCGATGGAATTCCAGAGGGTTCCCGCGCCAGCCAGGGT AAGTCCCTGTCTGAGGGCATGTTGAACGTGAACAATATTGATATGGTCCGCAAGCTCAAT GACATCGCCCAGGAACGCGGGCAGTCACTTGCGGAGATGGCGCTTGCATGGGTGCTGCGC GAGCAAAGAGAGTACGGCGCCGGATTACCG >RXN03164-downstream TGACCAGTGCATTGATTGGTGCT RXS00088-coding Region ATCGAAGACAACCACGGGACCGAAGGGATCTCCCTGCCAATCGAGGGCGTCGCTGCGACCGACAACCGC GCATTCGAACTGCTTGATCGCTGGGGTGTAGAGCTCGTTGCAGCTCCACTTCAGCTGGTTCCATTTACC GTTACGGGCTACACCGAAGAGGGCGGGGTCGCTAACCTTGGCTCCCACGGCGAGCCAGACCTGGAAGCA CTTGCTGCTGCACAGCCTTGCCTGATCATCAACGGCCAGCGCTTGGCTCAGTACTACGATGACATCATT GCCCTGAACCCTGACGCAACCGTTGTTGAGCTAGACCCACGCGATGGCGAGCCACTTGACGAGGAGCTT ATCCGGCAGGCTGAAACCCTCGGTGAGATCTTCGGGGAAGAAGAAGATGCTGCAAAGATCGTTGCTGAT TTCGAGTCCGCACTTGAGCGCGCTAAGACCGCATACGCAGCAATCTCCGACCAGACCGTCATGGCAGTT AACGTTTCCGGCGGAAACATTGGCTACATCGCTGCTTCCGTTGGACGCACCTACGGTCCAATCTTCGAC CTGGTTGGACTCACCCCAGCACTCGAGGTTGGCAACGCGTCCTCCGACCAGGAGGGCGACGACATTAAC GTCGAAGCAATCGCAGCTGCAAACCCAGACCTGATCCTGGTCATGGACGGCGATGGTGGCACCAGCACC CGCAACGAAGCTGATTACGTTCCAGCAGAGCAGATGGTCTCCGACAATGAAGCACTGGGAAACGTCAAG GCTGTCACCGACGGATACGTTTACTACGCACCTGCAGATACCTACACCAAGGAAAACATCATCACCTAC ACCGAGATCCTCAACGGCATGGCAGATATGTTCGAGAAGGCAGCTCAG RXS00088-3′-Region TAGGGGATCGATCCCACACTGAC RXS00372-5′-Region GCAGACATTTCCATAAGTCGTGCGAAATGCGCGCATTCATGTAAAGATGTTATTTCCTCCCCCAAACAC TCCTTAAAATTTCAAGAAGGGCCTTATTTTC RXS00372-coding Region ATGTCTTCGAAGCACCCTTTGAAGCGGAGTGCCGTTACTGTTTTTGGACTCGGCGCTTGCGCTGCTCTC CTCGTGGCTTGCTCTGAAGCTTCTGAGGACGTTTCCAGCGCAGAGACCACCACTGCAAGCTCTTCCGCT AACGCATCCGATGCAGCCGGTGAAAAAGTAACGATCACCGTCTACACCTCTGAGCGTGAGGAAAAGGTC GATGAGATCAACAAGGCGTTCATGGAAGCCAACCCAGATATTGAGGTTGAGGTGTAGCGCGCTGGTACT GGCGATCTGAGTGCTCGCATTGAAGCTGAAAAGGCATCCGGTTCTATCGAGGCTGATGTGTTGTGGGCT GCGGATGGTGCAACCTTTGAAACTTATGCAGCACAGGGCGACCTTGCAGAGCTGGAAGATGTTGAGACT TCCGACATGATTGAAGAGGCTCTGGATGCTGAGAACTTTTATGTAGGCACCCGCATCATCCCAACCGTG ATTGCATACAACACTGAAGTTGTTGATCAGGCTGAGCTTCCTACGTCTTGGGCTGATCTGACTGATCCT AAGTATGCAGGCGAACTGGTCATGCCGGATCCAGCTGTGTCTGGTGCTGCAGCCTTCAATGCTTCTGTG TGGAAGAACGACCCTGCGCTTGGCGAAGCCTGGATCACCGCCTTGGGTGAAAACCAACCAATGATCGCT CAGTCCAACGGCCCAACCTCCCAGGAGATCGCTGGCGGTGGCCACCCAGTGGGCATCGTGGTGGACTAC TTGGTGCGCGACTTGGCTGCTGGTGGATCTCCAATCGACACCATCTACGCATCGGAGGGTTCTCCTTAC ATCACTGAGCCTGCAGGTGTGTTCGCTGATTCTGAAAAGAAGGAAGCAGCCGAGCGCTACATCAACTTC CTGCTGTGTGTTGAAGGGCAGGAAATCGCAGTTGAGCAGGCATACCTGCCAGTGCGTGAAGATGTCGGA ACTCCAGAGGGCACCCCCGAGTTGGCTGACATCGAGCTCATGACCCCTGACCTGGAGGTTGTAACCGCT GATAAGGGGGCTGCTGTTGAGTTCTTCGAAAACGCAATGAAC RXS00372-3′-Region TAGTTTTCCTATGCAGTTATCTC RXS00453-5′-Region TAGTGGGGCGTGAAAAAATAGCTGATTTAAGAGGAGAAGCAACCCCGTGGCGAAATTGCTATTCAGGTT GGGGCGATGGTCCTATAATCGCAAGTGGATT RXS00453-coding Region GTGATTTCGGCATGGCTAGTTATTTTGGCCATTGTTGGTGGTCTGGCCCTGACGATGCAGAAGGGGTTG AGTAACTCTTTCACTATTGAAGACACCCCTTCGATTGATGCCAGTGTTTCTCTGGTTGAAAATTTCCCT GATCAGACGAACCCGGTGACGGCCGCGGGAGTTAACGTGGTTTTCCAATCCCCGGAAGGAACCACGCTT GATGATCCTCAGATGATGACTGCGATGGATGCAGTCGTTGATTACATTGAGGACAATTTGCCTGATTTT GGTGGGGGAGAGCGCTTCGGCAATCCTGTTGAGGTGTCTCCTGCGTTGGAAGAGATGGTCATCGAGCAG ATGACCAGCATGGGGCTTCCTGAGGAAACCGCTGCAAAGGATGCTGCCAATCTGGCGGTGTTGAGCGAA GACAAAACCATTGGCTACACCTCTTTCAACATTGATGTTGAGGCCGCAGAATATGTGGAGCAAAAACAC CGCGATGTGATCAACGAAGCGATGCAAATCGGTGAAGATTTAGGTGTCCGGGTGGAAGCCGGTGGACCT GCTTTCGGTGATCCAATTCAGATTGAAACCACCAGTGAGATCATCGGTATTGGCATCGCGTTCATCGTG TTGATTTTCACCTTTGGTTCTTTGATTGCTGCAGGCTTGCCTTTGATTACCGCGGTGATCGGCGTGGGC ATTGGTGCGCTGGCAATTGTGCTGGCCACGGCGTTTACTGATCTCAACAATGTGACTCCAGTGCTCGCA GTGATGATTGGCCTGGCCGTGGGCATTGACTACGCGCTGTTTATTTTGTCTAGGTACCGTGCGGAGTAT AAGCGCATGCCACGTGCCGATGCTGCCGGAATGGCGGTGGGCACAGCTGGTAGTGCGGTGGTGTTTGCT GGCGCGACGGTGATTATCGCGCTGGTAGCCCTCATCATTGCGGATATCGGATTCCTCACGGCCATGGGT ATTTCTGCGGCGTTTACGGTGTTCGTGGCTGTGCTCATTGCGTTGACGTTTATCCCGGCGCTGTTGGGT GTGTTTGGTGGTCATGCGTTCAAGGGCAAGATCCCTGGAATTGGTGGAAACCCAACGCCAAAGCAGACG TGGGAGCAAGCGCTTAATCGTCGTTCGAAGGGTCGCTCATGGGTCAAGCTTGTACAGAAAGCACCGGGT CTTGTGGTGGCAGTGGTGGTCTTGGGTCTTGGTGCCTTGAGCATTGCTGCAATGAACCTGCAGTTGTCA CTGCGTTCTGACTCCACCTCCAATATTGATACCACTGAGCGTCAGTCGGCTGATTTGATGGCAGAGGGC TTTGGCGCGGGCGTTAATGCGCCGTTCTTGGTCATCGTCGATACGCATGAGGTCAATGCTGATTCCACC GCATTGCAGCCACTGATTGAGGCACAGGAGCCTGAAGAGGGCGAGTTCGATCGGGAGGAGGCGGCTGGT TTTGCTACCTATATGTATGTCACGCAGAGCTACAATTCCAACATCGATGTGAAGAATGCGCAGATCATC AGCGTCAATGATGATTTCACTGCGGCGCAGATTCTCGTGACTCCATACACCGGACCTGCGGATAAAGAG ACCCCTGAGTTGATGCACGTGCTGCGTGCGCAGGAAGCTCAGATTGAGGATGTTACGGGAACTGAACTG GGTACCACTGGGTTTACGGCGGTTCAGTTGGACATTACTGAGCAGCTGGAAGACGCAATGCCGGTTTAC CTCGCTGTGGTTGTTGGTTTGGCTATTTTCCTCCTCATTCTGGTGTTCCGTTCCCTGCTTGTTCCGCTG GTTGCTGGCCTTGGCTTCTTGTTGTCTGTGGGTGCGGCCTTCGGTGCGACGGTGTTGGTCTGGCAGGAG GGCTTCGGTGGCTTTGTGAACACCCCTGGTCCGCTGATTTCCTTCATGCCGATCTTCCTCATCGGCGTG ACCTTCGGTTTGGCCATGGACTATCAGGTGTTCCTTGTGACTCGCATGCGCGAGCACTACACCCACCAC AATGGCAAGGGACAGCCTGGTTCCAAGTACACCCCGGTTGAGCAGTCAGTGATTGAAGGCTTCACGCAG GGCTCCCGCGTGGTTACAGCAGCGGCACTGATCATGATTGCCGTGTTCGTGGCGTTTATTGATCAGCCG TTGCCATTTATTAAGATCTTCGGTTTCGCGTTGGGTGCGGGCGTGTTTTTCGATGCTTTCTTCATTCGC ATGGGTCTGGTCCCCGCGTCGATGTTCCTGATGGGCAAGGCCACGTGGTGGATGCCTAAGTGGCTGGAT CGAATTCTGCCAAGTTTGGACATTGAAGGCACCGCACTGGAGAAGGAATGGGAGGAGAAGCAGGCTGCA CGT RXS00453-3′-Region TAGACTTGGCACCTATGTCAGAT RXS00479-5′-Region TAGATCCCAAGGCTCAAAATTTATTACTTAAACAAGTTGAGCAACTAGCCAGCCGCAAATCTTAGAACT AACCTTTACGCCTTTAACGGAAGTGAATTTG RXS00479-coding Region ATGTCTACTAGCATCACAACAGAGAACAAGAAGAAATCTGGTCCTCCTCGCTTGATGAGAATCTTTCTG CCCGCCTTGCTAATTTTAGTTTGGCTTGTAGGAGCTGGAGTCGGCGGTCCTTATTTTGGCAAGGTTAGT GAGGTCTCCTCCAACAGCCAGACCACATATCTGCCAGAATCTGCCGATGCCACTCAAGTACAGGAACAG TTGGGAGATTTTACTGATTCTGAATCCATCCCAGCCATTGTCGTAATGGTCAGCGATGAACCCTTAACA CAGCAAGACATCACACAACTCAATGAAGTTGTTGCTGGGCTTTCAGAATTAGACATAGTTTCCGATGAA GTCTCCCCTGCTATTCCATCCGAGGACGGCAGAGCTGTCCAAGTGTTTGTCCCCCTCAATCCATCAGCG GAGCTGACGGAAAGCGTCGAGAAGCTCTCTGAGACCTTGACCCAGCAAACGCCGGACTATGTGAGCAGC TATGTGACCGGACCGGCTGGGTTTACCGCTGATCTCAGCGCAGCTTTCGCGGGTATTGATGGGCTAGTC CTAGCAGTCGCCTTGGCTGCCGTCCTTGTCATTCTTGTCATCGTCTATCGCTCCTTCATTCTGCCCATC GCCGTGCTTGCCACCAGTTTGTTTGCGCTGACTGTAGCTCTATTGGTGGTGTGGTGGCTAGCTAAGTGG GACATCCTGCTGCTTTCGGGTCAGACTCAAGGCATCCTCTTCATTCTGGTCATTGGCGCCGCCAGCGAC TACTCATTGCTATACGTTGCTCGTTTCCGTGAAGAGTTACGCGTTCAACAAGATAAAGGGATAGCCACA GGGAAAGCCATCCGGGCATCGGTGGAACCCATTCTTGCCTCGGGCAGCACTGTTATTGCGGGCCTCCTT TGTTTGCTATTTAGTGATTTGAAATCTAACTCCACGCTAGGTCCAGTAGCTTCGGTGGGCATTATTTTT GCAATGGTTTGTGCTCTTACTCTGCTACCAGCCCTGCTGTTTGTATTCGGTCGGGTGGCCTTTTGGCCC AAGCGACCAAAATACGAACCTGAAAAAGCGCGTGCGAAAAACGACATCCCCGCCAGCGGGATCTGGTCA AAAGTGGCTGATTTAGTGGAGCAGCATCCTCGTGCAATCTGGGTATGTACACTTATTGTGGTTCTCTTG GGTGCGGCTTTCGTTCCCACACTAAAAGCGGACGGTGTGTCCCAATCCGACCTAGTTCTGGGTTCCTCT GAAGCACGTGATGGCCAGCAGGCTTTAGGCGAACACTTCCCCGGTGGATCCGGCAGTCCTGGTTATATT ATCGTTGATGAAACACAGGCAGCACAGGCTGCTGACGTAGTCCTTAACAACGACAATTTCGAGACTGTA ACTGTAACTAGTGCTGAGTCCCGCTCTGGCTCAGCCCCAATCACCGCTGACGGTATTGTGCCGTTAGGT TCTGGTACAGCTCCAGGCCCGGTAGTTGTAGAAGGGCAAGTCCTTTTACAAGCAACACTTGTCGAAGCA CCAGATTCCGAAGAAGCTCAAAAAGCTATTCGCAGTATCCGCCAAACTTTTGCAGATGAAAATATATCA GCGGTAGTAGGCGGTGTCACTGCAACTTCCGTAGACACTAACGATGCCTCCATCCATGACCGCAACCTG ATCATCCCAATTGTATTGCTGGTCATTTTGGTTATTCTCATGCTGTTGCTGCGGTCTATTGTCGCACCA CTCCTGCTAGTAGTCACCACCGTGGTGTCTTTTGCTACTGCTTTAGGCGTGGCTGCTTTACTTTTCAAT CACGTTTTCAGTTTCCCAGGAGCAGACCCCGCAGTACCTCTCTACGGATTTGTATTTTTAGTAGCCTTG GGCATCGACTACAACATTTTCTTAGTCACCCGAATCCGTGAAGAAACCAAAACCCACGGCACAAGACTT GGAATTCTTCGAGGCCTGACAGTAACCGGCGGAGTAATTACCTCAGCTGGAGTAGTTCTCGCCGCAACG TTCGCAGCACTCTATGTCATCCCAATTCTATTCCTGGCACAAATTGGCTTCATTGTCGCTTTTGGAGTT CTTATTGATACCCTGCTCGTTCGCGCCTTCTTGGTGCCTGCTTTGTTCTACGACATCGGACCGAAAATC TGGTGGCCGTCAAAATTGTCCAATCAGAAATACCAGAAGCAGCCTCAGCTA RXS00479-3′-Region TGACACACCAAAATTCGGCTGTC RXS00654-5′-Region CAGCAATAGCGATTATTGCTTGATTGTGTGTTTTTAGATCTTCGGTTCTCTTCACTCAACTGCTGTGAA GTGCCACCTGTTTGGAAAGGCGAACACGATA RXS00654-coding Region GTGCTCGATATTTTGATTTACCCGGTGTCTGGAGTGATGAAGCTGTGGCACCTGCTTCTTCACAACGTT GCGGGTTTGGACGATTCACTGGCGTGGTTCTTTTCCCTTTTCGGCCTTGTCATCACGATCCGTGCAATT ATCGCGCCTTTCACCTGGCAGATGTATAAGTCGGGCCGCACTGCCGCACATATTCGTCCTCACCGCGCT GCGCTCCGGGAAGAATACAAGGGAAAGTACGATGAAGCGTCCATTCGGGAGTTGCAGAAGCGCCAGAAT GATTTGAATAAGGAATACGGCATTAACCCGCTGGCAGGTTGTGTGCCTGGGCTGATCCAGATACCGATT GTCCTTGGTCTTTACTGGGCACTTCTCCGCATGGCTCGCCCTGAAGGTGGTTTGGAAAATCCCGTCTTC CAGTCGATCGGCTTCCTAACTCCTGAGGAAGTGGAATCTTTCCTCGCTGGTCGCGTGAGCAATGTGCCT CTGCCCGCTTATGTTTCGATGCCCACTGAGCAGCTAAAATATTTGAGCACCACGCAGGCGGAAGTTCTT AGTTTCGTTTTGCCACTGTTCATCACAGCCGCAATCCTCACCGCAATCAACATGGCGATGTCCATGTAC CGCAGCTTCCAAACCAACGATTACGCATCCGGATTCTCTAACGGCATGCTGAAGTTCATGATCGTGATG TCGATCCTCGCGCCGATCTTCCCACTGTCCCTTGGCCTCACAGGAGCATTCCCCACAGCAATCGCACTC TATTGGGTGAGCAACAAGCTGTGGACGCTCCTCCAAACAATCATCATGATGGTCATTTTGGAACGCAAA TACCCACTTACCGACGATTTCAAAGTGCACCACCTAGAGCAGCGCGACATCTACCGCGCAAAACAAAAA GAAAAGCGCATCTTGCTGTGGACACGACGCAAAAACCGCGCCCTGATGATTCTCACCGCATGGAACGCC TCAACGCTTCACGCAACAAACGTGGAACTCACGAAAAGCCGTACTGCCGAAATCAACGAAGCAAAACAG GCCCGCAAAGAAATCGCGAACAAGAGGCGCGAAACGCAACGTGAAATGAACCGCGGCGCCATGCAGCGC TTAAAGCAGCGTCGGGCTGAGGTTAAAGCTAAAAAGAAGGGGCTTATCGACGCCTCCCCCAACGAAGAT ACCCCTTCGGAAAATGAAGAAACTAAATTGAGTAGTCCGCAGGTGGAGCCGACAACAACTGCCGAGCCA AATCGCGAGCCGTCTCAAGAGGAC RXS00654-3′-Region TGATGTTGTGGACCAATCGAGAT RXS0075B-5′-Region TTCAAGTTTGGCTGTGACTCATGTCGCACATAGTATTTCAATCACCGGATCCGCAGGATTGCAAAATGC TGGGGAATATTCATAACAACGGAGGTCAGTC RXS00758-coding Region ATGACTTTGAAGAAGTCTCTCGCTGTAACCACGGCGGCTGCACTTGCTTTGAGCCTTGCCGCTTGGTCG TCCGACTCCTCGTCCGACAGCTGCTCATCCTCATCAGGCAGCGAAGGCGGCGACAACTACGTCCTCGTC AACGGCACTGAGCCAGAGAACGCGCTCGTCCCAGGCAACACCAACGAAGTAGGTGGCGGTCGCATGGTC GACAGCATCTTCTCCGGCCTGGTCTACTACGACGTCGAGGGCTCCCCTGTCAACGATGTTGCAGAGTCC ATCGAACTCGAAGGTGACAAGACCTACCGCATCACCATCAAAGACGGCCAGACCTTCACCGATGGCACC CCAGTTACGGCTGAGAGCTTTGTCAACGCATGGAACTACAACGTAGCTAACAGCACGCTGTCCTCCTAC TTCTTTGAGTCCATCGTCGGCTACGAAGAAGGCGTCGAGTCCATGGAAGGCCTCCAGGTCGTCGACGAC ACCACCTTCACCGTCGAGCTCACCCAGCCTGAGTCCGACTTCCCACTGCGCCTGGGATACTCCGCATTC TTCCCGCTTCCTGAATCCGCATTTGACGACATGGACGCATTCGGTGAGAACCCAATCGGCAACGGTCCA TACAAGCTCCAAGAGTGGAACCACAACCAGGACGCCACCATCGTTCCTAACGCGGACTACACCGGTGGA CGCCAGGCTCAGAACGACGGCGTGAAGTTCATCTTCTACCCAACCTTCGACTCCGCTTACGCGGACCTG CTCTCCGACAACTTGGATGTGCTGGACGCTATCCCAGACTCCGCGTTCTCCTCCTTCGAGGACGAGCTC TCTGGCCGTTCCATCAACCAGCCTTCCGCTGTGTTCCAGTCCTTCACGATCCCGGAGAGCCTTGAGCAC TTCTCCGGCGAAGAAGGCGTGCTGCGTCGCCAGGCCATCTCCTTGGCCGTCAACCGCGACGAGATCACC CAAACCATCTTCGAAGGGACCCGCACCCCAGCGACGGACTTCACCTCCCCTGTCATCGACGGACACTCT GATTCCCTCCAGGGCGCAGATGTCTTGACCTACGATCCAGAGCGCGCTCAGGAACTGTGGGCACAGGCA GACGAGATCAGCCCTTGGTCCGGCGAGTTCTCCATCTCCTACAACGCAGACGGTGGACACCAGGCATGG GTGGACGCAACCGCCAATTCCATCCGCAACACCCTGGGTATCGACGCCATCGGCAACCCATACCCAGAC TTCAAGTCCCTGCGTGACGATGTCACCAACCGCACCATCAACGGCGCATTCCGCACCGGCTGGCAGGCA GACTACCCGTCCTTGGGGAACTTCCTCGGACCTTTGTACGGCACCGGTGCAGGCTCCAACGATGGTGAC TACTCCAACCCAGATTTCGATGCCAAGGTCGCCGAAGCAGCAAACGCGGCCGATGTTGACGCATCAACC CCGCTATACAACGAAGCACAGGAAATCCTGCTCCAGGATCTGCCAGCGATCCCAACTTGGTACTCCAAC GCAGTTGGTGGATACTCCACCAACGTGGACAACGTGGAATTCCAGTGGAACTCGCAACCTGCGTACTAC CAGATCACCAAGAAC RXS00758-3′-Region TAGTAGCTTCGGACCACCCGCTC RXS00912-5′-Region CCACACCTTTGAAAGGAGCTAAGGG RXS00912-coding Region ATGGACAACAGCGTCTACACAGCAGGCCTCACAATCGCAGCTGCCTTTTTCATGCTGTCGTTCATCTTC ACCATCTACCGCATCATCGTCGGGCCCAACTCCATCGATCGCCTACTCGGCCTGGACGGAACCGTCTCC ATGATTCAATGCTCCATGGCCACCTACATCTGCTGGACACTCGACACCACCGTCACCAACTTCATGATG GTCATCGCACTCTTAGGATTCATCAGCTCTGTATCCGTAGCCCGCTTCCGCAAGAGGGATGGTGCC RXS00912-3′-Region TAAATGACCCTGCAACTATTCAC RXS00932-5′-Region CCCAATTAATTTATGCACTTCGGTGAGGTTACTCACAAAGAGTAGCGTGCAAAGCCCAGCAATAAGGTG ATGTTTCAACGATTAGGTTACGGTAGGGGCC RXS00932-coding Region ATGACGGCACAGAAACTTCACCGTTTTGCAGCCCTTTTAGAAATGGGTACCTGGACCCTGCTGATCATC GGCATGATCTTAAAATACAGTGGAGTGACAGACGCCGTAACCCGTATTGCCGGCGGTATCCACGGGTTT GGCTTGCTCTGTTTTGCAGCCATCACCATCACCGTGTGGATCAATAATAAGTGGACATTCCCGCAGGGT ATCGCAGGTTTGATCGTCTCTGTTATCGCGTGGGGTGCATTGCCATTTGCATTGTGGGGAGACAAGAAG GGCCTCGTTGGCGGCGGATGGCGCTTTTCAGATCGGTGGGAAAAGCCACACACTTTCTTTGACAAGATC TTGGCTCAATTGGTCAGGCACCCAATCGGATCCATTTTAATTCTGCTGGTGATTATCGCCGTCGTCTTG TGTATGTTGCTGGCGATGGGACCACCTTATGATCCAGATGCCATCGCAAACACTGTGGAT RXS00932-3′-Region TAAACAACAGCCTCCTTCACATG RXS01346-5′-Region AAGGTGTGGTGAGTCACTGGCTAGATTTGATTTGTTGGCCATACCAAATCGGCCCACACAGGCACGTTG CAAACAGGAACGCTCACCCATAGGAGATTTA RXS01346-coding Region ATGCGCACAGCCACAAAAGTCATCGCAACAGTGATGGCCTCAACCCTGGCTATCGGGCTGGCATCTTGT TCCAGCTCTAGTGGCACCGCAGACGTGAATTAGGTATCCGTCAACGGCACCGAACCTCAGCGCGGACTC ATCCCGGGCGACACCAATGAAAACGGCGGTGGGCGAGTGGTGGACATGCTGTACTCTGGGCTCGTCTAC TTTGATGAAGCTGGCGTTGCTCAAAATGACCTGGCGGCATCAATTGACCAGGAAACAGACACCACCTAC AAAATCACTTTGCGTGATGGCATCAAATTCAGTGACGGATCGGATATTACTGCGAGTGATTTTGTGGAT ACCTGGAATTTTGTAGTGGAAAATGGACTGCTCAACACTTCTTTCTTCTCACCGATTAAAGGGTATGAG GAGGGCGTGGAAACGCTCGAGGGTTTGAATGTGGTGGATGATCGCACATTTACCATCGAGCTTGCCCAA CCGGATTCTGAGTTCACCCAACGCATTGGCTACTACGGTTTTGCACCGATGCCAGCTTCGGCTCGCGAT GATATTGACGCCTTTGGTGAAAACCCCGTGTCCTCTGGCCCTTACAAACTAGAGCAGTGGGATCACAAC GCAGAACTGAAAGTGGTGGCCAATGAACACTACGATGGCCCGCGCGCAGCCAACAACGATGGGTTGAAG TACGTGTTCTACGCCGAAAATGATGCAGCTTATTCAGATCTGTTGGCTGGAAACCTAGATGTGCTGGAT CTCATTCCACCATCGGCGTACACCACCTATGAAGAGGAACTGTCGGGTCGATCCATTAATCAACCTGCG GCCTCCTATCTGGAACTCTCCATTCGCATGGAATCCGCCAACTTTGAAGGGCAACAGGGACAGTTGCGT CGACAAGCAATTTCTATGGCGATTAACCGTGAAGAAATCGCTGAGCAGATCTTCGCCGGCACCTACACG CCTGCGCTCGACTTCACCGCGCCCGTGCTCGACGGCTGGGGCGATGATTTGAACGGCAATGACGTGCTG ACTTTCCAGCCTGACAAGGCCCGTGAGCTGTGGGAAGACGCTGAGGAGATCGCACCTTTTGAGGGCGAA TTGCAGATCAGTTACAACGCGGATGTTCCCAACCGGGAATGGGTGGATGCGGTAGCAAACAGGATCAGC AACGAATTAGACGTCAACGCCACTGGCAATCCTTTCCCCGATTTTAAATCCTTCCGCGACACATACCGC ACCACCGGATTGGATGGGGGCTACCGCACCGCGTGGTTTGCGGACTACCCAAGCATCGGCAACTTCCTT GGACCTAACTACACCTCGGGCGTGGCCTCCAACGATGCCAAGTACGAAAACCCAGAATTTGATCAATTG ATTGCCGACGCCGCAGCAGCCTCCACCAAGGAGGAAACCTTCCAGGCATATGCGCAGGCCCAGGAAATG TTGTTGCGCGATCTTCCCGCAATCCCACTGTGGTACCCGAATGTGGTTGGCGGCTACTCAGAATCCGTG GACAACGTCTCCGTAAACTGGAAGGCCATACCTGTTTATTGGGCAATTACAAAGCAA RXS01346-3′-Region TAAAGTCATTAACCTAAATCCGG RXS01425-5′-Region AGTCCCTATTAATCCCAAGGAGTTTCGACTCACAGTGCTCAATTTCATTTATTGGCCAATTTGGGCCAT TCTGTGGTTCTGGCATAAAGCGTTCAGCTTT RXS01425-coding Region GTGCTGAGCCCAGATTCCGGAATTACCTGGGCCTTGTCGATGATGTTCTTGACCTTCACCGTGGGTATG GTTCTGGTCAAGCCGATGGTCAACACCATGCGTTCACAGCGCAAGATGCAAGACATGGCTCCAAAGATG CAGGCCATCCGCGAGAAGTACAAAAATGACCAGCAGAAGATGATGGAGGAGACCCGCAAACTTCAAAAA GAAGTGGGCGTTAACCCCATCGCAGGCTGTTTGCCAATGTTGGTGCAGATCCCAGTGTTCCTGGGTCTG TTCCACGTGCTGCGCTCCTTCAACCGCACCGGTTCTGGCGTTGGCCAGCTGGAAATGACCGTTGAGCAA AACGCGAACACCCCGAACTACATCTTCGGTGTCGACGAGGTTCAGTCCTTCCTGCGTGCAGACCTGTTC GGTGCGCCACTGTCGTCCTACATCACCATGCCTGCTGACGCGTTCGACGCGTTCCTTGGCCTGGATGTC TCCCGCCTCAACATCGCGCTGGTTGCAGCTCCAATGATTTTGATCATTGTCGTGGCAACTCACATGAAC GCGCGTCTGTCCGTCAACCGCCAGGAAGCTCGCAAGGCAGCCGGCAAGCAGCAGGCCGCTTCCAGCGAT CAGATGGCCATGCAGATGCAAATGATGAACAAGATGATGCTCTGGTTCATGCCAGCCACCATTTTGTTC ACCGGCTTCATCTGGACCATCGGTCTTCTTGTCTACATGATGTCGAACAACGTGTGGAGCTTCTTCCAG CAGCGCTACATCTTCGCCAAGATGGACGCTGAGGAAGCAGCTGAGGAGGAGGAAAAGCGCGCAGCAAAG CGCACTACCGCTCCAAAGCCTGGCGTGAAGCCAGAAAACCCCAAGAAGCGTAAGAAG RXS01425-3′-Region TAAAACTTCACTAAAAAGCGCCA RXS01658-coding Region GATCCACAGATCCTGTCACCAACCTTCACCCAGCAACAGCAGCTGCGAAACTTCTACGGTTTCCCAGAC CAGCTGGCGATGGACCGCTTTGAAGTAGATGGCAAACTCCGCGACTTTGTTGTGGCAGCACGTGAGCTC GATCCAAACGCCCTGCAGCAAAACCAGCAGGACTGGATTAACCGTCAGACTGTTTATACCCACGGCAAC GGCTTCATTGCAGCTCAAGCAAACCAGGTGGATGAGGTCGCCCGCGACGTCGGATCCACTCGTGGTGGT TACCCTGTCTACACCGTCTCTGATTTGCAGTCGAATGCTGGTGCTGGAGAAAGCGAAGATGCTGAGGAG CTTGGCATCAAGGTTGATGAGGCTCGTGTGTACTACGGACCACTGATTGCTTCTGCGACTGATGGTGCT GACTACGCAATTGTCGGTGACACCGGCGATGGCCCAGTCGAGTAGGACACTGACACCTCCAGCTACACC TACGAAGGTGCTGGCGGCGTGGACATTGGAAACATGGTGAACCGTGCGATGTTTGCATTGCGCTACCAG GAAATGAACATGCTCCTGTCTGATCGTGTTGGTTCCGAATCCAAGATCCTATTTGAGCGCGATCCTCGT TCCCGTGTGGAAAAGGTTGCACCTTGGTTGACCACTGACTCCAAGAGCTACCCAACTGTGATTGATGGT CGCATCAAGTGGATCGTCGATGGCTACACCACCTTGGATAGTCTTCCGTACTCCACGCGCACCTGACTG ACGGAAGCGACTCAGGATGCTGTCATGCCTGACGGCACCCGACAGCCACTGATCAGAGATAGGGTCGGT TACATCCGCAACTCCGTGAAGGCTGTTGTTGATGCGTACGACGGAACTGTTGAACTCTACGAATTCGAC ACCGAAGATCCTGTTCTGAAGGCATGGCGTGGCGTGTTCCCAGACACCGTGAAGGACGGGTCGGAGATT TCCGATGAGCTTCGCGCACACCTGCGTTACCCAGAAGATTTGTTCAAGGTCCAGCGTGACATGCTGGCC AAGTACAACGTTGATGATTCTGGAACATTCTTCACCAACGATGCGTTCTGGTCTGTCCCAGGTGACCCA ACTGCAGGGGAGGGCCGCCAGGAACTTAAGCAGCCTCCTTACTACGTGGTGGCAGCAGACCCAGAGACC GGTGAGTCCAGCTTCCAGCTGATCACCCCGTTCCGTGGACTTGAGGGCGAGTACCTCTCTGCACACATG TCTGCGTCGTCTGATCCAGTTACCTACGGTGAAATCAGTGTTCGTGTGCTGCCTACGGATTCTGTGACC CAGGGTCCAAAGGAGGCCCAGGATGCGATGATGTCATGTGACCAGGTTGCTCAGGACCAAACACTGTGG CGTGGATCGAACGATCTGCACAACGGAAACCTGTTGACGTTGCCAGTTGGTGGCGGAGAGATCCTCTAC GTTGAGCGGATTTACTCGCAGCGCAAGGATCAGGCATCGGCGTTGCCGAAGCTTCTGCGCGTGCTGGTC TTCTACAAGGGTCAGGTTGGTTACGCACCAACGATCGCTGAAGCCCTATCGCAGGTCGGCATTGATCCG AAGGAAGCGCAGGACATCGAAGAGGTAGATGGCACCGCTACGACGCCATCGACTGATGAGACTGACACT GACACTGATCAGCCTGCAACCGAAACCCCAACTGCACCAGTGAGTGAGGCGGAAGGAATCGCGGCCATC AACGATGCGTTGAGCAACCTTGAAGCTGCTCGCGATAGCTCTTTCGAAGAGTATGGTCGTGCACTCGAT GCGCTTGATCGTGCCGTCGATAGCTACCAGTCCGCACAG RXS01658-3′-Region TAGCGTTTGAGTAAACAGCCCGA RXS01677-5′-Region GTCGGCATAGTTGAGTTTTATTCATGGCTTTTAGCTAGGCGACTTTAGTTGAGGGCTTTTAGTTGAGGG CTTCCCAGCAGGGATGGTTAAGGAGAATTCA RXS01G77-coding Region GTGAACCAACAGAGTAAAAAGTGGCTCGTACCGACACTGGTCGTCATCATTGCAGTGCTCCTCATCGCA GTTGTTCTGTTGATGTACCGAGGAAATGCGAGTGATACGGCCGAGGGCGTTTCAGCCGCTGCGACTTCG GACTCGGCTGCTGCTTCGACTGCTGCTTGGGGTTCCGCTTCTGGTGGTGCGGACTCCGATCTGACCAGC GTGGAAGCACGCGACCCTTCCGACCCTGTTGCGGTGGGAGACGTTGATGCACCTGTTGGGTTAGTGGTG TTTTGCGACTAGCAATGCCCGTTCTGTGGAAAGTGGAGGGATGAAACGGTGCCACAGATGATGAAGCAT GTGGAAGATGGAAACCTCCGCATTGAATGGCGTGAAGTGAACATCTTTGGAGAACCATCTGAGCGTGGA GCTCGCGCGGCATACGCTGCGGGTTTGCAGGACGCATACTTGGAATACCACAACGCACTCTTTGCCAAC GGTGAAAAACCCAGCGAAGACCTGCTCAGCGAAGAGGGACTTATTAAGCTTGCTGGTGACCTTGGACTA GACGAATCGAAATTCACTGCCGATTTCCAATCCCCTGAAACTGCAGTCGCAATTGCGCAACATCAACAG CTGGGAATCGATGTTGGCGCCTACTCCACCCCAGCTTTCCTCCTAGGTGGCCAGCCAATCATGGGCGCT CAGCCTGCTTCTGTATTTGAAGCCGCCTTCGAGCAAGCACTGGCAGCGAAAGAA RXS01677-3′-Region TAAACCGTGGATGTCGGCCTAGT RXS02586-5′-Region TTCTCTGAGATCGTCATGATGAAGTACATCGGGTTCGGCATGATCGCAGCGCTGATTCTGGATGCCACC ATCATCCGCATGCTGCTTGTCCCCCGCCGTG RXS02586-coding Region ATGCACCTGCTTCGCGACGACAACTGGTGGGCACCGGGCTTCGTTAAAAAGGCCTACACCGTCATGGGT CACGGCTCTGAGGTGGAGGAAGCACCTCGCCCAACCAGCCGTCGCCTCAACGACGATGAGGAAGTCACC GTGCATGAAGCAGTTGTCGCTGGCGATACCGTGGCATCTCGCGGTGGTTTGAGCACGCAGGAAAACCGT GATCTGGTGTCCTTCGTGGAACTTAAGGCTCGTTTGGAAAAGCGCAGGCTTGAGGATCTAGAT RXS02586-3′-Region TAAATCTATGCGAGGATTTTTCA RXS02587-5′-Region AGCCTGGATAACCTGCGAGACGGTGGCGCATGGCTGCAGCCGTTCCGCCCTCTGACTGCCTTGTTATCC AACCGCCACAATTCCCAGGAGTAATCCACCC RXS02587-coding Region GTGTTTTCTAAATGGGGCCACTTTGCTTACAGATTTAGGCGCATTGTTCCGTTAGTCGTCATCGCCGGG ATTTTGGCTTTGTTTGTGATTTTCGGCACCAAGCTGGGCGACCGCATGAGCCAGGAAGGATGGGATGAT CCTGGTTCTTCCTCGACCGCTGCGGCGCGCATCGAGTTGGAGACCTTTGGGCGTGACAATGAGGGCGAT GTCGTGTTGCTGTTTAGTGCGCGTGAAGGCACTTCTTTCGATGATGCAGAGGTGTTCTCCAGCATCTCT GGCTACTTAGATGGGCTAATCGAGAACAACCCTGATGAAGTCAGCCACATCAACAGCTACTTTGACACT CGTAATGAAAATCTCCTCAGGAAAGACGGCACCCAAACCTTTGCAGCTCTCGGGCTGAAAGGTGACGGC GAGCAAACGCTGAAGGACTTGCGGGAGATTGAAGATCAGCTCCATCCGGACAACCTTGCCGGTGGCGTC ACCACTGAGGTCGCGGGTGCCACCGCTGTAGCCGACGCACTCGATGAGGGCATGGCTGGCGATATTTCA CGCGCCGAAGTTTTTGCGCTGCCTTTCGTGGGTATGTTGCTGCTCATCGTGTTTGGCTCAGTTGTTGCC GCGGCGATGCCATTGATCGTGGGCATTTTGTGCATCTTGGGTTCGCTGGGCATCTTGGCAATTTTGGCT GGATTCTTCCAGGTCAAGGTATTTGCACAATGTGTTGTGACCCTTCTGGGCTTGGGTCTTGCCATTGAC TATGGCTTATTCATGGTCTCTCGTTTCCGTGAGGAAATGGATAAGGGCACCCCGGTTGAACAGGCTGTT GCGACGAGTACGGCGACCGCGGGTAAGACTGTGGTGTTGTCTGCAGCGATGGTGGCTGTGGCGCTGTCC GGGTTGTTTGTTTTCCGACAGGCTTTCTTGAAGTCGGTGGCATTGGGTGCGATTTCGGCGGTTGGCCTT GCTGCTTTGATGTCGGTGACGGTGTTGCCGTCGCTGTTCAGCATGTTGGGTAAGAATATCGATAAGTGG AGTTTGCGTCGCACTGCTCGAACAGCGCGCCGTTTGGAAGACACCATTTGGTACCGCGTGCCGGCATGG GCAATGCGCCATGCCAAGGCAGTGACCGTGGGCGTCGTATTGCTCTTGCTTGCTCTTACAGTGCGGTTG ACGGGCGTGAAATTCGGCGGCATCAATGAAACGTATCTGCCACCAGCTAACGACACCCGCGTCGCCCAA GAGCGTTTCGACGAGGCGTTTCCCGCCTTCCGCACCGAGCCGGTCAAGCTTGTGGTCACCGGGGCGGAC AACAACCAGCTGATCGATATCTATGTTCAGGCCAACGAAGTTGAGGGACTGACAGATCGTTTCACCGCA GGTGCGACTACCGATGATGGCACCACGGTGTTGTCTACTGGTATTCAGGATCGTTCCCTCAATGAGCAG GTAGTGGAGCAGCTTCGCGCTATTTCCGTCCCTGAGGGCGTTGAGGTGCAGATCGGTGGCACTCCAGCC ATGGAGATCGAATCCATTGAGGCGCTCTTTGAAAAGCTCCTCTGGATGGCTCTCTACATTGTGCTGGCC ACTTTCATCCTCATGGCATTGGTATTTGGTTCGGTGATTTTGCCGGCGAAGGGCATCATCATGACCATT CTGGGTATGGGTGCCACCTTGGGTATTCTCACCTTGATGTTCGTGGATGGCGTGGGTGCCAGCGCATTG AACTTCTCCCCTGGCCCACTGATGAGTCCAGTGCTGGTGCTGATCATGGCTATTATTTACGGACTTTCC ACCGACTATGAGGTGTTCCTGGTATCTCGCATGGTGGAGGCCCGCGATAAAGGCGAATCCACCGACGAC GCCATCAGATACGGCACTGCACACACCGGATCTATGATCACCGCGGCCGCACTGATCATGATTGTGGTC TGTGGAGCGTTTGGTTTCTCTGAGATCGTCATGATGAAGTACATCGCGTTCGGCATGATCGCAGCGCTG ATTCTGGATGCGACCATCATCCGCATGCTGCTTGTCCCCCGCCGTGATGCACCTGCTTCGCGACGACAA CTGGTGGGCACCCGGCTTCGT RXS02587-3′-Region TAAAAAGGCGTACACCGTCATGG RXS02590-5′-Region GCCCCAAAGGCTTAAAGTAATGGGCATGCCCACTGCTTCTTCGACCAAAAGCTACGCTGCGGTCTTACC TCCACCTGGCCCCTCGTGGGCTGGTTCCCTC RXS02590-coding Region ATGGGCATCTCATTGTTGTCATCACTGTTGAAAATCCATGGTTTTCCAGTCGTCGCAGATTTCTTCTTC GCGTTAGCTGTTGTGGTGGCAATTGTCATTATTGGCGGTTGGCTAATCTACCGCTCTCCTTCATTCAAA ACTGAAGTCATGCCGGCATGGGCAATGCTGTCCATGGGTTTGATCGCATTGGGAACTGCAAGCCCCGTA GTTTTGGGTGATGATCTGTGGGGATTTATGTTTGTGTGCTGGTCTATTGGCACAGCCGTGGGACTTGTT GCCTATTCCTTATATATAACGGCCATTTTGCGATCTAAGGCGGGCAGACCAACTTTTGCGTGGGGTCTT CCTCTTGTCACGCCGATGGTTGCTTCCACCTCGGCAGCACAACTCCATGAGCACTTTGAACTTCCGGCG ATGCTGTGGGTTTGTTTCGGGCTCTTCCTTTTAACTTTGGCGTCTGCACCAGGAGTTTTTACCCGAGTG TATTTCTACTATTTCGGCCCCAAGGCGCAGGGCATCCCACTGATGGCAACACCAACATCATGGATTCCT TTGGGTATGGTGGGCCAATCCACTGCAGCAGCTCAGCTCATCGGTGCGTCCTTTGGATCCAAGACAGCA ATCACAATGGGCATTATTTACGGCATCATCATGGGAATTTTTACGATTCCTCTGGGAGCCATCGCTCAC TTTGTGTTCTACAGAGCTGTTTTCAAAGGGGCGACATACAGCCCCACATGGTGGGCCAGTACCTTCCCA GTTGGCACTTTGAGTTTGGGTGGGCATTTTTTATCACAGAGCACCGGAGTGGAGTGGTTTAACTACTTC AGCCTGTACTTGATTGCTTTAATGCTCTTTCATGTCATCGTGTCCACCATCGCCGGTACGATTGCAGTA ATGAGAAGAATCGTCGGAAAGCTTAAATCTCAACTGGCC RXS02590-3′-Region TAAATTGCAGGGAGAGGTCTAAA RXS02932-5′-Region CACTACTGCGTTAAGGTATGAAAGTTCGCACACCAGCGATTTAATTGTGTGGCCACGACTAGCACGACC ATTTCAGTTTTAACTTTCTTGGAGTTTTCTA RXS02932-coding Region GTGTCCAAAACAGAAGAAGGCCGTTCAGCGGGCATAATTATTTACGCGTTTCCAACTTTCATTCTGGTG GGCGCGATCATTGCGTTTATCTTCCCGGAACCATTGATTCCGCTGACAAACTACATTAATATCTTCCTC ACGATCATCATGTTCACCATGGGTTTGAGCTTGACGGTGCCCGATTTTCAGATGGTGGTTAAACGTCCA CTGCCTATCTTGATCGGTGTAGTAGCGCAGTTTGTCATCATGCCATTCCTGGCGATCGTGGTTGCGAAA ATGTTCAACCTCAACCCAGCACTGGCCGTTGGCCTTCTCATGCTGGGATCCGTTCCGGGTGGCACCTCC TCCAATGTGATTGCGTTTCTCGCCCGAGGAGATGTCGCGCTATCGGTCACCATGACCTCTGTGTCCACC ATTGTTTCCCCAATCATGACGCCTTTCCTGATGCTCATGCTGGCAGGTAGTGAAACCGCGGTCGATGGT GGAGGCATGGCGTGGAGTTTGGTACAAACAGTGCTGGTGCCTGTGATCATCGGCCTAGTTCTGCGTGTC TTCTTGAACAAGTGGATCGACAAGATTTTGCCGATCGTTCGTTATCTCTCCATCCTCGGTATCGGTGGC GTGGTGTTCGGCGCAGTCGCAGCCAACGCGGAACGACTCGTGTCTGTCGGAGTCATCGTGTTCGTTGCA GTTATCGTGCACAACGTACTTGGATACGTTGTGGGATACCTCACCGGCCGTGTATTCAAATTCCCAGAA GGAGCAAACCGCACCATGGCGATTGAAATCGGAACCCAATCCGCAGGCCTGGCATCGGGAATGGCAGGA CGATTCTTCACCCCAGAAGCAGCCCTTCCAGGTGCTGTCGCTGCCTTGGTCCACAACATCACCGGCGCA GTTTATGTTGGGCTGGTACGAAACAGGCCTTTGACTAAGGCATCAAGGAAGAAGGAATCCGTCGCGGTT TCCAGC RXS02932-3′-Region TAACTTATTTGCTGGCCGTTAGA RXS03042-5′-Region ATGACACCGGCGCGACGTATGGCATTACTGGCGTACCCCAATTTACGATGACATCTCTGCTCGCCTCGG CGACGTCCTGGTTCCTTACGTTCTGATCGTT RXS03042-coding Region TTGGTTCTAGCGTTCCTCGTGCTGTTGCTCGTGTTCCGGTCCATTTGGGTCCCATTGATCGCGGCTCTG GGCTTTGGCTTGTCAGTTCTGGCTACCTTTGGTGCTACGGTGGCGATCTTCCAAGAAGGTGCTTTCGGC ATCATCGACGATCCTCAGGCACTGCTGTCCTTCTTGCCGATCATGCTCATCGGCGTGGTATTTGGTCTG GCCATGGATTACCAGATCTTCCTCGTTACTCGTATGCGTGAGGGCTTGAGCAAGGGCAAGAGTGCGGGC AACGCAACGTCGAATGGTTTCAAGCACGGTGCGCGCGTGGTCACTGCTGCGGGGCTGATCATGGTGTCT GTGTTCGCGGCATTCATAGCGCAGGACATGGCGTTTATTAAGACCATGGGCTTTGCTCTGGGCGTTGCT GTGTTCTTCGATGCCTTCGTTGTTCGCATGATGATTATCCCTGCAACAATGTTCCTGCTTGATGACAAG GCTTGGTGGCTACCTAAGTGGTTGGATAAGATTCTTCCCAACGTTGATGTTGAAGGTGAGGGTCTTAGT GAACTACATGAGGCTCGCACCGAGGAACTGAAGGAAAATGTAGGTGTCGGGGCT RXS03042-3′-Region TAGAGAAACAAAAAAGGCTGCTA RXS03075-5′-Region TGTGCAAAATTGCATTCAGGCTGAAAAATTCCTAAAGGGACTCCGTCCGAATAATTGGAAAGCCCAGAA GAACAGTCAACTCCTAGATTAAAGGATAATC RXS03075-coding Region GTGGCGAAATTCCTGTATAAGTTAGGCTCCACGGCCTATCAAAAGAAATGGCCGTTTCTTGCGGTCTGG CTCGTGATTCTCATAGGTATCACGACGCTGGCGGGGCTGTATGCCAAGCCAACGTCGAGTAGCTTCTCT ATCCCTGGTCTTGATTCTGTCACGACCATGGAGAAGATGCAGGAGCGTTTCCCTGGTTCGGATGATGCA ACATCGGCTCCCACTGGTTCTGTCGTCATTCAGGCACCGGAAGGCAAGACCCTCACTGATCCTGAGGTT GGGGCTGAAGTAAACCAGATGCTTGATGAGGTTCGGGCGACTGGTGTGCTGAAGGATGCTGATTCCGTT GTGGATCCTGTGTTGGCTGCGCAGGGTGTGGCTGCTCAGATGACCCCAGCCCTGGAGGCTGAGGGTGTA CCTGCGGAGAAGATCGCCGCAGATATTGAGTCGATTAGTCCACTGAGTGCAGATGAGACTACCGGCATC ATCTCGATGACTTTTGATGCAGATTCTGCCATGGATATATCCGCAGAGGATCGTGAGAAGGTCACCAAT ATTCTTGATGAATACGATGACGGCGATCTGACTGTTGTCTACAACGGCAACGTGTTTGGCGCAGCTGCA ACCAGCTTGGACATGACCTCTGAGCTCATCGGCCTGCTGGTGGCTGCGGTCGTTCTTATCGTGACCTTC GGTTCGTTCATCGCTGCCGGTATGCCGCTGATCTCT RXS03124-coding Region ATGACTGCTACCCTGGCGTCGATGATTGGTCTGGCTGTGGGTATCGACTACGCGCTATTTATCGTGTCC CGTTTCGGCAATGAGTTGATTTGTCAGACTGGCGCTAATGATCTGGAGCCAAAGGAATTGGCTGAGCGT CTGCGCACCATGCCGTTGGCTGCTGGTGCGCATGCGATGGGAATGGCTGTGGGCACTGCGGGTTCTGCG GTTGTATTCGCGGGTACCACGGTGCTGATCGCTCTGGTTGCTCTGTCGATCATTAATATTCCATTTCTA ACCGTGATGGCCATTGCTGCCGCAATCACCGTTGCCATCGCAGTTCTGGTTGCTCTGTCCTTCCTCCCA GCTGTGCTTGGCCTGGTTGGCACTGGCATCTTCGCAGCACGCGTGCCTGGACCTAAGGTTCCGGATCCT GAGGACGAGAAGCCAACGATGGGTCTGAAGTGGGTCCGCCTTGTGCGCAAGATGCCGGTGGCTTACCTG CTGGTTGGCGTCGTTTTGCTTGGTGCAATCGCAATTCCTGCGACCAATATGCGCCTGGCCATGCCGACT GATGGCACCTCCACGCTGGGCACCGGGCCGCGCACGGGGTATGACATGACGGCAGATGCGTTCGGCCCG GGCCGCAACGCGCCCATGATTGCGCTTATCGACGCAACCGACGTGCCTGAGGAAGAACGCCCATTGGTG TTTGGACAGGCGGTGGAGCAATTCTTGAACACTGATGGTGTGAAGAATGCTCAGATCACTCAGACCACG GAGAATTTCGATACCGCGCAGATCGTGTTAGCGCAGAATTTGATGCGATCGATGAGCGCACCTCTGAGA CTCTCGCAACTCTTCGTGCAGATGCTGAGACCTTCGCTGATGACACCGGCGCGACGTATGGCATTACTG GCGTCACCCCAATTTACGATGACATCTCTGCTCGCCTCGGCGACGTCCTGGTTCCTTACGTTC RXS03124-3′-Region TGATCGTTTTGGTTCTAGCGTTG RXS03125-5′-Region TGACACCGGCGCGACGTATGGCATTACTGGCGTCACCCCAATTTACGATGACATCTCTGCTCGCCTCGG CGACGTCCTGGTTCCTTACGTTCTGATCGTT RXS03125-coding Region TTGGTTCTAGCGTTCCTCGTGCTGTTGCTCGTGTTCCGGTCCATTTGGGTCCCATTGATCGCGGCTCTG GGCTTTGGCTTGTCAGTTCTGGCTACCTTTGGTGCTACCGTGGCGATCTTCCAAGAAGGTGCTTTCGGC ATCATCGACGATCCTCAGCCACTGCTGTGCTTC RXS03220-coding Region ATGGGCTTAAGGGAAATTTTGTCCAGCAAGTGGCTTGTGCGCATCCTCCTGGTAGGTATCGGATTGGGT GTCGCACAGCAGCTGACCGGCATCAACTCCATCATGTACTACGGCCAGGTTGTTCTCATTGAGGCTGGT TTCTCCGAGAATGCAGCTCTGATCGCCAACGTGGCGCCAGGAGTGATCGCAGTTGTCGGTGCATTCATC GCACTGTGGATGATGGATGGTATCAACCGCCGTACCACCGTCATTAGCGGTTATTCTCTCACCACCATT AGCCACGTATTGATCGGTATCGCATGCGTAGCATTCCCAGTGGGCGATCCTCTTCGCCCCTACGTTATC TTGACTCTGGTTGTGGTCTTGGTGGGATCGATGCAGAGCTTCCTCAACGTAGCTACCTGGGTTATGCTG TCTGAGCTCTTCCCGCTGGCAATGCGCGGTTTGGCAATCGGTATCTCAGTGTTCTTCCTCTGGATCGCA AACGCGTTCCTCGGATTGTTCTTGCCAACCATCATGGAAGCAGTAGGACTAACCGGAACCTTCTTCATG TTCGCCGGAATCGGTGTGGTTGCCTTGATCTTCATCTAGACCCAGGTTCCTGAAACTCGTGGACGTACC TTGGAGGAGATTGATGAGGATGTTACTTCCGGTGTCATTTTCAACAAGGACATCCGAAAAGGAAAGGTG CAC RXS03220-3′-Region TAAAAACCCAGACACTGCATAGATAACACG RXS03221-5′-Region CAAAAGTATTCAAAAAAAGTTTGTTATGTACCATTGACGGGACATATCGTGTCTGCCACGATTAAAGAC ATTGGTGATGTGAATCACTGCCTACTACATC RXS03221-coding Region GTGTTTCGTGACCCTGCACCTCCAAGTAAGGGCACGACAAACTTAGGAGACAAGATGGCTAGTACCTTC ATTCAGGCCGACAGCCCTGAAAAAAGTAAGAAGCTGCCCCCACTCACAGAAGGTCCGTATAGAAAGCGG CTATTCTACGTTGCACTAGTTGCGACGTTTGGTGGGCTGCTCTTCGGATATGACACCGGAGTAATCAAC GGTGCACTCAACCCAATGACACGTGAGCTCGGACTAACCGCGTTCACCGAGGGTGTTGTAACTTCTTCC CTGCTGTTTGGTGCAGCAGCTGGTGCGATGTTTTTCGGTCGCATTTCCGACAACTGGGGTCGCCGGAAA ACAATCATCTCACTTGCAGTAGCTTTCTTTGTCGGCACCATGATCTGCGTGTTTGCTCCATCTTTTGCA GTAATGGTTGTCGGACGTGTGCTTCTTGGACTCGCAGTTGGTGGCGCTTCCACTGTTGTCCCTGTCTAC CTGGCTGAACTTGCTCCTTTTGAAATCCGTGGCTCACTGGCTGGCCGTAATGAGTTGATGATTGTTGTT GGTCAGCTCGCAGCTTTTGTCATCAATGCGATTATTGGAAATGTTTTTGGACACCACGATGGTGTGTGG CGCTACATGCTGGCAATTGCCGCAATCCCAGCAATTGCCCTCTTCTTTGGAATG

TABLE 4 ALIGNMENT RESULTS length % homology Date of ID # (NT) Genbank Hit Length Accession Name of Genbank Hit Source of Genbank Hit (GAP) Deposit rxa00001 1251 GB_BA1:SRMSIK 2384 Y08921 S. reticuli gene encoding Msik protein and orf1. Streptomyces reticuli 63,746 21-MAR-1997 GB_BA1:SLU12007 1602 U12007 Streptomyces lividans 1326 ATP binding protein MsiK (msiK) gene, Streptomyces lividans 62,951 30-MAR-1996 complete cds. GB_BA1:MTCY16B7 43430 Z81331 Mycobacterium tuberculosis H37Rv complete genome; segment 123/162. Mycobacterium 41,425 17-Jun-98 tuberculosis rxa00002 807 GB_BA1:MTV018 53450 AL021899 Mycobacterium tuberculosis H37Rv complete genome; segment 90/162. Mycobacterium 37,913 18-Jun-98 tuberculosis GB_EST22:AU020788 558 AU020788 AU020788 Mouse eight-cell stage embryo cDNA Mus musculus cDNA Mus musculus 38,757 19-OCT-1998 clone J0538B03 3′, mRNA sequence. GB_PR3:AC004160 143751 AC004160 Homo sapiens BAC clone GS164B05 from 7p21-p22, complete sequence. Homo sapiens 35,687 20-Feb-98 rxa00089 1122 GB_EST27:AI461009 570 AI461009 sa77g07.y1 Gm-c1004 Glycine max cDNA clone GENOME SYSTEMS Glycine max 37,833 01-DEC-1999 CLONE ID: Gm-c1004-5365 5′ similar to TR: O04014 O04014 RIBOSOMAL PROTEIN S6 RPS6-1.;, mRNA sequence. GB_EST32:AI736780 474 AI736780 sb33d08.y1 Gm-c1012 Glycine max cDNA clone GENOME SYSTEMS Glycine max 37,367 06-DEC-1999 CLONE ID: Gm-c1012-232 5′ similar to TR: O04014 O04014 RIBOSOMAL PROTEIN S6 RPS6-1.;, mRNA sequence. GB_EST30:AI637616 280 AI637616 tt10c03.x1 NCI_CGAP_GC6 Homo sapiens cDNA clone IMAGE: 2240356 Homo sapiens 37,455 27-Apr-99 3′, mRNA sequence. rxa00090 1242 GB_PL1:SCYOR023C 1989 Z74931 S. cerevisiae chromosome XV reading frame ORF YOR023c. Saccharomyces 36,078 11-Aug-97 cerevisiae GB_GSS15:AQ659370 487 AQ659370 Sheared DNA-5C3.TR Sheared DNA Trypanosoma brucei genomic clone Trypanosoma brucei 44,920 23-Jun-99 Sheared DNA-5C3, genomic survey sequence. GB_PL1:MZEHSZEIN 2123 L29505 Zea mays high sulfur zein gene, complete cds. Zea mays 37,245 24-MAR-1994 rxa00099 1296 GB_HTG1:HSDA14C6 155908 AL049732 Homo sapiens chromosome X clone RP6-14C6, *** SEQUENCING IN Homo sapiens 35,984 23-Nov-99 PROGRESS ***, in unordered pieces. GB_HTG1:HSDA14C6 155908 AL049732 Homo sapiens chromosome X clone RP6-14C6, *** SEQUENCING IN Homo sapiens 35,984 23-Nov-99 PROGRESS ***, in unordered pieces. GB_PL2:ATF22I13 93760 AL035539 Arabidopsis thaliana DNA chromosome 4, BAC clone F22I13 (ESSA Arabidopsis thaliana 35,161 27-Aug-99 project). rxa00123 1242 GB_PL1:OS4CL 5225 X52623 Rice 4-CL gene for 4-coumarate-CoA ligase (EC 6.2.1.12). Oryza sativa 39,330 7-Apr-93 GB_BA1:AB020531 6445 AB020531 Escherichia coli plasmid pTZ3721 gene cluster containing the mphB gene Escherichia coli 36,923 20-Feb-99 for macrolide 2′-phosphotransferase II, complete cds. GB_PL1:OS4CL 5225 X52623 Rice 4-CL gene for 4-coumarate-CoA ligase (EC 6.2.1.12). Oryza sativa 39,118 7-Apr-93 rxa00160 696 GB_EST11:AA270696 178 AA270696 va46g09.r1 Soares mouse 3NME12 5 Mus musculus cDNA clone Mus musculus 46,067 26-MAR-1997 IMAGE: 734464 5′ similar to gb: M17886 60S ACIDIC RIBOSOMAL PROTEIN P1 (HUMAN); gb: U29402 Mus musculus acidic ribosomal phosphoprotein P1 mRNA, complete (MOUSE);, mRNA sequence. GB_HTG3:AC010829 149101 AC010829 Homo sapiens clone 6_J_21, LOW-PASS SEQUENCE SAMPLING. Homo sapiens 36,880 23-Sep-99 GB_HTG3:AC010829 149101 AC010829 Homo sapiens clone 6_J_21, LOW-PASS SEQUENCE SAMPLING. Homo sapiens 36,880 23-Sep-99 rxa00193 594 GB_PR3:AC005826 177585 AC005826 Homo sapiens clone UWGC: rg041a03 from 7p14-15, complete sequence. Homo sapiens 37,012 16-OCT-1998 GB_HTG2:AC007076 95477 AC007076 Homo sapiens clone DJ0698F07, *** SEQUENCING IN PROGRESS ***, 1 Homo sapiens 37,012 5-Jun-99 unordered pieces. GB_HTG2:AC007076 95477 AC007076 Homo sapiens clone DJ0698F07, *** SEQUENCING IN PROGRESS ***, 1 Homo sapiens 37,012 5-Jun-99 unordered pieces. rxa00203 1035 GB_GSS3:B88972 699 B88972 CIT-HSP-2173C11.TR CIT-HSP Homo sapiens genomic clone 2173C11, Homo sapiens 41,411 25-Jun-98 genomic survey sequence. GB_GSS11:AQ290299 642 AQ290299 nbxb0036N17r CUGI Rice BAC Library Oryza sativa genomic clone Oryza sativa 38,245 03-DEC-1998 nbxb0036N17r, genomic survey sequence. GB_EST20:AA843374 479 AA843374 aj16e10.s1 Soares_parathyroid_tumor_NbHPA Homo sapiens cDNA clone Homo sapiens 34,874 31-DEC-1998 IMAGE: 1390506 3′, mRNA sequence. rxa00204 1695 GB_BA1:SC3F9 19830 AL023862 Streptomyces coelicolor cosmid 3F9. Streptomyces coelicolor 49,556 10-Feb-99 GB_BA2:AF160811 10671 AF160811 Bacillus stearothermophilus L-arabinose transport, ATP binding protein Bacillus 51,004 28-Jul-99 (araG), L-arabinose membrane permease (araH), AraR (araR), L-ribulose 5- stearothermophilus phosphate 4-epimerase (araD), L-ribulokinase (araB), L-arabinose isomerase (araA), and IS5377 transposase genes, complete cds. GB_BA2:MPAE000056 16213 AE000056 Mycoplasma pneumoniae section 56 of 63 of the complete genome. Mycoplasma 34,895 18-Nov-96 pneumoniae rxa00270 1011 GB_BA1:MLCB1770 37821 Z70722 Mycobacterium leprae cosmid B1770. Mycobacterium leprae 37,089 29-Aug-97 GB_GSS4:AQ681972 452 AQ681972 HS_5503_B2_C02_T7A RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 40,099 28-Jun-99 genomic clone Plate = 1079 Col = 4 Row = F, genomic survey sequence. GB_VI:IVU47137 986 U47137 Inkoo virus Prototype KN3641 nucleocapsid protein and non-structural Inkoo virus 37,061 22-Aug-96 protein genes, complete cds. rxa00311 978 GB_VI:VMVY16780 186986 Y16780 variola minor virus complete genome. variola minor virus 37,722 2-Sep-99 GB_VI:VARCG 186103 L22579 Variola major virus (strain Bangladesh-1975) complete genome. Variola major virus 38,558 12-Jan-95 GB_VI:VVCGAA 185578 X69198 Variola virus DNA complete genome. Variola virus 39,518 13-DEC-1996 rxa00312 549 GB_HTG4:AC011190 164409 AC011190 Homo sapiens clone hRPK.24_A_1, *** SEQUENCING IN PROGRESS Homo sapiens 34,741 19-OCT-1999 ***, 31 unordered pieces. GB_HTG4:AC011190 164409 AC011190 Homo sapiens clone hRPK.24_A_1, *** SEQUENCING IN PROGRESS Homo sapiens 34,741 19-OCT-1999 ***, 31 unordered pieces. GB_HTG4:AC011190 164409 AC011190 Homo sapiens clone hRPK.24_A_1, *** SEQUENCING IN PROGRESS Homo sapiens 34,807 19-OCT-1999 ***, 31 unordered pieces. rxa00345 1074 GB_HTG2:AC007356 185382 AC007356 Drosophila melanogaster chromosome 2 clone BACR24H09 (D595) RPCI- Drosophila 36,364 2-Aug-99 98 24.H.9 map 49A-49B strain y; cn bw sp, *** SEQUENCING IN melanogaster PROGRESS ***, 13 unordered pieces. GB_HTG2:AC007356 185382 AC0007356 Drosophila melanogaster chromosome 2 clone BACR24H09 (D595) RPCI- Drosophila 36,364 2-Aug-99 98 24.H.9 map 49A-49B strain y; cn bw sp, *** SEQUENCING IN melanogaster PROGRESS ***, 13 unordered pieces. GB_HTG2:AC005814 183922 AC005814 Drosophila melanogaster chromosome 3 clone BACR48M07 (D471) RPCI- Drosophila 38,031 30-Jul-99 98 48.M.7 map 64A6-64B6 strain y; cn bw sp, *** SEQUENCING IN melanogaster PROGRESS ***, 11 unordered pieces. rxa00378 2733 GB_BA2:ALW243431 26953 AJ243431 Acinetobacter Iwoffii wzc, wzb, wza, weeA, weeB, wceC, wzx, wzy, weeD, Acinetobacter Iwoffii 36,717 01-OCT-1999 weeE, weeF, weeG, weeH, weeI, weeJ, weeK, galU, ugd, pgi, galE, pgm (partial) and mip (partial) genes (emulsan biosynthetic gene cluster), strain RAG-1. GB_BA2:ALW243431 26953 AJ243431 Acinetobacter Iwoffii wzc, wzb, wza, weeA, weeB, wceC, wzx, wzy, weeD, Acinetobacter Iwoffii 36,394 01-OCT-1999 weeE, weeF, weeG, weeH, weeI, weeJ, weeK, galU, ugd, pgi, galE, pgm (partial) and mip (partial) genes (emulsan biosynthetic gene cluster), strain RAG-1. GB_RO:MMCOL3A1 43601 X52046 M. musculus COL3A1 gene for collagen alpha-I. Mus musculus 35,159 8-Nov-94 rxa00412 1203 GB_BA1:ECU70214 123171 U70214 Escherichia coli chromosome minutes 4-6. Escherichia coli 39,914 21-Sep-96 GB_BA1:ECOTSF 91430 D83536 Escherichia coli genomic DNA. (4.1-6.1 min). Escherichia coli 39,828 28-MAY-1999 GB_HTG3:AC011366 177590 AC011366 Homo sapiens chromosome 5 clone CIT-HSPC_568L21, *** Homo sapiens 46,212 06-OCT-1999 SEQUENCING IN PROGRESS ***, 82 unordered pieces. rxa00413 1020 GB_PR3:AC005209 184130 AC005209 Homo sapiens chromosome 17, clone hRPK.628_O_18, complete Homo sapiens 34,028 24-Jul-98 sequence. GB_PR3:HUMIL8R 13089 M99412 Human interleukin-8 receptor (IL8RB) gene, complete cds. Homo sapiens 37,934 22-Apr-98 GB_PR4:AC006974 90241 AC006974 Homo sapiens PAC clone DJ0958B11 from 7q33-q36, complete sequence. Homo sapiens 37,948 29-Jul-99 rxa00431 912 GB_BA1:MSGY126 37164 AD000012 Mycobacterium tuberculosis sequence from clone y126. Mycobacterium 66,776 10-DEC-1996 tuberculosis GB_BA1:MTY13D12 37085 Z80343 Mycobacterium tuberculosis H37Rv complete genome; segment 156/162. Mycobacterium 66,776 17-Jun-98 tuberculosis GB_BA1:MSGB971CS 37566 L78821 Mycobacterium leprae cosmid B971 DNA sequence. Mycobacterium leprae 39,429 15-Jun-96 rxa00444 960 GB_PR4:AC007564 194058 AC007564 Homo sapiens 12q22 BAC RPCI11-513P18 (Roswell Park Cancer Institute Homo sapiens 35,220 3-Jul-99 Human BAC Library) complete sequence. GB_HTG4:AC007553 271496 AC007553 Homo sapiens chromosome 12q22-102.7-103.4 clone RPCI11-557K11, *** Homo sapiens 35,408 21-OCT-1999 SEQUENCING IN PROGRESS ***, 70 unordered pieces. GB_HTG4:AC007553 271496 AC007553 Homo sapiens chromosome 12q22-102.7-103.4 clone RPCI11-557K11, *** Homo sapiens 35,408 21-OCT-1999 SEQUENCING IN PROGRESS ***, 70 unordered pieces. rxa00445 1035 GB_HTG3:AC011455_0 244238 AC011455 Homo sapiens chromosome 19 clone CIT-HSPC_360G5, *** Homo sapiens 35,455 19-Dec-99 SEQUENCING IN PROGRESS ***, 287 unordered pieces. GB_HTG3:AC011455_0 244238 AC011455 Homo sapiens chromosome 19 clone CIT-HSPC_360G5, *** Homo sapiens 35,455 19-Dec-99 SEQUENCING IN PROGRESS ***, 287 unordered pieces. GB_HTG3:AC011455_0 244238 AC011455 Homo sapiens chromosome 19 clone CIT-HSPC_360G5, *** Homo sapiens 41,511 19-Dec-99 SEQUENCING IN PROGRESS ***, 287 unordered pieces. rxa00466 rxa00482 771 GB_PR4:AF119709 43566 AF119709 Homo sapiens chromosome 8q24 BAC clone H103, complete sequence. Homo sapiens 36,724 28-Feb-99 GB_RO:AC005960 158414 AC005960 Mus musculus chromosome 17 BAC citb20h22 from the MHC region, Mus musculus 39,836 01-DEC-1998 complete sequence. GB_RO:MUSMHH2M4X 3994 L14278 Mouse MHC class I H2-M4 gene, exons 1-5. Mus musculus 32,713 11-Aug-93 rxa00523 1149 GB_BA2:AF176902 3032 AF176902 Corynebacterium diphtheriae IRP1B (irp1B), IRP1C (irp1C), and IRP1D Corynebacterium 58,781 5-Sep-99 (irp1D) genes, complete cds. diphtheriae GB_HTG3:AC002489 91638 AC002489 Mus musculus chromosome X clone 592 map X, *** SEQUENCING IN Mus musculus 37,819 3-Aug-99 PROGRESS ***, 8 unordered pieces. GB_HTG3:AC002489 91638 AC002489 Mus musculus chromosome X clone 592 map X, *** SEQUENCING IN Mus musculus 37,819 3-Aug-99 PROGRESS ***, 8 unordered pieces. rxa00525 1386 GB_BA1:D90917 154619 D90917 Synechocystis sp. PCC6803 complete genome, 27/27, 3418852-3573470. Synechocystis sp. 46,966 7-Feb-99 GB_PL1:AOF132610 477 AJ132610 Asparagus officinalis mRNA for intracellular pathogenesis-related protein, Asparagus officinalis 38,819 1-Feb-99 isoform 4. GB_PAT:A26571 737 A26571 A. officinalis AoPR1 gene. Asparagus officinalis 37,620 28-Sep-95 rxa00596 576 GB_PR3:AC004659 129577 AC004659 Homo sapiens chromosome 19, CIT-HSP-87m17 BAC clone, complete Homo sapiens 34,321 02-MAY-1998 sequence. GB_PR3:AC004659 129577 AC004659 Homo sapiens chromosome 19, CIT-HSP-87m17 BAC clone, complete Homo sapiens 35,739 02-MAY-1998 sequence. GB_PR1:HUMCBP2 2047 D83174 Human mRNA for collagen binding protein 2, complete cds. Homo sapiens 40,404 6-Feb-99 rxa00634 1506 GB_BA1:BRLBIOAD 2272 D14083 Brevibacterium flavum genes for 7,8-diaminopelargonic acid Corynebacterium 39,111 3-Feb-99 aminotransferase and dethiobiotin synthetase, complete cds. glutamicum GB_PAT:E08643 285 E08643 Base sequence having the promoter function in Corynebacterium Corynebacterium 39,111 29-Sep-97 microorganisms. glutamicum GB_HTG2:AC006174 203407 AC006174 Homo sapiens chromosome 10 clone CIT987SK-1057L21 map 10q25, *** Homo sapiens 37,517 09-DEC-1998 SEQUENCING IN PROGRESS ***, 6 unordered pieces. rxa00665 601 GB_BA1:SCI30A 35033 AL096811 Streptomyces coelicolor cosmid I30A. Streptomyces coelicolor 38,095 22-Jul-99 A3(2) GB_PR3:AC002366 259202 AC002366 Human Xp22 BAC CT-285I15 (from CalTech/Research Genetics), PAC Homo sapiens 33,045 11-Jun-98 RPCI1-27C22 (from Roswell Park Cancer Center), and Cosmid U35B5 (from Lawrence Livermore), complete sequence. GB_PR3:AC002366 259202 AC002366 Human Xp22 BAC CT-285I15 (from CalTech/Research Genetics), PAC Homo sapiens 35,214 11-Jun-98 RPCI1-27C22 (from Roswell Park Cancer Center), and Cosmid U35B5 (from Lawrence Livermore), complete sequence. rxa00702 1830 GB_BA1:PLNRTABC 6449 Z19598 P. laminosum nrtA-PhI, nir-PhI, nrtB-PhI and nrtC-PhI genes. Phormidium laminosum 40,550 7-Feb-96 GB_GSS10:AQ256518 704 AQ256518 nbxb0016M14r CUGI Rice BAC Library Oryza sativa genomic clone Oryza sativa 41,477 23-OCT-1998 nbxb0016M14r, genomic survey sequence. GB_BA1:AAC243194 1720 AJ243194 Alicyclobacillus acidocaldarius kdpA gene. Alicyclobacillus 39,740 21-Jun-99 acidocaldarius rxa00728 892 GB_EST21:AA974252 426 AA974252 oq14a01.s1 NCI_CGAP_GC4 Homo sapiens cDNA clone IMAGE: 1586280 Homo sapiens 42,236 7-Jul-98 3′ similar to SW:LIPA_ECOLI P25845 LIPOIC ACID SYNTHETASE; contains MER22.t2 MER22 repetitive element;, mRNA sequence. GB_HTG2:AC004060 124000 AC004060 Homo sapiens chromosome 4, *** SEQUENCING IN PROGRESS ***, 10 Homo sapiens 38,106 21-Jul-98 unordered pieces. GB_HTG2:AC004060 124000 AC004060 Homo sapiens chromosome 4, *** SEQUENCING IN PROGRESS ***, 10 Homo sapiens 38,106 21-Jul-98 unordered pieces. rxa00732 1670 GB_BA2:AE000241 10160 AE000241 Escherichia coli K-12 MG1655 section 131 of 400 of the complete genome. Escherichia coli 40,024 12-Nov-98 GB_HTG3:AC010073 121859 AC010073 Homo sapiens chromosome 15 clone BAC 16E3 map 15q25, LOW-PASS Homo sapiens 39,001 11-Sep-99 SEQUENCE SAMPLING. GB_BA1:D90783 15399 D90783 E. coli genomic DNA, Kohara clone #272(32.4-32.7 min.). Escherichia coli 40,024 29-MAY-1997 rxa00759 1047 GB_BA1:MTV025 121125 AL022121 Mycobacterium tuberculosis H37Rv complete genome; segment 155/162. Mycobacterium 39,960 24-Jun-99 tuberculosis GB_PL1:BPNIR1 2472 X60093 B. pendula mRNA for nitrite reductase. Betula pendula 38,106 19-MAR-1992 GB_BA1:MTV025 121125 AL022121 Mycobacterium tuberculosis H37Rv complete genome; segment 155/162. Mycobacterium 41,618 24-Jun-99 tuberculosis rxa00760 1155 GB_BA2:AF092918 20758 AF092918 Pseudomonas alcaligenes outer membrane Xcp-secretion system gene Pseudomonas 40,450 06-DEC-1998 cluster. alcaligenes GB_BA1:SCI7 34893 AL096743 Streptomyces coelicolor cosmid I7. Streptomyces coelicolor 40,352 1-Jul-99 GB_BA1:D90763 18199 D90763 E. coli genomic DNA, Kohara clone #252(28.1-28.4 min.). Escherichia coli 38,747 29-MAY-1997 rxa00774 777 GB_EST8:AA020814 419 AA020814 ze63h10.s1 Soares retina N2b4HR Homo sapiens cDNA clone Homo sapiens 37,500 30-Jan-97 IMAGE: 363715 3′ similar to PIR:A35715 A35715 fodrin alpha chain - human;, mRNA sequence. GB_PL2:ATAC004521 104797 AC004521 Arabidopsis thaliana chromosome II BAC F4I1 genomic sequence, Arabidopsis thaliana 36,411 12-MAY-1998 complete sequence. GB_PL2:ATAC004521 104797 AC004521 Arabidopsis thaliana chromosome II BAC F4I1 genomic sequence, Arabidopsis thaliana 38,589 12-MAY-1998 complete sequence. rxa00775 894 GB_BA1:MTV043 68848 AL022004 Mycobacterium tuberculosis H37Rv complete genome; segment 40/162. Mycobacterium 66,107 24-Jun-99 tuberculosis GB_BA2:AF045938 777 AF045938 Mycobacterium smegmatis putative ABC transporter nucleotide binding Mycobacterium 73,454 02-MAY-1998 subunit (mtp1) gene, complete cds. smegmatis GB_BA1:MLU15182 40123 U15182 Mycobacterium leprae cosmid B2266. Mycobacterium leprae 63,494 09-MAR-1995 rxa00776 1044 GB_PR3:HS453C12 147620 AL021578 Human DNA sequence from clone 453C12 on chromosome 20q12-13.12, Homo sapiens 35,833 23-Nov-99 complete sequence. GB_PR3:AC004877 128361 AC004877 Homo sapiens PAC clone DJ0751H13 from 7q35-qter, complete sequence. Homo sapiens 38,754 19-Sep-98 GB_PR3:HS300I2 63796 AL035660 Human DNA sequence from clone 300I2 on chromosome 20q12-13.12, Homo sapiens 32,233 23-Nov-99 complete sequence. rxa00777 1188 GB_BA1:ASAJ187 6213 AJ000187 Arthrobacter sp. catA gene. Arthrobacter sp. 49,694 5-Jul-99 GB_IN1:CELT20D4 42052 U80029 Caenorhabditis elegans cosmid T20D4. Caenorhabditis elegans 36,457 04-DEC-1996 GB_GSS4:AQ693388 531 AQ693388 HS_5458_A2_D10_T7A RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 38,123 6-Jul-99 genomic clone Plate = 1034 Col = 20 Row = G, genomic survey sequence. rxa00828 576 GB_GSS1:CNS00ZMZ 796 AL097877 Drosophila melanogaster genome survey sequence SP6 end of BAC Drosophila 39,286 26-Jul-99 BACN02F13 of DrosBAC library from Drosophila melanogaster (fruit fly), melanogaster genomic survey sequence. GB_BA1:PSEBPH 4169 D16407 Pseudomonas sp. bphE, bphG, bphF and ORF4 genes. Pseudomonas sp. 36,364 4-Feb-99 GB_GSS9:AQ156606 668 AQ156606 nbxb0008K19r CUGI Rice BAC Library Oryza sativa genomic clone Oryza sativa 36,364 12-Sep-98 nbxb0008K19r, genomic survey sequence. rxa00832 1173 GB_PR4:AC006504 210137 AC006504 Homo sapiens chromosome 19, BAC 326584 (CIT-B-459F4), complete Homo sapiens 40,545 4-Feb-99 sequence. GB_GSS12:AQ417775 642 AQ417775 RPCI-11-197B9.TVRPCI-11 Homo sapiens genomic clone RPCI-11- Homo sapiens 44,286 23-MAR-1999 197B9, genomic survey sequence. GB_PR4:AC006504 210137 AC006504 Homo sapiens chromosome 19, BAC 326584 (CIT-B-459F4), complete Homo sapiens 35,886 4-Feb-99 sequence. rxa00934 1206 GB_BA1:MLCL581 36225 Z96801 Mycobacterium leprae cosmid L581. Mycobacterium leprae 38,243 24-Jun-97 GB_BA1:MTCY1A10 25949 Z95387 Mycobacterium tuberculosis H37Rv complete genome; segment 117/162. Mycobacterium 38,350 17-Jun-98 tuberculosis GB_PR3:HS434O14 135928 AL022398 Homo sapiens DNA sequence from PAC 434O14 on chromosome 1q32.3.-41. Homo sapiens 36,788 23-Nov-99 Contains the HSD11B1 gene for Hydroxysteroid (11-beta) Dehydrogenase 1, the ADORA2BP adenosine A2b receptor LIKE pseudogene, the IRF6 gene for Interferon Regulatory Factor 6 and two novel genes. Contains ESTs and GSSs, complete sequence. rxa00939 1308 GB_BA1:MTCY251 38380 Z74410 Mycobacterium tuberculosis H37Rv complete genome; segment 5/162. Mycobacterium 49,462 17-Jun-98 tuberculosis GB_PAT:I26656 3250 I26656 Sequence 1 from U.S. Pat. No. 5559011. Unknown. 49,462 07-OCT-1996 GB_BA2:SCJ1 36925 AL109962 Streptomyces coelicolor cosmid J1. Streptomyces coelicolor 49,228 24-Sep-99 A3(2) rxa00942 327 GB_IN1:CELT19D2 28406 U42846 Caenorhabditis elegans cosmid T19D2. Caenorhabditis elegans 43,910 19-DEC-1995 GB_PR4:AC004905 134350 AC004905 Homo sapiens PAC clone DJ0845I21 from 7q11.21-q11.23, complete Homo sapiens 35,505 12-Jan-99 sequence. GB_IN1:CELF18C5 29095 U29097 Caenorhabditis elegans cosmid F18C5. Caenorhabditis elegans 37,107 15-Jun-95 rxa00950 1029 GB_BA1:SLTNRB 2849 X73633 S. longisporoflavus TnrB gene. Streptomyces 52,255 9-Aug-94 longisporoflavus GB_BA1:MTCI364 29540 Z93777 Mycobacterium tuberculosis H37Rv complete genome; segment 52/162. Mycobacterium 38,872 17-Jun-98 tuberculosis GB_BA1:MSGY367 35336 AD000008 Mycobacterium tuberculosis sequence from clone y367. Mycobacterium 39,921 03-DEC-1996 tuberculosis rxa00960 1058 GB_PL2:ATAC009325 105543 AC009325 Arabidopsis thaliana chromosome III BAC F4P13 genomic sequence, Arabidopsis thaliana 36,074 08-OCT-1999 complete sequence. GB_BA2:U59485 29078 U59485 Agrobacterium tumefaciens AtrC (atrC) gene, partial cds; AtrB (atrB), AtrA Agrobacterium 39,884 16-Jul-99 (atrA), AttA1 (attA1), AttA2 (attA2), AttB (attB), AttC (attC), AttD (attD), AttE tumefaciens (attE), and AttF (attF) genes, complete cds; AttG (attG) gene, alternative splice products, complete cds; AttH (attH), AttI (attI), AttJ (attJ), AttK (attK), AttL (attL), AttM (attM), AttO (attO), AttP (attP), AttR (attR), AttS (attS), AttT (attT), AttU (attU), attV (attV), AttW (attW), AttX (attX), AttY (attY), AttZ (attZ), AtsA (atsA), AtsB (atsB), AtsC (atsC), and AtsD (atsD) genes, complete cds; and AtsE (atsE) gene, partial cds. GB_PL2:ATAC009325 105543 AC009325 Arabidopsis thaliana chromosome III BAC F4P13 genomic sequence, Arabidopsis thaliana 36,162 08-OCT-1999 complete sequence. rxa00980 1917 GB_BA1:MTCY10D7 39800 Z79700 Mycobacterium tuberculosis H37Rv complete genome; segment 44/162. Mycobacterium 48,176 17-Jun-98 tuberculosis GB_GSS10:AQ255373 639 AQ255373 mgxb0012D24r CUGI Rice Blast BAC Library Magnaporthe grisea genomic Magnaporthe grisea 38,624 23-OCT-1998 clone mgxb0012D24r, genomic survey sequence. GB_EST26:AU004809 728 AU004809 AU004809 Bombyx mori p50(Daizo) Bombyx mori cDNA clone ws20873, Bombyx mori 38,223 19-Jan-99 mRNA sequence. rxa01000 rxa01002 927 GB_BA2:AE001197 10039 AE001197 Treponema pallidum section 13 of 87 of the complete genome. Treponema pallidum 37,161 16-Jul-98 GB_PL1:HVPGLYH 3790 Y10099 H. vulgare mRNA for novel P-glycoprotein homologue. Hordeum vulgare 42,239 24-OCT-1997 GB_IN1:AB003329 4328 AB003329 Leishmania amazonensis LaMDR1 multidrug resistance gene, complete Leishmania 40,176 24-MAR-1999 cds. amazonensis rxa01003 927 GB_HTG2:HSJ168B21 67973 AL118518 Homo sapiens chromosome 6 clone RP1-168B21 map q26-27, *** Homo sapiens 35,159 03-DEC-1999 SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG2:HSJ168B21 67973 AL118518 Homo sapiens chromosome 6 clone RP1-168B21 map q26-27, *** Homo sapiens 35,159 03-DEC-1999 SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG2:HSJ168B21 67973 AL118518 Homo sapiens chromosome 6 clone RP1-168B21 map q26-27, *** Homo sapiens 39,956 03-DEC-1999 SEQUENCING IN PROGRESS ***, in unordered pieces. rxa01006 958 GB_IN2:S74163 2630 S74163 Drosophila sp. T-related protein (Trg) mRNA, complete cds. Drosophila sp. 37,131 06-OCT-1999 GB_PR4:AF130343 292721 AF130343 Homo sapiens chromosome 8 clone PAC 87.2 map 8q24.1, complete Homo sapiens 34,398 9-Jul-99 sequence. GB_HTG3:AC009415 186991 AC009415 Homo sapiens clone NH0576H09,*** SEQUENCING IN PROGRESS ***, Homo sapiens 36,325 21-Aug-99 5 unordered pieces. rxa01012 1764 GB_BA1:SYOATPBP 2883 D14438 Synechococcus elongatus genes for ATP-binding protein and Mn- Synechococcus 50,346 3-Feb-99 stabilizing protein. elongatus GB_BA1:BSU20909 6404 U20909 Bacillus subtilis permease system App operon AppD (appD), AppF(appF), Bacillus subtilis 50,376 23-Feb-95 AppA (appA), AppB (appB), and AppC (appC) genes, complete cds. GB_BA2:ECOPOTABCD 4385 M64519 E. coli transport protein (potA, potB, potC and potD) genes, complete cds. Escherichia coli 42,881 17-Jun-96 rxa01013 818 GB_IN2:AC005930 41284 AC005930 Leishmania major chromosome 3 clone L712 strain Friedlin, complete Leishmania major 40,444 13-Nov-99 sequence. GB_PR2:HS1110P6 40033 AL049175 Human DNA sequence from clone 1110P6 on chromosome Xq21.1-22.3. Homo sapiens 36,981 23-Nov-99 Contains a putative CpG island, complete sequence. GB_IN2:AC005930 41284 AC005930 Leishmania major chromosome 3 clone L712 strain Friedlin, complete Leishmania major 44,121 13-Nov-99 sequence. rxa01070 1509 GB_BA2:U32795 10038 U32795 Haemophilus influenzae Rd section 110 of 163 of the complete genome. Haemophilus influenzae 44,668 29-MAY-1998 Rd GB_PR4:AC004985 159507 AC004985 Homo sapiens clone DJ1165K10, complete sequence. Homo sapiens 37,508 7-Aug-99 GB_PR3:AC005244 127506 AC005244 Homo sapiens chromosome 17, clone hRPK.471_L_13, complete Homo sapiens 33,176 7-Aug-98 sequence. rxa01094 736 GB_BA1:CORPYKI 2795 L27126 Corynebacterium pyruvate kinase gene, complete cds. Corynebacterium 99,558 07-DEC-1994 glutamicum GB_BA1:SC4G6 36917 AL096884 Streptomyces coelicolor cosmid 4G6. Streptomyces coelicolor 37,569 23-Jul-99 A3(2) GB_HTG1:CNS01DS1 216986 AL121612 Homo sapiens chromosome 14 clone R-179A9, *** SEQUENCING IN Homo sapiens 38,577 15-OCT-1999 PROGRESS ***, in unordered pieces. rxa01141 948 GB_HTG2:HSJ395C13 150336 AL117344 Homo sapiens chromosome 6 clone RP3-395C13 map q25.2-26, *** Homo sapiens 36,538 03-DEC-1999 SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG2:HSJ395C13 150336 AL117344 Homo sapiens chromosome 6 clone RP3-395C13 map q25.2-26, *** Homo sapiens 36,538 03-DEC-1999 SEQUENCING IN PROGRESS ***, in unordered pieces. GB_HTG2:HSJ395C13 150336 AL117344 Homo sapiens chromosome 6 clone RP3-395C13 map q25.2-26, Homo sapiens 37,908 03-DEC-1999 ***SEQUENCING IN PROGRESS ***, in unordered pieces. rxa01142 621 GB_BA1:CORAIA 4705 L09232 Corynebacterium glutamicum acetohydroxy acid synthase (ilvB) and (ilvN) Corynebacterium 35,897 23-Feb-95 genes, and acetohydroxy acid isomeroreductase (ilvC) gene, complete cds. glutamicum GB_BA1:SCH35 45396 AL078610 Streptomyces coelicolor cosmid H35. Streptomyces coelicolor 52,295 4-Jun-99 GB_BA2:AFACHRRA 7390 J05278 Ralstonia eutropha ChrB (chrB), ChrA (chrA), ChrC (chrC), ChrD (chrD), Ralstonia eutropha 54,589 26-MAR-1999 YbiB (ybiB), pirin, and heat shock protein sigma-32 (RP32) genes, complete cds. rxa01164 1758 GB_GSS14:AQ555104 609 AQ555104 RPCI-11-415H1.TJ RPCI-11 Homo sapiens genomic clone RPCI-11- Homo sapiens 40,000 28-MAY-1999 415H1, genomic survey sequence. GB_BA2:AE000309 13453 AE000309 Escherichia coli K-12 MG1655 section 199 of 400 of the complete genome. Escherichia coli 39,261 12-Nov-98 GB_GSS14:AQ548213 668 AQ548213 RPCI-11-415H4.TV RPCI-11 Homo sapiens genomic clone RPCI-11- Homo sapiens 41,176 28-MAY-1999 415H4, genomic survey sequence. rxa01168 933 GB_BA1:MTV018 53450 AL021899 Mycobacterium tuberculosis H37Rv complete genome; segment 90/162. Mycobacterium 38,033 18-Jun-98 tuberculosis GB_PL2:ATAC003033 84254 AC003033 Arabidopsis thaliana chromosome II BAC T21L14 genomic sequence, Arabidopsis thaliana 37,486 19-DEC-1997 complete sequence. GB_PL2:ATAC003033 84254 AC003033 Arabidopsis thaliana chromosome II BAC T21L14 genomic sequence, Arabidopsis thaliana 38,142 19-DEC-1997 complete sequence. rxa01185 667 GB_BA2:AF013987 3150 AF013987 Vibrio cholerae strain 0395 putative ABC transporter ATP-binding protein, Vibrio cholerae 44,128 21-MAY-1998 sigma54 (rpoN), putative sigma54 modulation protein and nitrogen regulatory IIA protein (ptsN) genes, complete cds. GB_BA1:SASTPSMP 1848 Z30588 S. aureus (RN4220) genes for potential ABC transporter and potential Staphylococcus aureus 43,402 25-MAY-1995 membrane spanning protein. GB_PR3:HS357I16 134506 AL021921 Homo sapiens DNA sequence from PAC 357I16 on chromosome 1p36.13. Homo sapiens 38,957 23-Nov-99 Contains GSSs, genomic marker D1S449 and a CA repeat polymorphism, complete sequence. rxa01188 1227 GB_PR3:HSN21F1 39212 Z94162 Human DNA sequence from cosmid N21F1 on chromosome 22 Contains Homo sapiens 37,277 23-Nov-99 exon trap and STS, complete sequence. GB_EST38:AW066174 455 AW066174 687007C06.y1 687 —Early embryo from Delaware Zea mays cDNA, mRNA Zea mays 42,439 12-OCT-1999 sequence. GB_GSS4:AQ719542 493 AQ719542 HS_5529_B2_A02_SP6E RPCI-11 Human Male BAC Library Homo Homo sapiens 39,837 14-Jul-99 sapiens genomic clone Plate = 1105 Col = 4 Row = B, genomic survey sequence. rxa01247 357 GB_BA2:AF127374 63734 AF127374 Streptomyces lavendulae LinA homolog, cytochrome P450 hydroxylase Streptomyces 38,592 27-MAY-1999 ORF4, cytochrome P450 hydroxylase ORF3, MitT (mitT), MitS (mitS), MitR lavendulae (mitR), MitQ (mitQ), MitP (mitP), MitO (mitO), MitN (mitN), MitM (mitM), MitL (mitL), MitK (mitK), MitJ (mitJ), MitI (mitI), MitH (mitH), MitG (mitG), MitF (mitF), MitE (mitE), MitD (mitD), MitC (mitC), MitB (mitB), MitA (mitA), MmcA (mmcA), MmcB (mmcB), MmcC (mmcC), MmcD (mmcD), MmcE (mmcE), MmcF (mmcF), MmcG (mmcG), MmcH (mmcH), MmcI (mmcI), MmcJ (mmcJ), MmcK (mmcK), MmcL (mmcL), MmcM (mmcM), MmcN (mmcN), MmcO (mmcO), Mrd (mrd), MmcP (mmcP), MmcQ (mmcQ), MmcR (mmcR), MmcS (mmcS), MmcT (mmcT), MmcU (mmcU), MmcV (mmcV), Mct (mct), MmcW (mmcW), MmcX (mmcX), and MmcY (mmcY) genes, complete cds; and unknown genes. GB_BA2:AF127374 63734 AF127374 Streptomyces lavendulae LinA homolog, cytochrome P450 hydroxylase Streptomyces 45,915 27-MAY-1999 ORF4, cytochrome P450 hydroxylase ORF3, MitT (mitT), MitS (mitS), MitR lavendulae (mitR), MitQ (mitQ), MitP (mitP), MitO (mitO), MitN (mitN), MitM (mitM), MitL (mitL), MitK (mitK), MitJ (mitJ), MitI (mitI), MitH (mitH), MitG (mitG), MitF (mitF), MitE (mitE), MitD (mitD), MitC (mitC), MitB (mitB), MitA (mitA), MmcA (mmcA), MmcB (mmcB), MmcC (mmcC), MmcD (mmcD), MmcE (mmcE), MmcF (mmcF), MmcG (mmcG), MmcH (mmcH), MmcI (mmcI), MmcJ (mmcJ), MmcK (mmcK), MmcL (mmcL), MmcM (mmcM), MmcN (mmcN), MmcO (mmcO), Mrd (mrd), MmcP (mmcP), MmcQ (mmcQ), MmcR (mmcR), MmcS (mmcS), MmcT (mmcT), MmcU (mmcU), MmcV (mmcV), Mct (mct), MmcW (mmcW), MmcX (mmcX), and MmcY (mmcY) genes, complete cds; and unknown genes. GB_PR4:AC006039 176257 AC006039 Homo sapiens clone NH0319F03, complete sequence. Homo sapiens 30,899 05-MAY-1999 rxa01285 749 GB_BA1:SCI51 40745 AL109848 Streptomyces coelicolor cosmid I51. Streptomyces coelicolor 38,627 16-Aug-99 A3(2) GB_BA2:SCF34 38995 AL109974 Streptomyces coelicolor cosmid F34. Streptomyces coelicolor 38,586 24-Sep-99 A3(2) GB_BA2:MSU10425 4261 U10425 Mycobacterium smegmatis ferric exochelin uptake proteins FxuB (fxuB), Mycobacterium 61,230 07-DEC-1994 FxuA (fxuA) genes, complete cds, FxuC (fxuC) gene, partial cds, and ferric smegmatis exochelin biosynthesis protein FxbA (fxbA) gene, complete cds. rxa01289 1167 GB_BA1:SCI51 40745 AL109848 Streptomyces coelicolor cosmid I51. Streptomyces coelicolor 35,456 16-Aug-99 A3(2) GB_BA1:SCI51 40745 AL109848 Streptomyces coelicolor cosmid I51. Streptomyces coelicolor 37,576 16-Aug-99 A3(2) GB_EST31:AI704930 227 AI704930 UI-R-AB1-ys-c-07-0-UI.s1 UI-R-AB1 Rattus norvegicus cDNA clone UI-R- Rattus norvegicus 38,326 3-Jun-99 AB1-ys-c-07-0-UI 3′, mRNA sequence. rxa01290 1287 GB_HTG2:AC006892 299081 AC006892 Caenorhabditis elegans clone Y69A2, *** SEQUENCING IN PROGRESS Caenorhabditis elegans 33,727 26-Feb-99 ***, 10 unordered pieces. GB_HTG2:AC006892 299081 AC006892 Caenorhabditis elegans clone Y69A2, *** SEQUENCING IN PROGRESS Caenorhabditis elegans 33,727 26-Feb-99 ***, 10 unordered pieces. GB_PR3:HS508I15 131353 AL021707 Human DNA sequence from clone 508I15 on chromosome 22q12-13 Homo sapiens 34,803 23-Nov-99 Contains gene for GTPBP1 (GTP binding protein 1), two novel genes KIAA0063 and KIAA0668, an mRNA, ESTs, STSs, GSSs, a CA repeat (D22S272) and CpG islands, complete sequence. rxa01297 921 GB_BA1:MTCY16B7 43430 Z81331 Mycobacterium tuberculosis H37Rv complete genome; segment 123/162. Mycobacterium 38,133 17-Jun-98 tuberculosis GB_BA1:MSGY414A 40121 AD000007 Mycobacterium tuberculosis sequence from clone y414a. Mycobacterium 61,716 03-DEC-1996 tuberculosis GB_HTG4:AC010181 185244 AC010181 Homo sapiens chromosome 3 seeders clone RPCI11-68L1, *** Homo sapiens 34,807 21-OCT-1999 SEQUENCING IN PROGRESS ***, 26 unordered pieces. rxa01298 1053 GB_BA1:MTCY16B7 43430 Z81331 Mycobacterium tuberculosis H37Rv complete genome; segment 123/162. Mycobacterium 38,160 17-Jun-98 tuberculosis GB_BA1:MSGY414A 40121 AD000007 Mycobacterium tuberculosis sequence from clone y414a. Mycobacterium 58,611 03-DEC-1996 tuberculosis GB_PL1:SCYJL013C 2289 Z49288 S. cerevisiae chromosome X reading frame ORF YJL013c. Saccharomyces 36,180 11-Aug-97 cerevisiae rxa01303 1458 GB_BA1:TTAJ5043 837 AJ225043 Thermus thermophilus partial narK gene. Thermus thermophilus 55,245 18-Jun-98 GB_PL2:AC010675 84723 AC010675 Arabidopsis thaliana chromosome I BAC T17F3 genomic sequence, Arabidopsis thaliana 37,058 11-Nov-99 complete sequence. GB_GSS9:AQ170862 518 AQ170862 HS_3165_B2_F03_T7 CIT Approved Human Genomic Sperm Library D Homo sapiens 38,610 17-OCT-1998 Homo sapiens genomic clone Plate = 3165 Col = 6 Row = L, genomic survey sequence. rxa01323 2388 GB_BA1:MTCY10D7 39800 Z79700 Mycobacterium tuberculosis H37Rv complete genome; segment 44/162. Mycobacterium 53,376 17-Jun-98 tuberculosis GB_BA1:MTCY39 38500 Z74025 Mycobacterium tuberculosis H37Rv complete genome; segment 89/162. Mycobacterium 39,197 17-Jun-98 tuberculosis GB_BA1:MTCY251 38380 Z74410 Mycobacterium tuberculosis H37Rv complete genome; segment 5/162. Mycobacterium 52,698 17-Jun-98 tuberculosis rxa01338 1925 GB_IN1:DROPROS 6422 M81389 D. melanogaster Pros protein (prospero) mRNA, complete cds. Drosophila 37,229 26-Apr-93 melanogaster GB_EST9:AA060074 688 AA060074 mj73f07.r1 Soares mouse p3NMF19.5 Mus musculus cDNA clone Mus musculus 39,919 23-Sep-96 IMAGE: 481765 5′ similar to gb: X00246 Mouse mRNA with a Set 1 repetitive element for a class I (MOUSE);, mRNA sequence. GB_EST16:AA560009 437 AA560009 vI16a01.r1 Stratagene mouse Tcell 937311 Mus musculus cDNA clone Mus musculus 37,071 18-Aug-97 IMAGE: 972360 5′, mRNA sequence. rxa01395 294 GB_BA1:CGLYSEG 2374 X96471 C. glutamicum lysE and lysG genes. Corynebacterium 38,462 24-Feb-97 glutamicum GB_IN1:CELF28B3 36262 AF003136 Caenorhabditis elegans cosmid F28B3. Caenorhabditis elegans 37,241 31-DEC-1997 GB_GSS13:AQ486324 573 AQ486324 RPCI-11-264E18.TJ RPCI-11 Homo sapiens genomic clone RPCI-11- Homo sapiens 39,785 24-Apr-99 264E18, genomic survey sequence. rxa01411 888 GB_EST24:AU035428 756 AU035428 AU035428 Sugano mouse brain mncb Mus musculus cDNA clone MNCb- Mus musculus 37,112 08-OCT-1998 0438, mRNA sequence. GB_GSS12:AQ399225 621 AQ399225 mgxb0019C11f CUGI Rice Blast BAC Library Magnaporthe grisea genomic Magnaporthe grisea 36,430 06-MAR-1999 clone mgxb0019C11f, genomic survey sequence. GB_EST18:T42211 337 T42211 5474 Lambda-PRL2 Arabidopsis thaliana cDNA clone 111C20T7, mRNA Arabidopsis thaliana 42,433 7-Jan-98 sequence. rxa01454 367 GB_GSS5:AQ818876 486 AQ818876 HS_5297_B1_E12_SP6E RPCI-11 Human Male BAC Library Homo Homo sapiens 36,585 26-Aug-99 sapiens genomic clone Plate = 873 Col = 23 Row = J, genomic survey sequence. GB_EST19:AA778691 650 AA778691 af87h03.s1 Soares_testis_NHT Homo sapiens cDNA clone 1049045 3′ Homo sapiens 32,344 5-Feb-98 similar to contains L1.t2 L1 repetitive element;, mRNA sequence. GB_GSS15:AQ599724 543 AQ599724 HS_5354_B1_B01_T7A RPCI-11 Human Male BAC Library Homo sapiens Homo sapiens 39,773 10-Jun-99 genomic clone Plate = 930 Col = 1 Row = D, genomic survey sequence. rxa01455 585 GB_PL2:AF002169 5217 AF002169 Neurospora crassa coxl translation protein CYA5 (cya5) gene, complete Neurospora crassa 39,161 24-MAR-1999 cds. GB_PL2:AF002169 5217 AF002169 Neurospora crassa coxl translation protein CYA5 (cya5) gene, complete Neurospora crassa 37,565 24-MAR-1999 cds. rxa01625 324 GB_EST36:AV200593 300 AV200593 AV200593 Yuji Kohara unpublished cDNA Caenorhabditis elegans cDNA Caenorhabditis elegans 43,284 26-Jul-99 clone yk577f10 3′, mRNA sequence. GB_PL1:S48358 414 S48358 tRNA Trp [Saccharomyces cerevisiae, Genomic, 414 nt]. Saccharomyces 37,143 08-MAY-1993 cerevisiae GB_GSS8:AQ005856 390 AQ005856 CIT-HSP-2292G20.TR CIT-HSP Homo sapiens genomic clone 2292G20, Homo sapiens 39,205 27-Jun-98 genomic survey sequence. rxa01756 1431 GB_HTG4:AC009886 163668 AC009886 Homo sapiens chromosome 15 clone 437_N_14 map 15, *** Homo sapiens 35,865 19-OCT-1999 SEQUENCING IN PROGRESS ***, 11 unordered pieces. GB_HTG4:AC009886 163668 AC009886 Homo sapiens chromosome 15 clone 437_N_14 map 15, *** Homo sapiens 35,865 19-OCT-1999 SEQUENCING IN PROGRESS ***, 11 unordered pieces. GB_EST6:N47950 424 N47950 yy84d12.s1 Soares_multiple_sclerosis_2NbHMSP Homo sapiens cDNA Homo sapiens 38,261 14-Feb-96 clone IMAGE: 280247 3′, mRNA sequence. rxa01808 1172 GB_BA1:SEABCT 1976 X80735 S. erythraea (NCIMB 8594) ertX gene for putative ABC tranporter. Saccharopolyspora 63,607 07-DEC-1995 erythraea GB_BA1:MTV047 10866 AL022002 Mycobacterium tuberculosis H37Rv complete genome; segment 75/162. Mycobacterium 40,563 17-Jun-98 tuberculosis GB_BA1:ECOUW93 338534 U14003 Escherichia coli K-12 chromosomal region from 92.8 to 00.1 minutes. Escherichia coli 35,112 17-Apr-96 rxa01822 605 GB_HTG3:AC008480 106822 AC008480 Homo sapiens chromosome 5 clone CIT-HSPC_397O13, *** Homo sapiens 35,940 3-Aug-99 SEQUENCING IN PROGRESS ***, 36 unordered pieces. GB_HTG3:AC008480 106822 AC008480 Homo sapiens chromosome 5 clone CIT-HSPC_397O13, *** Homo sapiens 35,940 3-Aug-99 SEQUENCING IN PROGRESS ***, 36 unordered pieces. GB_PL2:CNS01B8L 660 AL113917 Botrytis cinerea strain T4 cDNA library under conditions of nitrogen Botryotinia fuckeliana 43,322 2-Sep-99 deprivation. rxa01900 1422 GB_BA2:AF056309 4346 AF056309 Streptomyces argillaceus membrane protein and mithramycin regulator Streptomyces 39,199 27-Jan-99 MtmR (mtmR) genes, complete cds. argillaceus GB_EST25:AU045582 273 AU045582 AU045582 Mouse sixteen-cell-embryo cDNA Mus musculus cDNA clone Mus musculus 61,172 09-DEC-1998 J0937H06 3′, mRNA sequence. GB_EST15:AA458642 217 AA458642 aa16b10.s1 Soares_NhHMPu_S1 Homo sapiens cDNA clone Homo sapiens 43,056 9-Jun-97 IMAGE: 813403 3′ similar to TR: G496330 G496330 IKBL MRNA.;, mRNA sequence. rxa01939 1854 GB_BA1:MTV025 121125 AL022121 Mycobacterium tuberculosis H37Rv complete genome; segment 155/162. Mycobacterium 38,145 24-Jun-99 tuberculosis GB_BA1:SC2A11 22789 AL031184 Streptomyces coelicolor cosmid 2A11. Streptomyces coelicolor 45,783 5-Aug-98 GB_BA2:AE000431 11575 AE000431 Escherichia coli K-12 MG1655 section 321 of 400 of the complete genome. Escherichia coli 38,384 12-Nov-98 rxa01972 717 GB_HTG2:AC007650 166670 AC007650 Drosophila melanogaster chromosome 3 clone BACR30G22 (D688) RPCI- Drosophila 37,712 2-Aug-99 98 30.G.22 map 87F-87F strain y; cn bw sp, *** SEQUENCING IN melanogaster PROGRESS ***, 101 unordered pieces. GB_HTG2:AC007650 166670 AC007650 Drosophila melanogaster chromosome 3 clone BACR30G22 (D688) RPCI- Drosophila 37,712 2-Aug-99 98 30.G.22 map 87F-87F strain y; cn bw sp, *** SEQUENCING IN melanogaster PROGRESS ***, 101 unordered pieces. GB_HTG2:AC008204 138364 AC008204 Drosophila melanogaster chromosome 3 clone BACR04E17 (D762) RPCI- Drosophila 36,827 2-Aug-99 98 04.E.17 map 95E-95F strain y; cn bw sp, *** SEQUENCING IN melanogaster PROGRESS***, 96 unordered pieces. rxa01995 1461 GB_HTG7:AC008065 172383 AC008065 Homo sapiens clone RP11-284E18, *** SEQUENCING IN PROGRESS ***, Homo sapiens 37,213 09-DEC-1999 4 unordered pieces. GB_GSS5:AQ805794 426 AQ805794 HS_3192_A2_C04_MR CIT Approved Human Genomic Sperm Library D Homo sapiens 41,148 9-Aug-99 Homo sapiens genomic clone Plate = 3192 Col = 8 Row = E, genomic survey sequence. GB_GSS10:AQ173736 436 AQ173736 HS_3194_A1_C04_MR CIT Approved Human Genomic Sperm Library D Homo sapiens 40,421 17-OCT-1998 Homo sapiens genomic clone Plate = 3194 Col = 7 Row = E, genomic survey sequence. rxa02034 1089 GB_PR4:AC002531 197900 AC002531 Homo sapiens chromosome Y, clone 486_O_8, complete sequence. Homo sapiens 36,934 13-OCT-1999 GB_PR2:HSB7L1C4 106710 AL078476 Homo sapiens chromosome 21 BAC B7L1C4, complete sequence. Homo sapiens 34,454 9-Nov-99 GB_IN2:CELF26D11 36161 AF068716 Caenorhabditis elegans cosmid F26D11. Caenorhabditis elegans 36,524 29-MAY-1998 rxa02035 rxa02062 1293 GB_BA1:MTCI364 29540 Z93777 Mycobacterium tuberculosis H37Rv complete genome; segment 52/162. Mycobacterium 38,606 17-Jun-98 tuberculosis GB_EST34:AV153141 305 AV153141 AV153141 Mus musculus hippocampus C57BL/6J adult Mus musculus Mus musculus 37,705 7-Jul-99 cDNA clone 2900053B17, mRNA sequence. GB_BA1:PHU88400 3855 U88400 Prochlorothrix hollandica hoxUYH operon, hydrogenase diaphorase subunit Prochlorothrix 38,712 05-MAY-1997 (hoxU) gene, partial cds, and bidirectional hydrogenase small subunit hollandica (hoxY), unknown protein, and bidirectional hydrogenase large subunit (hoxH) genes, complete cds. rxa02068 1230 GB_GSS13:AQ488513 673 AQ488513 RPCI-11-243J24.TV RPCI-11 Homo sapiens genomic clone RPCI-11- Homo sapiens 36,567 24-Apr-99 243J24, genomic survey sequence. GB_GSS13:AQ488513 673 AQ488513 RPCI-11-243J24.TV RPCI-11 Homo sapiens genomic clone RPCI-11- Homo sapiens 36,567 24-Apr-99 243J24, genomic survey sequence. rxa02079 738 GB_PR4:AC006531 167525 AC006531 Homo sapiens chromosome 16 clone 113K5, complete sequence. Homo sapiens 37,870 7-Feb-99 GB_BA1:DLARGD 1471 L42615 Deleya cupida 16S ribosomal RNA (16S rRNA) gene. Halomonas cupida 40,476 3-Jan-96 GB_BA1:AF009342 1482 AF009342 Haemophilus ducreyi ribosomal protein L11 gene, partial cds, and Haemophilus ducreyi 34,813 22-Jul-97 ribosomal protein L1 gene, complete cds. rxa02096 1815 GB_BA1:MTV033 21620 AL021928 Mycobacterium tuberculosis H37Rv complete genome; segment 11/162. Mycobacterium 48,302 17-Jun-98 tuberculosis GB_BA2:MSU10425 4261 U10425 Mycobacterium smegmatis ferric exochelin uptake proteins FxuB (fxuB), Mycobacterium 41,282 07-DEC-1994 FxuA (fxuA) genes, complete cds, FxuC (fxuC) gene, partial cds, and ferric smegmatis exochelin biosynthesis protein FxbA (fxbA) gene, complete cds. GB_EST30:AV018477 249 AV018477 AV018477 Mus musculus 18-day embryo C57BL/6J Mus musculus cDNA Mus musculus 42,169 28-Aug-99 clone 1190005G23, mRNA sequence. rxa02119 1764 GB_BA1:SCARD1GN 2321 X84374 S. capreolus ard1 gene. Streptomyces capreolus 49,857 23-Aug-95 GB_PL2:SPBC29A3 42770 AL022299 S. pombe chromosome II cosmid c29A3. Schizosaccharomyces 37,269 02-DEC-1999 pombe GB_HTG1:CEY47H10 296589 Z95311 Caenorhabditis elegans chromosome I clone Y47H10, *** SEQUENCING Caenorhabditis elegans 34,160 7-Sep-99 IN PROGRESS ***, in unordered pieces. rxa02200 1233 GB_PR3:HSA494O16 50502 AL117328 Human DNA sequence from clone 494O16 on chromosome 22, complete Homo sapiens 38,648 23-Nov-99 sequence. GB_HTG2:AC008161 158440 AC008161 Mus musculus clone 182_H_5 *** SEQUENCING IN PROGRESS ***, 29 Mus musculus 35,938 28-Jul-99 unordered pieces. GB_HTG2:AC008161 158440 AC008161 Mus musculus clone 182_H_5, *** SEQUENCING IN PROGRESS ***, 29 Mus musculus 35,938 28-Jul-99 unordered pieces. rxa02222 rxa02312 1482 GB_BA1:ECOUW93 338534 U14003 Escherichia coli K-12 chromosomal region from 92.8 to 00.1 minutes. Escherichia coli 60,729 17-Apr-96 GB_BA2:AE000492 10181 AE000492 Escherichia coli K-12 MG1655 section 382 of 400 of the complete genome. Escherichia coli 60,729 12-Nov-98 GB_BA1:BSUB0004 213190 Z99107 Bacillus subtilis complete genome (section 4 of 21): from 600701 to Bacillus subtilis 35,670 26-Nov-97 813890. rxa02313 1344 GB_EST30:AV013722 344 AV013722 AV013722 Mus musculus 18-day embryo C57BL/6J Mus musculus cDNA Mus musculus 39,941 25-Aug-99 clone 1110049L02, mRNA sequence. GB_EST29:AI596306 356 AI596306 ve20b05.y1 Soares mouse NbMH Mus musculus cDNA clone Mus musculus 40,395 21-Apr-99 IMAGE: 818673 5′, mRNA sequence. GB_EST29:AI595357 335 AI595357 ve20b05.x1 Soares mouse NbMH Mus musculus cDNA clone Mus musculus 35,821 21-Apr-99 IMAGE: 818673 3′, mRNA sequence. rxa02348 rxa02353 491 GB_BA2:AF175299 8140 AF175299 Sinorhizobium meliloti ThuR (thuR), ThuE (thuE), ThuF (thuF), ThuG Sinorhizobium meliloti 51,674 30-Aug-99 (thuG), ThuK (thuK), ThuA (thuA), and ThuB (thuB) genes, complete cds. GB_HTG3:AC008675 206439 AC008675 Homo sapiens chromosome 5 clone CIT978SKB_45I8 *** SEQUENCING Homo sapiens 38,351 3-Aug-99 IN PROGRESS ***, 43 unordered pieces. GB_HTG3:AC008672 131573 AC008672 Homo sapiens chromosome 5 clone CIT978SKB_3B12, *** SEQUENCING Homo sapiens 40,289 3-Aug-99 IN PROGRESS ***, 71 unordered pieces. rxa02354 957 GB_PR3:HS357K22 145638 AL022720 Human DNA sequence from clone 357K22 on chromosome Xq27.1-27.3 Homo sapiens 34,926 23-Nov-99 Contains EST, STS, GSS, complete sequence. GB_IN1:D87738 1849 D87738 Branchiostoma belcheri mRNA for cytoplasmic actin BbCA1, complete cds. Branchiostoma belcheri 39,788 2-Apr-99 GB_IN1:PIOACTA 4172 M26501 Starfish (P. ochraceus) cytoplasmic actin gene, complete cds. Pisaster ochraceus 40,178 26-Apr-93 rxa02394 1434 GB_HTG5:AC007521 173897 AC007521 Drosophila melanogaster chromosome X clone BACR49A04 (D698) RPCI- Drosophila 34,954 17-Nov-99 98 49.A.4 map 10A2-10B2 strain y; cn bw sp, *** SEQUENCING IN melanogaster PROGRESS ***, 56 unordered pieces. GB_HTG3:AC010357 302201 AC010357 Homo sapiens chromosome 5 clone CITB-H1_2030B19, *** Homo sapiens 38,411 15-Sep-99 SEQUENCING IN PROGRESS ***, 12 unordered pieces. GB_HTG3:AC010357 302201 AC010357 Homo sapiens chromosome 5 clone CITB-H1_2030B19, *** Homo sapiens 38,411 15-Sep-99 SEQUENCING IN PROGRESS ***, 12 unordered pieces. rxa02438 882 GB_BA1:SC7B7 13800 AL009199 Streptomyces coelicolor cosmid 7B7. Streptomyces coelicolor 53,592 02-DEC-1997 GB_BA1:SC3F9 19830 AL023862 Streptomyces coelicolor cosmid 3F9. Streptomyces coelicolor 47,166 10-Feb-99 GB_BA1:SCF43A 35437 AL096837 Streptomyces coelicolor cosmid F43A. Streptomyces coelicolor 44,987 13-Jul-99 A3(2) rxa02439 1146 GB_PAT:E16763 2517 E16763 gDNA encoding aspartate transferase (AAT). Corynebacterium 39,600 28-Jul-99 glutamicum GB_HTG1:HSDJ753D5 184025 AL049693 Homo sapiens chromosome 6 clone RP4-753D5, *** SEQUENCING IN Homo sapiens 36,894 23-Nov-99 PROGRESS ***, in unordered pieces. GB_HTG1:HSDJ753D5 184025 AL049693 Homo sapiens chromosome 6 clone RP4-753D5, *** SEQUENCING IN Homo sapiens 36,894 23-Nov-99 PROGRESS ***, in unordered pieces. rxa02441 780 GB_EST7:W61724 312 W61724 md66b02.r1 Soares mouse embryo NbME13.5 14.5 Mus musculus cDNA Mus musculus 42,308 7-Jun-96 clone IMAGE: 373323 5′ similar to gb: L23769 Mouse microfibril-associated glycoprotein (MOUSE);, mRNA sequence. GB_PR4:AC008115 158431 AC008115 Homo sapiens 12p12-27.2-31.7 BAC RPCI11-180M15 (Roswell Park Homo sapiens 37,286 09-OCT-1999 Cancer Institute Human BAC Library) complete sequence. GB_EST29:AI622043 586 AI622043 486032B05.x2 486 - leaf primordia cDNA library from Hake lab Zea mays Zea mays 36,364 22-Apr-99 cDNA, mRNA sequence. rxa02442 972 GB_PR4:AC007870 134757 AC007870 Genomic sequence for Homo sapiens clone 4P6, complete sequence. Homo sapiens 37,110 12-Aug-99 GB_PR4:AC007870 134757 AC007870 Genomic sequence for Homo sapiens clone 4P6, complete sequence. Homo sapiens 34,941 12-Aug-99 GB_PAT:AR053765 4624 AR053765 Sequence 5 from U.S. Pat. No. 5834263. Unknown. 38,988 29-Sep-99 rxa02447 1118 GB_EST36:AI881490 551 AI881490 606069G06.y1 606 - Ear tissue cDNA library from Schmidt lab Zea mays Zea mays 49,534 21-Jul-99 cDNA, mRNA sequence. GB_PL1:CKRNAHUP3 1605 X75440 C. kessleri HUP3 mRNA. Chlorella kessleri 42,935 28-Jun-95 GB_PL1:CKHUP1 2481 Y07520 Chlorella kessleri HUP1 mRNA for H(+)/hexose cotransporter. Chlorella kessleri 43,379 12-Sep-93 rxa02451 1647 GB_BA1:BRLBIOAD 2272 D14083 Brevibacterium flavum genes for 7,8-diaminopelargonic acid Corynebacterium 40,496 3-Feb-99 aminotransferase and dethiobiotin synthetase, complete cds. glutamicum GB_PAT:E08643 285 E08643 Base sequence having the promoter function in Corynebacterium Corynebacterium 37,193 29-Sep-97 microorganisms. glutamicum GB_PL2:EFI245745 3194 AJ245745 Endomyces fibuliger ura3 gene for orotidine-5′-phosphate decarboxylase. Saccharomycopsis 38,889 24-Aug-99 fibuligera rxa02491 1377 GB_BA1:MTCY20G9 37218 Z77162 Mycobacterium tuberculosis H37Rv complete genome; segment 25/162. Mycobacterium 55,745 17-Jun-98 tuberculosis GB_BA1:CGLEUA 3492 X70959 C. glutamicum gene leuA for isopropylmalate synthase. Corynebacterium 38,253 10-Feb-99 glutamicum GB_PR3:AC004764 68048 AC004764 Homo sapiens chromosome 5, P1 clone 255g5 (LBNL H61), complete Homo sapiens 34,821 29-MAY-1998 sequence. rxa02507 1524 GB_PR4:AC000134 203300 AC000134 Homo sapiens Chromosome 11q13 BAC Clone 137c7, complete sequence. Homo sapiens 37,087 06-MAY-1999 GB_PR2:HS227L5 85304 AL031585 Human DNA sequence from clone 227L5 on chromosome Xp11.22-11.3. Homo sapiens 38,718 23-Nov-99 Contains a Keratin, Type 1 Cytoskeletal 18 (KRT18, CYK18, K18, CK18) pseudogene and an STS, complete sequence. GB_PR4:AC000134 203300 AC000134 Homo sapiens Chromosome 11q13 BAC Clone 137c7, complete sequence. Homo sapiens 35,955 06-MAY-1999 rxa02515 879 GB_BA1:SCC22 22115 AL096839 Streptomyces coelicolor cosmid C22. Streptomyces coelicolor 36,219 12-Jul-99 GB_BA1:MTV007 32806 AL021184 Mycobacterium tuberculosis H37Rv complete genome; segment 64/162. Mycobacterium 63,026 17-Jun-98 tuberculosis GB_BA1:MLCL536 36224 Z99125 Mycobacterium leprae cosmid L536. Mycobacterium leprae 36,468 04-DEC-1998 rxa02562 843 GB_HTG7:AC011197 167967 AC011197 Homo sapiens clone RP11-322C8, *** SEQUENCING IN PROGRESS ***, Homo sapiens 36,675 08-DEC-1999 19 unordered pieces. GB_PAT:AR008238 6553 AR008238 Sequence 1 from U.S. Pat. No. 5753442. Unknown. 39,251 04-DEC-1998 GB_GSS4:AQ712494 469 AQ712494 HS_2137_A1_A12_T7C CIT Approved Human Genomic Sperm Library D Homo sapiens 35,664 13-Jul-99 Homo sapiens genomic clone Plate = 2137 Col = 23 Row = A, genomic survey sequence. rxa02595 1287 GB_BA1:MSGB983CS 36788 L78828 Mycobacterium leprae cosmid B983 DNA sequence. Mycobacterium leprae 39,905 15-Jun-96 GB_BA1:MLCB1883 43505 AL022486 Mycobacterium leprae cosmid B1883. Mycobacterium leprae 52,909 27-Aug-99 GB_GSS1:CNS0056G 994 AL057090 Drosophila melanogaster genome survey sequence T7 end of BAC # Drosophila 31,315 3-Jun-99 BACR11M23 of RPCI-98 library from Drosophila melanogaster (fruit fly), melanogaster genomic survey sequence. rxa02597 rxa02605 618 GB_BA1:MXENO201 390 X92571 M. xenopi gene for 32 kDa protein (partial). Mycobacterium xenopi 55,738 15-Jan-98 GB_BA1:MXENO201 390 X92571 M. xenopi gene for 32 kDa protein (partial). Mycobacterium xenopi 59,233 15-Jan-98 rxa02614 852 GB_BA1:SCH35 45396 AL078610 Streptomyces coelicolor cosmid H35. Streptomyces coelicolor 50,976 4-Jun-99 GB_BA2:AF126201 12402 AF126201 Pseudomonas putida strain S-313 sulfate ester desulfurization gene locus, Pseudomonas putida 46,763 12-OCT-1999 complete sequence. GB_BA1:SC8B7 14634 AL031225 Streptomyces coelicolor cosmid 8B7. Streptomyces coelicolor 38,026 7-Aug-98 rxa02616 834 GB_BA1:SCD78 36224 AL034355 Streptomyces coelicolor cosmid D78. Streptomyces coelicolor 43,705 26-Nov-98 GB_EST28:AI509984 534 AI509984 mj18e06.y1 Soares mouse embryo NbME13.5 14.5 Mus musculus cDNA Mus musculus 38,653 12-MAR-1999 clone IMAGE: 476482 5′, mRNA sequence. GB_EST8:AA050633 522 AA050633 mj18e06.r1 Soares mouse embryo NbME13.5 14.5 Mus musculus cDNA Mus musculus 41,602 9-Sep-96 clone IMAGE: 476482 5′, mRNA sequence. rxa02627 866 GB_GSS6:AQ826046 427 AQ826046 HS_5311_B2_B01_SP6E RPCI-11 Human Male BAC Library Homo Homo sapiens 38,095 27-Aug-99 sapiens genomic clone Plate = 887 Col = 2 Row = D, genomic survey sequence. GB_PR2:HS329F2 24753 AL031710 Human DNA sequence from clone LA16-329F2 on chromosome 16, Homo sapiens 38,580 22-Nov-99 complete sequence. GB_GSS10:AQ255771 621 AQ255771 nbxb0014E22r CUGI Rice BAC Library Oryza sativa genomic clone Oryza sativa 34,622 23-OCT-1998 nbxb0014E22r, genomic survey sequence. rxa02628 528 GB_BA1:RCAHIMA 5403 M84030 Rhodobacter capsulatus integration host factor (himA) gene, complete cds. Rhodobacter capsulatus 37,452 26-Apr-93 GB_GSS13:AQ476201 312 AQ476201 CITBI-E1-2592P3.TF CITBI-E1 Homo sapiens genomic clone 2592P3, Homo sapiens 43,182 23-Apr-99 genomic survey sequence. GB_EST38:AW054154 648 AW054154 614079C04.x1 614 - root cDNA library from Walbot Lab Zea mays cDNA, Zea mays 37,657 21-Sep-99 mRNA sequence. rxa02650 702 GB_EST19:AA803900 441 AA803900 GM14564.5prime GM Drosophila melanogaster ovary pOT2 Drosophila Drosophila 40,394 25-Nov-98 melanogaster cDNA clone GM14564 5prime, mRNA sequence. melanogaster GB_EST19:AA803900 441 AA803900 GM14564.5prime GM Drosophila melanogaster ovary pOT2 Drosophila Drosophila 37,757 25-Nov-98 melanogaster cDNA clone GM14564 5prime, mRNA sequence. melanogaster rxa02660 762 GB_PR3:HS308O1 166715 Z93403 Human genomic DNA sequence from clone 308O1 on chromosome Xp11.3-11.4. Homo sapiens 33,912 23-Nov-99 Contains EST, CA repeat, STS, GSS, CpG island. GB_PR3:AC003669 159446 AC003669 Homo sapiens Xp22 BAC GS-594A7 (Genome Systems Human BAC Homo sapiens 35,734 24-MAR-1998 library) contains Bmx gene, complete sequence. GB_HTG3:AC010923 152021 AC010923 Drosophila melanogaster chromosome X clone BACR19K15 (D897) RPCI- Drosophila 28,070 08-OCT-1999 98 19.K.15 map 15B-15E strain y; cn bw sp, *** SEQUENCING IN melanogaster PROGRESS ***, 175 unordered pieces. rxa02661 342 GB_HTG2:AC007802 118569 AC007802 Drosophila melanogaster chromosome 2 clone BACR07I11 (D648) RPCI- Drosophila 43,373 2-Aug-99 98 07.I.11 map 58A1-58A2 strain y; cn bw sp, *** SEQUENCING IN melanogaster PROGRESS ***, 70 unordered pieces. GB_HTG2:AC007802 118569 AC007802 Drosophila melanogaster chromosome 2 clone BACR07I11 (D648) RPCI- Drosophila 43,373 2-Aug-99 98 07.I.11 map 58A1-58A2 strain y; cn bw sp, *** SEQUENCING IN melanogaster PROGRESS ***, 70 unordered pieces. GB_EST2:R04660 288 R04660 pk27b04.r1 Kuwabara Mixed stage C. briggsae Caenorhabditis briggsae Caenorhabditis 47,009 31-MAR-1995 cDNA, mRNA sequence. briggsae rxa02663 1518 GB_BA1:SC9F2 11908 AL035559 Streptomyces coelicolor cosmid 9F2. Streptomyces coelicolor 45,964 25-Feb-99 GB_BA1:MTCY50 36030 Z77137 Mycobacterium tuberculosis H37Rv complete genome; segment 55/162. Mycobacterium 38,998 17-Jun-98 tuberculosis GB_BA1:D90721 16578 D90721 Escherichia coli genomic DNA. (18.6-19.0 min). Escherichia coli 44,325 7-Feb-99 rxa02664 783 GB_BA2:U32798 10423 U32798 Haemophilus influenzae Rd section 113 of 163 of the complete genome. Haemophilus influenzae 39,868 29-MAY-1998 Rd GB_BA1:HIU17295 9424 U17295 Haemophilus influenzae dppB, dppC, dppD, dppF, isn, artP, artl/J, artQ, Haemophilus influenzae 49,298 4-Apr-96 and artM genes, complete cds, and opa gene, partial cds. GB_BA2:U32792 11306 U32792 Haemophilus influenzae Rd section 107 of 163 of the complete genome. Haemophilus influenzae 39,764 29-MAY-1998 Rd rxa02684 987 GB_PR2:CNS00006 181433 AL049775 Human chromosome 14 DNA sequence *** IN PROGRESS *** BAC R- Homo sapiens 36,961 17-Jun-99 497E19 of RPCI-11 library from chromosome 14 of Homo sapiens (Human), complete sequence. GB_HTG3:AC009857 148241 AC009857 Homo sapiens clone 2_F_6, *** SEQUENCING IN PROGRESS ***, 9 Homo sapiens 35,380 3-Sep-99 unordered pieces. GB_HTG3:AC009857 148241 AC009857 Homo sapiens clone 2_F_6, *** SEQUENCING IN PROGRESS ***, 9 Homo sapiens 35,380 3-Sep-99 unordered pieces. rxa02728 936 GB_BA1:YEHEMSTUV 3901 X77867 Y. enterocolitica hemS, hemT, hemU and hemV genes. Yersinia enterocolitica 48,253 11-OCT-1996 GB_BA1:ECOUW76 225419 U00039 E. coli chromosomal region from 76.0 to 81.5 minutes. Escherichia coli 39,177 7-Nov-96 GB_HTG3:AC008616 112626 AC008616 Homo sapiens chromosome 19 clone CIT978SKB_144D21, *** Homo sapiens 41,741 3-Sep-99 SEQUENCING IN PROGRESS ***, 49 unordered pieces. rxa02750 939 GB_GSS15:AQ663436 430 AQ663436 HS_2160_B2_F10_T7C CIT Approved Human Genomic Sperm Library D Homo sapiens 42,020 23-Jun-99 Homo sapiens genomic clone Plate = 2160 Co = 20 Row = L, genomic survey sequence. GB_GSS15:AQ663436 430 AQ663436 HS_2160_B2_F10_T7C CIT Approved Human Genomic Sperm Library D Homo sapiens 39,161 23-Jun-99 Homo sapiens genomic clone Plate = 2160 Col = 20 Row = L, genomic survey sequence. rxa02795 1560 GB_HTG5:AC011134 192982 AC011134 Homo sapiens clone 1_A_23, *** SEQUENCING IN PROGRESS ***, 22 Homo sapiens 35,630 5-Nov-99 unordered pieces. GB_HTG5:AC011134 192982 AC011134 Homo sapiens clone 1_A_23, *** SEQUENCING IN PROGRESS ***, 22 Homo sapiens 34,643 5-Nov-99 unordered pieces. GB_BA1:MTCY50 36030 Z77137 Mycobacterium tuberculosis H37Rv complete genome; segment 55/162. Mycobacterium 39,934 17-Jun-98 tuberculosis rxa02808 281 GB_PR4:AC004897 90731 AC004897 Homo sapiens PAC clone DJ0811N16 from 7q34-q36, complete sequence. Homo sapiens 42,804 19-Aug-99 GB_RO:AC002121 84056 AC002121 Genomic sequence from Mouse 11, complete sequence. Mus musculus 39,130 10-Jul-97 GB_PR4:AC005078 73231 AC005078 Homo sapiens BAC clone RG252K19 from 7p15.2-p21, complete Homo sapiens 37,175 18-MAR-1999 sequence. rxs03220 725 GB_PL1:CKHUP2 2353 X66855 C. kessleri HUP2 mRNA. Chlorella kessleri 45,328 17-Feb-97 GB_EST38:AW048153 383 AW048153 UI-M-BH1-alq-h-05-0-UI.s1 NIH_BMAP_M_S2 Mus musculus cDNA clone Mus musculus 41,758 18-Sep-99 UI-M-BH1-alq-h-05-0-UI 3′, mRNA sequence. GB_PL1:CKHUP2 2353 X66855 C. kessleri HUP2 mRNA. Chlorella kessleri 38,106 17-Feb-97 rxs03221 776 GB_BA1:BSUB0010 233780 Z99113 Bacillus subtilis complete genome (section 10 of 21): from 1781201 Bacillus subtilis 52,282 28-Nov-97 to 2014980. GB_BA1:BSU66480 26114 U66480 Bacillus subtilis SpoVK (spoVK), YnbA (ynbA), YnbB (ynbB), GlnR Bacillus subtilis 52,282 22-Jan-97 (glnR), glutamine synthetase (glnA), YnaA (ynaA), YnaB (ynaB), YnaC (ynaC), YnaD (ynaD), YnaE (ynaE), YnaF (ynaF), YnaG (ynaG), YnaH (ynaH), YnaI (ynaI), YnaJ (ynaJ), xylan beta-1,4-xylosidase (xynB), xylose repressor (xyIR), xylose isomerase (xyIA), xylulose kinase (xyIB), YncB (yncB), YncC (yncC), YncD (yncD) and YncE (yncE) genes, complete cds. GB_BA1:BSUB0010 233780 Z99113 Bacillus subtilis complete genome (section 10 of 21): from 1781201 Bacillus subtilis 36,983 26-Nov-97 to 2014980.

TABLE 2 GENES IDENTIFIED FROM GENBANK GenBank ™ Accession No. Gene Name Gene Function Reference A09073 ppg Phosphoenol pyruvate carboxylase Bachmann, B. et al. “DNA fragment coding for phosphoenolpyruvat corboxylase, recombinant DNA carrying said fragment, strains carrying the recombinant DNA and method for producing L-aminino acids using said strains,” Patent: EP 0358940-A 3 Mar. 21, 1990 A45579, Threonine dehydratase Moeckel, B. et al. “Production of L-isoleucine by means of recombinant A4581, micro-organisms with deregulated threonine dehydratase,” Patent: WO A45583, 9519442-A 5 Jul. 20, 1995 A45585 A45587 AB003132 murC; ftsQ; Kobayashi, M. et al. “Cloning, sequencing, and characterization of the ftsZ ftsZ gene from coryneform bacteria,” Biochem. Biophys. Res. Commun., 236(2): 383-388 (1997) AB015023 murC; ftsQ Wachi, M. et al. “A murC gene from Coryneform bacteria,” Appl. Microbiol. Biotechnol., 51(2): 223-228 (1999) AB018530 dtsR Kimura, E. et al. “Molecular cloning of a novel gene, dtsR, which rescues the detergent sensitivity of a mutant derived from Brevibacterium lactofermentum,” Biosci. Biotechnol. Biochem., 60(10): 1565-1570 (1996) AB018531 dtsR1; dtsR2 AB020624 murI D-glutamate racemase AB023377 tkt transketolase AB024708 gltB; gltD Glutamine 2-oxoglutarate aminotransferase large and small subunits AB025424 acn aconitase AB027714 rep Replication protein AB027715 rep; aad Replication protein; aminoglycoside adenyltransferase AF005242 argC N-acetylglutamate-5-semialdehyde dehydrogenase AF005635 glnA Glutamine synthetase AF030405 hisF cyclase AF030520 argG Argininosuccinate synthetase AF031518 argF Ornithine carbamolytransferase AF036932 aroD 3-dehydroquinate dehydratase AF038548 pyc Pyruvate carboxylase AF038651 dciAE; apt; Dipeptide-binding protein; adenine Wehmeier, L. et al. “The role of the Corynebacterium glutamicum rel gene in rel phosphoribosyltransferase; GTP (p)ppGpp metabolism,” Microbiology, 144: 1853-1862 (1998) pyrophosphokinase AF041436 argR Arginine repressor AF045998 impA Inositol monophosphate phosphatase AF048764 argH Argininosuccinate lyase AF049897 argC; argJ; N-acetylglutamylphosphate reductase; argB; argD; ornithine acetyltransferase; N- argF; argR; acetylglutamate kinase; acetylornithine argG; argH transminase; ornithine carbamoyltransferase; arginine repressor; argininosuccinate synthase; argininosuccinate lyase AF050109 inhA Enoyl-acyl carrier protein reductase AF050166 hisG ATP phosphoribosyltransferase AF051846 hisA Phosphoribosylformimino-5-amino-1- phosphoribosyl-4-imidazolecarboxamide isomerase AF052652 metA Homoserine O-acetyltransferase Park, S. et al. “Isolation and analysis of metA, a methionine biosynthetic gene encoding homoserine acetyltransferase in Corynebacterium glutamicum,” Mol. Cells., 8(3): 286-294 (1998) AF053071 aroB Dehydroquinate synthetase AF060558 hisH Glutamine amidotransferase AF086704 hisE Phosphoribosyl-ATP- pyrophosphohydrolase AF114233 aroA 5-enolpyruvylshikimate 3-phosphate synthase AF116184 panD L-aspartate-alpha-decarboxylase precursor Dusch, N. et al. “Expression of the Corynebacterium glutamicum panD gene encoding L-aspartate-alpha-decarboxylase leads to pantothenate overproduction in Escherichia coli,” Appl. Environ. Microbiol., 65(4)1530-1539 (1999) AF124518 aroD; aroE 3-dehydroquinase; shikimate dehydrogenase AF124600 aroC; aroK; Chorismate synthase; shikimate kinase; 3- aroB; pepQ dehydroquinate synthase; putative cytoplasmic peptidase AF145897 inhA AF145898 inhA AJ001436 ectP Transport of ectoine, glycine betaine, Peter, H. et al. “Corynebacterium glutamicum is equipped with four secondary proline carriers for compatible solutes: Identification, sequencing, and characterization of the proline/ectoine uptake system, ProP, and the ectoine/proline/glycine betaine carrier, EctP,” J. Bacteriol., 180(22): 6005-6012 (1998) AJ004934 dapD Tetrahydrodipicolinate succinylase Wehrmann, A. et al. “Different modes of diaminopimelate synthesis and their (incomplete^(i)) role in cell wall integrity: A study with Corynebacterium glutamicum,” J. Bacteriol., 180(12): 3159-3165 (1998) AJ007732 ppc; secG; Phosphoenolpyruvate-carboxylase; ?; high amt; ocd; affinity ammonium uptake protein; soxA putative ornithine-cyclodecarboxylase; sarcosine oxidase AJ010319 ftsY, glnB, Involved in cell division; PII protein; Jakoby, M. et al. “Nitrogen regulation in Corynebacterium glutamicum; glnD; srp; uridylyltransferase (uridylyl-removing Isolation of genes involved in biochemical characterization of corresponding amtP enzmye); signal recognition particle; low proteins,” FEMS Microbiol., 173(2): 303-310 (1999) affinity ammonium uptake protien AJ132968 cat Chloramphenicol aceteyl transferase AJ224946 mqo L-malate: quinone oxidoreductase Molenaar, D. et al. “Biochemical and genetic characterization of the membrane-associated malate dehydrogenase (acceptor) from Corynebacterium glutamicum,” Eur. J. Biochem., 254(2): 395-403 (1998) AJ238250 ndh NADH dehydrogenase AJ238703 porA Porin Lichtinger, T. et al. “Biochemical and biophysical characterization of the cell wall porin of Corynebacterium glutamicum: The channel is formed by a low molecular mass polypeptide,” Biochemistry, 37(43): 15024-15032 (1998) D17429 Transposable element IS31831 Vertes, A. A. et al. “Isolation and characterization of IS31831, a transposable element from Corynebacterium glutamicum,” Mol. Microbiol., 11(4): 739-746 (1994) D84102 odhA 2-oxoglutarate dehydrogenase Usuda, Y. et al. “Molecular cloning of the Corynebacterium glutamicum (Brevibacterium lactofermentum AJ12036) odhA gene encoding a novel type of 2-oxoglutarate dehydrogenase,” Microbiology, 142: 3347-3354 (1996) E01358 hdh; hk Homoserine dehydrogenase; homoserine Katsumata, R. et al. “Production of L-thereonine and L-isoleucine,” Patent: JP kinase 1987232392-A 1 Oct. 12, 1987 E01359 Upstream of the start codon of homoserine Katsumata, R. et al. “Production of L-thereonine and L-isoleucine,” Patent: JP kinase gene 1987232392-A 2 Oct. 12, 1987 E01375 Tryptophan operon E01376 trpL; trpE Leader peptide; anthranilate synthase Matsui, K. et al. “Tryptophan operon, peptide and protein coded thereby, utilization of tryptophan operon gene expression and production of tryptophan,” Patent: JP 1987244382-A 1 Oct. 24, 1987 E01377 Promoter and operator regions of Matsui, K. et al. “Tryptophan operon, peptide and protein coded 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1 Dec. 27, 1993 E06111 Mutated Prephenate dehydratase Kikuchi, T. et al. “Production of L-phenylalanine by fermentation method,” Patent: JP 1993344881-A 1 Dec. 27, 1993 E06146 Acetohydroxy acid synthetase Inui, M. et al. “Gene capable of coding Acetohydroxy acid synthetase and its use,” Patent: JP 1993344893-A 1 Dec. 27, 1993 E06825 Aspartokinase Sugimoto, M. et al. “Mutant aspartokinase gene,” patent: JP 1994062866-A 1 Mar. 08, 1994 E06826 Mutated aspartokinase alpha subunit Sugimoto, M. et al. “Mutant aspartokinase gene,” patent: JP 1994062866-A 1 Mar. 08, 1994 E06827 Mutated aspartokinase alpha subunit Sugimoto, M. et al. “Mutant aspartokinase gene,” patent: JP 1994062866-A 1 Mar. 08, 1994 E07701 secY Honno, N. et al. “Gene DNA participating in integration of membraneous protein to membrane,” Patent: JP 1994169780-A 1 Jun. 21, 1994 E08177 Aspartokinase Sato, Y. et al. “Genetic DNA capable of coding Aspartokinase released from feedback inhibition and its utilization,” Patent: JP 1994261766-A 1 Sep. 20, 1994 E08178, Feedback inhibition-released Sato, Y. et al. “Genetic DNA capable of coding Aspartokinase released from E08179, Aspartokinase feedback inhibition and its utilization,” Patent: JP 1994261766-A 1 E08180, Sep. 20, 1994 E08181, E08182 E08232 Acetohydroxy-acid isomeroreductase Inui, M. et al. “Gene DNA coding acetohydroxy acid isomeroreductase,” Patent: JP 1994277067-A 1 Oct. 04, 1994 E08234 secE Asai, Y. et al. “Gene DNA coding for translocation machinery of protein,” Patent: JP 1994277073-A 1 Oct. 04, 1994 E08643 FT aminotransferase and desthiobiotin Hatakeyama, K. et al. “DNA fragment having promoter function in synthetase promoter region coryneform bacterium,” Patent: JP 1995031476-A 1 Feb. 03, 1995 E08646 Biotin synthetase Hatakeyama, K. et al. “DNA fragment having promoter function in coryneform bacterium,” Patent: JP 1995031476-A 1 Feb. 03, 1995 E08649 Aspartase Kohama, K. et al “DNA fragment having promoter function in coryneform bacterium,” Patent: JP 1995031478-A 1 Feb. 03, 1995 E08900 Dihydrodipicolinate reductase Madori, M. et al. “DNA fragment containing gene coding Dihydrodipicolinate acid reductase and utilization thereof,” Patent: JP 1995075578-A 1 Mar. 20, 1995 E08901 Diaminopimelic acid decarboxylase Madori, M. et al. “DNA fragment containing gene coding Diaminopimelic acid decarboxylase and utilization thereof,” Patent: JP 1995075579-A 1 Mar. 20, 1995 E12594 Serine hydroxymethyltransferase Hatakeyama, K. et al. “Production of L-trypophan,” Patent: JP 1997028391-A 1 Feb. 04, 1997 E12760, transposase Moriya, M. et al. “Amplification of gene using artificial transposon,” Patent: E12759, JP 1997070291-A Mar. 18, 1997 E12758 E12764 Arginyl-tRNA synthetase; diaminopimelic Moriya, M. et al. “Amplification of gene using artificial transposon,” Patent: acid decarboxylase JP 1997070291-A Mar. 18, 1997 E12767 Dihydrodipicolinic acid synthetase Moriya, M. et al. “Amplification of gene using artificial transposon,” Patent: JP 1997070291-A Mar. 18, 1997 E12770 aspartokinase Moriya, M. et al. “Amplification of gene using artificial transposon,” Patent: JP 1997070291-A Mar. 18, 1997 E12773 Dihydrodipicolinic acid reductase Moriya, M. et al. “Amplification of gene using artificial transposon,” Patent: JP 1997070291-A Mar. 18, 1997 E13655 Glucose-6-phosphate dehydrogenase Hatakeyama, K. et al. “Glucose-6-phosphate dehydrogenase and DNA capable of coding the same,” Patent: JP 1997224661-A 1 Sep. 02, 1997 L01508 IlvA Threonine dehydratase Moeckel, B. et al. “Functional and structural analysis of the threonine dehydratase of Corynebacterium glutamicum,” J. Bacteriol., 174: 8065-8072 (1992) L07603 EC 4.2.1.15 3-deoxy-D-arabinoheptulosonate-7- Chen, C. et al. “The cloning and nucleotide sequence of Corynebacterium phosphate synthase glutamicum 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase gene,” FEMS Microbiol. Lett., 107: 223-230 (1993) L09232 IlvB; ilvN; Acetohydroxy acid synthase large subunit; Keilhauer, C. et al. “Isoleucine synthesis in Corynebacterium glutamicum: ilvC Acetohydroxy acid synthase small subunit; molecular analysis of the ilvB-ilvN-ilvC operon,” J. Bacteriol., 175(17): Acetohydroxy acid isomeroreductase 5595-5603 (1993) L18874 PtsM Phosphoenolpyruvate sugar Fouet, A et al. “Bacillus subtilis sucrose-specific enzyme II of the phosphotransferase phosphotransferase system: expression in Escherichia coli and homology to enzymes II from enteric bacteria,” PNAS USA, 84(24): 8773-8777 (1987); Lee, J. K. et al. “Nucleotide sequence of the gene encoding the Corynebacterium glutamicum mannose enzyme II and analyses of the deduced protein sequence,” FEMS Microbiol. Lett., 119(1-2): 137-145 (1994) L27123 aceB Malate synthase Lee, H-S. et al. “Molecular characterization of aceB, a gene encoding malate synthase in Corynebacterium glutamicum,” J. Microbiol. Biotechnol., 4(4): 256-263 (1994) L27126 Pyruvate kinase Jetten, M. S. et al. “Structural and functional analysis of pyruvate kinase from Corynebacterium glutamicum,” Appl. Environ. Microbiol., 60(7): 2501-2507 (1994) L28760 aceA Isocitrate lyase L35906 dtxr Diphtheria toxin repressor Oguiza, J. A. et al. “Molecular cloning, DNA sequence analysis, and characterization of the Corynebacterium diphtheriae dtxR from Brevibacterium lactofermentum,” J. Bacteriol., 177(2): 465-467 (1995) M13774 Prephenate dehydratase Follettie, M. T. et al. “Molecular cloning and nucleotide sequence of the Corynebacterium glutamicum pheA gene,” J. Bacteriol., 167: 695-702 (1986) M16175 5S rRNA Park, Y-H. et al. “Phylogenetic analysis of the coryneform bacteria by 56 rRNA sequences,” J. Bacteriol., 169: 1801-1806 (1987) M16663 trpE Anthranilate synthase, 5′ end Sano, K. et al. “Structure and function of the trp operon control regions of Brevibacterium lactofermentum, a glutamic-acid-producing bacterium,” Gene, 52: 191-200 (1987) M16664 trpA Tryptophan synthase, 3′ end Sano, K. et al. “Structure and function of the trp operon control regions of Brevibacterium lactofermentum, a glutamic-acid-producing bacterium,” Gene, 52: 191-200 (1987) M25819 Phosphoenolpyruvate carboxylase O'Regan, M. et al. “Cloning and nucleotide sequence of the Phosphoenolpyruvate carboxylase-coding gene of Corynebacterium glutamicum ATCC13032,” Gene, 77(2): 237-251 (1989) M85106 23S rRNA gene insertion sequence Roller, C. et al. “Gram-positive bacteria with a high DNA G + C content are characterized by a common insertion within their 23S rRNA genes,” J. Gen. Microbiol., 138: 1167-1175 (1992) M85107, 23S rRNA gene insertion sequence Roller, C. et al. “Gram-positive bacteria with a high DNA G + C content are M85108 characterized by a common insertion within their 23S rRNA genes,” J. Gen. Microbiol., 138: 1167-1175 (1992) M89931 aecD; brnQ; Beta C-S lyase; branched-chain amino Rossol, I. et al. “The Corynebacterium glutamicum aecD gene encodes a C-S yhbw acid uptake carrier; hypothetical lyase with alpha, beta-elimination activity that degrades aminoethylcysteine,” protein yhbw J. Bacteriol., 174(9): 2968-2977 (1992); Tauch, A. et al. “Isoleucine uptake in Corynebacterium glutamicum ATCC 13032 is directed by the brnQ gene product,” Arch. Microbiol., 169(4): 303-312 (1998) S59299 trp Leader gene (promoter) Herry, D. M. et al. “Cloning of the trp gene cluster from a tryptophan- hyperproducing strain of Corynebacterium glutamicum: identification of a mutation in the trp leader sequence,” Appl. Environ. Microbiol., 59(3): 791-799 (1993) U11545 trpD Anthranilate phosphoribosyltransferase O'Gara, J. P. and Dunican, L. K. (1994) Complete nucleotide sequence of the Corynebacterium glutamicum ATCC 21850 tpD gene.” Thesis, Microbiology Department, University College Galway, Ireland. U13922 cglIM; Putative type II 5-cytosoine Schafer, A. et al. “Cloning and characterization of a DNA region encoding a cglIR; clgIIR methyltransferase; putative type II stress-sensitive restriction system from Corynebacterium glutamicum ATCC restriction endonuclease; putative type I or 13032 and analysis of its role in intergeneric conjugation with Escherichia type III restriction endonuclease coli,” J. Bacteriol., 176(23): 7309-7319 (1994); Schafer, A. et al. “The Corynebacterium glutamicum cglIM gene encoding a 5-cytosine in an McrBC- deficient Escherichia coli strain,” Gene, 203(2): 95-101 (1997) U14965 recA U31224 ppx Ankri, S. et al. “Mutations in the Corynebacterium glutamicumproline biosynthetic pathway: A natural bypass of the proA step,” J. Bacteriol., 178(15): 4412-4419 (1996) U31225 proC L-proline: NADP+ 5-oxidoreductase Ankri, S. et al. “Mutations in the Corynebacterium glutamicumproline biosynthetic pathway: A natural bypass of the proA step,” J. Bacteriol., 178(15): 4412-4419 (1996) U31230 obg; proB; ?; gamma glutamyl kinase; similar to D- Ankri, S. et al. “Mutations in the Corynebacterium glutamicumproline unkdh isomer specific 2-hydroxyacid biosynthetic pathway: A natural bypass of the proA step,” J. Bacteriol., dehydrogenases 178(15): 4412-4419 (1996) U31281 bioB Biotin synthase Serebriiskii, I. G., “Two new members of the bio B superfamily: Cloning, sequencing and expression of bio B genes of Methylobacillus flagellatum and Corynebacterium glutamicum,” Gene, 175: 15-22 (1996) U35023 thtR; accBC Thiosulfate sulfurtransferase; acyl CoA Jager, W. et al. “A Corynebacterium glutamicum gene encoding a two-domain carboxylase protein similar to biotin carboxylases and biotin-carboxyl-carrier proteins,” Arch. Microbiol., 166(2); 76-82 (1996) U43535 cmr Multidrug resistance protein Jager, W. et al. “A Corynebacterium glutamicum gene conferring multidrug resistance in the heterologous host Escherichia coli,” J. Bacteriol., 179(7): 2449-2451 (1997) U43536 clpB Heat shock ATP-binding protein U53587 aphA-3 3′5″-aminoglycoside phosphotransferase U89648 Corynebacterium glutamicum unidentified sequence involved in histidine biosynthesis, partial sequence X04960 trpA; trpB; Tryptophan operon Matsui, K. et al. “Complete nucleotide and deduced amino acid sequences of trpC; trpD; the Brevibacterium lactofermentum tryptophan operon,” Nucleic Acids Res., trpE; trpG; 14(24): 10113-10114 (1986) trpL X07563 lys A DAP decarboxylase (meso- Yeh, P. et al. “Nucleic sequence of the lysA gene of Corynebacterium diaminopimelate decarboxylase, glutamicum and possible mechanisms for modulation of its expression,” Mol. EC 4.1.1.20) Gen. Genet., 212(1): 112-119 (1988) X14234 EC 4.1.1.31 Phosphoenolpyruvate carboxylase Eikmanns, B. J. et al. “The Phosphoenolpyruvate carboxylase gene of Corynebacterium glutamicum: Molecular cloning, nucleotide sequence, and expression,” Mol. Gen. Genet., 218(2): 330-339 (1989); Lepiniec, L. et al. “Sorghum Phosphoenolpyruvate carboxylase gene family: structure, function and molecular evolution,” Plant. Mol. Biol., 21 (3): 487-502 (1993) X17313 fda Fructose-bisphosphate aldolase Von der Osten, C. H. et al. “Molecular cloning, nucleotide sequence and fine- structural analysis of the Corynebacterium glutamicum fda gene: structural comparison of C. glutamicum fructose-1, 6-biphosphate aldolase to class I and class II aldolases,” Mol. Microbiol., X53993 dapA L-2, 3-dihydrodipicolinate synthetase (EC Bonnassie, S. et al. “Nucleic sequence of the dapA gene from 4.2.1.52) Corynebacterium glutamicum,” Nucleic Acids Res., 18(21): 6421 (1990) X54223 AttB-related site Cianciotto, N. et al. “DNA sequence homology between att B-related sites of Corynebacterium diphtheriae, Corynebacterium ulcerans, Corynebacterium glutamicum, and the attP site of lambdacorynephage,” FEMS. Microbiol, Lett., 66: 299-302 (1990) X54740 argS; lysA Arginyl-tRNA synthetase; Marcel, T. et al. “Nucleotide sequence and organization of the upstream region Diaminopimelate decarboxylase of the Corynebacterium glutamicum lysA gene,” Mol. Microbiol., 4(11): 1819-1830 (1990) X55994 trpL; trpE Putative leader peptide; anthranilate Heery, D. M. et al. “Nucleotide sequence of the Corynebacterium glutamicum synthase component 1 trpE gene,” Nucleic Acids Res., 18(23): 7138 (1990) X56037 thrC Threonine synthase Han, K. S. et al. “The molecular structure of the Corynebacterium glutamicum threonine synthase gene,” Mol. Microbiol., 4(10): 1693-1702 (1990) X56075 attB-related Attachment site Cianciotto, N. et al. “DNA sequence homology between att B-related sites of site Corynebacterium diphtheriae, Corynebacterium ulcerans, Corynebacterium glutamicum, and the attP site of lambdacorynephage,” FEMS. Microbiol, Lett., 66: 299-302 (1990) X57226 lysC-alpha; Aspartokinase-alpha subunit; Kalinowski, J. et al. “Genetic and biochemical analysis of the Aspartokinase lysC-beta; Aspartokinase-beta subunit; aspartate beta from Corynebacterium glutamicum,” Mol. Microbiol., 5(5): 1197-1204 (1991); asd semialdehyde dehydrogenase Kalinowski, J. et al. “Aspartokinase genes lysC alpha and lysC beta overlap and are adjacent to the aspertate beta-semialdehyde dehydrogenase gene asd in Corynebacterium glutamicum,” Mol. Gen. Genet., 224(3): 317-324 (1990) X59403 gap; pgk; tpi Glyceraldehyde-3-phosphate; Eikmanns, B. J. “Identification, sequence analysis, and expression of a phosphoglycerate kinase; triosephosphate Corynebacterium glutamicum gene cluster encoding the three glycolytic isomerase enzymes glyceraldehyde-3-phosphate dehydrogenase, 3-phosphoglycerate kinase, and triosephosphate isomeras,” J. Bacteriol., 174(19): 6076-6086 (1992) X59404 gdh Glutamate dehydrogenase Bormann, E. R. et al. “Molecular analysis of the Corynebacterium glutamicum gdh gene encoding glutamate dehydrogenase,” Mol. Microbiol., 6(3): 317-326 (1992) X60312 lysI L-lysine permease Seep-Feldhaus, A. H. et al. “Molecular analysis of the Corynebacterium glutamicum lysl gene involved in lysine uptake,” Mol. Microbiol., 5(12): 2995-3005 (1991) X66078 cop1 Ps1 protein Joliff, G. et al. “Cloning and nucleotide sequence of the csp1 gene encoding PS1, one of the two major secreted proteins of Corynebacterium glutamicum: The deduced N-terminal region of PS1 is similar to the Mycobacterium antigen 85 complex,” Mol. Microbial., 6(16): 2349-2362 (1992) X66112 glt Citrate synthase Eikmanns, B. J. et al. “Cloning sequence, expression and transcriptional analysis of the Corynebacterium glutamicum gltA gene encoding citrate synthase,” Microbiol., 140: 1817-1828 (1994) X67737 dapB Dihydrodipicolinate reductase X69103 csp2 Surface layer protein PS2 Peyret, J. L. et al. “Characterization of the cspB gene encoding PS2, an ordered surface-layer protein in Corynebacterium glutamicum,” Mol. Microbiol., 9(1): 97-109 (1993) X69104 IS3 related insertion element Bonamy, C. et al. “Identification of IS1206, a Corynebacterium glutamicum IS3-related insertion sequence and phylogenetic analysis,” Mol. Microbial., 14(3): 571-581 (1994) X70959 leuA Isopropylmalate synthase Patek, M. et al. “Leucine synthesis in Corynebacterium glutamicum: enzyme activities, structure of leuA, and effect of leuA inactivation on lysine synthesis,” Appl. Environ. Microbiol., 60(1): 133-140 (1994) X71489 icd Isocitrate dehydrogenase (NADP+) Eikmanns, B. J. et al. “Cloning sequence analysis, expression, and inactivation of the Corynebacterium glutamicum icd gene encoding isocitrate dehydrogenase and biochemical characterization of the enzyme,” J. Bacteriol., 177(3): 774-782 (1995) X72855 GDHA Glutamate dehydrogenase (NADP+) X75083, mtrA 5-methyltryptophan resistance Heery, D. M. et al. “A sequence from a tryptophan-hyperproducing strain of X70584 Corynebacterium glutamicum encoding resistance to 5-methyltryptophan,” Biochem. Biophys. Res. Commun., 201(3): 1255-1262 (1994) X75085 recA Fitzpatrick, R. et al. “Construction and characterization of recA mutant strains of Corynebacterium glutamicum and Brevibacterium lactofermentum,” Appl. Microbiol. Biotechnol., 42(4): 575-580 (1994) X75504 aceA; thiX Partial Isocitrate lyase; ? Reinscheid, D. J. et al. “Characterization of the isocitrate lyase gene from Corynebacterium glutamicum and biochemical analysis of the enzyme,” J. Bacteriol., 176(12): 3474-3483 (1994) X76875 ATPase beta-subunit Ludwig, W. et al. “Phylogenetic relationships of bacteria based on comparative sequence analysis of elongation factor Tu and ATP-synthase beta-subunit genes,” Antonie Van Leeuwenhoek, 64: 285-305 (1993) X77034 tuf Elongation factor Tu Ludwig, W. et al. “Phylogenetic relationships of bacteria based on comparative sequence analysis of elongation factor Tu and ATP-synthase beta-subunit genes,” Antonie Van Leeuwenhoek, 64: 285-305 (1993) X77384 recA Billman-Jacobe, H. “Nucleotide sequence of a recA gene from Corynebacterium glutamicum,” DNA Seq., 4(6): 403-404 (1994) X78491 aceB Malate synthase Reinscheid, D. J. et al. “Malate synthase from Corynebacterium glutamicum pta-ack operon encoding phosphotransacetylase: sequence analysis,” Microbiology, 140: 3099-3108 (1994) X80629 16S rDNA 16S ribosomal RNA Rainey, F. A. et al. “Phylogenetic analysis of the genera Rhodococcus and Norcardia and evidence for the evolutionary origin of the genus Norcardia from within the radiation of Rhodococcus species,” Microbiol., 141: 523-528 (1995) X81191 gluA; gluB; Glutamate uptake system Kronemeyer, W. et al. “Structure of the gluABCD cluster encoding the gluC; gluD glutamate uptake system of Corynebacterium glutamicum,” J. Bacteriol., 177(5): 1152-1158 (1995) X81379 dapE Succinyldiaminopimelate desuccinylase Wehrmann, A. et al. “Analysis of different DNA fragments of Corynebacterium glutamicum complementing dapE of Escherichia coli,” Microbiology, 40: 3349-56 (1994) X82061 16S rDNA 165 ribosomal RNA Ruimy, R. et al. “Phylogeny of the genus Corynebacterium deduced from analyses of small-subunit ribosomal DNA sequences,” Int. J. Syst. Bacteriol., 45(4): 740-746 (1995) X82928 asd; lysC Aspartate-semialdehyde dehydrogenase; ? Serebrijski, I. et al. “Multicopy suppression by asd gene and osmotic stress- dependent complementation by heterologous proA in proA mutants,” J. Bacteriol., 177(24): 7255-7260 (1995) X82929 proA Gamma-glutamyl phosphate reductase Serebrijski, I. et al. “Multicopy suppression by asd gene and osmotic stress- dependent complementation by heterologous proA in proA mutants,” J. Bacteriol., 177(24): 7255-7260 (1995) X84257 16S rDNA 16S ribosomal RNA Pascual, C. et al. “Phylogenetic analysis of the genus Corynebacterium based on 16S rRNA gene sequences,” Int. J. Syst. Bacteriol., 45(4): 724-728 (1995) X85965 aroP; dapE Aromatic amino acid permease; ? Wehrmann, A. et al. “Functional analysis of sequences adjacent to dapE of Corynebacterium glutamicumproline reveals the presence of aroP, which encodes the aromatic amino acid transporter,” J. Bacteriol., 177(20): 5991-5993 (1995) X86157 argB; argC; Acetylglutamate kinase; N-acetyl-gamma- Sakanyan, V. et al. “Genes and enzymes of the acetyl cycle of arginine argD; argF; glutamyl-phosphate reductase; biosynthesis in Corynebacterium glutamicum: enzyme evolution in the early argJ acetylornithine aminotransferase; ornithine steps of the arginine pathway,” Microbiology, 142: 99-108 (1996) carbamoyltransferase; glutamate N- acetyltransferase X89084 pta; ackA Phosphate acetyltransferase; acetate kinase Reinscheid, D. J. et al. “Cloning, sequence analysis, expression and inactivation of the Corynebacterium glutamicum pta-ack operon encoding phosphotransacetylase and acetate kinase,” Microbiology, 145: 503-513 (1999) X89850 attB Attachment site Le Marrec, C. et al. “Genetic characterization of site-specific integration functions of phi AAU2 infecting “Arthrobacter aureus C70,” J. Bacteriol., 178(7): 1996-2004 (1996) X90356 Promoter fragment F1 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90357 Promoter fragment F2 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90358 Promoter fragment F10 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90359 Promoter fragment F13 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90360 Promoter fragment F22 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90361 Promoter fragment F34 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90362 Promoter fragment F37 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90363 Promoter fragment F45 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90364 Promoter fragment F64 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90365 Promoter fragment F75 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90366 Promoter fragment PF101 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90367 Promoter fragment PF104 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X90368 Promoter fragment PF109 Patek, M. et al. “Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif,” Microbiology, 142: 1297-1309 (1996) X93513 amt Ammonium transport system Siewe, R. M. et al. “Functional and genetic characterization of the (methyl) ammonium uptake carrier of Corynebacterium glutamicum,” J. Biol. Chem., 271(10): 5398-5403 (1996) X93514 betP Glycine betaine transport system Peter, H. et al. “Isolation, characterization, and expression of the Corynebacterium glutamicum betP gene, encoding the transport system for the compatible solute glycine betaine,” J. Bacteriol., 178(17): 5229-5234 (1996) X95649 orf4 Patek, M. et al. “Identification and transcriptional analysis of the dapB-ORF2- dapA-ORF4 operon of Corynebacterium glutamicum, encoding two enzymes involved in L-lysine synthesis,” Biotechnol. Lett., 19: 1113-1117 (1997) X96471 lysE; lysG Lysine exporter protein; Lysine export Vrljic, M. et al. “A new type of transporter with a new type of cellular regulator protein function: L-lysine export from Corynebacterium glutamicum,” Mol. Microbiol., 22(5): 815-826 (1996) X96580 panB; panC; 3-methyl-2-oxobutanoate Sahm, H. et al. “D-pantothenate synthesis in Corynebacterium glutamicum and xylB hydroxymethyltransferase; pantoate-beta- use of panBC and genes encoding L-valine synthesis for D-pantothenate alanine ligase; xylulokinase overproduction,” Appl. Environ. Microbiol., 65(5): 1973-1979 (1999) X96962 Insertion sequence IS1207 and transposase X99289 Elongation factor P Ramos, A. et al. “Cloning, sequencing and expression of the gene encoding elongation factor P in the amino-acid producer Brevibacterium lactofermentum (Corynebacterium glutamicum ATCC 13869),” Gene, 198: 217-222 (1997) Y00140 thrB Homoserine kinase Mateos, L. M. et al. “Nucleotide sequence of the homoserine kinase (thrB) gene of the Brevibacterium lactofermentum,” Nucleic Acids Res., 15(9): 3922 (1987) Y00151 ddh Meso-diaminopimelate D-dehydrogenase Ishino, S. et al. “Nucleotide sequence of the meso-diaminopimelate D- (EC 1.4.1.16) dehydrogenase gene from Corynebacterium glutamicum,” Nucleic Acids Res., 15(9): 3917 (1987) Y00476 thrA Homoserine dehydrogenase Mateos, L. M. et al. “Nucleotide sequence of the homoserine dehydrogenase (thrA) gene of the Brevibacterium lactofermentum,” Nucleic Acids Res., 15(24): 10598 (1987) Y00546 hom; thrB Homoserine dehydrogenase; homoserine Peoples, O. P. et al. “Nucleotide sequence and fine structural analysis of the kinase Corynebacterium glutamicum hom-thrB operon,” Mol. Microbiol., 2(1): 63-72 (1988) Y08964 murC; ftsQ/ UPD-N-acetylmuramate-alanine ligase; Honrubia, M. P. et al. “Identification, characterization, and chromosomal divD; ftsZ division initiation protein or cell division organization of the ftsZ gene from Brevibacterium lactofermentum,” Mol. Gen. protein; cell division protein Genet., 259(1): 97-104 (1998) Y09163 putP High affinity proline transport system Peter, H. et al. “Isolation of the putP gene of Corynebacterium glutamicumproline and characterization of a low-affinity uptake system for compatible solutes,” Arch. Microbiol., 168(2): 143-15 (1997) Y09548 pyc Pyruvate carboxylase Peters-Wendisch, P. G. et al. “Pyruvate carboxylase from Corynebacterium glutamicum: characterization, expression and inactivation of the pyc gene,” Microbiology, 144: 915-927 (1998) Y09578 leuB 3-isopropylmalate dehydrogenase Patek, M. et al. “Analysis of the leuB gene from Corynebacterium glutamicum,” Appl. Microbiol. Biotechnol., 50(1): 42-47 (1998) Y12472 Attachment site bacteriophage Phi-16 Moreau, S. et al. “Site-specific integration of corynephage Phi-16: The construction of an integration vector,” Microbiol., 145: 539-548 (1999) Y12537 proP Proline/ectoine uptake system protein Peter, H. et al. “Corynebacterium glutamicum is equipped with four secondary carriers for compatible solutes: Identification, sequencing, and characterization of the proline/ectoine uptake system, ProP, and the ectoine/proline/glycine betaine carrier, EctP,” J. Bacteriol., 180(22): 6005-6012 (1998) Y13221 glnA Glutamine synthetase I Jakoby, M. et al. “Isolation of Corynebacterium glutamicum glnA gene encoding glutamine synthetase I,” FEMS Microbiol. Lett., 154(1): 81-88 (1997) Y16642 lpd Dihydrolipoamide dehydrogenase Y18059 Attachment site Corynephage 304L Moreau, S. et al. “Analysis of the integration functions of &phi;304L: An integrase module among corynephages,” Virology, 255(1): 150-159 (1999) Z21501 argS; lysA Arginyl-tRNA synthetase; Oguiza, J. A. et al. “A gene encoding arginyl-tRNA synthetase is located in the diaminopimelate decarboxylase (partial) upstream region of the lysA gene in Brevibacterium lactofermentum: Regulation of argS-lysA cluster expression by arginine,” J. Bacteriol., 175(22): 7356-7362 (1993) Z21502 dapA; dapB Dihydrodipicolinate synthase; Pisabarro, A. et al. “A cluster of three genes (dapA, orf2, and dapB) of dihydrodipicolinate reductase Brevibacterium lactofermentum encodes dihydrodipicolinate reductase, and a third polypeptide of unknown function,” J. Bacteriol., 175(9): 2743-2749 (1993) Z29563 thrC Threonine synthase Malumbres, M. et al. “Analysis and expression of the thrC gene of the encoded threonine synthase,” Appl. Environ. Microbiol., 60(7)2209-2219 (1994) Z46753 16S rDNA Gene for 16S ribosomal RNA Z49822 sigA SigA sigma factor Oguiza, J. A. et al “Multiple sigma factor genes in Brevibacterium lactofermentum: Characterization of sigA and sigB,” J. Bacteriol., 178(2): 550-553 (1996) Z49823 galE; dtxR Catalytic activity UDP-galactose 4- Oguiza, J. A. et al “The galE gene encoding the UDP-galactose 4-epimerase of epimerase; diphtheria toxin regulatory Brevibacterium lactofermentum is coupled transcriptionally to the dmdR protein gene,” Gene, 177: 103-107 (1996) Z49824 orf1; sigB ?; SigB sigma factor Oguiza, J. A. et al “Multiple sigma factor genes in Brevibacterium lactofermentum: Characterization of sigA and sigB,” J. Bacteriol., 178(2): 550-553 (1996) Z66534 Transposase Correia, A. et al. “Cloning and characterization of an IS-like element present in the genome of Brevibacterium lactofermentum ATCC 13869,” Gene, 170(1): 91-94 (1996) ¹A sequence for this gene was published in the indicated reference. However, the sequence obtained by the inventors of the present application is significantly longer than the published version. It is believed that the published version relied on an incorrect start codon, and thus represents only a fragment of the actual coding region.

TABLE 1 GENES IN THE APPLICATION Nucleic Amino Acid Acid SEQ ID SEQ ID Identification NT NT NO NO Code Contig. Start Stop Function 1 2 RXA00775 GR00205 6057 5287 PHOSPHATE TRANSPORT ATP-BINDING PROTEIN PSTB 3 4 RXA00776 GR00205 7016 6096 PHOSPHATE TRANSPORT SYSTEM PERMEASE PROTEIN PSTA 5 6 RXA00777 GR00205 8098 7034 PHOSPHATE TRANSPORT SYSTEM PERMEASE PROTEIN PSTC 7 8 RXA00774 GR00205 4546 5199 PHOSPHATE TRANSPORT SYSTEM REGULATORY PROTEIN 9 10 RXA00204 GR00032 3783 2212 RIBOSE TRANSPORT ATP-BINDING PROTEIN RBSA 11 12 RXA02438 GR00709 3236 2478 RIBOSE TRANSPORT ATP-BINDING PROTEIN RBSA 13 14 RXA00203 GR00032 2152 1241 RIBOSE TRANSPORT SYSTEM PERMEASE PROTEIN RBSC 15 16 RXA00270 GR00041 2720 1833 RIBOSE TRANSPORT SYSTEM PERMEASE PROTEIN RBSC 17 18 RXA02439 GR00709 4258 3236 RIBOSE TRANSPORT SYSTEM PERMEASE PROTEIN RBSC 19 20 RXN02994 VV0070 2 724 GLUTAMINE TRANSPORT ATP-BINDING PROTEIN GLNQ 21 22 F RXA01245 GR00360 2 1768 COPPER/POTASSIUM-TRANSPORTING ATPASE B (EC 3.6.1.36) Lipoprotein and Lipopolysaccharide synthesis Nucleic Amino Acid Acid SEQ ID SEQ ID Identification NT NT NO NO Code Contig. Start Stop Function 23 24 RXA00002 GR00001 2278 1595 DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE (EC 2.4.1.83)/APOLIPOPROTEIN N-ACYLTRANSFERASE (EC 2.3.1.-) 25 26 RXA00160 GR00024 4044 4616 LIPOPROTEIN NLPD/LPPB HOMOLOG PRECURSOR 27 28 RXA00345 GR00064 90 1040 Zn-binding lipoprotein 29 30 RXA00413 GR00092 3859 2963 OUTER MEMBRANE LIPOPROTEIN 3 PRECURSOR 31 32 RXA00482 GR00119 18891 18244 OUTER MEMBRANE LIPOPROTEIN BLC PRECURSOR 33 34 RXN01164 VV0117 15894 14260 DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE (EC 2.4.1.83)/APOLIPOPROTEIN N-ACYLTRANSFERASE (EC 2.3.1.-) 35 36 F RXA01164 GR00332 1579 5 DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE (EC 2.4.1.83)/APOLIPOPROTEIN N-ACYLTRANSFERASE (EC 2.3.1.-) 37 38 RXN01168 VV0117 14224 13415 DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE (EC 2.4.1.83)/APOLIPOPROTEIN N-ACYLTRANSFERASE (EC 2.3.1.-) 39 40 F RXA01168 GR00333 1285 566 DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE (EC 2.4.1.83)/APOLIPOPROTEIN N-ACYLTRANSFERASE (EC 2.3.1.-) 41 42 RXN02062 VV0222 3159 1990 Lipopolysaccharide N-acetylglucosaminyltransferase 43 44 F RXA02062 GR00626 3159 1990 Lipopolysaccharide N-acetylglucosaminyltransferase 45 46 RXA02222 GR00651 9420 9794 PUTATIVE HOST CELL SURFACE-EXPOSED LIPOPROTEIN 47 48 RXA02313 GR00665 5812 4592 Lipopolysaccharide N-acetylglucosaminyltransferase 49 50 RXA02491 GR00720 902 2155 Lipopolysaccharide N-acetylglucosaminyltransferase 51 52 RXN02595 VV0098 11098 9935 Lipopolysaccharide N-acetylglucosaminyltransferase 53 54 F RXA02595 GR00741 19052 19702 Lipopolysaccharide N-acetylglucosaminyltransferase 55 56 RXA02616 GR00745 598 1308 LIPOPROTEIN NLPD PRECURSOR 57 58 RXA02627 GR00747 2981 2139 DTXR/IRON-REGULATED LIPOPROTEIN PRECURSOR 59 60 RXA02650 GR00752 1460 2038 LIPOPROTEIN SIGNAL PEPTIDASE (EC 3.4.23.36) 61 62 RXA01094 GR00306 2703 1756 PROLIPOPROTEIN DIACYLGLYCERYL TRANSFERASE (EC 2.4.99.-) 63 64 RXN00934 VV0171 15181 14099 (AE000805) LPS biosynthesis RfbU related protein [Methanobacterium thermoautotrophicum] 65 66 F RXA00934 GR00253 6835 6047 (AE000805) LPS biosynthesis RfbU related protein [Methanobacterium thermoautotrophicum] 67 68 RXA02605 GR00742 11557 12051 ANTIGEN 85-B PRECURSOR ABC-Transporter Nucleic Amino Acid Acid SEQ ID SEQ ID Identification NT NT NO NO Code Contig. Start Stop Function 69 70 RXN00525 VV0079 26304 27566 Hypothetical ABC Transporter Permease Protein 71 72 F RXA00525 GR00136 664 5 Hypothetical ABC Transporter Permease Protein 73 74 F RXA00556 GR00146 1 594 Hypothetical ABC Transporter Permease Protein 75 76 RXA02750 GR00764 5079 5894 Hypothetical ABC Transporter Permease Protein 77 78 RXN02096 VV0126 20444 22135 Hypothetical ABC Transporter Permease Protein 79 80 F RXA02096 GR00629 15458 16774 Hypothetical ABC Transporter Permease Protein 81 82 RXA02562 GR00732 796 1515 PUTATIVE ABC TRANSPORTER 83 84 RXA00950 GR00260 173 1078 similar to ABC transporter (ATP-binding protein) START CODON GTG 85 86 RXA02119 GR00636 4222 2582 similar to ABC transporter (ATP-binding protein) 87 88 RXA01185 GR00338 2451 1594 ATP-BINDING PROTEIN 89 90 RXN00412 VV0086 53923 52844 Hypothetical Amino Acid ABC Transporter ATP-Binding Protein 91 92 F RXA00412 GR00092 2764 1685 ATP-BINDING PROTEIN ABC 93 94 RXN02925 VV0104 543 2759 COPPER/POTASSIUM-TRANSPORTING ATPASE B (EC 3.6.1.36) 95 96 RXN00939 VV0079 45152 43917 COPPER/POTASSIUM-TRANSPORTING ATPASE B (EC 3.6.1.36) 97 98 F RXA00939 GR00256 1501 1334 COPPER/POTASSIUM-TRANSPORTING ATPASE B (EC 3.6.1.36) 99 100 RXN01323 VV0082 4321 6585 COPPER/POTASSIUM-TRANSPORTINGATPASE B (EC 3.6.1.36) 101 102 F RXA01323 GR00385 1175 3439 similar to heavy metal-transporting ATPase 103 104 RXN00702 VV0005 12478 10772 COBALT TRANSPORT ATP-BINDING PROTEIN CBIO 105 106 F RXA00702 GR00182 2165 846 COBALT TRANSPORT ATP-BINDING PROTEIN CBIO 107 108 RXN00828 VV0180 1376 1828 COBALT TRANSPORT ATP-BINDING PROTEIN CBIO 109 110 F RXA00828 GR00223 1687 1319 COBALT TRANSPORT ATP-BINDING PROTEIN CBIO 111 112 RXN03020 VV0139 606 4 GLUTAMINE TRANSPORT ATP-BINDING PROTEIN GLNQ 113 114 RXN00726 VV0188 1 591 GLUTAMINE TRANSPORT ATP-BINDING PROTEIN GLNQ 115 116 RXN02570 VV0101 11699 12340 MALTOSE TRANSPORT SYSTEM PERMEASE PROTEIN MALF 117 118 RXN02354 VV0095 473 1306 MALTOSE TRANSPORT SYSTEM PERMEASE PROTEIN MALG 119 120 F RXA02354 GR00682 473 1261 MALTOSE TRANSPORT SYSTEM PERMEASE PROTEIN MALG 121 122 RXN00001 VV0196 4023 2896 MALTOSE/MALTODEXTRIN TRANSPORT ATP-BINDING PROTEIN MALK 123 124 F RXA00001 GR00001 1386 259 SN-GLYCEROL-3-PHOSPHATE TRANSPORT ATP-BINDING PROTEIN UGPC 125 126 RXN02356 VV0051 1868 873 MALTOSE/MALTODEXTRIN TRANSPORT ATP-BINDING PROTEIN MALK 127 128 RXN02455 VV0196 1273 5 MALTOSE-BINDING PROTEIN PRECURSOR 129 130 RXN02795 VV0176 29237 27801 OLIGOPEPTIDE TRANSPORT ATP-BINDING PROTEIN APPF 131 132 F RXA02795 GR00778 3 1097 OLIGOPEPTIDE TRANSPORT ATP-BINDING PROTEIN APPF 133 134 RXN01939 VV0139 22695 20965 OLIGOPEPTIDE TRANSPORT ATP-BINDING PROTEIN OPPD 135 136 F RXA00761 GR00203 8530 9120 OLIGOPEPTIDE TRANSPORT ATP-BINDING PROTEIN OPPD 137 138 F RXA01939 GR00556 2042 1440 OLIGOPEPTIDE TRANSPORT ATP-BINDING PROTEIN OPPD 139 140 RXN00759 VV0139 24645 23722 OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN OPPB 141 142 F RXA00759 GR00203 6580 7503 OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN OPPB 143 144 RXN00431 VV0112 8987 8199 O-ANTIGEN EXPORT SYSTEM ATP-BINDING PROTEIN RFBE 145 146 F RXA00431 GR00099 119 793 ABCA PROTEIN two-component ABC transporter involved in the metabolism of two wall teichoic acids 147 148 RXN00732 VV0132 1 1647 PROBABLE TRANSPORT ATP-BINDING PROTEIN MSBA 149 150 F RXA00732 GR00196 826 5 PROBABLE TRANSPORT ATP-BINDING PROTEIN MSBA 151 152 F RXA00734 GR00197 863 411 Hypothetical ABC Transporter ATP-Binding Protein 153 154 RXN01808 VV0216 3 1151 PUTATIVE ABC TRANPORTER 155 156 F RXA01808 GR00509 8993 7875 PUTATIVE ABC TRANPORTER 157 158 RXN02975 VV0231 252 4 Hypothetical ABC Transporter ATP-Binding Protein 159 160 RXN03116 VV0090 38067 38675 MALTOSE/MALTODEXTRIN TRANSPORT ATP-BINDING PROTEIN MALK 161 162 RXN03108 VV0077 5535 5801 NITRATE TRANSPORT ATP-BINDING PROTEIN NRTD 163 164 RXN03129 VV0122 24042 22819 SN-GLYCEROL-3-PHOSPHATE TRANSPORT ATP-BINDING PROTEIN UGPC 165 166 F RXA01890 GR00541 874 155 SN-GLYCEROL-3-PHOSPHATE TRANSPORT ATP-BINDING PROTEIN UGPC 167 168 RXN02945 VV0180 492 1424 COBALT TRANSPORT ATP-BINDING PROTEIN CBIO Other transporters Nucleic Amino Acid Acid SEQ ID SEQ ID Identification NT NT NO NO Code Contig. Start Stop Function 169 170 RXA01247 GR00361 256 489 COPPER/POTASSIUM-TRANSPORTING ATPASE B (EC 3.6.1.36) 171 172 RXN00099 VV0129 18876 17704 CYANATE TRANSPORT PROTEIN CYNX 173 174 F RXA00099 GR00014 8172 9344 CYANATE TRANSPORT PROTEIN CYNX 175 176 RXA00634 GR00166 3732 5114 DI-/TRIPEPTIDE TRANSPORTER 177 178 RXA02451 GR00710 3484 5007 DI-/TRIPEPTIDE TRANSPORTER 179 180 RXA02394 GR00697 1895 585 DICARBOXYLATE TRANSPORTER 181 182 RXA01012 GR00288 3748 2108 DIPEPTIDE TRANSPORT ATP-BINDING PROTEIN DPPD 183 184 RXA02660 GR00753 548 1186 DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN DPPB 185 186 RXA02661 GR00753 1239 1457 DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN DPPB 187 188 RXA02034 GR00619 1787 822 DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN DPPB 189 190 RXA01013 GR00288 4549 3755 DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN DPPC 191 192 RXN02933 VV0176 30042 29233 DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN DPPC 193 194 F RXA02033 GR00619 800 12 DIPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN DPPC 195 196 RXA01006 GR00287 862 5 DIPEPTIDE TRANSPORTER PROTEIN DPPB 197 198 RXA02312 GR00665 4459 3101 D-SERINE/D-ALANINE/GLYCINE TRANSPORTER 199 200 RXA00090 GR00013 6644 7762 FERRIC ANGUIBACTIN TRANSPORT SYSTEM PERMEASE PROTEIN FATC 201 202 RXA00089 GR00013 5656 6654 FERRIC ANGUIBACTIN TRANSPORT SYSTEM PERMEASE PROTEIN FATD 203 204 RXN01285 VV0215 1780 1055 FERRIC ENTEROBACTIN TRANSPORT ATP-BINDING PROTEIN FEPC 205 206 F RXA01285 GR00371 3 545 FERRIC ENTEROBACTIN TRANSPORT ATP-BINDING PROTEIN FEPC 207 208 RXA02728 GR00761 184 996 FERRIC ENTEROBACTIN TRANSPORT ATP-BINDING PROTEIN FEPC 209 210 RXN03080 VV0045 1670 2449 FERRIC ENTEROBACTIN TRANSPORT ATP-BINDING PROTEIN FEPC 211 212 F RXA02864 GR10007 2806 2027 FERRIC ENTEROBACTIN TRANSPORT ATP-BINDING PROTEIN FEPC 213 214 RXN00523 VV0194 1363 338 FERRIC ENTEROBACTIN TRANSPORT PROTEIN FEPG 215 216 F RXA00523 GR00135 30 779 FERRIC ENTEROBACTIN TRANSPORT PROTEIN FEPG 217 218 RXA01289 GR00372 2376 3419 FERRIC ENTEROBACTIN TRANSPORT PROTEIN FEPG 219 220 RXA01290 GR00372 3412 4575 FERRIC ENTEROBACTIN TRANSPORT PROTEIN FEPG 221 222 RXA01822 GR00516 6 587 FERRIC ENTEROBACTIN TRANSPORT PROTEIN FEPG 223 224 RXN00466 VV0086 63271 64266 Ferrichrome transport proteins 225 226 F RXA00466 GR00117 947 1933 Ferrichrome transport proteins 227 228 RXN03081 VV0045 2476 2934 FERRIENTEROBACTIN-BINDING PERIPLASMIC PROTEIN PRECURSOR 229 230 F RXA02863 GR10007 2000 1026 Ferrichrome transport proteins 231 232 RXS03221 GALACTOSE-PROTON SYMPORT 233 234 F RXA01986 GR00575 622 5 GALACTOSE-PROTON SYMPORT 235 236 RXN02447 VV0107 14297 13203 GALACTOSE-PROTON SYMPORT 237 238 F RXA02447 GR00710 1 270 GALACTOSE-PROTON SYMPORT 239 240 F RXA02769 GR00771 1 711 GALACTOSE-PROTON SYMPORT 241 242 RXS503220 D-XYLOSE-PROTON SYMPORT 243 244 F RXA02762 GR00768 346 630 D-XYLOSE PROTON-SYMPORTER 245 246 F RXA02761 GR00768 153 353 GALACTOSE-PROTON SYMPORT 247 248 RXA00123 GR00019 7029 5911 MAGNESIUM AND COBALT TRANSPORT PROTEIN CORA 249 250 RXA02441 GR00709 5940 5284 MANGANESE TRANSPORT SYSTEM ATP-BINDING PROTEIN MNTA 251 252 RXN02442 VV0217 5970 6818 zinc transport system membrane protein 253 254 F RXA02442 GR00709 5970 6818 MANGANESE TRANSPORT SYSTEM MEMBRANE PROTEIN MNTB 255 256 RXA01756 GR00498 2069 762 MG2+ TRANSPORTER MGTE 257 258 RXA02068 GR00627 2 1120 MG2+ TRANSPORTER MGTE 259 260 RXA00665 GR00174 135 572 MG2+/CITRATE COMPLEX SECONDARY TRANSPORTER 261 262 RXA02808 GR00789 1 258 MG2+/CITRATE COMPLEX SECONDARY TRANSPORTER 263 264 RXN00444 VV0112 20785 19949 MOLYBDENUM TRANSPORT SYSTEM PERMEASE PROTEIN MODB 265 266 F RXA00444 GR00106 626 1402 MOLYBDENUM TRANSPORT SYSTEM PERMEASE PROTEIN MODB 267 268 RXN02614 VV0313 5964 5236 TAURINE TRANSPORT ATP-BINDING PROTEIN TAUB 269 270 F RXA02614 GR00743 5964 5236 NITRATE TRANSPORT ATP-BINDING PROTEIN NRTC 271 272 RXN01142 VV0077 5805 6302 NITRATE TRANSPORT ATP-BINDING PROTEIN NRTD 273 274 F RXA01142 GR00320 721 302 NITRATE TRANSPORT ATP-BINDING PROTEIN NRTD 275 276 RXN01141 VV0077 4644 5468 NITRATE TRANSPORT PROTEIN NRTA 277 278 F RXA01135 GR00318 327 4 NITRATE TRANSPORT PROTEIN NRTA 279 280 F RXA01141 GR00319 636 175 NITRATE TRANSPORT PROTEIN NRTA 281 282 RXA00728 GR00193 1658 2449 NOPALINE TRANSPORT SYSTEM PERMEASE PROTEIN NOCM 283 284 RXA02663 GR00753 2059 3453 OLIGOPEPTIDE TRANSPORT ATP-BINDING PROTEIN OPPD 285 286 RXA02664 GR00753 3611 4270 OLIGOPEPTIDE TRANSPORT ATP-BINDING PROTEIN OPPF 287 288 RXA00760 GR00203 7499 8530 OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN OPPC 289 290 RXA02035 GR00619 3295 1787 PERIPLASMIC DIPEPTIDE TRANSPORT PROTEIN PRECURSOR 291 292 RXN01002 VV0106 8858 8055 PHOSPHONATES TRANSPORT ATP-BINDING PROTEIN PHNC 293 294 F RXA01002 GR00285 3 419 PHOSPHONATES TRANSPORT ATP-BINDING PROTEIN PHNC 295 296 RXN01000 VV0106 7252 6407 PHOSPHONATES TRANSPORT SYSTEM PERMEASE PROTEIN PHNE 297 298 F RXA01000 GR00284 2 541 PHOSPHONATES TRANSPORT SYSTEM PERMEASE PROTEIN PHNE 299 300 RXA01003 GR00285 419 1222 PHOSPHONATES TRANSPORT SYSTEM PERMEASE PROTEIN PHNE 301 302 RXN00193 VV0371 1 594 POTENTIAL STARCH DEGRADATION PRODUCTS TRANSPORT SYSTEM PERMEASE AMYD 303 304 F RXA00193 GR00029 10101 9259 POTENTIAL STARCH DEGRADATION PRODUCTS TRANSPORT SYSTEM PERMEASE AMYD 305 306 RXN01298 VV0116 2071 1142 POTENTIAL STARCH DEGRADATION PRODUCTS TRANSPORT SYSTEM PERMEASE PROTEIN AMYD 307 308 F RXA01298 GR00374 1254 862 POTENTIAL STARCH DEGRADATION PRODUCTS TRANSPORT SYSTEM PERMEASE PROTEIN AMYD 309 310 F RXA02422 GR00705 8200 8634 POTENTIAL STARCH DEGRADATION PRODUCTS TRANSPORT SYSTEM PERMEASE PROTEIN AMYD 311 312 RXN02515 VV0087 962 1717 Hypothetical ABC Transporter ATP-Binding Protein 313 314 F RXA02515 GR00723 964 1719 PROBABLE ATP-DEPENDENT TRANSPORTER YCF16 315 316 RXN01995 VV0182 2139 3476 PUTATIVE 3-(3-HYDROXYPHENYL) PROPIONATE TRANSPORT PROTEIN 317 318 F RXA01995 GR00584 1362 2015 PUTATIVE 3-(3-HYDROXYPHENYL) PROPIONATE TRANSPORT PROTEIN 319 320 RXA01188 GR00339 1585 482 PUTATIVE TRANSPORT PROTEIN SGAT 321 322 RXA01972 GR00569 2116 1523 QUATERNARY AMINE TRANSPORTER 323 324 RXA00311 GR00053 1592 738 SHIKIMATE TRANSPORTER 325 326 RXA00312 GR00053 2066 1641 SHIKIMATE TRANSPORTER 327 328 RXN01411 VV0050 26015 26779 SHIKIMATE TRANSPORTER 329 330 F RXA01411 GR00412 1 327 SHIKIMATE TRANSPORTER 331 332 RXA01900 GR00544 2822 4120 SHIKIMATE TRANSPORTER 333 334 RXA02507 GR00720 19760 21160 SHIKIMATE TRANSPORTER 335 336 RXA00445 GR00107 21 932 SN-GLYCEROL-3-PHOSPHATE TRANSPORT ATP-BINDING PROTEIN UGPC 337 338 RXA02353 GR00682 6 473 SN-GLYCEROL-3-PHOSPHATE TRANSPORT SYSTEM PERMASE PROTEIN UGPA 339 340 RXA01297 GR00374 826 29 SN-GLYCEROL-3-PHOSPHATE TRANSPORT SYSTEM PERMEASE PROTEIN 341 342 RXS00088 VV0027 2 877 FERRIC ANGUIBACTIN-BINDING PROTEIN PRECURSOR 343 344 RXS00372 VV0226 3456 2380 PERIPLASMIC-IRON-BINDING PROTEIN SHIB 345 346 RXS02590 VV0098 15313 16248 MALIC ACID TRANSPORT PROTEIN 347 348 RXS00758 VV0139 26428 24827 PERIPLASMIC OLIGOPEPTIDE-BINDING PROTEIN PRECURSOR 349 350 RXS01346 VV0123 5120 6694 PERIPLASMIC OLIGOPEPTIDE-BINDING PROTEIN PRECURSOR 351 352 RXS00912 VV0339 552 280 potassium efflux system protein phaF 353 354 RXS00453 VV0076 1173 3521 Drug Transporter 355 356 RXS00932 VV0171 13120 13593 Drug Transporter 357 358 RXS00479 VV0086 42008 39819 Drug Transporter 359 360 RXS02586 VV0098 19854 20123 Drug Transporter 361 362 RXS02587 VV0098 17807 19897 Drug Transporter 363 364 RXS03042 VV0018 2440 1835 Drug Transporter 365 366 RXS03075 VV0042 2491 3216 Drug Transporter 367 368 RXS03124 VV0108 4 963 Drug Transporter 369 370 RXS03125 VV0108 972 1142 Drug Transporter Channel Proteins Nucleic Amino Acid Acid SEQ ID SEQ ID Identification NT NT NO NO Code Contig. Start Stop Function 371 372 RXA00596 GR00159 335 787 potassium efflux system protein phaE 373 374 RXA02079 GR00628 9034 9648 CATION EFFLUX SYSTEM PROTEIN CZCD 375 376 RXA01303 GR00376 1724 390 NITRITE EXTRUSION PROTEIN 377 378 RXA02079 GR00628 9034 9648 CATION EFFLUX SYSTEM PROTEIN CZCD 379 380 RXN00832 VV0180 3133 4182 CALCIUM/PROTON ANTIPORTER 381 382 F RXA00832 GR00224 2239 1685 CALCIUM/PROTON ANTIPORTER 383 384 RXN00378 VV0223 8027 5418 Cation transport ATPases 385 386 F RXA00378 GR00081 3271 1499 Cation transport ATPases 387 388 RXA00942 GR00257 2406 2203 CATION-TRANSPORTING ATPASE PACS (EC 3.6.1.-) 389 390 RXN01338 VV0032 2 1903 CATION-TRANSPORTING ATPASE PACS (EC 3.6.1.-) 391 392 F RXA01338 GR00389 6964 5087 CATION-TRANSPORTING ATPASE PACS (EC 3.6.1.-) 393 394 RXA01625 GR00452 3850 3650 CATION-TRANSPORTING ATPASE PACS (EC 3.6.1.-) 395 396 RXA02220 GR00651 3205 5880 CATION-TRANSPORTING ATPASE PMA1 (EC 3.6.1.-) 397 398 RXN00980 VV0149 2635 4428 CATION-TRANSPORTING P-TYPE ATPASE B (EC 3.6.1.-) 399 400 F RXA00980 GR00276 2648 3286 CATION-TRANSPORTING P-TYPE ATPASE B (EC 3.6.1.-) 401 402 RXN02348 VV0078 6027 7910 KUP SYSTEM POTASSIUM UPTAKE PROTEIN 403 404 F RXA02348 GR00677 1719 586 KUP SYSTEM POTASSIUM UPTAKE PROTEIN 405 406 F RXA02344 GR00676 682 5 KUP SYSTEM POTASSIUM UPTAKE PROTEIN 407 408 RXN00960 VV0075 1139 105 PROTON/SODIUM-GLUTAMATE SYMPORT PROTEIN 409 410 F RXA00960 GR00266 563 105 PROTON/SODIUM-GLUTAMATE SYMPORT PROTEIN 411 412 RXA01070 GR00299 2089 704 PROTON/SODIUM-GLUTAMATE SYMPORT PROTEIN 413 414 RXA02628 GR00748 6 410 LARGE CONDUCTANCE MECHANOSENSITIVE CHANNEL 415 416 RXN03164 VV0277 1586 2455 POTASSIUM CHANNEL BETA SUBUNIT 417 418 F RXA01395 GR00408 6106 5021 POTASSIUM CHANNEL BETA SUBUNIT Other membrane proteins Nucleic Amino Acid Acid SEQ ID SEQ ID Identification NT NT NO NO Code Contig. Start Stop Function 419 420 RXA02597 GR00742 2329 542 OUTER MEMBRANE USHER PROTEIN FIMC PRECURSOR 421 422 RXA01454 GR00420 270 4 integral membrane protein 423 424 RXA01455 GR00420 745 284 integral membrane protein 425 426 RXA02684 GR00754 8923 8060 MEMBRANE-BOUND PROTEIN LYTR 427 428 RXN02391 VV0176 3525 3923 (U59457 Pseudomonas aeruginosa ankyrin (ankB) gene, complete cds [Pseudomonas aeruginosa] 429 430 RXN02549 VV0098 3165 5867 PUTATIVE INTEGRAL MEMBRANE PROTEIN 431 432 RXN00808 VV0009 63243 64700 PUTATIVE MEMBRANE PROTEIN 433 434 RXS01425 VV0050 2679 3563 60 KD INNER-MEMBRANE PROTEIN 435 436 RXS01658 VV0010 44183 42351 membrane protein 437 438 RXS01677 VV0179 12923 12180 membrane protein 439 440 RXS02932 VV0176 23391 24362 Membrane Spanning Protein 441 442 F RXA02402 GR00700 747 4 (AF027868) putative transporter [Bacillius subtilis] 443 444 RXS00654 VV0109 6289 5024 6O KD INNER-MEMBRANE PROTEIN 

1. An isolated nucleic acid molecule selected from the group consisting of a) an isolated nucleic acid molecule from Corynebacterium glutamicum encoding an MCT protein, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1, or a complement thereof; b) an isolated Corynebacterium glutamicum nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of those sequences set forth in Appendix A, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1, or a complement thereof; c) an isolated nucleic acid molecule which encodes a polypeptide comprising an amino acid sequence selected from the group consisting of those sequences set forth in Appendix B, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1, or a complement thereof; d) an isolated nucleic acid molecule which encodes a naturally occurring allelic variant of a polypeptide comprising an amino acid sequence selected from the group consisting of those sequences set forth in Appendix B, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1, or a complement thereof; e) an isolated nucleic acid molecule comprising a nucleotide sequence which is at least 50% identical to an entire nucleotide sequence selected from the group consisting of those sequences set forth in Appendix A, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1, or a complement thereof; and f) an isolated nucleic acid molecule comprising a fragment of at least 15 contiguous nucleotides of a nucleotide sequence selected from the group consisting of those sequences set forth in Appendix A, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1, or a complement thereof.
 2. The isolated nucleic acid molecule of claim 1, wherein said nucleic acid molecule from Corynebacterium glutamicum encodes an MCT protein involved in the production of a fine chemical.
 3. An isolated nucleic acid molecule comprising the nucleic acid molecule of claim 1 and a nucleotide sequence encoding a heterologous polypeptide.
 4. A vector comprising the nucleic acid molecule of claim
 1. 5. The vector of claim 4, which is an expression vector.
 6. A host cell transfected with the expression vector of claim
 5. 7. The host cell of claim 6, wherein said cell is a microorganism.
 8. The host cell of claim 7, wherein said cell belongs to the genus Corynebacterium or Brevibacterium.
 9. A method of producing a polypeptide comprising culturing the host cell of claim 6 in an appropriate culture medium to, thereby, produce the polypeptide.
 10. A method for producing a fine chemical, comprising culturing the cell of claim 6 such that the fine chemical is produced.
 11. The method of claim 10, wherein said method further comprises the step of recovering the fine chemical from said culture.
 12. The method of claim 10, wherein said cell belongs to the genus Corynebacterium or Brevibacterium.
 13. The method of claim 10, wherein said cell is selected from the group consisting of Corynebacterium glutamicum, Corynebacterium herculis, Corynebacterium, lilium, Corynebacterium acetoacidophilum, Corynebacterium acetoglutamicum, Corynebacterium acetophilum, Corynebacterium ammoniagenes, Corynebacterium fujiokense, Corynebacterium nitrilophilus, Brevibacterium ammoniagenes, Brevibacterium butanicum, Brevibacterium divaricatum, Brevibacterium flavum, Brevibacterium healii, Brevibacterium ketoglutamicum, Brevibacterium ketosoreductum, Brevibacterium lactofermentum, Brevibacterium linens, Brevibacterium paraffinolyticum, and those strains set forth in Table
 3. 14. The method of claim 10, wherein expression of the nucleic acid molecule from said vector results in modulation of production of said fine chemical.
 15. The method of claim 10, wherein said fine chemical is selected from the group consisting of organic acids, proteinogenic and nonproteinogenic amino acids, purine and pyrimidine bases, nucleosides, nucleotides, lipids, saturated and unsaturated fatty acids, diols, carbohydrates, aromatic compounds, vitamins, cofactors, polyketides, and enzymes.
 16. The method of claim 10, wherein said fine chemical is an amino acid selected from the group consisting of lysine, glutamate, glutamine, alanine, aspartate, glycine, serine, threonine, methionine, cysteine, valine, leucine, isoleucine, arginine, proline, histidine, tyrosine, phenylalanine, and tryptophan.
 17. An isolated polypeptide selected from the group consisting of a) an isolated MCT polypeptide from Corynebacterium glutamicum; b) an isolated polypeptide comprising an amino acid sequence selected from the group consisting of those sequences set forth in Appendix B, provided that the amino acid sequence is not encoded by any of the F-designated genes set forth in Table 1; c) an isolated polypeptide comprising a naturally occurring allelic variant of a polypeptide comprising an amino acid sequence selected from the group consisting of those sequences set forth in Appendix B, provided that the amino acid sequence is not encoded by any of the F-designated genes set forth in Table 1; d) an isolated polypeptide which is encoded by a nucleic acid molecule comprising a nucleotide sequence which is at least 50% identical to an entire nucleotide sequence selected from the group consisting of those sequences set forth in Appendix A, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1; e) an isolated polypeptide comprising an amino acid sequence which is at least 50% identical to an entire amino acid sequence selected from the group consisting of those sequences set forth in Appendix B, provided that the amino acid sequence is not encoded by any of the F-designated genes set forth in Table 1; and f) an isolated polypeptide comprising a fragment of a polypeptide comprising an amino acid sequence selected from the group consisting of those sequences set forth in Appendix B, provided that the amino acid sequence is not encoded by any of the F-designated genes set forth in Table 1, wherein said polypeptide fragment maintains a biological activity of the polypeptide comprising the amino sequence.
 18. The isolated polypeptide of claim 17, wherein said polypeptide is involved in the production of a fine chemical.
 19. The isolated polypeptide of claim 17, further comprising heterologous amino acid sequences.
 20. A method for diagnosing the presence or activity of Corynebacterium diphtheriae in a subject, comprising detecting the presence of at least one of the nucleic acid molecules of claim 1, thereby diagnosing the presence or activity of Corynebacterium diphtheriae in the subject.
 21. A method for diagnosing the presence or activity of Corynebacterium diphtheriae in a subject, comprising detecting the presence of at least one of the polypeptide molecules of claim 17, thereby diagnosing the presence or activity of Corynebacterium diphtheriae in the subject.
 22. A host cell comprising a nucleic acid molecule selected from the group consisting of a) a nucleic acid molecule set forth in Appendix A, wherein the nucleic acid molecule is disrupted by at least one technique selected from the group consisting of a point mutation, a truncation, an inversion, a deletion, an addition, a substitution and homologous recombination; b) a nucleic acid molecule set forth in Appendix A, wherein the nucleic acid molecule comprises one or more nucleic acid modifications as compared to the sequence set forth in Appendix A, wherein the modification is selected from the group consisting of a point mutation, a truncation, an inversion, a deletion, an addition and a substitution; and c) a nucleic acid molecule set forth in Appendix A, wherein the regulatory region of the nucleic acid molecule is modified relative to the wild-type regulatory region of the molecule by at least one technique selected from the group consisting of a point mutation, a truncation, an inversion, a deletion, an addition, a substitution and homologous recombination. 